- Clinical Study
- Trends in the Diagnosis and Treatment of Patients with Medullary Thyroid Carcinoma in Korea
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Hwa Young Ahn, Jae Eun Chae, Hyemi Moon, Junghyun Noh, Young Joo Park, Sin Gon Kim
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Endocrinol Metab. 2020;35(4):811-819. Published online November 20, 2020
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DOI: https://doi.org/10.3803/EnM.2020.709
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Abstract
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- Background
Thyroid cancer is becoming increasingly common worldwide, but little is known about the epidemiology of medullary thyroid carcinoma (MTC). This study investigated the current status of the incidence and treatment of MTC using Korean National Health Insurance Service (NHIS) data for the entire Korean population from 2004 to 2016.
Methods This study included 1,790 MTC patients identified from the NHIS database.
Results The age-standardized incidence rate showed a slightly decreasing or stationary trend during the period, from 0.25 per 100,000 persons in 2004 to 0.19 in 2016. The average proportion of MTC among all thyroid cancers was 0.5%. For initial surgical treatment, 65.4% of patients underwent total thyroidectomy. After surgery, external-beam radiation therapy (EBRT) was performed in 10% of patients, a proportion that increased from 6.7% in 2004 to 11.0% in 2016. Reoperations were performed in 2.7% of patients (n=49) at a median of 1.9 years of follow-up (interquartile range, 1.2 to 3.4). Since November 2015, 25 (1.4%) patients with MTC were prescribed vandetanib by December 2016.
Conclusion The incidence of MTC decreased slightly with time, and the proportion of patients who underwent total thyroidectomy was about 65%. EBRT, reoperation, and tyrosine kinase inhibitor therapy are additional treatments after initial surgery for advanced MTC in Korea.
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Citations
Citations to this article as recorded by 
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Mijin Kim, Seung Chan Kim, Jinmi Kim, Bo Hyun Kim Diabetes & Metabolism Journal.2025; 49(1): 49. CrossRef - Treatment and management of medullary thyroid microcarcinoma: a 10-year retrospective study from a single center
Bin Liu, Ying Peng, Yanjun Su, Chang Diao, Ruochuan Cheng Endocrine.2024; 86(3): 1081. CrossRef - Management of Giant Thyroid Tumors in Patients with Multiple Comorbidities in a Tertiary Head and Neck Surgery Center
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ELHAM SHAKIBA, SETI BOROOMAND, SIMA KHERADMAND KIA, MEHDI HEDAYATI Oncology Research.2024; 32(6): 1011. CrossRef - Big Data Research in the Field of Endocrine Diseases Using the Korean National Health Information Database
Sun Wook Cho, Jung Hee Kim, Han Seok Choi, Hwa Young Ahn, Mee Kyoung Kim, Eun Jung Rhee Endocrinology and Metabolism.2023; 38(1): 10. CrossRef - Update on C-Cell Neuroendocrine Neoplasm: Prognostic and Predictive Histopathologic and Molecular Features of Medullary Thyroid Carcinoma
Chan Kwon Jung, Shipra Agarwal, Jen-Fan Hang, Dong-Jun Lim, Andrey Bychkov, Ozgur Mete Endocrine Pathology.2023; 34(1): 1. CrossRef - Mouse Models to Examine Differentiated Thyroid Cancer Pathogenesis: Recent Updates
Hye Choi, Kwangsoon Kim International Journal of Molecular Sciences.2023; 24(13): 11138. CrossRef - Partial preservation of the normal thyroid gland based on tumor diameter may be possible in small medullary thyroid carcinoma: a two-center 15-year retrospective study
Guiming Fu, Xiaoyi Li, Fengli Guo, Xianhui Ruan, Wei Zhang, Weijing Zhang, Yaping Zhang, Yibo Chen, Chunhua Li, Jin Chen, Xiangqian Zheng, Zhaohui Wang, Ming Gao Frontiers in Oncology.2023;[Epub] CrossRef - Association of Socioeconomic Status With Long-Term Outcome in Survivors After Out-of-Hospital Cardiac Arrest: Nationwide Population-Based Longitudinal Study
Kyung Hun Yoo, Yongil Cho, Jaehoon Oh, Juncheol Lee, Byuk Sung Ko, Hyunggoo Kang, Tae Ho Lim, Sang Hwan Lee JMIR Public Health and Surveillance.2023; 9: e47156. CrossRef - Preoperative identification of low-risk medullary thyroid carcinoma: potential application to reduce total thyroidectomy
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Xin Wu, Binglu Li, Chaoji Zheng Technology in Cancer Research & Treatment.2022;[Epub] CrossRef - Understanding and Utilizing Claim Data from the Korean National Health Insurance Service (NHIS) and Health Insurance Review & Assessment (HIRA) Database for Research
Dae-Sung Kyoung, Hun-Sung Kim Journal of Lipid and Atherosclerosis.2022; 11(2): 103. CrossRef - Unilateral Surgery for Medullary Thyroid Carcinoma: Seeking for Clinical Practice Guidelines
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Weili Liang, Jinyuan Shi, Hui Zhang, Guixu Lv, Tiantian Wang, Yong Wang, Bin Lv, Luchuan Li, Qingdong Zeng, Lei Sheng Surgery.2022; 172(5): 1385. CrossRef - Constitutive Cytomorphologic Features of Medullary Thyroid Carcinoma Using Different Staining Methods
Chih-Yi Liu, Chien-Chin Chen, Andrey Bychkov, Shipra Agarwal, Yun Zhu, Jen-Fan Hang, Chiung-Ru Lai, Hee Young Na, So Yeon Park, Weiwei Li, Zhiyan Liu, Deepali Jain, Ayana Suzuki, Mitsuyoshi Hirokawa, Noel Chia, Min En Nga, Tikamporn Jitpasutham, Somboon K Diagnostics.2021; 11(8): 1396. CrossRef - Metastatic Lymph Node Ratio for Predicting Recurrence in Medullary Thyroid Cancer
Jinyoung Kim, Jun Park, Hyunju Park, Min Sun Choi, Hye Won Jang, Tae Hyuk Kim, Sun Wook Kim, Jae Hoon Chung Cancers.2021; 13(22): 5842. CrossRef - A High Frequency of Lobectomy Instead of Total Thyroidectomy to Treat Medullary Thyroid Cancer in Korea: Data from the Korean National Health Insurance Service
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