- Diabetes, obesity and metabolism
- Reference Standards for C-Peptide in Korean Population: A Korean Endocrine Hormone Reference Standard Data Center Study
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Jooyoung Cho, Ho-Chan Cho, Ohk-Hyun Ryu, Hyo-Jeong Kim, Chang Geun Kim, Young Ran Yun, Choon Hee Chung, on Behalf of the Task Force Team for Korean Hormone Reference Standards
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Endocrinol Metab. 2024;39(3):489-499. Published online May 9, 2024
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DOI: https://doi.org/10.3803/EnM.2023.1888
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Abstract
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- Background
The Korean Endocrine Hormone Reference Standard Data Center (KEHRS DC) has created reference standards (RSs) for endocrine hormones since 2020. This study is the first of its kind, wherein the KEHRS DC established RSs for serum Cpeptide levels in a healthy Korean population.
Methods Healthy Korean adults were recruited from May 2021 to September 2023. After excluding participants according to our criteria, serum samples were collected; each participant could then choose between fasting glucose only or fasting glucose plus an oral glucose tolerance test (OGTT). If their sample showed high glucose (≥100 mg/dL) or hemoglobin A1c (HbA1c) (≥5.70%), their C-peptide levels were excluded from analyzing the RSs.
Results A total of 1,532 participants were recruited; however, only the data of 1,050 participants were analyzed after excluding those whose samples showed hyperglycemia or high HbA1c. Post-30-minute OGTT data from 342 subjects and post-120-minute OGTT data from 351 subjects were used. The means±2 standard deviations and expanded uncertainties of fasting, post-30-minute and 120-minute OGTT C-peptide levels were 1.26±0.82 and 0.34–3.18, 4.74±3.57 and 1.14–8.33, and 4.85±3.58 and 1.25–8.34 ng/mL, respectively. Serum C-peptide levels correlated with obesity, serum glucose levels, and HbA1c levels.
Conclusion The RSs for serum C-peptide levels established in this study are expected to be useful in both clinical and related fields.
- Polyglandular Autoimmune Syndrome Type III with Primary Hypoparathyroidism
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Sang Jin Kim, Sang-Yoon Kim, Han-Byul Kim, Hyukwon Chang, Ho-Chan Cho
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Endocrinol Metab. 2013;28(3):236-240. Published online September 13, 2013
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DOI: https://doi.org/10.3803/EnM.2013.28.3.236
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Abstract
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Polyglandular autoimmune syndrome is defined as multiple endocrine gland insufficiencies accompanied by autoimmune diseases of the endocrine and nonendocrine system. After Schmidt introduced a case of nontuberculosis adrenal gland dysfunction with thyroiditis in 1926, Neufeld defined polyglandular autoimmune syndrome by I, II, and III subtypes in 1980 by their presentation of occurrence age, heredity methods, relationship with human leukocyte antigen, and accompanying diseases. We report a case of a 32-year-old female with polyglandular autoimmune syndrome III accompanied by type 1 diabetes mellitus that was treated with insulin (36 units per day) for 11 years. She had insulin deficiency and Hashimoto thyroiditis as an autoimmune disorder. In addition, she had several features similar to Albright's hereditary osteodystrophy including short stature, truncal obesity, round face, short neck, low intelligence (full IQ 84), and decreased memory. Although Albright's hereditary osteodystrophy is morphological evidence of pseudohypoparathyroidism or pseudopseudohypoparathyroidism, she had primary hypoparathyroidism on laboratory results. Here, we report a case of polyglandular autoimmune syndrome III with type 1 diabetes mellitus, autoimmune thyroiditis, and primary hypoparathyroidism, accompanied by clinical features similar to Albright's hereditary osteodystrophy.
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Citations
Citations to this article as recorded by
- Autoimmune polyglandular syndrome type III associated with antineutrophil cytoplasmic autoantibody-mediated crescentic glomerulonephritis
Shiyuan Tian, Baofeng Xu, Ziwei Liu, Rui Liu Medicine.2020; 99(7): e19179. CrossRef - Hypoparathyroidism: Genetics and Diagnosis
Michael Mannstadt, Luisella Cianferotti, Rachel I Gafni, Francesca Giusti, Elizabeth Helen Kemp, Christian A Koch, Kelly L Roszko, Liam Yao, Gordon H Guyatt, Rajesh V Thakker, Weibo Xia, Maria-Luisa Brandi Journal of Bone and Mineral Research.2020; 37(12): 2615. CrossRef - A rare case of polyglandular autoimmune syndrome type IIIc with primary antibody failure
Adina Elena Stanciu, Florentina Sava, Gergely Toldi Gynecological Endocrinology.2018; 34(4): 283. CrossRef - Autoimmune Polyendocrine Syndrome Type IIIC and Ankylosing Spondylitis; a Case Report
Ali Javinani, Hamid Reza Aghaei Meybodi, Ahmad Reza Jamshidi, Farhad Gharibdoost, Hoda Kavosi Rheumatology Research.2016;[Epub] CrossRef - Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
Won-Young Lee Endocrinology and Metabolism.2014; 29(3): 251. CrossRef
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