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Ho Jin Kim  (Kim HJ) 2 Articles
Clinical Study
A Novel Index Using Soluble CD36 Is Associated with the Prevalence of Type 2 Diabetes Mellitus: Comparison Study with Triglyceride-Glucose Index
Ho Jin Kim, Jun Sung Moon, Il Rae Park, Joong Hee Kim, Ji Sung Yoon, Kyu Chang Won, Hyoung Woo Lee
Endocrinol Metab. 2017;32(3):375-382.   Published online September 18, 2017
DOI: https://doi.org/10.3803/EnM.2017.32.3.375
  • 4,236 View
  • 46 Download
  • 9 Web of Science
  • 12 Crossref
AbstractAbstract PDFPubReader   
Background

Plasma soluble cluster determinant 36 (sCD36) level is closely related with insulin resistance and atherosclerosis, but little is known whether it could be a surrogate for estimating risk of developing diabetes or not. To address this, we evaluated association between sCD36 index, the product of sCD36 and fasting plasma glucose (FPG), and the prevalence of type 2 diabetes mellitus (T2DM), and then compared with triglyceride-glucose (TyG) index which has been suggested simple index for insulin resistance.

Methods

This was cross-sectional study, and participants were classified as normal glucose tolerance (NGT), prediabetes, and T2DM according to glucose tolerance. The formula of TyG index was ‘ln [FPG (mg/dL)×triglyceride (mg/dL)/2],’ and the sCD36 index was ‘ln [sCD36 (pg/mL)×FPG (mg/dL)/2].’

Results

One hundred and fifty-five subjects (mean age, 55.2 years) were enrolled, and patients with T2DM were 75. Both indexes were significantly increased in prediabetes and T2DM rather than NGT, and sCD36 index was positively correlated with both glycosylated hemoglobin and homeostasis model assessment of insulin resistance (r=0.767 and r=0.453, respectively; P<0.05) and negatively with homeostasis model assessment estimate of β-cell function (r=−0.317). The odds ratio (OR) of sCD36 index for T2DM was 4.39 (95% confidential interval, 1.51 to 12.77) after adjusting age, gender, blood pressure, smoking, alcohol, non-high density lipoprotein cholesterol and high-sensitivity C-reactive protein. However, OR of TyG index did not remained significance after adjustment.

Conclusion

sCD36 index has an independent association with the risk of T2DM, and showed better correlation than TyG index. These results suggest sCD36 index might be useful surrogate marker for the risk of diabetes.

Citations

Citations to this article as recorded by  
  • The triglyceride-glucose index as an indicator of insulin resistance and cardiometabolic risk in Brazilian adolescents
    Miriam Beatrís Reckziegel, Patrik Nepomuceno, Tania Machado, Jane Dagmar Pollo Renner, Hildegard Hedwig Pohl, Carlos Alberto Nogueira-de-Almeida, Elza Daniel de Mello
    Archives of Endocrinology and Metabolism.2023;[Epub]     CrossRef
  • The association of soluble cluster of differentiation 36 with metabolic diseases: A potential biomarker and therapeutic target
    Yun Li, Yaxi Chen, Xiong Z. Ruan
    Pediatric Discovery.2023;[Epub]     CrossRef
  • Kidney lipid dysmetabolism and lipid droplet accumulation in chronic kidney disease
    Alla Mitrofanova, Sandra Merscher, Alessia Fornoni
    Nature Reviews Nephrology.2023; 19(10): 629.     CrossRef
  • Diabetic cardiac autonomic neuropathy: insulin resistance, lipid profile, and omega-3 polyunsaturated fatty acids
    Martin-Yurii Markevich, Volodymyr Segin, Victoria Serhiyenko, Alexandr Serhiyenko
    InterConf.2023; (35(163)): 213.     CrossRef
  • Insulin resistance estimated by estimated glucose disposal rate predicts outcomes in acute ischemic stroke patients
    Zhengzhao Lu, Yunyun Xiong, Xueyan Feng, Kaixuan Yang, Hongqiu Gu, Xingquan Zhao, Xia Meng, Yongjun Wang
    Cardiovascular Diabetology.2023;[Epub]     CrossRef
  • Usefulness of SPISE Index for Screening and Detection of Early Stages of Insulin Resistance among Chilean Young Adults
    Isabel Pereyra González, Sandra Lopez-Arana
    Annals of Nutrition and Metabolism.2023; 79(4): 372.     CrossRef
  • Oxidative Stress Induced by Lipotoxicity and Renal Hypoxia in Diabetic Kidney Disease and Possible Therapeutic Interventions: Targeting the Lipid Metabolism and Hypoxia
    Seung Yun Chae, Yaeni Kim, Cheol Whee Park
    Antioxidants.2023; 12(12): 2083.     CrossRef
  • Proteomic analysis of epicardial adipose tissue from heart disease patients with concomitant heart failure with preserved ejection fraction
    Shan He, Huagang Zhu, Jianjun Zhang, Xiaopeng Wu, Lei Zhao, Xinchun Yang
    International Journal of Cardiology.2022; 362: 118.     CrossRef
  • DIABETIC CARDIAC AUTONOMIC NEUROPATHY: SIMVASTATIN, INSULIN RESISTANCE AND LIPIDS
    Victoria Serhiyenko, Marta Hotsko, Samir Ajmi, Alexandr Serhiyenko
    InterConf.2022; (18(95)): 531.     CrossRef
  • New insights into renal lipid dysmetabolism in diabetic kidney disease
    Alla Mitrofanova, George Burke, Sandra Merscher, Alessia Fornoni
    World Journal of Diabetes.2021; 12(5): 524.     CrossRef
  • The Role of CD36 in Type 2 Diabetes Mellitus: β-Cell Dysfunction and Beyond
    Jun Sung Moon, Udayakumar Karunakaran, Elumalai Suma, Seung Min Chung, Kyu Chang Won
    Diabetes & Metabolism Journal.2020; 44(2): 222.     CrossRef
  • The Multifunctionality of CD36 in Diabetes Mellitus and Its Complications—Update in Pathogenesis, Treatment and Monitoring
    Kamila Puchałowicz, Monika Ewa Rać
    Cells.2020; 9(8): 1877.     CrossRef
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A Case of Rhino-orbital Mucormycoses with Orbital Apex Syndrome in Diabetic Patient.
Jung Koo Kim, Sam Kwon, Jong Bo Yoon, Sung Min Yoon, Dong Oh Kang, Jae Hee Kim, Sang Gon Shin, Jung Won Park, In Bum Lee, Ho Jin Kim, Seung Wan Kang
J Korean Endocr Soc. 1998;13(4):677-683.   Published online January 1, 2001
  • 1,033 View
  • 23 Download
AbstractAbstract PDF
Rhino-orbital mucormycosis is a rare fungal infection that involves paranasal sinus and orbits and usually presented as acute invasive fungal sinusitis or orbital apex syndrome. It often occurs in patients with poorly controlled diabetes mellitus especially during or following episode of diabetic ketoacidosis. If the condition is not treated, the fungal infection may disseminated into the brain and death usually occurs in a day to week. Exenteration is often needed as a therapy. We have experienced a case of rhino-orbital mucormycosis that presented as a orbital apex syndrome and confirmed by maxillary and periorbital soft tissue biopsy. A 56-year-old female suffered from diabetes mellitus for 3 years was admitted with rapidly progressive visual acuity loss and left hemi-facial numbness. She was treated with daily intravenous amphotericin B and intraconal amphotericin B irrigation and packing. Exenteration was not neccisated.
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