Hyponatremia is an electrolyte abnormality commonly found in clinical practice. It is important to diagnose the underlying etiology of the hyponatremia and correct it appropriately because severe hyponatremia can cause serious complications and substantially increase the risk of mortality. Although hypothyroidism is known to be a cause of hyponatremia, it is rare that hyponatremia occurs in relation to hypothyroidism induced by thyroid hormone withdrawal in patients with differentiated thyroid cancer. We report a case of a 76-year-old woman with papillary thyroid carcinoma presenting with severe hyponatremia related to hypothyroidism induced by thyroid hormone withdrawal for radio-active iodine whole-body scanning, who was treated by thyroid hormone replacement and hydration. Considering that the incidence of differentiated thyroid cancer is rapidly increasing, physicians should be aware that, although uncommon, hyponatremia can occur in patients undergoing radioiodine therapy or diagnostic testing.

Citations

Citations to this article as recorded by  

• Effect of preparation method for radioactive iodine therapy on serum electrolytes
  Noriko Takata, Masao Miyagawa, Tomohisa Okada, Naoto Kawaguchi, Yutaka Fujimoto, Yoshihiro Kouchi, Shintaro Tsuruoka, Kotaro Uwatsu, Teruhito Kido
  Japanese Journal of Radiology.2023; 41(11): 1247.     CrossRef
• MANAGEMENT OF ENDOCRINE DISEASE: Hypothyroidism-associated hyponatremia: mechanisms, implications and treatment
  G Liamis, T D Filippatos, A Liontos, M S Elisaf
  European Journal of Endocrinology.2017; 176(1): R15.     CrossRef
• Articles in 'Endocrinology and Metabolism' in 2014
  Won-Young Lee
  Endocrinology and Metabolism.2015; 30(1): 47.     CrossRef
• Parathyroid hormone-related protein serves as a prognostic indicator in oral squamous cell carcinoma
  Zhongjing Lv, Xiangbing Wu, Wei Cao, ZongZe Shen, Lizhen Wang, FuRong Xie, JianJun Zhang, Tong Ji, Ming Yan, WanTao Chen
  Journal of Experimental & Clinical Cancer Research.2014;[Epub]     CrossRef
• Hyponatremia and the Thyroid: Causality or Association?
  Kevin Pantalone, Betul Hatipoglu
  Journal of Clinical Medicine.2014; 4(1): 32.     CrossRef