Endocrinology and Metabolism

Hyun Jeong Jeon (Jeon HJ)

3 Articles

Clinical Study
Association between Bsm1 Polymorphism in Vitamin D Receptor Gene and Diabetic Retinopathy of Type 2 Diabetes in Korean Population: Yong Joo Hong, Eun Seok Kang, Myoung Jin Ji, Hyung Jin Choi, Taekeun Oh, Sung-Soo Koong, Hyun Jeong Jeon; Endocrinol Metab. 2015;30(4):469-474. Published online December 31, 2015; DOI: https://doi.org/10.3803/EnM.2015.30.4.469

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Abstract PDF PubReader Crossref - TDM

Background

Type 2 diabetes is one of the most common diseases with devastating complications. However, genetic susceptibility of diabetic complications has not been clarified. The vitamin D endocrine system is related with calcification and lipolysis, insulin secretion, and may be associated with many complicated disease including diabetes and cardiovascular disease. Recent studies reported that single nucleotide polymorphisms of vitamin D receptor (VDR) gene were associated with diabetic complications.

Methods

In present study, we evaluated the association of BsmI polymorphism of VDR with diabetic complications in Korean diabetes patients. Total of 537 type 2 diabetic subjects from the Endocrinology Clinic of Chungbuk National University Hospital were investigated. Polymerase chain reaction-restriction fragment length polymorphism was used to test the genotype and allele frequency of BsmI (rs1544410; BB, Bb, bb) polymorphisms.

Results

Mean age was 62.44±10.64 years and mean disease duration was 13.65±7.39 years. Patients with B allele (BB or Bb) was significantly associated with lower risk of diabetic retinopathy (severe non-proliferative diabetic retinopathy or proliferative retinopathy; 7.4%, 5/68) compared with patients without B allele (bb; 17.3%, 81/469; P=0.035). This association was also significant after adjusting for hemoglobin A1c level, body mass index, age, sex, and diabetes mellitus duration, concurrent dyslipidemia and hypertension (odds ratio, 2.99; 95% confidence interval, 1.08 to 8.29; P=0.035) in logistic regression analysis.

Conclusion

Our findings suggest that B allele of Bsm1 polymorphism in VDR gene is associated with lower risk of diabetic retinopathy in type 2 diabetic patients. Bsm1 genotype could be used as a susceptibility marker to predict the risk of diabetes complication.

Citations

Citations to this article as recorded by

Metabolic impact of the VDR rs1544410 in diabetic retinopathy
Caroline Severo de Assis, Tainá Gomes Diniz, João Otávio Scarano Alcântara, Vanessa Polyana Alves de Sousa Brito, Rayner Anderson Ferreira do Nascimento, Mayara Karla dos Santos Nunes, Alexandre Sérgio Silva, Isabella Wanderley de Queiroga Evangelista, Ma
PLOS ONE.2022; 17(2): e0263346. CrossRef
Vitamin D, the Vitamin D Receptor, Calcitriol Analogues and Their Link with Ocular Diseases
Miłosz Caban, Urszula Lewandowska
Nutrients.2022; 14(11): 2353. CrossRef
Vitamin D-Related Single Nucleotide Polymorphisms as Risk Biomarker of Cardiovascular Disease
Paula González Rojo, Cristina Pérez Ramírez, José María Gálvez Navas, Laura Elena Pineda Lancheros, Susana Rojo Tolosa, María del Carmen Ramírez Tortosa, Alberto Jiménez Morales
International Journal of Molecular Sciences.2022; 23(15): 8686. CrossRef
Effects of Vitamin D Receptor Genotype on Lipid Profiles and Retinopathy Risk in Type 2 Diabetes Patients: A Pilot Study
Hussam Alhawari, Yazun Jarrar, Dina Abulebdah, Sara J. Abaalkhail, Marah Alkhalili, Sura Alkhalili, Hussein Alhawari, Munther Momani, Mohammed N. Obeidat, Rand K. Fram, Mohammad A. Salahat, Su-Jun Lee
Journal of Personalized Medicine.2022; 12(9): 1488. CrossRef
Relation of vitamin D and BsmI variant with temporomandibular diseases in the Turkish population
S. Yildiz, M.K. Tumer, S. Yigit, A.F. Nursal, A. Rustemoglu, Y. Balel
British Journal of Oral and Maxillofacial Surgery.2021; 59(5): 555. CrossRef
The relationship between vitamin D receptor (VDR) rs2228570 and rs7975232 genetic variants and the risk of recurrent pregnancy loss
Zohreh Salari, Nasrollah Saleh-Gohari, Monire Rezapour, Ahamad Khosravi, Hadi Tavakkoli, Ehsan Salarkia, Fatemeh Karami-Robati
Meta Gene.2021; 27: 100833. CrossRef
Association of Bone Metabolism Indices and Bone Mineral Density with Diabetic Retinopathy in Elderly Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Inpatient Study in China
Xin Zhao, Lili Huo, Xiaofeng Yu, Xiaomei Zhang, Fabio Vescini
Journal of Diabetes Research.2021; 2021: 1. CrossRef
The Associations Between Vitamin D Receptor BsmI and ApaI Polymorphisms and Obesity in Korean Patients with Type 2 Diabetes Mellitus
Sang Won Nam, Jinwoo Choi, Hyun Jeong Jeon, Tae Keun Oh, Dong-Hwa Lee
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2021; Volume 14: 557. CrossRef
Vitamin D Deficiency at Mid-Pregnancy Is Associated with a Higher Risk of Postpartum Glucose Intolerance in Women with Gestational Diabetes Mellitus
Kyung-Soo Kim, Seok Won Park, Yong-Wook Cho, Soo-Kyung Kim
Endocrinology and Metabolism.2020; 35(1): 97. CrossRef
The role of vitamin D in the pathogenesis and treatment of diabetes mellitus: a narrative review
Maria Grammatiki, Spiros Karras, Kalliopi Kotsa
Hormones.2019; 18(1): 37. CrossRef
Vitamin D-binding protein and vitamin D receptor genotypes and 25-hydroxyvitamin D levels are associated with development of aortic and mitral valve calcification and coronary artery diseases
Amir Kiani, Ehsan Mohamadi-Nori, Asad Vaisi-Raygani, Maryam Tanhapour, Said Elahi-Rad, Fariborz Bahrehmand, Zohreh Rahimi, Tayebeh Pourmotabbed
Molecular Biology Reports.2019; 46(5): 5225. CrossRef
Is Hypovitaminosis D Related to Incidence of Type 2 Diabetes and High Fasting Glucose Level in Healthy Subjects: A Systematic Review and Meta-Analysis of Observational Studies
Shamaila Rafiq, Per Jeppesen
Nutrients.2018; 10(1): 59. CrossRef
Association between the vitamin D receptor gene polymorphisms and diabetic nephropathy risk: A meta-analysis
Fang Yin, Jing Liu, Ming-Xiu Fan, Xiao-Li Zhou, Xiao-Ling Zhang
Nephrology.2018; 23(2): 107. CrossRef
BSMI single nucleotide polymorphism in vitamin D receptor gene is associated with decreased circulatory levels of serum 25-hydroxyvitamin D among micro and macrovascular complications of type 2 diabetes mellitus
Krishnamoorthy Ezhilarasi, Umapathy Dhamodharan, Viswanathan Vijay
International Journal of Biological Macromolecules.2018; 116: 346. CrossRef
Diabetic macular oedema: under-represented in the genetic analysis of diabetic retinopathy
Suzanne Broadgate, Christine Kiire, Stephanie Halford, Victor Chong
Acta Ophthalmologica.2018; 96: 1. CrossRef
Expression of JAZF1, ABCC8, KCNJ11and Notch2 genes and vitamin D receptor polymorphisms in type 2 diabetes, and their association with microvascular complications
Maha A. Rasheed, Nagwa Kantoush, Nagwa Abd El-Ghaffar, Hebatallah Farouk, Solaf Kamel, Alshaymaa Ahmed Ibrahim, Aliaa Shalaby, Eman Mahmoud, Hala M. Raslan, Omneya M. Saleh
Therapeutic Advances in Endocrinology and Metabolism.2017; 8(6): 97. CrossRef
Vitamin D and diabetes mellitus: Causal or casual association?
M. Grammatiki, E. Rapti, S. Karras, R. A. Ajjan, Kalliopi Kotsa
Reviews in Endocrine and Metabolic Disorders.2017; 18(2): 227. CrossRef
The Association between Vitamin D Deficiency and Diabetic Retinopathy in Type 2 Diabetes: A Meta-Analysis of Observational Studies
Bang-An Luo, Fan Gao, Lu-Lu Qin
Nutrients.2017; 9(3): 307. CrossRef
The Association between VDR Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Systematic Review and Meta-Analysis
Yun Zhang, Wei Xia, Ping Lu, Huijuan Yuan
BioMed Research International.2016; 2016: 1. CrossRef
Candidate gene studies of diabetic retinopathy in human
Petra Priščáková, Gabriel Minárik, Vanda Repiská
Molecular Biology Reports.2016; 43(12): 1327. CrossRef

A Case of Lingual Thyroid Treated by 131I Ablation.: Myeong Ho Yeon, Yong Hyeok Choi, Young Rak Choi, Woo Ri Park, Hyung Jin Choi, Tae Keun Oh, Hyun Jeong Jeon; Endocrinol Metab. 2012;27(4):303-307. Published online December 20, 2012; DOI: https://doi.org/10.3803/EnM.2012.27.4.303

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Abstract PDF: A lingual thyroid is a rare developmental anomaly caused by the failure of the descent of the thyroid gland anlage early in the course of embryogenesis. The incidence of lingual thyroid has been reported to be 1/100,000. Lingual thyroid is often asymptomatic but may cause dysphagia, dysphonia, upper airway obstruction and hemorrhage. In this report, we described the case of a 50-year-old women experiencing lingual thyroid who had subclinical hypothyroidism. She underwent successful 131I ablation and has done well on thyroid hormone replacement therapy.

A Case of Cushing's Disease in Pregnancy.: Jeong Tae Kim, Mun Hyuk Sung, Woo Ri Park, Jeong Ho Han, Hye Suk Han, Young Kwang Sim, Tae Gun Oh, Hyun Jeong Jeon; Endocrinol Metab. 2011;26(4):348-354. Published online December 1, 2011; DOI: https://doi.org/10.3803/EnM.2011.26.4.348

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Abstract PDF: Developing Cushing's syndrome during pregnancy is rare because menstruation is irregular and hypercortisolism causes infertility. Developing Cushing's disease during pregnancy is very rare because there is even less ovulation than those with the adrenal adenoma. The clinical manifestations of Cushing's syndrome may easily be missed during pregnancy as the features of weight gain, hypertension, and hyperglycemia overlap with those that occur during a pregnancy. Diagnosing Cushing's syndrome during a pregnancy is complex because the biochemical features are obscured by the natural changes in the hypothalamic-pituitary-adrenal axis that occur during pregnancy. Having Cushing's syndrome during a pregnancy results in increased fetal and maternal complications, so early diagnosis and treatment are critical. We report the clinical and endocrine findings of a pregnant women with Cushing's disease who underwent transsphenoidal surgery after delivery.

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