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Il-Young Kim 1 Article
Diabetes
In Vivo and In Vitro Quantification of Glucose Kinetics: From Bedside to Bench
Il-Young Kim, Sanghee Park, Yeongmin Kim, Yewon Chang, Cheol Soo Choi, Sang-Hoon Suh, Robert R. Wolfe
Endocrinol Metab. 2020;35(4):733-749.   Published online December 23, 2020
DOI: https://doi.org/10.3803/EnM.2020.406
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  • 3 Crossref
AbstractAbstract PDFPubReader   ePub   
Like other substrates, plasma glucose is in a dynamic state of constant turnover (i.e., rates of glucose appearance [Ra glucose] into and disappearance [Rd glucose] from the plasma) while staying within a narrow range of normal concentrations, a physiological priority. Persistent imbalance of glucose turnover leads to elevations (i.e., hyperglycemia, Ra>Rd) or falls (i.e., hypoglycemia, Ra<Rd) in the pool size, leading to clinical conditions such as diabetes. Endogenous Ra glucose is divided into hepatic glucose production via glycogenolysis and gluconeogenesis (GNG) and renal GNG. On the other hand, Rd glucose, the summed rate of glucose uptake by tissues/organs, involves various intracellular metabolic pathways including glycolysis, the tricarboxylic acid (TCA) cycle, and oxidation at varying rates depending on the metabolic status. Despite the dynamic nature of glucose metabolism, metabolic studies typically rely on measurements of static, snapshot information such as the abundance of mRNAs and proteins and (in)activation of implicated signaling networks without determining actual flux rates. In this review, we will discuss the importance of obtaining kinetic information, basic principles of stable isotope tracer methodology, calculations of in vivo glucose kinetics, and assessments of metabolic flux in experimental models in vivo and in vitro.

Citations

Citations to this article as recorded by  
  • Postabsorptive and postprandial glucose and fat metabolism in postmenopausal women with breast cancer—Preliminary data after chemotherapy compared to healthy controls
    Kristian Buch-Larsen, Linn Gillberg, Haboon Ismail Ahmed, Simone Diedrichsen Marstrand, Michael Andersson, Gerrit van Hall, Charlotte Brøns, Peter Schwarz
    Nutrition.2024; 122: 112394.     CrossRef
  • Essential Amino Acid-Enriched Diet Alleviates Dexamethasone-Induced Loss of Muscle Mass and Function through Stimulation of Myofibrillar Protein Synthesis and Improves Glucose Metabolism in Mice
    Yeongmin Kim, Sanghee Park, Jinseok Lee, Jiwoong Jang, Jiyeon Jung, Jin-Ho Koh, Cheol Soo Choi, Robert R. Wolfe, Il-Young Kim
    Metabolites.2022; 12(1): 84.     CrossRef
  • Exploring Human Muscle Dynamics In Vivo Using Stable Isotope Tracers
    Il-Young Kim, Sanghee Park, Jiwoong Jang, Yeongmin Kim, Hee-Joo Kim
    Annals of Clinical Nutrition and Metabolism.2022; 14(2): 40.     CrossRef
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