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Hyun Jeong Jeon  (Jeon HJ) 3 Articles
Clinical Study
Association between Bsm1 Polymorphism in Vitamin D Receptor Gene and Diabetic Retinopathy of Type 2 Diabetes in Korean Population
Yong Joo Hong, Eun Seok Kang, Myoung Jin Ji, Hyung Jin Choi, Taekeun Oh, Sung-Soo Koong, Hyun Jeong Jeon
Endocrinol Metab. 2015;30(4):469-474.   Published online December 31, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.4.469
  • 4,060 View
  • 45 Download
  • 23 Web of Science
  • 22 Crossref
AbstractAbstract PDFPubReader   
Background

Type 2 diabetes is one of the most common diseases with devastating complications. However, genetic susceptibility of diabetic complications has not been clarified. The vitamin D endocrine system is related with calcification and lipolysis, insulin secretion, and may be associated with many complicated disease including diabetes and cardiovascular disease. Recent studies reported that single nucleotide polymorphisms of vitamin D receptor (VDR) gene were associated with diabetic complications.

Methods

In present study, we evaluated the association of BsmI polymorphism of VDR with diabetic complications in Korean diabetes patients. Total of 537 type 2 diabetic subjects from the Endocrinology Clinic of Chungbuk National University Hospital were investigated. Polymerase chain reaction-restriction fragment length polymorphism was used to test the genotype and allele frequency of BsmI (rs1544410; BB, Bb, bb) polymorphisms.

Results

Mean age was 62.44±10.64 years and mean disease duration was 13.65±7.39 years. Patients with B allele (BB or Bb) was significantly associated with lower risk of diabetic retinopathy (severe non-proliferative diabetic retinopathy or proliferative retinopathy; 7.4%, 5/68) compared with patients without B allele (bb; 17.3%, 81/469; P=0.035). This association was also significant after adjusting for hemoglobin A1c level, body mass index, age, sex, and diabetes mellitus duration, concurrent dyslipidemia and hypertension (odds ratio, 2.99; 95% confidence interval, 1.08 to 8.29; P=0.035) in logistic regression analysis.

Conclusion

Our findings suggest that B allele of Bsm1 polymorphism in VDR gene is associated with lower risk of diabetic retinopathy in type 2 diabetic patients. Bsm1 genotype could be used as a susceptibility marker to predict the risk of diabetes complication.

Citations

Citations to this article as recorded by  
  • The Vitamin D Receptor Bsm1 Variant is not Associated With Temporomandibular Disorder With or Without Bruxism
    Serkan YILDIZ, Serbülent YİĞİT, Ayşe Feyda NURSAL, Nevin KARAKUŞ, Mehmet Kemal TÜMER
    ADO Klinik Bilimler Dergisi.2024; 13(1): 100.     CrossRef
  • Association analysis between the VDR gene variants and type 2 diabetes
    Shabnam Salehizadeh, Sara Ramezani, Mojgan Asadi, Mahdi Afshari, Seyed Hamid Jamaldini, Farhad Adhami Moghadam, Mandana Hasanzad
    Journal of Diabetes & Metabolic Disorders.2023;[Epub]     CrossRef
  • Metabolic impact of the VDR rs1544410 in diabetic retinopathy
    Caroline Severo de Assis, Tainá Gomes Diniz, João Otávio Scarano Alcântara, Vanessa Polyana Alves de Sousa Brito, Rayner Anderson Ferreira do Nascimento, Mayara Karla dos Santos Nunes, Alexandre Sérgio Silva, Isabella Wanderley de Queiroga Evangelista, Ma
    PLOS ONE.2022; 17(2): e0263346.     CrossRef
  • Vitamin D, the Vitamin D Receptor, Calcitriol Analogues and Their Link with Ocular Diseases
    Miłosz Caban, Urszula Lewandowska
    Nutrients.2022; 14(11): 2353.     CrossRef
  • Vitamin D-Related Single Nucleotide Polymorphisms as Risk Biomarker of Cardiovascular Disease
    Paula González Rojo, Cristina Pérez Ramírez, José María Gálvez Navas, Laura Elena Pineda Lancheros, Susana Rojo Tolosa, María del Carmen Ramírez Tortosa, Alberto Jiménez Morales
    International Journal of Molecular Sciences.2022; 23(15): 8686.     CrossRef
  • Effects of Vitamin D Receptor Genotype on Lipid Profiles and Retinopathy Risk in Type 2 Diabetes Patients: A Pilot Study
    Hussam Alhawari, Yazun Jarrar, Dina Abulebdah, Sara J. Abaalkhail, Marah Alkhalili, Sura Alkhalili, Hussein Alhawari, Munther Momani, Mohammed N. Obeidat, Rand K. Fram, Mohammad A. Salahat, Su-Jun Lee
    Journal of Personalized Medicine.2022; 12(9): 1488.     CrossRef
  • Relation of vitamin D and BsmI variant with temporomandibular diseases in the Turkish population
    S. Yildiz, M.K. Tumer, S. Yigit, A.F. Nursal, A. Rustemoglu, Y. Balel
    British Journal of Oral and Maxillofacial Surgery.2021; 59(5): 555.     CrossRef
  • The relationship between vitamin D receptor (VDR) rs2228570 and rs7975232 genetic variants and the risk of recurrent pregnancy loss
    Zohreh Salari, Nasrollah Saleh-Gohari, Monire Rezapour, Ahamad Khosravi, Hadi Tavakkoli, Ehsan Salarkia, Fatemeh Karami-Robati
    Meta Gene.2021; 27: 100833.     CrossRef
  • Association of Bone Metabolism Indices and Bone Mineral Density with Diabetic Retinopathy in Elderly Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Inpatient Study in China
    Xin Zhao, Lili Huo, Xiaofeng Yu, Xiaomei Zhang, Fabio Vescini
    Journal of Diabetes Research.2021; 2021: 1.     CrossRef
  • The Associations Between Vitamin D Receptor BsmI and ApaI Polymorphisms and Obesity in Korean Patients with Type 2 Diabetes Mellitus
    Sang Won Nam, Jinwoo Choi, Hyun Jeong Jeon, Tae Keun Oh, Dong-Hwa Lee
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2021; Volume 14: 557.     CrossRef
  • Vitamin D Deficiency at Mid-Pregnancy Is Associated with a Higher Risk of Postpartum Glucose Intolerance in Women with Gestational Diabetes Mellitus
    Kyung-Soo Kim, Seok Won Park, Yong-Wook Cho, Soo-Kyung Kim
    Endocrinology and Metabolism.2020; 35(1): 97.     CrossRef
  • The role of vitamin D in the pathogenesis and treatment of diabetes mellitus: a narrative review
    Maria Grammatiki, Spiros Karras, Kalliopi Kotsa
    Hormones.2019; 18(1): 37.     CrossRef
  • Vitamin D-binding protein and vitamin D receptor genotypes and 25-hydroxyvitamin D levels are associated with development of aortic and mitral valve calcification and coronary artery diseases
    Amir Kiani, Ehsan Mohamadi-Nori, Asad Vaisi-Raygani, Maryam Tanhapour, Said Elahi-Rad, Fariborz Bahrehmand, Zohreh Rahimi, Tayebeh Pourmotabbed
    Molecular Biology Reports.2019; 46(5): 5225.     CrossRef
  • Is Hypovitaminosis D Related to Incidence of Type 2 Diabetes and High Fasting Glucose Level in Healthy Subjects: A Systematic Review and Meta-Analysis of Observational Studies
    Shamaila Rafiq, Per Jeppesen
    Nutrients.2018; 10(1): 59.     CrossRef
  • Association between the vitamin D receptor gene polymorphisms and diabetic nephropathy risk: A meta‐analysis
    Fang Yin, Jing Liu, Ming‐Xiu Fan, Xiao‐Li Zhou, Xiao‐Ling Zhang
    Nephrology.2018; 23(2): 107.     CrossRef
  • BSMI single nucleotide polymorphism in vitamin D receptor gene is associated with decreased circulatory levels of serum 25-hydroxyvitamin D among micro and macrovascular complications of type 2 diabetes mellitus
    Krishnamoorthy Ezhilarasi, Umapathy Dhamodharan, Viswanathan Vijay
    International Journal of Biological Macromolecules.2018; 116: 346.     CrossRef
  • Diabetic macular oedema: under‐represented in the genetic analysis of diabetic retinopathy
    Suzanne Broadgate, Christine Kiire, Stephanie Halford, Victor Chong
    Acta Ophthalmologica.2018; 96(A111): 1.     CrossRef
  • Expression of JAZF1, ABCC8, KCNJ11and Notch2 genes and vitamin D receptor polymorphisms in type 2 diabetes, and their association with microvascular complications
    Maha A. Rasheed, Nagwa Kantoush, Nagwa Abd El-Ghaffar, Hebatallah Farouk, Solaf Kamel, Alshaymaa Ahmed Ibrahim, Aliaa Shalaby, Eman Mahmoud, Hala M. Raslan, Omneya M. Saleh
    Therapeutic Advances in Endocrinology and Metabolism.2017; 8(6): 97.     CrossRef
  • Vitamin D and diabetes mellitus: Causal or casual association?
    M. Grammatiki, E. Rapti, S. Karras, R. A. Ajjan, Kalliopi Kotsa
    Reviews in Endocrine and Metabolic Disorders.2017; 18(2): 227.     CrossRef
  • The Association between Vitamin D Deficiency and Diabetic Retinopathy in Type 2 Diabetes: A Meta-Analysis of Observational Studies
    Bang-An Luo, Fan Gao, Lu-Lu Qin
    Nutrients.2017; 9(3): 307.     CrossRef
  • The Association between VDR Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Systematic Review and Meta-Analysis
    Yun Zhang, Wei Xia, Ping Lu, Huijuan Yuan
    BioMed Research International.2016; 2016: 1.     CrossRef
  • Candidate gene studies of diabetic retinopathy in human
    Petra Priščáková, Gabriel Minárik, Vanda Repiská
    Molecular Biology Reports.2016; 43(12): 1327.     CrossRef
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A Case of Lingual Thyroid Treated by 131I Ablation.
Myeong Ho Yeon, Yong Hyeok Choi, Young Rak Choi, Woo Ri Park, Hyung Jin Choi, Tae Keun Oh, Hyun Jeong Jeon
Endocrinol Metab. 2012;27(4):303-307.   Published online December 20, 2012
DOI: https://doi.org/10.3803/EnM.2012.27.4.303
  • 1,843 View
  • 26 Download
AbstractAbstract PDF
A lingual thyroid is a rare developmental anomaly caused by the failure of the descent of the thyroid gland anlage early in the course of embryogenesis. The incidence of lingual thyroid has been reported to be 1/100,000. Lingual thyroid is often asymptomatic but may cause dysphagia, dysphonia, upper airway obstruction and hemorrhage. In this report, we described the case of a 50-year-old women experiencing lingual thyroid who had subclinical hypothyroidism. She underwent successful 131I ablation and has done well on thyroid hormone replacement therapy.
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A Case of Cushing's Disease in Pregnancy.
Jeong Tae Kim, Mun Hyuk Sung, Woo Ri Park, Jeong Ho Han, Hye Suk Han, Young Kwang Sim, Tae Gun Oh, Hyun Jeong Jeon
Endocrinol Metab. 2011;26(4):348-354.   Published online December 1, 2011
DOI: https://doi.org/10.3803/EnM.2011.26.4.348
  • 1,867 View
  • 27 Download
AbstractAbstract PDF
Developing Cushing's syndrome during pregnancy is rare because menstruation is irregular and hypercortisolism causes infertility. Developing Cushing's disease during pregnancy is very rare because there is even less ovulation than those with the adrenal adenoma. The clinical manifestations of Cushing's syndrome may easily be missed during pregnancy as the features of weight gain, hypertension, and hyperglycemia overlap with those that occur during a pregnancy. Diagnosing Cushing's syndrome during a pregnancy is complex because the biochemical features are obscured by the natural changes in the hypothalamic-pituitary-adrenal axis that occur during pregnancy. Having Cushing's syndrome during a pregnancy results in increased fetal and maternal complications, so early diagnosis and treatment are critical. We report the clinical and endocrine findings of a pregnant women with Cushing's disease who underwent transsphenoidal surgery after delivery.
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