Endocrinology and Metabolism

Hyunah Kim (Kim H)

2 Articles

Diabetes, Obesity and Metabolism
Association between Lung Function and New-Onset Diabetes Mellitus in Healthy Individuals after a 6-Year Follow-up: Hwa Young Lee, Juyoung Shin, Hyunah Kim, Seung-Hwan Lee, Jae-Hyoung Cho, Sook Young Lee, Hun-Sung Kim; Endocrinol Metab. 2021;36(6):1254-1267. Published online December 13, 2021; DOI: https://doi.org/10.3803/EnM.2021.1249

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Background
We analyzed hemoglobin A1c (HbA1c) levels and various lung function test results in healthy individuals after a 6-year follow-up period to explore the influence of lung function changes on glycemic control.
Methods
Subjects whose HbA1c levels did not qualify as diabetes mellitus (DM) and who had at least two consecutive lung function tests were selected among the people who visited a health promotion center. Lung function parameters, including forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), FEV/FVC ratio, and forced expiratory flow 25% to 75% (FEF_25%−75%), were divided into four groups based on their baseline quantiles. To evaluate future DM onset risk in relation to lung function changes, the correlation between baseline HbA1c levels and changes in lung function parameters after a 6-year follow-up period was analyzed.
Results
Overall, 17,568 individuals were included; 0.9% of the subjects were diagnosed with DM. The individuals included in the quartile with FEV1/FVC ratio values of 78% to 82% had lower risk of DM than those in the quartile with FEV1/FVC ratio values of ≥86% after adjusting for age, sex, and body mass index (P=0.04). Baseline percent predicted FEV1, FVC, FEV1/FVC ratio, and FEF_25%−75%, and differences in the FEV1/FVC ratio or FEF_25%−75%, showed negative linear correlations with baseline HbA1c levels.
Conclusion
Healthy subjects with FEV1/FVC ratio values between 78% and 82% had 40% lower risk for future DM. Smaller differences and lower baseline FEV1/FVC ratio or FEF_25%−75% values were associated with higher baseline HbA1c levels. These findings suggest that airflow limitation affects systemic glucose control and that the FEV1/FVC ratio could be one of the factors predicting future DM risk in healthy individuals.

Citations

Citations to this article as recorded by

Glycemic Control and Lung Function in Younger and Older Patients with Diabetes
Nitita Piya-amornphan, Taweephol Sanpakdee, Chadaporn Permphet, António Raposo
Advances in Public Health.2024;[Epub] CrossRef
Effect modification of glycemic control on association of lung function with all-cause and cardiovascular mortality in persons with type 2 diabetes – A retrospective cohort study
Cheng-Chieh Lin, Chia-Ing Li, Chuan-Wei Yang, Chiu-Shong Liu, Chih-Hsueh Lin, Shing-Yu Yang, Tsai-Chung Li
Respiratory Medicine.2024; 234: 107804. CrossRef
The association of spirometric small airways obstruction with respiratory symptoms, cardiometabolic diseases, and quality of life: results from the Burden of Obstructive Lung Disease (BOLD) study
Ben Knox-Brown, Jaymini Patel, James Potts, Rana Ahmed, Althea Aquart-Stewart, Cristina Barbara, A. Sonia Buist, Hamid Hacene Cherkaski, Meriam Denguezli, Mohammed Elbiaze, Gregory E. Erhabor, Frits M. E. Franssen, Mohammed Al Ghobain, Thorarinn Gislason,
Respiratory Research.2023;[Epub] CrossRef
Diabetes-related perturbations in the integrity of physiologic barriers
Arshag D. Mooradian
Journal of Diabetes and its Complications.2023; 37(8): 108552. CrossRef
Association of MMP7 T > C Gene Variant (rs10502001) and Expression in Chronic Obstructive Pulmonary Disease
Saurabh Kumar, Suchit Swaroop, Akancha Sahu, Surya Kant, Monisha Banerjee
DNA and Cell Biology.2023; 42(9): 548. CrossRef
Association between glycated haemoglobin and the risk of chronic obstructive pulmonary disease: A prospective cohort study in UK biobank
Mengyao Li, Yanan Wan, Zheng Zhu, Pengfei Luo, Hao Yu, Jian Su, Dong Hang, Yan Lu, Ran Tao, Ming Wu, Jinyi Zhou, Xikang Fan
Diabetes, Obesity and Metabolism.2023; 25(12): 3599. CrossRef
Combined multi-omics analysis reveals oil mist particulate matter-induced lung injury in rats: Pathological damage, proteomics, metabolic disturbances, and lung dysbiosis
Huipeng Nie, Huanliang Liu, Yue Shi, Wenqing Lai, Xuan Liu, Zhuge Xi, Bencheng Lin
Ecotoxicology and Environmental Safety.2022; 241: 113759. CrossRef
Retrospective cohort analysis comparing changes in blood glucose level and body composition according to changes in thyroid‐stimulating hormone level
Hyunah Kim, Da Young Jung, Seung‐Hwan Lee, Jae‐Hyoung Cho, Hyeon Woo Yim, Hun‐Sung Kim
Journal of Diabetes.2022; 14(9): 620. CrossRef
Improving Machine Learning Diabetes Prediction Models for the Utmost Clinical Effectiveness
Juyoung Shin, Joonyub Lee, Taehoon Ko, Kanghyuck Lee, Yera Choi, Hun-Sung Kim
Journal of Personalized Medicine.2022; 12(11): 1899. CrossRef

Development of Clinical Data Mart of HMG-CoA Reductase Inhibitor for Varied Clinical Research: Hun-Sung Kim, Hyunah Kim, Yoo Jin Jeong, Tong Min Kim, So Jung Yang, Sun Jung Baik, Seung-Hwan Lee, Jae Hyoung Cho, In Young Choi, Kun-Ho Yoon; Endocrinol Metab. 2017;32(1):90-98. Published online February 28, 2017; DOI: https://doi.org/10.3803/EnM.2017.32.1.90

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58 Download
19 Web of Science
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Abstract PDF PubReader

Background

The increasing use of electronic medical record (EMR) systems for documenting clinical medical data has led to EMR data being increasingly accessed for clinical trials. In this study, a database of patients who were prescribed statins for the first time was developed using EMR data. A clinical data mart (CDM) was developed for cohort study researchers.

Methods

Seoul St. Mary's Hospital implemented a clinical data warehouse (CDW) of data for ~2.8 million patients, 47 million prescription events, and laboratory results for 150 million cases. We developed a research database from a subset of the data on the basis of a study protocol. Data for patients who were prescribed a statin for the first time (between the period from January 1, 2009 to December 31, 2015), including personal data, laboratory data, diagnoses, and medications, were extracted.

Results

We extracted initial clinical data of statin from a CDW that was established to support clinical studies; the data was refined through a data quality management process. Data for 21,368 patients who were prescribed statins for the first time were extracted. We extracted data every 3 months for a period of 1 year. A total of 17 different statins were extracted. It was found that statins were first prescribed by the endocrinology department in most cases (69%, 14,865/21,368).

Conclusion

Study researchers can use our CDM for statins. Our EMR data for statins is useful for investigating the effectiveness of treatments and exploring new information on statins. Using EMR is advantageous for compiling an adequate study cohort in a short period.

Citations

Citations to this article as recorded by

Ten-year Trends in Infectious Keratitis in South Korea
Chanjoon Park, Hye Yeon Yoon, Young Sik Yoo, Hyun Soo Lee, Hyung Bin Hwang, Kyung Sun Na, Yang Kyung Cho, Eun Chul Kim, So Hyang Chung, Hyun Seung Kim, Yong-Soo Byun
Journal of the Korean Ophthalmological Society.2024; 65(3): 181. CrossRef
Data Lake, Data Warehouse, Datamart, and Feature Store: Their Contributions to the Complete Data Reuse Pipeline
Antoine Lamer, Chloé Saint-Dizier, Nicolas Paris, Emmanuel Chazard
JMIR Medical Informatics.2024; 12: e54590. CrossRef
Clinical Data Warehousing: A Scoping Review
Zhan Wang, Catherine Craven, Mahanaz Syed, Melody Greer, Emel Seker, Shorab Syed, Meredith Nahm Zozus
Journal of the Society for Clinical Data Management.2024;[Epub] CrossRef
Long-term stroke and major bleeding risk in patients with non-valvular atrial fibrillation: A comparative analysis between non-vitamin K antagonist oral anticoagulants and warfarin using a clinical data warehouse
Hancheol Lee, Jung Hwa Hong, Kwon-Duk Seo
Frontiers in Neurology.2023;[Epub] CrossRef
Digital Health Data Quality Issues: Systematic Review
Rehan Syed, Rebekah Eden, Tendai Makasi, Ignatius Chukwudi, Azumah Mamudu, Mostafa Kamalpour, Dakshi Kapugama Geeganage, Sareh Sadeghianasl, Sander J J Leemans, Kanika Goel, Robert Andrews, Moe Thandar Wynn, Arthur ter Hofstede, Trina Myers
Journal of Medical Internet Research.2023; 25: e42615. CrossRef
Prediction of intradialytic hypotension using pre-dialysis features—a deep learning–based artificial intelligence model
Hanbi Lee, Sung Joon Moon, Sung Woo Kim, Ji Won Min, Hoon Suk Park, Hye Eun Yoon, Young Soo Kim, Hyung Wook Kim, Chul Woo Yang, Sungjin Chung, Eun Sil Koh, Byung Ha Chung
Nephrology Dialysis Transplantation.2023; 38(10): 2310. CrossRef
Carpal tunnel syndrome and tenosynovitis in women with breast cancer associated with hormone therapy
Dong Jae Shin, Kyung Eun Nam, Dae Heon Song, Sun Im, Sun Jae Won, Yeo Hyung Kim, Seong Hoon Lim, Jong In Lee
Medicine.2022; 101(5): e28786. CrossRef
Data Pseudonymization in a Range That Does Not Affect Data Quality: Correlation with the Degree of Participation of Clinicians
Soo-Yong Shin, Hun-Sung Kim
Journal of Korean Medical Science.2021;[Epub] CrossRef
Ten-year patient journey of stage III non-small cell lung cancer patients: A single-center, observational, retrospective study in Korea (Realtime autOmatically updated data warehOuse in healTh care; UNIVERSE-ROOT study)
Hyun Ae Jung, Jong-Mu Sun, Se-Hoon Lee, Jin Seok Ahn, Myung-Ju Ahn, Keunchil Park
Lung Cancer.2020; 146: 112. CrossRef
Real-time autOmatically updated data warehOuse in healThcare (ROOT: An Innovative and Automated Data Collection System) (Preprint)
Hyun Ae Jung, Oksoon Jeong, Dong Kyung Chang, Sehhoon Park, Jong-Mu Sun, Se-Hoon Lee, Jin Seok Ahn, Myung-Ju Ahn, Keunchil Park
JMIR Medical Informatics.2020;[Epub] CrossRef
Long-term effects of various types of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on changes in glomerular filtration rate in Korea
Seo Yeon Baik, Hyunah Kim, So Jung Yang, Tong Min Kim, Seung-Hwan Lee, Jae Hyoung Cho, Hyunyong Lee, Hyeon Woo Yim, Kun-Ho Yoon, Hun-Sung Kim
Frontiers of Medicine.2019; 13(6): 713. CrossRef
Proceed with Caution When Using Real World Data and Real World Evidence
Hun-Sung Kim, Ju Han Kim
Journal of Korean Medical Science.2019;[Epub] CrossRef
Change in ALT levels after administration of HMG‐CoA reductase inhibitors to subjects with pretreatment levels three times the upper normal limit in clinical practice
Hyunah Kim, Hyeseon Lee, Tong Min Kim, So Jung Yang, Seo Yeon Baik, Seung‐Hwan Lee, Jae‐Hyoung Cho, Hyunyong Lee, Hyeon Woo Yim, In Young Choi, Kun‐Ho Yoon, Hun‐Sung Kim
Cardiovascular Therapeutics.2018;[Epub] CrossRef
Developing a multi-center clinical data mart of ACEI and ARB for real-world evidence (RWE)
Hun-Sung Kim, Sue Hyun Lee, Tong Min Kim, Ju Han Kim
Clinical Hypertension.2018;[Epub] CrossRef
Comparative Analysis of the Suspected Heparin‐Induced Thrombocytopenia Level in Korea
Hun‐Sung Kim, Hyunah Kim, Yoo Jin Jeong, Hyunyong Lee, Hyeon Woo Yim, Ji il Kim, In Sung Moon, Jang‐Yong Kim
Basic & Clinical Pharmacology & Toxicology.2017; 121(4): 360. CrossRef
The differences in the incidence of diabetes mellitus and prediabetes according to the type of HMG-CoA reductase inhibitors prescribed in Korean patients
Tong Min Kim, Hyunah Kim, Yoo Jin Jeong, Sun Jung Baik, So Jung Yang, Seung-Hwan Lee, Jae-Hyoung Cho, Hyunyong Lee, Hyeon Woo Yim, In Young Choi, Kun-Ho Yoon, Hun-Sung Kim
Pharmacoepidemiology and Drug Safety.2017; 26(10): 1156. CrossRef
Use of Moderate‐Intensity Statins for Low‐Density Lipoprotein Cholesterol Level above 190 mg/dL at Baseline in Koreans
Hun‐Sung Kim, Hyeseon Lee, Sue Hyun Lee, Yoo Jin Jeong, Tong Min Kim, So Jung Yang, Sun Jung Baik, Hyunah Kim, Seung‐Hwan Lee, Jae Hyoung Cho, In‐Young Choi, Kun‐Ho Yoon, Ju Han Kim
Basic & Clinical Pharmacology & Toxicology.2017; 121(4): 272. CrossRef

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