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Jae Seung Hong  (Hong JS) 1 Article
Enhancement of Short-Term Memory by Methyl-6-(Phenylethynyl)-Pyridine in the BTBR T+tf/J Mouse Model of Autism Spectrum Disorder
Haijie Yang, Sung-Oh Huh, Jae Seung Hong
Endocrinol Metab. 2015;30(1):98-104.   Published online March 27, 2015
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  • 10 Citations
AbstractAbstract PDFPubReader   

Autism spectrum disorder (ASD) encompasses a range of disorders that are characterized by social and communication deficits and repetitive behaviors. This study evaluated the effect of methyl-6-(phenylethynyl)-pyridine (MPEP), an antagonist of the mGluR5 metabotropic glutamate receptor, on memory enhancement in the BTBR T+tf/J (BTBR) mouse strain, which has been recognized as a model of ASD.


The pharmacological effects of MPEP on memory and motor coordination were assessed using the Morris water maze and rotarod tests in BTBR and C57BL/6J (B6) mice. Furthermore, we performed morphological analyses of cerebellar foliation in BTBR and B6 mice using hematoxylin and eosin staining.


MPEP-treated BTBR mice exhibited improved learning and memory in the Morris water maze test. MPEP administration also improved motor coordination in the rotarod test. However, no significant difference was observed regarding the numbers of Purkinje cells in the cerebella of BTBR versus normal B6 mice.


This study suggests that the mGluR5 antagonist MPEP has the potential to ameliorate learning and memory dysfunction and impaired motor coordination in BTBR mice. These results further suggest that the BTBR mouse model may be useful in pharmacological studies investigating drugs that could potentially alleviate cognitive dysfunction in ASD.


Citations to this article as recorded by  
  • Postweaning social isolation and autism-like phenotype: A biochemical and behavioral comparative analysis
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    Behavioural Brain Research.2022; 428: 113891.     CrossRef
  • Postweaning Social Isolation and Autism-Like Phenotype: A Biochemical and Behavioral Comparative Analysis
    Alessandra Caruso, Laura Ricceri, Angela Caruso, Ferdinando Nicoletti, Alessandra Gaetano, Sergio SCACCIANOCE
    SSRN Electronic Journal .2021;[Epub]     CrossRef
  • Abnormal Cerebellar Development Is Involved in Dystonia-Like Behaviors and Motor Dysfunction of Autistic BTBR Mice
    Rui Xiao, Hongyu Zhong, Xin Li, Yuanyuan Ma, Ruiyu Zhang, Lian Wang, Zhenle Zang, Xiaotang Fan
    Frontiers in Cell and Developmental Biology.2020;[Epub]     CrossRef
  • Common functional variants of the glutamatergic system in Autism spectrum disorder with high and low intellectual abilities
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    Journal of Neural Transmission.2018; 125(2): 259.     CrossRef
  • Targeting mGlu5 Metabotropic Glutamate Receptors in the Treatment of Cognitive Dysfunction in a Mouse Model of Phenylketonuria
    Francesca Nardecchia, Rosamaria Orlando, Luisa Iacovelli, Marco Colamartino, Elena Fiori, Vincenzo Leuzzi, Sonia Piccinin, Robert Nistico, Stefano Puglisi-Allegra, Luisa Di Menna, Giuseppe Battaglia, Ferdinando Nicoletti, Tiziana Pascucci
    Frontiers in Neuroscience.2018;[Epub]     CrossRef
  • The BTBR mouse model of idiopathic autism – Current view on mechanisms
    K.Z. Meyza, D.C. Blanchard
    Neuroscience & Biobehavioral Reviews.2017; 76: 99.     CrossRef
  • Animal models for autism in 2017 and the consequential implications to drug discovery
    Kathryn K. Chadman
    Expert Opinion on Drug Discovery.2017; 12(12): 1187.     CrossRef
  • Dendritic overgrowth and elevated ERK signaling during neonatal development in a mouse model of autism
    Ning Cheng, Fawaz Alshammari, Elizabeth Hughes, Maryam Khanbabaei, Jong M. Rho, Thierry Amédée
    PLOS ONE.2017; 12(6): e0179409.     CrossRef
  • Bridging Autism Spectrum Disorders and Schizophrenia through inflammation and biomarkers - pre-clinical and clinical investigations
    Joana Prata, Susana G. Santos, Maria Inês Almeida, Rui Coelho, Mário A. Barbosa
    Journal of Neuroinflammation.2017;[Epub]     CrossRef
  • Modeling autism-relevant behavioral phenotypes in rats and mice
    Michela Servadio, Louk J.M.J. Vanderschuren, Viviana Trezza
    Behavioural Pharmacology.2015; 26(6): 522.     CrossRef
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