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Hee Jung Kim  (Kim HJ) 1 Article
A Case of Tumor-induced Osteomalacia with Elevated Fibroblast Growth Factor-23.
Hae Sung Kim, Hyun Seung Jung, Hee Jung Kim, Sung Yeon Kim, Sang Wan Kim, Chan Soo Shin, Chong Jai Kim, Seong Yeon Kim
J Korean Endocr Soc. 2007;22(2):142-148.   Published online April 1, 2007
DOI: https://doi.org/10.3803/jkes.2007.22.2.142
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  • 12 Crossref
AbstractAbstract PDF
Tumor-induced osteomalacia (TIO), a paraneoplastic disease, is characterized by hypophosphatemia, and caused by renal phosphate wasting inappropriately, normal or decreased 1, 25(OH)2D3 production, and defective calcification of cartilage and bone. Because the removal of the responsible tumor normalizes phosphate metabolism, unidentified humoral phosphaturic factors (phosphatonin) are believed to be responsible for this syndrome. These factors include fibroblast growth factor (FGF)-23, secreted frizzled-related protein-4 and matrix extracellular phosphoglycoprotein. However, no case of TIO producing FGF-23 has been clearly reported in Korea. Herein, a case of TIO producing FGF-23 in a 45-year-old woman is reported. The patient presented with a large tumor on her buttock, with severe bone and muscle pain. A histological examination of the tumor revealed a mixed connective tissue tumor, consisting of deposition of calcified materials and surrounding primitive spindle cells, with prominent vascularity. Whether FGF-23 is a secreted factor, as well as its levels of expression in tumors were investigated. An immunohistochemical study showed the tumor cells to be FGF-23 positive. Furthermore, the levels of serum FGF-23 were extremely high and an RT-PCR analysis, using total RNA from the tumor, revealed the abundant expression of FGF-23 mRNA. After removal of the tumor, all the biochemical and hormonal abnormalities disappeared, with marked symptomatic improvement.

Citations

Citations to this article as recorded by  
  • Change in Patient's Ages Who Took an Adenoidectomy for 30 Years
    Eun Jung Lee, Ji Hoon Kim, Hye Jin Hwang, Min Ki Kim, Min Seok Kang, Kyung-Su Kim
    Journal of Rhinology.2017; 24(1): 8.     CrossRef
  • Dietary assessment according to frequency of food consumed away from home among children and adolescents: Based on the 2010~2012 Korea National Health and Nutrition Examination Survey
    Yong-Suk Kwon, Wan-Soo Hong, Seyoung Ju
    Journal of Nutrition and Health.2016; 49(6): 471.     CrossRef
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    Jung Min Yoon
    Pediatric Gastroenterology, Hepatology & Nutrition.2014; 17(2): 85.     CrossRef
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    Jun-Hwee Kim, Myung-Joon Kim, Sok Hwan Lim, Jieun Kim, Mi-Jung Lee
    Korean Journal of Radiology.2013; 14(4): 677.     CrossRef
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    Young-Ju Jee, Young-Hae Kim
    The Korean Journal of Obesity.2013; 22(1): 39.     CrossRef
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    Choong-Kyun Noh, Min-Jeong Lee, Bu Kyung Kim, Yoon-Sok Chung
    Journal of Bone Metabolism.2013; 20(1): 51.     CrossRef
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    Gyu Jin Heo, So-Young Nam, Soo-Kyung Lee, Sang-Jin Chung, Ji hyun Yoon
    Korean Journal of Community Nutrition.2012; 17(2): 226.     CrossRef
  • Changes in Prevalence of Obesity and Underweight among Korean Children and Adolescents: 1998-2008
    Ki Eun Kim, Shin Hye Kim, Sangshin Park, Young-Ho Khang, Mi Jung Park
    The Korean Journal of Obesity.2012; 21(4): 228.     CrossRef
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    Resuscitation.2012; 83(9): 1129.     CrossRef
  • Lipid Profiles and Prevalence of Dyslipidemia in Korean Adolescents
    Shin Hye Kim, Byung Chul Ahn, Hyojee Joung, Mi Jung Park
    Endocrinology and Metabolism.2012; 27(3): 208.     CrossRef
  • Trends in obesity among Korean children using four different criteria
    Young-Ho Khang, Mi Jung Park
    International Journal of Pediatric Obesity.2011; 6(3-4): 206.     CrossRef
  • Usefulness of the Waist Circumference-to-Height Ratio in Screening for Obesity in Korean Children and Adolescents
    Joo Hyun Gil, Mi Na Lee, Hye Ah Lee, Hyesook Park, Jeong Wan Seo
    Korean Journal of Pediatric Gastroenterology and Nutrition.2010; 13(2): 180.     CrossRef
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