Skip Navigation
Skip to contents

Endocrinol Metab : Endocrinology and Metabolism

clarivate
OPEN ACCESS
SEARCH
Search

Author index

Page Path
HOME > BROWSE ARTICLES > Author index
Search
Jae Eun Chae 1 Article
Clinical Study
Trends in the Diagnosis and Treatment of Patients with Medullary Thyroid Carcinoma in Korea
Hwa Young Ahn, Jae Eun Chae, Hyemi Moon, Junghyun Noh, Young Joo Park, Sin Gon Kim
Endocrinol Metab. 2020;35(4):811-819.   Published online November 20, 2020
DOI: https://doi.org/10.3803/EnM.2020.709
  • 8,714 View
  • 212 Download
  • 18 Web of Science
  • 18 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
Thyroid cancer is becoming increasingly common worldwide, but little is known about the epidemiology of medullary thyroid carcinoma (MTC). This study investigated the current status of the incidence and treatment of MTC using Korean National Health Insurance Service (NHIS) data for the entire Korean population from 2004 to 2016.
Methods
This study included 1,790 MTC patients identified from the NHIS database.
Results
The age-standardized incidence rate showed a slightly decreasing or stationary trend during the period, from 0.25 per 100,000 persons in 2004 to 0.19 in 2016. The average proportion of MTC among all thyroid cancers was 0.5%. For initial surgical treatment, 65.4% of patients underwent total thyroidectomy. After surgery, external-beam radiation therapy (EBRT) was performed in 10% of patients, a proportion that increased from 6.7% in 2004 to 11.0% in 2016. Reoperations were performed in 2.7% of patients (n=49) at a median of 1.9 years of follow-up (interquartile range, 1.2 to 3.4). Since November 2015, 25 (1.4%) patients with MTC were prescribed vandetanib by December 2016.
Conclusion
The incidence of MTC decreased slightly with time, and the proportion of patients who underwent total thyroidectomy was about 65%. EBRT, reoperation, and tyrosine kinase inhibitor therapy are additional treatments after initial surgery for advanced MTC in Korea.

Citations

Citations to this article as recorded by  
  • Digital Phenotyping of Rare Endocrine Diseases Across International Data Networks and the Effect of Granularity of Original Vocabulary
    Seunghyun Lee, Namki Hong, Gyu Seop Kim, Jing Li, Xiaoyu Lin, Sarah Seager, Sungjae Shin, Kyoung Jin Kim, Jae Hyun Bae, Seng Chan You, Yumie Rhee, Sin Gon Kim
    Yonsei Medical Journal.2025; 66(3): 187.     CrossRef
  • Use of Glucagon-Like Peptide-1 Receptor Agonists Does Not Increase the Risk of Cancer in Patients with Type 2 Diabetes Mellitus
    Mijin Kim, Seung Chan Kim, Jinmi Kim, Bo Hyun Kim
    Diabetes & Metabolism Journal.2025; 49(1): 49.     CrossRef
  • Treatment and management of medullary thyroid microcarcinoma: a 10-year retrospective study from a single center
    Bin Liu, Ying Peng, Yanjun Su, Chang Diao, Ruochuan Cheng
    Endocrine.2024; 86(3): 1081.     CrossRef
  • Management of Giant Thyroid Tumors in Patients with Multiple Comorbidities in a Tertiary Head and Neck Surgery Center
    Daniela Vrinceanu, Mihai Dumitru, Andreea Marinescu, Crenguta Serboiu, Gabriela Musat, Mihai Radulescu, Matei Popa-Cherecheanu, Catalina Ciornei, Felicia Manole
    Biomedicines.2024; 12(10): 2204.     CrossRef
  • MicroRNAs in thyroid cancer with focus on medullary thyroid carcinoma: potential therapeutic targets and diagnostic/prognostic markers and web based tools
    ELHAM SHAKIBA, SETI BOROOMAND, SIMA KHERADMAND KIA, MEHDI HEDAYATI
    Oncology Research.2024; 32(6): 1011.     CrossRef
  • Big Data Research in the Field of Endocrine Diseases Using the Korean National Health Information Database
    Sun Wook Cho, Jung Hee Kim, Han Seok Choi, Hwa Young Ahn, Mee Kyoung Kim, Eun Jung Rhee
    Endocrinology and Metabolism.2023; 38(1): 10.     CrossRef
  • Update on C-Cell Neuroendocrine Neoplasm: Prognostic and Predictive Histopathologic and Molecular Features of Medullary Thyroid Carcinoma
    Chan Kwon Jung, Shipra Agarwal, Jen-Fan Hang, Dong-Jun Lim, Andrey Bychkov, Ozgur Mete
    Endocrine Pathology.2023; 34(1): 1.     CrossRef
  • Mouse Models to Examine Differentiated Thyroid Cancer Pathogenesis: Recent Updates
    Hye Choi, Kwangsoon Kim
    International Journal of Molecular Sciences.2023; 24(13): 11138.     CrossRef
  • Partial preservation of the normal thyroid gland based on tumor diameter may be possible in small medullary thyroid carcinoma: a two-center 15-year retrospective study
    Guiming Fu, Xiaoyi Li, Fengli Guo, Xianhui Ruan, Wei Zhang, Weijing Zhang, Yaping Zhang, Yibo Chen, Chunhua Li, Jin Chen, Xiangqian Zheng, Zhaohui Wang, Ming Gao
    Frontiers in Oncology.2023;[Epub]     CrossRef
  • Association of Socioeconomic Status With Long-Term Outcome in Survivors After Out-of-Hospital Cardiac Arrest: Nationwide Population-Based Longitudinal Study
    Kyung Hun Yoo, Yongil Cho, Jaehoon Oh, Juncheol Lee, Byuk Sung Ko, Hyunggoo Kang, Tae Ho Lim, Sang Hwan Lee
    JMIR Public Health and Surveillance.2023; 9: e47156.     CrossRef
  • Preoperative identification of low-risk medullary thyroid carcinoma: potential application to reduce total thyroidectomy
    Hyunju Park, Hyun Jin Ryu, Jung Heo, Man Ki Chung, Young Ik Son, Jung-Han Kim, Soo Yeon Hahn, Jung Hee Shin, Young Lyun Oh, Sun Wook Kim, Jae Hoon Chung, Jee Soo Kim, Tae Hyuk Kim
    Scientific Reports.2023;[Epub]     CrossRef
  • Clinical Characteristics, Surgical Management, and Prognostic Factors of Medullary Thyroid Carcinoma: A Retrospective, Single-Center Study
    Xin Wu, Binglu Li, Chaoji Zheng
    Technology in Cancer Research & Treatment.2022;[Epub]     CrossRef
  • Understanding and Utilizing Claim Data from the Korean National Health Insurance Service (NHIS) and Health Insurance Review & Assessment (HIRA) Database for Research
    Dae-Sung Kyoung, Hun-Sung Kim
    Journal of Lipid and Atherosclerosis.2022; 11(2): 103.     CrossRef
  • Unilateral Surgery for Medullary Thyroid Carcinoma: Seeking for Clinical Practice Guidelines
    Daqi Zhang, Carla Colombo, Hui Sun, Hoon Yub Kim, Antonella Pino, Simone De Leo, Giacomo Gazzano, Luca Persani, Gianlorenzo Dionigi, Laura Fugazzola
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Total thyroidectomy vs thyroid lobectomy for localized medullary thyroid cancer in adults: A propensity-matched survival analysis
    Weili Liang, Jinyuan Shi, Hui Zhang, Guixu Lv, Tiantian Wang, Yong Wang, Bin Lv, Luchuan Li, Qingdong Zeng, Lei Sheng
    Surgery.2022; 172(5): 1385.     CrossRef
  • Constitutive Cytomorphologic Features of Medullary Thyroid Carcinoma Using Different Staining Methods
    Chih-Yi Liu, Chien-Chin Chen, Andrey Bychkov, Shipra Agarwal, Yun Zhu, Jen-Fan Hang, Chiung-Ru Lai, Hee Young Na, So Yeon Park, Weiwei Li, Zhiyan Liu, Deepali Jain, Ayana Suzuki, Mitsuyoshi Hirokawa, Noel Chia, Min En Nga, Tikamporn Jitpasutham, Somboon K
    Diagnostics.2021; 11(8): 1396.     CrossRef
  • Metastatic Lymph Node Ratio for Predicting Recurrence in Medullary Thyroid Cancer
    Jinyoung Kim, Jun Park, Hyunju Park, Min Sun Choi, Hye Won Jang, Tae Hyuk Kim, Sun Wook Kim, Jae Hoon Chung
    Cancers.2021; 13(22): 5842.     CrossRef
  • A High Frequency of Lobectomy Instead of Total Thyroidectomy to Treat Medullary Thyroid Cancer in Korea: Data from the Korean National Health Insurance Service
    Sun Wook Cho
    Endocrinology and Metabolism.2020; 35(4): 784.     CrossRef
Close layer

Endocrinol Metab : Endocrinology and Metabolism
TOP