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In Kyoung Hwang  (Hwang IK) 2 Articles
Adrenal gland
Acromegaly with Normal Insulin-Like Growth Factor-1 Levels and Congestive Heart Failure as the First Clinical Manifestation
Hyae Min Lee, Sun Hee Lee, In-Ho Yang, In Kyoung Hwang, You Cheol Hwang, Kyu Jeung Ahn, Ho Yeon Chung, Hui-Jeong Hwang, In-Kyung Jeong
Endocrinol Metab. 2015;30(3):395-401.   Published online December 9, 2014
DOI: https://doi.org/10.3803/EnM.2015.30.3.395
  • 4,473 View
  • 44 Download
  • 7 Web of Science
  • 4 Crossref
AbstractAbstract PDFPubReader   

The leading cause of morbidity and mortality in patients with acromegaly is cardiovascular complications. Myocardial exposure to excessive growth hormone can cause ventricular hypertrophy, hypertension, arrhythmia, and diastolic dysfunction. However, congestive heart failure as a result of systolic dysfunction is observed only rarely in patients with acromegaly. Most cases of acromegaly exhibit high levels of serum insulin-like growth factor-1 (IGF-1). Acromegaly with normal IGF-1 levels is rare and difficult to diagnose. Here, we report a rare case of an acromegalic patient whose first clinical manifestation was severe congestive heart failure, despite normal IGF-1 levels. We diagnosed acromegaly using a glucose-loading growth hormone suppression test. Cardiac function and myocardial hypertrophy improved 6 months after transsphenoidal resection of a pituitary adenoma.

Citations

Citations to this article as recorded by  
  • Risk of Neurodegenerative Diseases in Patients With Acromegaly
    Sangmo Hong, Kyungdo Han, Kyung-Soo Kim, Cheol-Young Park
    Neurology.2022;[Epub]     CrossRef
  • Levels of Serum IGF-1, HCY, and Plasma BNP in Patients with Chronic Congestive Heart Failure and Their Relationship with Cardiac Function and Short-Term Prognosis
    Zhengyi Hu, Leifang Mao, Ling Wang, Weiguo Li
    Evidence-Based Complementary and Alternative Medicine.2022; 2022: 1.     CrossRef
  • Neurofibromatosis Type 1 with Concurrent Multiple Endocrine Disorders: Adenomatous Goiter, Primary Hyperparathyroidism, and Acromegaly
    Shigemitsu Yasuda, Ikuo Inoue, Akira Shimada
    Internal Medicine.2021; 60(15): 2451.     CrossRef
  • Metformin stimulates IGFBP-2 gene expression through PPARalpha in diabetic states
    Hye Suk Kang, Ho-Chan Cho, Jae-Ho Lee, Goo Taeg Oh, Seung-Hoi Koo, Byung-Hyun Park, In-Kyu Lee, Hueng-Sik Choi, Dae-Kyu Song, Seung-Soon Im
    Scientific Reports.2016;[Epub]     CrossRef
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Thyroid
Celiac Disease in a Predisposed Subject (HLA-DQ2.5) with Coexisting Graves' Disease
In Kyoung Hwang, Seon Hye Kim, Unjoo Lee, Sang Ouk Chin, Sang Youl Rhee, Seungjoon Oh, Jeong-Taek Woo, Sung-Woon Kim, Young Seol Kim, Suk Chon
Endocrinol Metab. 2015;30(1):105-109.   Published online March 27, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.1.105
  • 3,873 View
  • 32 Download
  • 5 Web of Science
  • 4 Crossref
AbstractAbstract PDFPubReader   

Celiac disease is an intestinal autoimmune disorder, triggered by ingestion of a gluten-containing diet in genetically susceptible individuals. The genetic predisposition is related to human leukocyte antigen (HLA) class II genes, especially HLA-DQ2-positive patients. The prevalence of celiac disease has been estimated to be ~1% in Europe and the USA, but it is rarer and/or underdiagnosed in Asia. We report a case of celiac disease in a predisposed patient, with a HLA-DQ2 heterodimer, and Graves' disease that was treated successfully with a gluten-free diet. A 47-year-old woman complained of persistent chronic diarrhea and weight loss over a 9 month period. Results of all serological tests and stool exams were negative. However, the patient was found to carry the HLA DQ2 heterodimer. Symptoms improved after a gluten-free diet was initiated. The patient has been followed and has suffered no recurrence of symptoms while on the gluten-free diet. An overall diagnosis of celiac disease was made in a genetically predisposed patient (HLA-DQ2 heterodimer) with Graves' disease.

Citations

Citations to this article as recorded by  
  • Celiac Disease Genetics, Pathogenesis, and Standard Therapy for Japanese Patients
    Tasuku Tamai, Kenji Ihara
    International Journal of Molecular Sciences.2023; 24(3): 2075.     CrossRef
  • Underutilization of diagnostic assays for celiac disease in Korea
    Rihwa Choi, Sang Gon Lee, Eun Hee Lee
    Journal of Clinical Laboratory Analysis.2021;[Epub]     CrossRef
  • Olmesartan is not associated with the risk of enteropathy: a Korean nationwide observational cohort study
    Seng Chan You, Hojun Park, Dukyong Yoon, Sooyoung Park, Boyoung Joung, Rae Woong Park
    The Korean Journal of Internal Medicine.2019; 34(1): 90.     CrossRef
  • Prevalence of celiac disease in Asia: A systematic review and meta‐analysis
    Prashant Singh, Shubhangi Arora, Alka Singh, Tor A Strand, Govind K Makharia
    Journal of Gastroenterology and Hepatology.2016; 31(6): 1095.     CrossRef
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