Insulin-like growth factor binding proteins (IGFBPs) are major regulators of insulin-like growth factor bioavailability and activity in metabolic signaling. Seven IGFBP family isoforms have been identified. Recent studies have shown that IGFBPs play a pivotal role in metabolic signaling and disease, including the pathogenesis of obesity, diabetes, and cancer. Although many studies have documented the various roles played by IGFBPs, transcriptional regulation of IGFBPs is not well understood. In this review, we focus on the regulatory mechanisms of IGFBP gene expression, and we summarize the findings of transcription factor activity in the IGFBP promoter region.

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• Loss of IGFBP2 mediates alveolar type 2 cell senescence and promotes lung fibrosis
  Chiahsuan Chin, Ranjithkumar Ravichandran, Kristina Sanborn, Timothy Fleming, Stephen B. Wheatcroft, Mark T. Kearney, Sofya Tokman, Rajat Walia, Michael A. Smith, David J. Flint, Thalachallour Mohanakumar, Ross M. Bremner, Angara Sureshbabu
  Cell Reports Medicine.2023; 4(3): 100945.     CrossRef
• Efficient generation of functional pancreatic β cells from dental-derived stem cells via laminin-induced differentiation
  Riham M. Aly, Hadeer A. Aglan, Ghada Nour Eldeen, Nadia S. Mahmoud, Eman H. Aboul-Ezz, Hanaa H. Ahmed
  Journal of Genetic Engineering and Biotechnology.2022;[Epub]     CrossRef
• Insulin-like growth factor signalling and its significance as a biomarker in fish and shellfish research
  S. Chandhini, Bushra Trumboo, Seena Jose, Tincy Varghese, M. Rajesh, V. J. Rejish Kumar
  Fish Physiology and Biochemistry.2021; 47(4): 1011.     CrossRef
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  Solmaz Maleki Dizaj, Aziz Eftekhari, Shakar Mammadova, Elham Ahmadian, Mohammadreza Ardalan, Soodabeh Davaran, Aygun Nasibova, Rovshan Khalilov, Mahbuba Valiyeva, Sevil Mehraliyeva, Ebrahim Mostafavi
  Applied Sciences.2021; 11(20): 9656.     CrossRef
• Producción de las proteínas de unión al factor de crecimiento insulinoide durante el desarrollo de la fibrosis hepática por hepatitis C crónica
  D. Rosique-Oramas, M. Martínez-Castillo, A. Raya, Z. Medina-Ávila, F. Aragón, J. Limón-Castillo, A. Hernández-Barragán, A. Santoyo, E. Montalvo-Javé, J.L. Pérez-Hernández, F. Higuera-de la Tijera, A. Torre, D. Kershenobich, G. Gutiérrez-Reyes
  Revista de Gastroenterología de México.2020; 85(4): 390.     CrossRef
• Interacción cardiorrenal y evolución de la insuficiencia cardiaca. ¿Tiene un papel la proteína de unión del factor de crecimiento de tipo insulina 2?
  Susana Ravassa, Javier Beaumont, Germán Cediel, Josep Lupón, Begoña López, Ramón Querejeta, Javier Díez, Antoni Bayés-Genís, Arantxa González
  Revista Española de Cardiología.2020; 73(10): 835.     CrossRef
• Molecular identification of grass carp igfbp2 and the effect of glucose, insulin, and glucagon on igfbp2 mRNA expression
  Guokun Yang, Wenli Zhao, Chaobin Qin, Liping Yang, Xiaolin Meng, Ronghua Lu, Xiao Yan, Xianglin Cao, Yanmin Zhang, Guoxing Nie
  Fish Physiology and Biochemistry.2020; 46(4): 1469.     CrossRef
• Production of insulin-like growth factor-binding proteins during the development of hepatic fibrosis due to chronic hepatitis C
  D. Rosique-Oramas, M. Martínez-Castillo, A. Raya, Z. Medina-Ávila, F. Aragón, J. Limón-Castillo, A. Hernández-Barragán, A. Santoyo, E. Montalvo-Javé, J.L. Pérez-Hernández, F. Higuera-de la Tijera, A. Torre, D. Kershenobich, G. Gutiérrez-Reyes
  Revista de Gastroenterología de México (English Edition).2020; 85(4): 390.     CrossRef
• Cardiorenal interaction and heart failure outcomes. A role for insulin-like growth factor binding protein 2?
  Susana Ravassa, Javier Beaumont, Germán Cediel, Josep Lupón, Begoña López, Ramón Querejeta, Javier Díez, Antoni Bayés-Genís, Arantxa González
  Revista Española de Cardiología (English Edition).2020;[Epub]     CrossRef
• Integration of single-cell datasets reveals novel transcriptomic signatures of β-cells in human type 2 diabetes
  Emanuele Bosi, Lorella Marselli, Carmela De Luca, Mara Suleiman, Marta Tesi, Mark Ibberson, Decio L Eizirik, Miriam Cnop, Piero Marchetti
  NAR Genomics and Bioinformatics.2020;[Epub]     CrossRef
• Transcriptional Analysis of FOXO1, C/EBP- and PPAR-2 Genes and Their association with Obesity-Related Insulin Resistance
  Boughanem, Cabrera-Mulero, Millán-Gómez, Garrido-Sánchez, Cardona, Tinahones, Moreno-Santos, Macías-González
  Genes.2019; 10(9): 706.     CrossRef
• Immune biomarkers in maternal plasma to identify histologic chorioamnionitis in women with preterm labor
  Jeong Woo Park, Kyo Hoon Park, Song Yi Kook, Young Mi Jung, Yu Mi Kim
  Archives of Gynecology and Obstetrics.2019; 299(3): 725.     CrossRef
• Insulin like growth factor binding protein 2 (IGFBP-2) for risk prediction in patients with severe aortic stenosis undergoing Transcatheter Aortic Valve Implantation (TAVI)
  Johanna Maria Muessig, Michael Lichtenauer, Bernhard Wernly, Malte Kelm, Marcus Franz, Laura Bäz, Paul Christian Schulze, Victoria Racher, Georg Zimmermann, Hans-Reiner Figulla, Vera Paar, Uta C. Hoppe, Philippe Rouet, Alexander Lauten, Christian Jung
  International Journal of Cardiology.2019; 277: 54.     CrossRef
• Molecular cloning and expression pattern of IGFBP-2a in black porgy (Acanthopagrus schlegelii) and evolutionary analysis of IGFBP-2s in the species of Perciformes
  Xinyi Zhang, Zhiyong Zhang, Zhenpeng Yu, Jiayi Li, Shuyin Chen, Ruijian Sun, Chaofeng Jia, Fei Zhu, Qian Meng, Shixia Xu
  Fish Physiology and Biochemistry.2019; 45(5): 1731.     CrossRef
• Current Insights into the Role of the Growth Hormone-Insulin-Like Growth Factor System in Short Children Born Small for Gestational Age
  Judith S. Renes, Jaap van Doorn, Anita C.S. Hokken-Koelega
  Hormone Research in Paediatrics.2019; 92(1): 15.     CrossRef
• Insulin-Like Growth Factor (IGF) System in Liver Diseases
  Agnieszka Adamek, Aldona Kasprzak
  International Journal of Molecular Sciences.2018; 19(5): 1308.     CrossRef
• IGFBP2 is a potential biomarker in acute kidney injury (AKI) and resveratrol-loaded nanoparticles prevent AKI
  Hai-Lun Li, Zhuan Yan, Zun-Ping Ke, Xiao-Feng Tian, Li-Li Zhong, Yong-Tao Lin, Yong Xu, Dong-Hui Zheng
  Oncotarget.2018; 9(93): 36551.     CrossRef
• Multiple optic gland signaling pathways implicated in octopus maternal behaviors and death
  Z. Yan Wang, Clifton W. Ragsdale
  Journal of Experimental Biology.2018;[Epub]     CrossRef
• Insulin-Like Growth Factor-Binding Proteins of Teleost Fishes
  Daniel Garcia de la Serrana, Daniel J. Macqueen
  Frontiers in Endocrinology.2018;[Epub]     CrossRef