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Izuki Amano  (Amano 1) 1 Article
The Role of Thyroid Hormone in the Regulation of Cerebellar Development
Sumiyasu Ishii, Izuki Amano, Noriyuki Koibuchi
Endocrinol Metab. 2021;36(4):703-716.   Published online August 9, 2021
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AbstractAbstract PDFPubReader   ePub   CrossRef-TDMCrossref - TDM
The proper organized expression of specific genes in time and space is responsible for the organogenesis of the central nervous system including the cerebellum. The epigenetic regulation of gene expression is tightly regulated by an intrinsic intracellular genetic program, local stimuli such as synaptic inputs and trophic factors, and peripheral stimuli from outside of the brain including hormones. Some hormone receptors are expressed in the cerebellum. Thyroid hormones (THs), among numerous circulating hormones, are well-known major regulators of cerebellar development. In both rodents and human, hypothyroidism during the postnatal developmental period results in abnormal morphogenesis or altered function. THs bind to the thyroid hormone receptors (TRs) in the nuclei and with the help of transcriptional cofactors regulate the transcription of target genes. Gene regulation by TR induces cell proliferation, migration, and differentiation, which are necessary for brain development and plasticity. Thus, the lack of TH action mediators may directly cause aberrant cerebellar development. Various kinds of animal models have been established in a bid to study the mechanism of TH action in the cerebellum. Interestingly, the phenotypes differ greatly depending on the models. Herein we summarize the actions of TH and TR particularly in the developing cerebellum.


Citations to this article as recorded by  
  • Targeting Thyroid Hormone/Thyroid Hormone Receptor Axis: An Attractive Therapy Strategy in Liver Diseases
    Qianyu Tang, Min Zeng, Linxi Chen, Nian Fu
    Frontiers in Pharmacology.2022;[Epub]     CrossRef
  • Histone Deacetylase 3 Inhibitor Alleviates Cerebellar Defects in Perinatal Hypothyroid Mice by Stimulating Histone Acetylation and Transcription at Thyroid Hormone-Responsive Gene Loci
    Alvin Susetyo, Sumiyasu Ishii, Yuki Fujiwara, Izuki Amano, Noriyuki Koibuchi
    International Journal of Molecular Sciences.2022; 23(14): 7869.     CrossRef
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