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Hyung Jin Choi  (Choi HJ) 10 Articles
Obesity and Metabolism
Digital Therapeutics for Obesity and Eating-Related Problems
Meelim Kim, Hyung Jin Choi
Endocrinol Metab. 2021;36(2):220-228.   Published online March 24, 2021
DOI: https://doi.org/10.3803/EnM.2021.107
  • 9,821 View
  • 418 Download
  • 14 Web of Science
  • 17 Crossref
AbstractAbstract PDFPubReader   ePub   
In recent years, digital technologies have rapidly advanced and are being applied to remedy medical problems. These technologies allow us to monitor and manage our physical and mental health in our daily lives. Since lifestyle modification is the cornerstone of the management of obesity and eating behavior problems, digital therapeutics (DTx) represent a powerful and easily accessible treatment modality. This review discusses the critical issues to consider for enhancing the efficacy of DTx in future development initiatives. To competently adapt and expand public access to DTx, it is important for various stakeholders, including health professionals, patients, and guardians, to collaborate with other industry partners and policy-makers in the ecosystem.

Citations

Citations to this article as recorded by  
  • What digital health technology types are used in mental health prevention and intervention? Review of systematic reviews for systematization of technologies
    Naomichi Tani, Hiroaki Fujihara, Kenji Ishii, Yoshiyuki Kamakura, Mafu Tsunemi, Chikae Yamaguchi, Hisashi Eguchi, Kotaro Imamura, Satoru Kanamori, Noriko Kojimahara, Takeshi Ebara
    Journal of Occupational Health.2024;[Epub]     CrossRef
  • Randomized controlled trial of digital therapeutics for temporomandibular disorder: A pilot study
    Sang-Yoon Park, Soo-Hwan Byun, Byoung-Eun Yang, Daehyun Kim, Bongju Kim, Jong-Ho Lee, Young-Kyun Kim
    Journal of Dentistry.2024; 147: 105030.     CrossRef
  • Comparing the Efficacy of Digital and In-Person Weight Loss Interventions for Patients with Obesity and Glycemic Disorders: Evidence from a Randomized Non-Inferiority Trial
    Katarína Moravcová, Markéta Sovová, Jaromír Ožana, Martina Karbanová, Jan Klásek, Agnieszka Barbara Kolasińska, Eliška Sovová
    Nutrients.2024; 16(10): 1510.     CrossRef
  • Feasibility and Acceptability Evaluation of a Digital Therapeutic Program for Improving Cancer Prevention: A Quasi-experimental Pre-post Interventional Pilot Study
    Xianwei Zhang, Sheng Zhang, Haiyan Zhang, Ziyou Xiong, Yi Li, Lufeng Li, Xitian Pi, Hongying Liu
    Journal of Cancer Education.2024;[Epub]     CrossRef
  • Digital therapeutics from bench to bedside
    Changwon Wang, Chungkeun Lee, Hangsik Shin
    npj Digital Medicine.2023;[Epub]     CrossRef
  • Digital Therapeutics: Emerging New Therapy for Nonalcoholic Fatty Liver Disease
    Run Zhou, Yunpeng Gu, Binbin Zhang, Tingting Kong, Wei Zhang, Jie Li, Junping Shi
    Clinical and Translational Gastroenterology.2023; 14(4): e00575.     CrossRef
  • KIOS: A smartphone app for self‐monitoring for patients with bipolar disorder
    Mehak Pahwa, Susan L. McElroy, Richard Priesmeyer, Gregg Siegel, Phyllis Siegel, Sharon Nuss, Charles L. Bowden, Rif S. El‐Mallakh
    Bipolar Disorders.2023;[Epub]     CrossRef
  • Digital Therapeutics as a New Therapeutic Modality: A Review from the Perspective of Clinical Pharmacology
    Benjamin Ribba, Richard Peck, Lucy Hutchinson, Imein Bousnina, Dario Motti
    Clinical Pharmacology & Therapeutics.2023; 114(3): 578.     CrossRef
  • eHealth in obesity care
    Bukhosi Raymond Sithole, Yannis Pappas, Gurch Randhawa
    Clinical Medicine.2023; 23(4): 347.     CrossRef
  • Strategies for Long-Term Weight Loss and Maintenance
    Yoo-Bin Seo
    Korean Journal of Family Practice.2023; 13(3): 128.     CrossRef
  • Implications of immersive technologies in healthcare sector and its built environment
    Eunsil Yang
    Frontiers in Medical Technology.2023;[Epub]     CrossRef
  • Cost-effectiveness analysis of digital therapeutics for home-based cardiac rehabilitation for patients with atrial fibrillation after catheter ablation
    Tianyi Liu, Zhijie Tang, Cheng Cai, Nan Wu, Jian Jia, Gang Yang, Wenhong Zhang
    DIGITAL HEALTH.2023;[Epub]     CrossRef
  • Cost-effectiveness analysis of digital therapeutics for home-based cardiac rehabilitation for patients with chronic heart failure: model development and data analysis
    Tianyi Liu, Yiyang Zhan, Silei Chen, Wenhong Zhang, Jian Jia
    Cost Effectiveness and Resource Allocation.2023;[Epub]     CrossRef
  • Comprehensive traditional East Asian medicine treatment strategy for obesity considering the therapeutic effects and adverse events
    Hongmin Chu, Byungsoo Kang, Bo-Young Youn, Kwan-il Kim, Jinbong Park, Jungtae Leem
    Medicine.2022; 101(6): e28673.     CrossRef
  • Clinical Evaluation of Digital Therapeutics: Present and Future
    Ki Young Huh, Jaeseong Oh, SeungHwan Lee, Kyung-Sang Yu
    Healthcare Informatics Research.2022; 28(3): 188.     CrossRef
  • Health-Related Indicators Measured Using Earable Devices: Systematic Review
    Jin-Young Choi, Seonghee Jeon, Hana Kim, Jaeyoung Ha, Gyeong-suk Jeon, Jeong Lee, Sung-il Cho
    JMIR mHealth and uHealth.2022; 10(11): e36696.     CrossRef
  • Clinical Efficacy of a Digital Intervention for Patients with Atopic Dermatitis: a Prospective Single-Center Study
    Sigrídur Lára Gudmundsdóttir, Tommaso Ballarini, María L. Ámundadóttir, Judit Mészáros, Jenna H. Eysteinsdóttir, Ragna H. Thorleifsdóttir, Sigrídur K. Hrafnkelsdóttir, Heida B. Bragadóttir, Saemundur Oddsson, Jonathan I. Silverberg
    Dermatology and Therapy.2022; 12(11): 2601.     CrossRef
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Clinical Study
Association between Bsm1 Polymorphism in Vitamin D Receptor Gene and Diabetic Retinopathy of Type 2 Diabetes in Korean Population
Yong Joo Hong, Eun Seok Kang, Myoung Jin Ji, Hyung Jin Choi, Taekeun Oh, Sung-Soo Koong, Hyun Jeong Jeon
Endocrinol Metab. 2015;30(4):469-474.   Published online December 31, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.4.469
  • 4,295 View
  • 50 Download
  • 23 Web of Science
  • 22 Crossref
AbstractAbstract PDFPubReader   
Background

Type 2 diabetes is one of the most common diseases with devastating complications. However, genetic susceptibility of diabetic complications has not been clarified. The vitamin D endocrine system is related with calcification and lipolysis, insulin secretion, and may be associated with many complicated disease including diabetes and cardiovascular disease. Recent studies reported that single nucleotide polymorphisms of vitamin D receptor (VDR) gene were associated with diabetic complications.

Methods

In present study, we evaluated the association of BsmI polymorphism of VDR with diabetic complications in Korean diabetes patients. Total of 537 type 2 diabetic subjects from the Endocrinology Clinic of Chungbuk National University Hospital were investigated. Polymerase chain reaction-restriction fragment length polymorphism was used to test the genotype and allele frequency of BsmI (rs1544410; BB, Bb, bb) polymorphisms.

Results

Mean age was 62.44±10.64 years and mean disease duration was 13.65±7.39 years. Patients with B allele (BB or Bb) was significantly associated with lower risk of diabetic retinopathy (severe non-proliferative diabetic retinopathy or proliferative retinopathy; 7.4%, 5/68) compared with patients without B allele (bb; 17.3%, 81/469; P=0.035). This association was also significant after adjusting for hemoglobin A1c level, body mass index, age, sex, and diabetes mellitus duration, concurrent dyslipidemia and hypertension (odds ratio, 2.99; 95% confidence interval, 1.08 to 8.29; P=0.035) in logistic regression analysis.

Conclusion

Our findings suggest that B allele of Bsm1 polymorphism in VDR gene is associated with lower risk of diabetic retinopathy in type 2 diabetic patients. Bsm1 genotype could be used as a susceptibility marker to predict the risk of diabetes complication.

Citations

Citations to this article as recorded by  
  • Association analysis between the VDR gene variants and type 2 diabetes
    Shabnam Salehizadeh, Sara Ramezani, Mojgan Asadi, Mahdi Afshari, Seyed Hamid Jamaldini, Farhad Adhami Moghadam, Mandana Hasanzad
    Journal of Diabetes & Metabolic Disorders.2023;[Epub]     CrossRef
  • The Vitamin D Receptor Bsm1 Variant is not Associated With Temporomandibular Disorder With or Without Bruxism
    Serkan YILDIZ, Serbülent YİĞİT, Ayşe Feyda NURSAL, Nevin KARAKUŞ, Mehmet Kemal TÜMER
    ADO Klinik Bilimler Dergisi.2023;[Epub]     CrossRef
  • Metabolic impact of the VDR rs1544410 in diabetic retinopathy
    Caroline Severo de Assis, Tainá Gomes Diniz, João Otávio Scarano Alcântara, Vanessa Polyana Alves de Sousa Brito, Rayner Anderson Ferreira do Nascimento, Mayara Karla dos Santos Nunes, Alexandre Sérgio Silva, Isabella Wanderley de Queiroga Evangelista, Ma
    PLOS ONE.2022; 17(2): e0263346.     CrossRef
  • Vitamin D, the Vitamin D Receptor, Calcitriol Analogues and Their Link with Ocular Diseases
    Miłosz Caban, Urszula Lewandowska
    Nutrients.2022; 14(11): 2353.     CrossRef
  • Vitamin D-Related Single Nucleotide Polymorphisms as Risk Biomarker of Cardiovascular Disease
    Paula González Rojo, Cristina Pérez Ramírez, José María Gálvez Navas, Laura Elena Pineda Lancheros, Susana Rojo Tolosa, María del Carmen Ramírez Tortosa, Alberto Jiménez Morales
    International Journal of Molecular Sciences.2022; 23(15): 8686.     CrossRef
  • Effects of Vitamin D Receptor Genotype on Lipid Profiles and Retinopathy Risk in Type 2 Diabetes Patients: A Pilot Study
    Hussam Alhawari, Yazun Jarrar, Dina Abulebdah, Sara J. Abaalkhail, Marah Alkhalili, Sura Alkhalili, Hussein Alhawari, Munther Momani, Mohammed N. Obeidat, Rand K. Fram, Mohammad A. Salahat, Su-Jun Lee
    Journal of Personalized Medicine.2022; 12(9): 1488.     CrossRef
  • Relation of vitamin D and BsmI variant with temporomandibular diseases in the Turkish population
    S. Yildiz, M.K. Tumer, S. Yigit, A.F. Nursal, A. Rustemoglu, Y. Balel
    British Journal of Oral and Maxillofacial Surgery.2021; 59(5): 555.     CrossRef
  • The relationship between vitamin D receptor (VDR) rs2228570 and rs7975232 genetic variants and the risk of recurrent pregnancy loss
    Zohreh Salari, Nasrollah Saleh-Gohari, Monire Rezapour, Ahamad Khosravi, Hadi Tavakkoli, Ehsan Salarkia, Fatemeh Karami-Robati
    Meta Gene.2021; 27: 100833.     CrossRef
  • Association of Bone Metabolism Indices and Bone Mineral Density with Diabetic Retinopathy in Elderly Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Inpatient Study in China
    Xin Zhao, Lili Huo, Xiaofeng Yu, Xiaomei Zhang, Fabio Vescini
    Journal of Diabetes Research.2021; 2021: 1.     CrossRef
  • The Associations Between Vitamin D Receptor BsmI and ApaI Polymorphisms and Obesity in Korean Patients with Type 2 Diabetes Mellitus
    Sang Won Nam, Jinwoo Choi, Hyun Jeong Jeon, Tae Keun Oh, Dong-Hwa Lee
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2021; Volume 14: 557.     CrossRef
  • Vitamin D Deficiency at Mid-Pregnancy Is Associated with a Higher Risk of Postpartum Glucose Intolerance in Women with Gestational Diabetes Mellitus
    Kyung-Soo Kim, Seok Won Park, Yong-Wook Cho, Soo-Kyung Kim
    Endocrinology and Metabolism.2020; 35(1): 97.     CrossRef
  • The role of vitamin D in the pathogenesis and treatment of diabetes mellitus: a narrative review
    Maria Grammatiki, Spiros Karras, Kalliopi Kotsa
    Hormones.2019; 18(1): 37.     CrossRef
  • Vitamin D-binding protein and vitamin D receptor genotypes and 25-hydroxyvitamin D levels are associated with development of aortic and mitral valve calcification and coronary artery diseases
    Amir Kiani, Ehsan Mohamadi-Nori, Asad Vaisi-Raygani, Maryam Tanhapour, Said Elahi-Rad, Fariborz Bahrehmand, Zohreh Rahimi, Tayebeh Pourmotabbed
    Molecular Biology Reports.2019; 46(5): 5225.     CrossRef
  • Is Hypovitaminosis D Related to Incidence of Type 2 Diabetes and High Fasting Glucose Level in Healthy Subjects: A Systematic Review and Meta-Analysis of Observational Studies
    Shamaila Rafiq, Per Jeppesen
    Nutrients.2018; 10(1): 59.     CrossRef
  • Association between the vitamin D receptor gene polymorphisms and diabetic nephropathy risk: A meta‐analysis
    Fang Yin, Jing Liu, Ming‐Xiu Fan, Xiao‐Li Zhou, Xiao‐Ling Zhang
    Nephrology.2018; 23(2): 107.     CrossRef
  • BSMI single nucleotide polymorphism in vitamin D receptor gene is associated with decreased circulatory levels of serum 25-hydroxyvitamin D among micro and macrovascular complications of type 2 diabetes mellitus
    Krishnamoorthy Ezhilarasi, Umapathy Dhamodharan, Viswanathan Vijay
    International Journal of Biological Macromolecules.2018; 116: 346.     CrossRef
  • Diabetic macular oedema: under‐represented in the genetic analysis of diabetic retinopathy
    Suzanne Broadgate, Christine Kiire, Stephanie Halford, Victor Chong
    Acta Ophthalmologica.2018; 96(A111): 1.     CrossRef
  • Expression of JAZF1, ABCC8, KCNJ11and Notch2 genes and vitamin D receptor polymorphisms in type 2 diabetes, and their association with microvascular complications
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    Therapeutic Advances in Endocrinology and Metabolism.2017; 8(6): 97.     CrossRef
  • Vitamin D and diabetes mellitus: Causal or casual association?
    M. Grammatiki, E. Rapti, S. Karras, R. A. Ajjan, Kalliopi Kotsa
    Reviews in Endocrine and Metabolic Disorders.2017; 18(2): 227.     CrossRef
  • The Association between Vitamin D Deficiency and Diabetic Retinopathy in Type 2 Diabetes: A Meta-Analysis of Observational Studies
    Bang-An Luo, Fan Gao, Lu-Lu Qin
    Nutrients.2017; 9(3): 307.     CrossRef
  • The Association between VDR Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Systematic Review and Meta-Analysis
    Yun Zhang, Wei Xia, Ping Lu, Huijuan Yuan
    BioMed Research International.2016; 2016: 1.     CrossRef
  • Candidate gene studies of diabetic retinopathy in human
    Petra Priščáková, Gabriel Minárik, Vanda Repiská
    Molecular Biology Reports.2016; 43(12): 1327.     CrossRef
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A Case of Lingual Thyroid Treated by 131I Ablation.
Myeong Ho Yeon, Yong Hyeok Choi, Young Rak Choi, Woo Ri Park, Hyung Jin Choi, Tae Keun Oh, Hyun Jeong Jeon
Endocrinol Metab. 2012;27(4):303-307.   Published online December 20, 2012
DOI: https://doi.org/10.3803/EnM.2012.27.4.303
  • 1,928 View
  • 26 Download
AbstractAbstract PDF
A lingual thyroid is a rare developmental anomaly caused by the failure of the descent of the thyroid gland anlage early in the course of embryogenesis. The incidence of lingual thyroid has been reported to be 1/100,000. Lingual thyroid is often asymptomatic but may cause dysphagia, dysphonia, upper airway obstruction and hemorrhage. In this report, we described the case of a 50-year-old women experiencing lingual thyroid who had subclinical hypothyroidism. She underwent successful 131I ablation and has done well on thyroid hormone replacement therapy.
Close layer
Characterization of Incidentally Detected Adrenal Pheochromocytoma.
Ye An Kim, Yul Hwangbo, Min Joo Kim, Hyung Jin Choi, Je Hyun Seo, Yenna Lee, Soo Heun Kwak, Eu Jeong Ku, Tae Jung Oh, Eun Roh, Jae Hyun Bae, Jung Hee Kim, Kyoung Soo Park, Seong Yeon Kim
Endocrinol Metab. 2012;27(2):132-137.   Published online June 20, 2012
DOI: https://doi.org/10.3803/EnM.2012.27.2.132
  • 2,417 View
  • 30 Download
  • 3 Crossref
AbstractAbstract PDF
BACKGROUND
In approach to an adrenal incidentaloma, early exclusion of pheochromocytoma is clinically important, due to the risk of catecholamine crisis. The aims of this study are to investigate the characteristics of incidentally detected pheochromocytomas, compared with that of the other adrenal incidentalomas, and to compare these characteristics with those of symptomatic pheochromocytomas. METHODS: In this retrospective study, we reviewed the medical records of 198 patients with adrenal incidentaloma from 2001 to 2010. We analyzed the clinical, laboratory and radiological data of pheochromocytomas, in comparison with those of the other adrenal incidentalomas. We also compared the characteristics of these incidentally detected pheochromocytomas with the medical records of 28 pathologically proven pheochromocytomas, diagnosed based on typical symptoms. RESULTS: Among the 198 patients with adrenal incidentaloma, nineteen patients were diagnosed with pheochromocytoma. Pheochromocytomas showed larger size and higher Hounsfield unit at precontrast computed tomography (CT) than did non-pheochromocytomas. All pheochromocytomas were larger than 2.0 cm, and the Hounsfield units were 19 or higher in precontrast CT. When both criteria of size > 2.0 cm and Hounsfield unit > 19 were met, the sensitivity and specificity for the diagnosis of pheochromocytoma were 100% and 79.3%, respectively. Compared with patients with pheochromocytoma, diagnosed based on typical symptoms, patients with incidentally detected pheochromocytoma were older, presented less often with hypertension, and showed lower levels of 24-hour urine metanephrine. CONCLUSION: Adrenal incidentaloma with < 2.0 cm in size or < or = 19 Hounsfield units in precontrast CT imaging was less likely to be a pheochromocytoma. Patients with incidentally discovered pheochromocytoma showed lower catecholamine metabolites, compared with those patients with symptomatic pheochromocytoma.

Citations

Citations to this article as recorded by  
  • Guidelines for the Management of Adrenal Incidentaloma: the Korean Endocrine Society, Committee of Clinical Practice Guidelines
    Jung-Min Lee, Mee Kyoung Kim, Seung-Hyun Ko, Jung-Min Koh, Bo-Yeon Kim, Sang-Wan Kim, Soo-Kyung Kim, Hae-Jin Kim, Ohk-Hyun Ryu, Juri Park, Jung-Soo Lim, Seong Yeon Kim, Young Kee Shong, Soon Jib Yoo
    The Korean Journal of Medicine.2017; 92(1): 4.     CrossRef
  • Clinical Guidelines for the Management of Adrenal Incidentaloma
    Jung-Min Lee, Mee Kyoung Kim, Seung-Hyun Ko, Jung-Min Koh, Bo-Yeon Kim, Sang Wan Kim, Soo-Kyung Kim, Hae Jin Kim, Ohk-Hyun Ryu, Juri Park, Jung Soo Lim, Seong Yeon Kim, Young Kee Shong, Soon Jib Yoo
    Endocrinology and Metabolism.2017; 32(2): 200.     CrossRef
  • Characterization of Incidentally Detected Adrenal Pheochromocytoma
    Soon Jib Yoo, Woohyeon Kim
    Endocrinology and Metabolism.2012; 27(2): 116.     CrossRef
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Primary Hyperaparathyroidism due to Cystic Parathyroid Adenoma not Detected on 99mTc-Sestamibi Scan.
Ah Reum Khang, Eun Ki Kim, Eun Young Nam, Sun Ju Byeon, Jung Hee Kim, Jung Hun Ohn, Eun Shil Hong, Hyung Jin Choi, Kyeong Cheon Jung, Myung Whun Sung, Chan Soo Shin, Kyong Soo Park, Seong Yeon Kim
Endocrinol Metab. 2012;27(1):83-88.   Published online March 1, 2012
DOI: https://doi.org/10.3803/EnM.2012.27.1.83
  • 41,990 View
  • 30 Download
  • 2 Crossref
AbstractAbstract PDF
Parathyroid cysts, which can be divided into functional and non-functional cysts, are rare causes of primary hyperparathyroidism. A technetium-99m-methoxyisobutylisonitrile (99mTc-sestamibi) parathyroid scan is a sensitive diagnostic tool for the localization, although it sometimes shows a false-negative result. Here we report a case of presumed cystic parathyroid adenoma based on clinical findings and analysis of cystic fluid with negative findings in a parathyroid scan. A 44-year-old male patient visited the hospital due to leg pain and compressive symptoms (dysphagia, hoarseness) that had started 4-5 months before. His serum calcium level was 14.4 mg/dL and his intact parathyroid hormone (iPTH) had increased to 478.1 pg/mL. On neck computed tomography, a cystic nodule measuring 6.2 cm was detected in the inferior part of the right thyroid gland. Sestamibi uptake for this nodule was not detected on 2-h delayed imaging, and fluorodeoxyglucose positron emission tomography showed only subtle uptake. Fine-needle aspiration was performed and intracystic iPTH had increased to 61,600 pg/mL. Focused parathyroidectomy guided by intraoperative iPTH monitoring led to successful enucleation of the right inferior parathyroid gland. A parathyroid adenoma was confirmed, and his laboratory results had normalized. This study shows that cystic parathyroid adenoma can sometimes be difficult to detect on a 99mTc-sestamibi parathyroid scan.

Citations

Citations to this article as recorded by  
  • Functional parathyroid cystic adenoma: A rare cause of hypercalcemic crisis with primary hyperparathyroidism
    BS Sumana, M Sabaretnam, Vijaya Sarathi, Akshatha Savith
    Indian Journal of Pathology and Microbiology.2015; 58(4): 487.     CrossRef
  • Normocalcemic primary hyperparathyroidism: long-term follow-up associated with multiple adenomas
    Larissa Pimentel, Sirley Portela, Alyne Loureiro, Francisco Bandeira
    Arquivos Brasileiros de Endocrinologia & Metabologia.2014; 58(5): 583.     CrossRef
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Medical Service Utilization with Osteoporosis.
Sunmee Jang, Chanmi Park, Suhyun Jang, Hyun Koo Yoon, Chan Soo Shin, Deog Yoon Kim, Yong Chan Ha, Seong Su Lee, Hyung Jin Choi, Young Kyun Lee, Bom Taeck Kim, Ji Yeob Choi
Endocrinol Metab. 2010;25(4):326-339.   Published online December 1, 2010
DOI: https://doi.org/10.3803/EnM.2010.25.4.326
  • 3,090 View
  • 54 Download
  • 43 Crossref
AbstractAbstract PDF
BACKGROUND
Although osteoporosis is increasing in the elderly population, attempts to analyze the patterns of medical service utilization for osteoporosis are currently not sufficient. The medical services and treatment patterns were investigated using Korea's National Health Insurance claims data, which includes all of the Korean population. METHODS: Through the patient identification algorithm developed by using the administrative claims data in 2007, the adult patients (between 50-100 years) with osteoporosis were identified. The age and gender of the patients who used medical service for osteoporosis were described, in relation with six dichotomous variables. The medical service use patterns such as the type of medical institution and conducting bone mineral density measurement were investigated. RESULTS: The number of patients who used medical service were 1,230,580 (females 89.9%). Sixty one point six percent of the patients were prescribed osteoporosis medicine (indicated for osteoporosis only), and 12.9% of the patients had experienced osteoporotic fracture. The primary medical institutions for treatment were clinics (54.3%), while hospitals were mainly used among the patients with a history of fracture and disease or drug use that may induce secondary osteoporosis. The number of visited medical institutions was 6.4 (as an outpatient) and 0.2 (as admissions) during 6 months. The proportion of patients who conducted bone mineral density measurements within one year before and after the diagnosis of osteoporosis was 66.7% and DXA was the most frequently used densitometry (46.3%). The average number of days for the prescriptions for osteoporosis medicine was 70 days. CONCLUSION: In order to prevent further osteoporotic fractures, appropriate management and treatment should be implemented for osteoporosis patients. To do this, we need to understand the current state of medical service utilization and the treatment of osteoporosis using the National Health Insurance claims data.

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    Jung-Yoon Kang, Leejung Choi, Ben Johnson, Hyowon Yang
    Journal of Bone Metabolism.2022; 29(2): 83.     CrossRef
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    Yejee Lim, Jeonghoon Ha, Kun Ho Yoon, Ki Hyun Baek, Moo-Il Kang
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    Healthcare.2021; 9(3): 324.     CrossRef
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    Jihae Jeong, Ju-Young Shin
    Korean Journal of Clinical Pharmacy.2021; 31(1): 27.     CrossRef
  • Estimating the future clinical and economic benefits of improving osteoporosis diagnosis and treatment among women in South Korea: a simulation projection model from 2020 to 2040
    Micah Jackson, Kyu Hyun Yang, Matthew Gitlin, Zachary Wessler
    Archives of Osteoporosis.2021;[Epub]     CrossRef
  • Long-Term Effect of Diabetes on Reoperation After Lumbar Spinal Surgery: A Nationwide Population-Based Sample Cohort Study
    Chang-Hyun Lee, Chi Heon Kim, Chun Kee Chung, Yunhee Choi, Min-Jung Kim, Dahae Yim, Seung Heon Yang, Dong Hwan Kim, Young San Ko, Sung Bae Park
    World Neurosurgery.2020; 139: e439.     CrossRef
  • Incidence and Management Trends of Osteoporotic Vertebral Compression Fractures in South Korea: A Nationwide Population-Based Study
    Sung Hoon Choi, Dong-Yun Kim, Ja Wook Koo, Seung Gun Lee, Soo-Young Jeong, Chang-Nam Kang
    Asian Spine Journal.2020; 14(2): 220.     CrossRef
  • Identification of herpes zoster high‐risk group using Charlson comorbidity index: A nationwide retrospective cohort study
    Soo Ick Cho, Dong Hun Lee, Young Min Park
    The Journal of Dermatology.2020; 47(1): 47.     CrossRef
  • The Impact of Korean Medicine Treatment on the Incidence of Parkinson’s Disease in Patients with Inflammatory Bowel Disease: A Nationwide Population-Based Cohort Study in South Korea
    Hyeonseok Noh, Jeongju Jang, Seungwon Kwon, Seung-Yeon Cho, Woo-Sang Jung, Sang-Kwan Moon, Jung-Mi Park, Chang-Nam Ko, Ho Kim, Seong-Uk Park
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    Jong-myung Jung, Chun Kee Chung, Chi Heon Kim, Yunhee Choi, Min-Jung Kim, Dahae Yim, Seung Heon Yang, Chang Hyun Lee, Sung Hwan Hwang, Dong Hwan Kim, Joon Ho Yoon, Sung Bae Park
    Spine.2020; 45(18): 1277.     CrossRef
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    Ja Seo Koo, Seong Hwan Moon, Hankil Lee, Sohee Park, Yun Mi Yu, Hye-Young Kang, Robert Daniel Blank
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A Case of Aortic Dissection Associated with Cushing's Syndrome.
Soo Heon Kwak, Eun Jung Lee, Sun Wook Cho, Hyung Jin Choi, Eun Kyung Lee, Young Min Cho, Seong Yeon Kim
J Korean Endocr Soc. 2006;21(6):556-559.   Published online December 1, 2006
DOI: https://doi.org/10.3803/jkes.2006.21.6.556
  • 1,816 View
  • 26 Download
AbstractAbstract PDF
Herein is reported the case of a 43-year-old woman, who experienced an acute aortic dissection associated with underlying Cushing's syndrome. The patient had central obesity and a moon face of ten years duration, but had never sought medical consultation. On the day of her presentation, she experienced a severe chest pain radiating to her back. Computed tomography revealed a Stanford type B acute aortic dissection and a left adrenal mass. From her hormonal study results, clinical symptoms and signs, she was diagnosed with Cushing's syndrome, which was due to a left adrenal adenoma. After medical treatment to stabilize the aortic dissection, she underwent left adrenalectomy. The aortic lesion of the present patient suggests that hypercortisolemia arising from Cushing's syndrome might be related to the development of acute aortic dissection.
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A Case of Adrenocortical Carcinoma showing Variable Cortisol Production during the Clinical Course.
Yun Hyi Ku, Hyung Jin Choi, Jin Taek Kim, Ji Won Yoon, Eun Kyung Lee, Hwa Young Cho, Mi Yeon Kang, Jie Seon Lee, Young Min Cho, Seong Yeon Kim
J Korean Endocr Soc. 2006;21(5):419-423.   Published online October 1, 2006
DOI: https://doi.org/10.3803/jkes.2006.21.5.419
  • 1,563 View
  • 21 Download
AbstractAbstract PDF
Patients with adrenocortical carcinoma (ACC) present with evidence of excessive adrenal steroid hormone in approximately 60% of cases, in which rapidly progressing Cushing's syndrome with or without virilization is the most frequent presentation. Some patients experience an increase or a decline in cortisol production through the progression of their ACC. We report on an unusual case of a cortisol-producing ACC, and the patient presented with a decline in cortisol production, followed by an increase in cortisol production, through the progression of the tumor. A 65-year-old woman who manifested with facial edema and weight gain was diagnosed with Cushing's syndrome, caused by cortisol producing ACC. The patient was treated with adrenalectomy. However, 8 months later, a metastatic hepatic tumor of recurred ACC was detected. At that time, the hormonal evaluation revealed that the liver mass did not produce any hormones. The patient was treated with metastatectomy. Four months later, a relapsed tumor was detected. Increased cortisol production was observed at that time. We speculate there was a change in the clonal dominance within the ACC and this change might cause such a difference. This is the first case report of ACC that showed variable hormone production during progression.
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A Case of Primary Reninism Manifested by Hypertension with Hypokalemia.
Hyung Jin Choi, Eui Sil Hong, Young Min Cho, Do Joon Park, Chan Soo Shin, Kyong Soo Park, Seong Yeon Kim, Bo Youn Cho, Hong Kyu Lee
J Korean Endocr Soc. 2005;20(2):168-173.   Published online April 1, 2005
DOI: https://doi.org/10.3803/jkes.2005.20.2.168
  • 1,956 View
  • 29 Download
  • 1 Crossref
AbstractAbstract PDF
Primary reninism is a rare cause of hypertension manifesting along with hypokalemia. A high level of plasma renin activity and a high level of serum aldosterone are the whole markers of primary reninism. Upon making the diagnosis of primary reninism, other more common causes of aldosteronism must be differentiated, such as renovascular hypertension and primary aldosteronism. Primary reninism is commonly caused by juxtaglomerular cell tumor, which is one of the curable causes of hypertension, and this can be successfully treated by conservative surgery. We report here on a case of primary reninism that was caused by juxtaglomerular cell tumor that developed in a 22-year-old female patient. She was recently diagnosed with hypertension and hypokalemia. She had markedly elevated plasma renin activity and an increased serum aldosterone concentration. Computed tomography revealed a mass located in the right kidney and selective renal vein sampling suggested that the mass was secreting an excess of renin. Right nephrectomy was done and her hypertension with hypokalemia was successfully treated. We report here a case of primary reninism that presented with juxtaglomerular cell tumor along with a review of the literature

Citations

Citations to this article as recorded by  
  • Reninoma: a rare cause of curable hypertension
    Ji Hye Kim, Ji Hyun Kim, Myung Hyun Cho, Eujin Park, Hye Sun Hyun, Yo Han Ahn, Hee Gyung Kang, Kyung Chul Moon, Il-Soo Ha, Hae Il Cheong
    Korean Journal of Pediatrics.2019; 62(4): 144.     CrossRef
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A Case of Protein-losing Enteropathy with an Abnormal Cortisol Response to ACTH Stimulation.
Hong Il Kim, Bo Kyeong Koo, You Jin Lee, Eun Jung Lee, Soo Heon Kwak, Sun Wook Cho, Hyung Jin Choi, Young Min Cho, Seong Yeon Kim
J Korean Endocr Soc. 2005;20(1):90-95.   Published online February 1, 2005
DOI: https://doi.org/10.3803/jkes.2005.20.1.90
  • 1,749 View
  • 25 Download
AbstractAbstract PDF
We hereby report a case of a 62-year-old male patient who was misdiagnosed with adrenal insufficiency during the course of protein-losing enteropathy caused by superior mesenteric arterial thrombosis. The patient was suspected to have adrenal insufficiency due to hyponatremia and severe weakness. The cortisol responses to the initial challenge of 250microgram ACTH were inadequate (maximum serum cortisol level after ACTH challenge was 10.9microgram/dL), while the serum albumin concentration was 1.9g/dL. Subsequently, intravenous steroid therapy was given to the patient. However, after bowel resection, the serum albumin level increased to 3.4g/dL and the cortisol response to the follow-up rapid ACTH stimulation was completely normal. Accordingly, we discontinued steroid replacement and discharged the patient without any problem. In conclusion, measuring total serum cortisol in a patient with hypo-pro-teinemia may lead to misdiagnosis of adrenal insufficiency. In such cases, caution should be exercised in interpreting the results in terms of total serum cortisol level or measurement of serum free cortisol levels should be considered.
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