Skip Navigation
Skip to contents

Endocrinol Metab : Endocrinology and Metabolism

clarivate
OPEN ACCESS
SEARCH
Search

Author index

Page Path
HOME > BROWSE ARTICLES > Author index
Search
Han Seok Choi  (Choi HS) 11 Articles
Diabetes, Obesity and Metabolism
Big Data Articles (National Health Insurance Service Database)
Big Data Research in the Field of Endocrine Diseases Using the Korean National Health Information Database
Sun Wook Cho, Jung Hee Kim, Han Seok Choi, Hwa Young Ahn, Mee Kyoung Kim, Eun Jung Rhee
Endocrinol Metab. 2023;38(1):10-24.   Published online February 9, 2023
DOI: https://doi.org/10.3803/EnM.2023.102
  • 3,033 View
  • 247 Download
  • 8 Web of Science
  • 15 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
The Korean National Health Information Database (NHID) contains big data combining information obtained from the National Health Insurance Service and health examinations. Data are provided in the form of a cohort, and the NHID can be used to conduct longitudinal studies and research on rare diseases. Moreover, data on the cause and date of death are provided by Statistics Korea. Research and publications based on the NHID have increased explosively in the field of endocrine disorders. However, because the data were not collected for research purposes, studies using the NHID have limitations, particularly the need for the operational definition of diseases. In this review, we describe the characteristics of the Korean NHID, operational definitions of endocrine diseases used for research, and an overview of recent studies in endocrinology using the Korean NHID.

Citations

Citations to this article as recorded by  
  • Associations Between Physical Activity and the Risk of Hip Fracture Depending on Glycemic Status: A Nationwide Cohort Study
    Kyoung Min Kim, Kyoung Jin Kim, Kyungdo Han, Yumie Rhee
    The Journal of Clinical Endocrinology & Metabolism.2024; 109(3): e1194.     CrossRef
  • Weight change in patients with new‐onset type 2 diabetes mellitus and its association with remission: Comprehensive real‐world data
    Jinyoung Kim, Bongseong Kim, Mee Kyoung Kim, Ki‐Hyun Baek, Ki‐Ho Song, Kyungdo Han, Hyuk‐Sang Kwon
    Diabetes, Obesity and Metabolism.2024; 26(2): 567.     CrossRef
  • Diabetes severity and the risk of depression: A nationwide population-based study
    Yunjung Cho, Bongsung Kim, Hyuk-Sang Kwon, Kyungdo Han, Mee Kyoung Kim
    Journal of Affective Disorders.2024; 351: 694.     CrossRef
  • Information Bias Might Exaggerate Lung Cancer Risk of Patients With Rheumatoid Arthritis
    Nobuyuki Horita, Kaoru Takase-Minegishi
    Journal of Thoracic Oncology.2024; 19(2): 348.     CrossRef
  • Diabetes severity is strongly associated with the risk of active tuberculosis in people with type 2 diabetes: a nationwide cohort study with a 6-year follow-up
    Ji Young Kang, Kyungdo Han, Seung-Hwan Lee, Mee Kyoung Kim
    Respiratory Research.2023;[Epub]     CrossRef
  • Research on obesity using the National Health Information Database: recent trends
    Eun-Jung Rhee
    Cardiovascular Prevention and Pharmacotherapy.2023; 5(2): 35.     CrossRef
  • Pituitary Diseases and COVID-19 Outcomes in South Korea: A Nationwide Cohort Study
    Jeonghoon Ha, Kyoung Min Kim, Dong-Jun Lim, Keeho Song, Gi Hyeon Seo
    Journal of Clinical Medicine.2023; 12(14): 4799.     CrossRef
  • Risk of Pancreatic Cancer and Use of Dipeptidyl Peptidase 4 Inhibitors in Patients with Type 2 Diabetes: A Propensity Score-Matching Analysis
    Mee Kyoung Kim, Kyungdo Han, Hyuk-Sang Kwon, Soon Jib Yoo
    Endocrinology and Metabolism.2023; 38(4): 426.     CrossRef
  • Prevalence, Treatment Status, and Comorbidities of Hyperthyroidism in Korea from 2003 to 2018: A Nationwide Population Study
    Hwa Young Ahn, Sun Wook Cho, Mi Young Lee, Young Joo Park, Bon Seok Koo, Hang-Seok Chang, Ka Hee Yi
    Endocrinology and Metabolism.2023; 38(4): 436.     CrossRef
  • Is Thyroid Dysfunction Associated with Unruptured Intracranial Aneurysms? A Population-Based, Nested Case–Control Study from Korea
    Hyeree Park, Sun Wook Cho, Sung Ho Lee, Kangmin Kim, Hyun-Seung Kang, Jeong Eun Kim, Aesun Shin, Won-Sang Cho
    Thyroid®.2023; 33(12): 1483.     CrossRef
  • Risk of Cause-Specific Mortality across Glucose Spectrum in Elderly People: A Nationwide Population-Based Cohort Study
    Joonyub Lee, Hun-Sung Kim, Kee-Ho Song, Soon Jib Yoo, Kyungdo Han, Seung-Hwan Lee
    Endocrinology and Metabolism.2023; 38(5): 525.     CrossRef
  • Risk of depression in patients with acromegaly in Korea (2006-2016): a nationwide population-based study
    Shinje Moon, Sangmo Hong, Kyungdo Han, Cheol-Young Park
    European Journal of Endocrinology.2023; 189(3): 363.     CrossRef
  • Cumulative effect of impaired fasting glucose on the risk of dementia in middle-aged and elderly people: a nationwide cohort study
    Jin Yu, Kyu-Na Lee, Hun-Sung Kim, Kyungdo Han, Seung-Hwan Lee
    Scientific Reports.2023;[Epub]     CrossRef
  • Long-Term Cumulative Exposure to High γ-Glutamyl Transferase Levels and the Risk of Cardiovascular Disease: A Nationwide Population-Based Cohort Study
    Han-Sang Baek, Bongseong Kim, Seung-Hwan Lee, Dong-Jun Lim, Hyuk-Sang Kwon, Sang-Ah Chang, Kyungdo Han, Jae-Seung Yun
    Endocrinology and Metabolism.2023; 38(6): 770.     CrossRef
  • Increased Risk of Hip Fracture in Patients with Acromegaly: A Nationwide Cohort Study in Korea
    Jiwon Kim, Namki Hong, Jimi Choi, Ju Hyung Moon, Eui Hyun Kim, Eun Jig Lee, Sin Gon Kim, Cheol Ryong Ku
    Endocrinology and Metabolism.2023; 38(6): 690.     CrossRef
Close layer
Calcium & Bone Metabolism
Big Data Articles (National Health Insurance Service Database)
Hip Fracture Risk According to Diabetic Kidney Disease Phenotype in a Korean Population
Seung Eun Lee, Juhwan Yoo, Kyoung-Ah Kim, Kyungdo Han, Han Seok Choi
Endocrinol Metab. 2022;37(1):148-158.   Published online February 28, 2022
DOI: https://doi.org/10.3803/EnM.2021.1315
  • 3,141 View
  • 108 Download
  • 5 Web of Science
  • 5 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
Diabetic kidney disease (DKD) is associated with an elevated risk of fractures. However, little is known about the association between proteinuric or non-proteinuric DKD and the risk of hip fracture. Thus, we investigated the incidence of hip fractures among Korean adults with type 2 diabetes mellitus (T2DM) stratified by DKD phenotype.
Methods
In this retrospective cohort study using the Korean National Health Insurance Service database, patients with T2DM who received at least one general health checkup between 2009 and 2012 were followed until the date of hip fracture, death, or December 31, 2018. We classified the DKD phenotype by proteinuria and estimated glomerular filtration rate (eGFR), as follows: no DKD (PUGFR), proteinuric DKD with normal eGFR (PU+GFR), non-proteinuric DKD with reduced eGFR (PUGFR+), and proteinuric DKD with reduced eGFR (PU+GFR+)
Results
The cumulative incidence of hip fractures was highest in the PU+GFR+ group, followed by the PUGFR+ group and the PU+GFR group. After adjustment for confounding factors, the hazard ratio (HR) for hip fracture was still highest in the PU+GFR+ group. However, the PU+GFR group had a higher HR for hip fracture than the PUGFR+ group (PU+GFR+ : HR, 1.69; 95% confidence interval [CI], 1.57 to 1.81; PU+GFR : HR, 1.37; 95% CI, 1.30 to 1.46; PUGFR+ : HR, 1.20; 95% CI, 1.16 to 1.24 using the PUGFR group as the reference category).
Conclusion
The present study demonstrated that DKD was significantly associated with a higher risk of hip fracture, with proteinuria as a major determinant.

Citations

Citations to this article as recorded by  
  • Proteinuria screening and risk of bone fracture: a retrospective cohort study using a nationwide population-based database
    Akira Okada, Akira Honda, Hideaki Watanabe, Yusuke Sasabuchi, Shotaro Aso, Kayo Ikeda Kurakawa, Masaomi Nangaku, Toshimasa Yamauchi, Hideo Yasunaga, Hirotaka Chikuda, Takashi Kadowaki, Satoko Yamaguchi
    Clinical Kidney Journal.2024;[Epub]     CrossRef
  • Fracture risks associated with sodium-glucose cotransporter-2 inhibitors in type 2 diabetes patients across eGFR and albuminuria categories: A population-based study in Hong Kong
    David Tak Wai Lui, Tingting Wu, Eric Ho Man Tang, Ivan Chi Ho Au, Chi Ho Lee, Yu Cho Woo, Kathryn Choon Beng Tan, Carlos King Ho Wong
    Diabetes Research and Clinical Practice.2023; 197: 110576.     CrossRef
  • Diagnose und Management der Osteoporose bei Diabetes mellitus (Update 2023)
    Christian Muschitz, Alexandra Kautzky-Willer, Yvonne Winhofer, Martina Rauner, Judith Haschka, Daniel Cejka, Robert Wakolbinger-Habel, Peter Pietschmann
    Wiener klinische Wochenschrift.2023; 135(S1): 207.     CrossRef
  • Association between exercise and risk of fractures in new-onset type 2 diabetes: a retrospective cohort study
    Seung Eun Lee, Juhwan Yoo, Bong-Seong Kim, Kyoung-Ah Kim, Kyungdo Han, Han Seok Choi
    Archives of Osteoporosis.2023;[Epub]     CrossRef
  • Two-Year Changes in Diabetic Kidney Disease Phenotype and the Risk of Heart Failure: A Nationwide Population-Based Study in Korea
    Seung Eun Lee, Juhwan Yoo, Han Seok Choi, Kyungdo Han, Kyoung-Ah Kim
    Diabetes & Metabolism Journal.2023; 47(4): 523.     CrossRef
Close layer
Bone Metabolism
Why Do We Need Proactive Management for Fracture Prevention in Long-Term Glucocorticoid Users?
Han Seok Choi
Endocrinol Metab. 2020;35(3):549-551.   Published online September 22, 2020
DOI: https://doi.org/10.3803/EnM.2020.308
  • 3,356 View
  • 73 Download
PDFPubReader   ePub   
Close layer
Miscellaneous
Influence of Vitamin D Deficiency on Progression of Experimental Otitis Media in Rats
Hee-Bok Kim, So Hyun Lim, Chang Gun Cho, Han Seok Choi
Endocrinol Metab. 2018;33(2):296-304.   Published online June 21, 2018
DOI: https://doi.org/10.3803/EnM.2018.33.2.296
  • 3,836 View
  • 45 Download
  • 2 Web of Science
  • 2 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background

Vitamin D plays an important role in the immune response against infection. The purpose of the present study was to investigate the influence of vitamin D deficiency on the progression of otitis media (OM) using an experimental rat model.

Methods

Four-week-old male Sprague-Dawley rats (n=72) were divided into two groups based on their diet: a control diet group (n=36) and a vitamin D-deficient diet group (n=36). After 8 weeks of diet, experimental OM was induced by inoculation of non-typeable Haemophilus influenzae in the middle ear cavity. The rats were evaluated with otomicroscopy to determine the inflammation in the middle ear mucosa on days 1, 2, 4, 7, and 14 post-inoculation. Bullae from sacrificed rats were collected and analyzed histologically.

Results

The middle ear mucosa from rats with vitamin D deficiency showed a significantly higher thickness than that of controls during the course of OM. The maximum mucosal thickness was 56.0±9.1 µm in the vitamin D deficiency group, and 43.9±9.8 µm in the control group, although there was no significant difference in the tympanic membrane score between the two groups evaluated with otomicroscopy. An immunohistochemical study showed increased expression of interleukin 6 (IL-6) and tumor necrosis factor α in rats manifesting vitamin D deficiency and decreased expression of IL-10 compared with controls.

Conclusion

Our results showed that vitamin D deficiency may exacerbate the pathophysiological changes of OM via altered cytokine production. Therefore, maintaining vitamin D status in the optimal range may be beneficial for proper management of OM.

Citations

Citations to this article as recorded by  
  • The role of vitamin D in subjective tinnitus—A case-control study
    Magdalena Nowaczewska, Stanisław Osiński, Maria Marzec, Michał Wiciński, Katarzyna Bilicka, Wojciech Kaźmierczak, Rafael da Costa Monsanto
    PLOS ONE.2021; 16(8): e0255482.     CrossRef
  • Vitamin D and Otitis Media
    Rebecca E. Walker, Jim Bartley, Carlos A. Camargo, Edwin A. Mitchell
    Current Allergy and Asthma Reports.2019;[Epub]     CrossRef
Close layer
Clinical Study
Effects of Single Vitamin D3 Injection (200,000 Units) on Serum Fibroblast Growth Factor 23 and Sclerostin Levels in Subjects with Vitamin D Deficiency
Dongdong Zhang, Da Hea Seo, Han Seok Choi, Hye-Sun Park, Yoon-Sok Chung, Sung-Kil Lim
Endocrinol Metab. 2017;32(4):451-459.   Published online December 14, 2017
DOI: https://doi.org/10.3803/EnM.2017.32.4.451
  • 4,393 View
  • 50 Download
  • 8 Web of Science
  • 10 Crossref
AbstractAbstract PDFPubReader   
Background

Vitamin D deficiency remains common in all age groups and affects skeletal and non-skeletal health. Fibroblast growth factor 23 is a bone-derived hormone that regulates phosphate and 1,25-dihydroxyvitamin D homeostasis as a counter regulatory factor. 1,25-Dihydroxyvitamin D stimulates fibroblast growth factor 23 synthesis in bone, while fibroblast growth factor 23 suppresses 1,25-dihydroxyvitamin D production in the kidney. The aim of this study was to evaluate the effects of vitamin D3 intramuscular injection therapy on serum fibroblast growth factor 23 concentrations, and several other parameters associated with bone metabolism such as sclerostin, dickkopf-1, and parathyroid hormone.

Methods

A total of 34 subjects with vitamin D deficiency (defined by serum 25-hydroxyvitamin D levels below 20 ng/mL) were randomly assigned to either the vitamin D injection group (200,000 units) or placebo treatment group. Serum calcium, phosphate, urine calcium/creatinine, serum 25-hydroxyvitamin D, fibroblast growth factor 23, sclerostin, parathyroid hormone, and dickkopf-1 levels were serially measured after treatment.

Results

Comparing the vitamin D injection group with the placebo group, no significant changes were observed in serum fibroblast growth factor 23, parathyroid hormone, or dickkopf-1 levels. Serum sclerostin concentrations transiently increased at week 4 in the vitamin D group. However, these elevated levels declined later and there were no statistically significant differences as compared with baseline levels.

Conclusion

Serum fibroblast factor 23, sclerostin, parathyroid hormone, and dickkopf-1 levels were not affected significantly by single intramuscular injection of vitamin D3.

Citations

Citations to this article as recorded by  
  • Effect of vitamin D supplementation on circulating fibroblast growth factor-23 concentration in adults with prediabetes
    Lisa Ceglia, Anastassios G. Pittas, Bess Dawson-Hughes
    Aging Clinical and Experimental Research.2023; 35(3): 525.     CrossRef
  • Fibroblast Growth Factor 23 in COVID-19: An Observational Study
    Athena Myrou, Theodoros Aslanidis, Keli Makedou, Athanasios Mitsianis, Aikaterini Thisiadou, Paraskevi Karalazou, Georgios Chatzopoulos, Anastasios Papadopoulos, Antonios Kalis, Dimitrios Giagkoulis, Fotios Lezgidis, Christos Savopoulos
    Cureus.2023;[Epub]     CrossRef
  • The effect of vitamin D supplementation on serum levels of fibroblast growth factor- 23: A systematic review and meta-analysis of randomized controlled trials
    Fatemeh Meshkini, Sepideh Soltani, Cain C.T. Clark, Vivian Tam, David Meyre, Omid Toupchian, Sahar Saraf-Bank, Shima Abdollahi
    The Journal of Steroid Biochemistry and Molecular Biology.2022; 215: 106012.     CrossRef
  • Serum sclerostin levels in osteoporotic fracture patients
    Erwin A. Gorter, Casper R. Reinders, Pieta Krijnen, Natasha M. Appelman-Dijkstra, Inger B. Schipper
    European Journal of Trauma and Emergency Surgery.2022; 48(6): 4857.     CrossRef
  • Clinical Utility of Preoperative Vitamin D3 Injection for Preventing Transient Hypocalcemia after Total Thyroidectomy
    Kwangsoon Kim, Cho Rok Lee, Sang-Wook Kang, Jandee Lee, Jong Ju Jeong, Kee-Hyun Nam, Woong Youn Chung, Claudio Casella
    International Journal of Endocrinology.2021; 2021: 1.     CrossRef
  • The effect of vitamin D supplementation on fibroblast growth factor‐23 in patients with chronic kidney disease: A systematic review and meta‐analysis
    Elmira Karimi, Sama Bitarafan, Seyed Mohammad Mousavi, Nikan Zargarzadeh, Pari Mokhtari, Jessie Hawkins, Alipasha Meysamie, Fariba Koohdani
    Phytotherapy Research.2021; 35(10): 5339.     CrossRef
  • Pharmacodynamics of Oral Cholecalciferol in Healthy Individuals with Vitamin D Deficiency: A Randomized Open-Label Study
    Angelo Fassio, Davide Gatti, Maurizio Rossini, Camilla Benini, Elena Fracassi, Eugenia Bertoldo, Ombretta Viapiana, Stefano Milleri, Matteo Gatti, Giovanni Adami
    Nutrients.2021; 13(7): 2293.     CrossRef
  • Vitamin D Deficiency at Mid-Pregnancy Is Associated with a Higher Risk of Postpartum Glucose Intolerance in Women with Gestational Diabetes Mellitus
    Kyung-Soo Kim, Seok Won Park, Yong-Wook Cho, Soo-Kyung Kim
    Endocrinology and Metabolism.2020; 35(1): 97.     CrossRef
  • Effects of vitamin D supplementation on bone turnover markers and other bone-related substances in subjects with vitamin D deficiency
    Rolf Jorde, Astrid Kamilla Stunes, Julia Kubiak, Ragnar Joakimsen, Guri Grimnes, Per Medbøe Thorsby, Unni Syversen
    Bone.2019; 124: 7.     CrossRef
  • Vitamin D Enhances the Efficacy of Topical Artificial Tears in Patients With Dry Eye Disease
    Jin Sun Hwang, Yoon Pyo Lee, Young Joo Shin
    Cornea.2019; 38(3): 304.     CrossRef
Close layer
Clinical Study
Obesity and Hyperglycemia in Korean Men with Klinefelter Syndrome: The Korean Endocrine Society Registry
Seung Jin Han, Kyung-Soo Kim, Wonjin Kim, Jung Hee Kim, Yong-ho Lee, Ji Sun Nam, Ji A Seo, Bu Kyung Kim, Jihyun Lee, Jin Ook Chung, Min-Hee Kim, Tae-Seo Sohn, Han Seok Choi, Seong Bin Hong, Yoon-Sok Chung
Endocrinol Metab. 2016;31(4):598-603.   Published online December 20, 2016
DOI: https://doi.org/10.3803/EnM.2016.31.4.598
  • 5,105 View
  • 33 Download
  • 20 Web of Science
  • 18 Crossref
AbstractAbstract PDFPubReader   
Background

The aim of this study was to investigate the prevalence of obesity in Korean men with Klinefelter syndrome (KS) and the associated risk factors for obesity and hyperglycemia.

Methods

Data were collected retrospectively from medical records from 11 university hospitals in Korea between 1994 and 2014. Subjects aged ≥18 years with newly diagnosed KS were enrolled. The following parameters were recorded at baseline before treatment: chief complaint, height, weight, fasting glucose level, lipid panel, blood pressure, testosterone, luteinizing hormone, follicle-stimulating hormone, karyotyping patterns, and history of hypertension, diabetes, and dyslipidemia.

Results

Data were analyzed from 376 of 544 initially enrolled patients. The rate of the 47 XXY chromosomal pattern was 94.1%. The prevalence of obesity (body mass index ≥25 kg/m2) in Korean men with KS was 42.6%. The testosterone level was an independent risk factor for obesity and hyperglycemia.

Conclusion

Obesity is common in Korean men with KS. Hypogonadism in patients with KS was associated with obesity and hyperglycemia.

Citations

Citations to this article as recorded by  
  • A dual-center study of predictive factors for sperm retrieval through microdissection testicular sperm extraction and intracytoplasmic sperm injection outcomes in men with non-mosaic Klinefelter syndrome
    Jong Hyeun Baeck, Tae Jin Kim, Tae Heon Kim, Seung-Ryeol Lee, Dong Soo Park, Hwang Kwon, Ji Eun Shin, Dong Hyeon Lee, Young Dong Yu
    Investigative and Clinical Urology.2023; 64(1): 41.     CrossRef
  • Cardiorespiratory fitness in adolescents and young adults with Klinefelter syndrome – a pilot study
    Julia Spiekermann, Kathrin Sinningen, Beatrice Hanusch, Michaela Kleber, Michael M. Schündeln, Cordula Kiewert, Heide Siggelkow, Jakob Höppner, Corinna Grasemann
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Metabolic Profile in a Cohort of Young Sicilian Patients with Klinefelter’s Syndrome: The Role of Irisin
    Stefano Radellini, Valentina Guarnotta, Vincenzo Sciabica, Giuseppe Pizzolanti, Carla Giordano, Vito Angelo Giagulli
    International Journal of Endocrinology.2022; 2022: 1.     CrossRef
  • Metabolic and Nutritional Aspects in Paediatric Patients with Klinefelter Syndrome: A Narrative Review
    Chiara Mameli, Giulia Fiore, Arianna Sangiorgio, Marta Agostinelli, Giulia Zichichi, Gianvincenzo Zuccotti, Elvira Verduci
    Nutrients.2022; 14(10): 2107.     CrossRef
  • Klinefelter syndrome in an adolescent with severe obesity, insulin resistance, and hyperlipidemia, successfully treated with testosterone replacement therapy
    Shota Fukuhara, Jun Mori, Hisakazu Nakajima
    Clinical Pediatric Endocrinology.2021; 30(3): 127.     CrossRef
  • Glucose metabolic disorder in Klinefelter syndrome: a retrospective analysis in a single Chinese hospital and literature review
    Shixuan Liu, Tao Yuan, Shuoning Song, Shi Chen, Linjie Wang, Yong Fu, Yingyue Dong, Yan Tang, Weigang Zhao
    BMC Endocrine Disorders.2021;[Epub]     CrossRef
  • What Every Internist-Endocrinologist Should Know about Rare Genetic Syndromes in Order to Prevent Needless Diagnostics, Missed Diagnoses and Medical Complications: Five Years of ‘Internal Medicine for Rare Genetic Syndromes’
    Anna G. W. Rosenberg, Minke R. A. Pater, Karlijn Pellikaan, Kirsten Davidse, Anja A. Kattentidt-Mouravieva, Rogier Kersseboom, Anja G. Bos-Roubos, Agnies van Eeghen, José M. C. Veen, Jiske J. van der Meulen, Nina van Aalst-van Wieringen, Franciska M. E. H
    Journal of Clinical Medicine.2021; 10(22): 5457.     CrossRef
  • Klinefelter Syndrome and Diabetes
    Mark J. O’Connor, Emma A. Snyder, Frances J. Hayes
    Current Diabetes Reports.2019;[Epub]     CrossRef
  • Endocrine aspects of Klinefelter syndrome
    Adriana Herrera Lizarazo, Michelle McLoughlin, Maria G. Vogiatzi
    Current Opinion in Endocrinology, Diabetes & Obesity.2019; 26(1): 60.     CrossRef
  • Sex differences in metabolism and cardiometabolic disorders
    Karthickeyan Chella Krishnan, Margarete Mehrabian, Aldons J. Lusis
    Current Opinion in Lipidology.2018; 29(5): 404.     CrossRef
  • Klinefelter Syndrome: Integrating Genetics, Neuropsychology, and Endocrinology
    Claus H Gravholt, Simon Chang, Mikkel Wallentin, Jens Fedder, Philip Moore, Anne Skakkebæk
    Endocrine Reviews.2018; 39(4): 389.     CrossRef
  • Sex differences in obesity, lipid metabolism, and inflammation—A role for the sex chromosomes?
    Temeka Zore, Maria Palafox, Karen Reue
    Molecular Metabolism.2018; 15: 35.     CrossRef
  • Klinefelter syndrome, insulin resistance, metabolic syndrome, and diabetes: review of literature and clinical perspectives
    Andrea Salzano, Roberta D’Assante, Liam M. Heaney, Federica Monaco, Giuseppe Rengo, Pietro Valente, Daniela Pasquali, Eduardo Bossone, Daniele Gianfrilli, Andrea Lenzi, Antonio Cittadini, Alberto M. Marra, Raffaele Napoli
    Endocrine.2018; 61(2): 194.     CrossRef
  • Síndrome de Klinefelter y riesgo cardiovascular
    A. Yamaguchi, P. Knoblovits
    Hipertensión y Riesgo Vascular.2018; 35(4): 195.     CrossRef
  • Articles inEndocrinology and Metabolismin 2016
    Won-Young Lee
    Endocrinology and Metabolism.2017; 32(1): 62.     CrossRef
  • Sex differences in obesity: X chromosome dosage as a risk factor for increased food intake, adiposity and co-morbidities
    Karen Reue
    Physiology & Behavior.2017; 176: 174.     CrossRef
  • Klinefelter Syndrome with Morbid Obesity Before Bariatric Surgery: A Case Report
    Parisa Janmohammadi, Gholamreza Mohammadi-Farsani, Hana Arghavani, Mahmoud Arshad, Tayebeh Mokhber
    Journal of Minimally Invasive Surgical Sciences.2017;[Epub]     CrossRef
  • Klinefelter Syndrome and Metabolic Disorder
    Ji Cheol Bae
    Endocrinology and Metabolism.2016; 31(4): 535.     CrossRef
Close layer
Clinical Study
Serum γ-Glutamyl Transferase Is Inversely Associated with Bone Mineral Density Independently of Alcohol Consumption
Han Seok Choi, Kwang Joon Kim, Yumie Rhee, Sung-Kil Lim
Endocrinol Metab. 2016;31(1):64-71.   Published online March 16, 2016
DOI: https://doi.org/10.3803/EnM.2016.31.1.64
  • 4,016 View
  • 36 Download
  • 9 Web of Science
  • 9 Crossref
AbstractAbstract PDFPubReader   
Background

γ-Glutamyl transferase (GGT) is a well-known marker of chronic alcohol consumption or hepatobiliary diseases. A number of studies have demonstrated that serum levels of GGT are independently associated with cardiovascular and metabolic disorders. The purpose of this study was to test if serum GGT levels are associated with bone mineral density (BMD) in Korean adults.

Methods

A total of 462 subjects (289 men and 173 women), who visited Severance Hospital for medical checkup, were included in this study. BMD was measured using dual energy X-ray absorptiometry. Cross-sectional association between serum GGT and BMD was evaluated.

Results

As serum GGT levels increased from the lowest tertile (tertile 1) to the highest tertile (tertile 3), BMD decreased after adjusting for confounders such as age, body mass index, amount of alcohol consumed, smoking, regular exercise, postmenopausal state (in women), hypertension, diabetes mellitus, and hypercholesterolemia. A multiple linear regression analysis showed a negative association between log-transformed serum GGT levels and BMD. In a multiple logistic regression analysis, tertile 3 of serum GGT level was associated with an increased risk for low bone mass compared to tertile 1 (odds ratio, 2.271; 95% confidence interval, 1.340 to 3.850; P=0.002).

Conclusion

Serum GGT level was inversely associated with BMD in Korean adults. Further study is necessary to fully elucidate the mechanism of the inverse relationship.

Citations

Citations to this article as recorded by  
  • Association of gamma-glutamyl transferase variability with risk of osteoporotic fractures: A nationwide cohort study
    Dongyeop Kim, Jee Hyun Kim, Heajung Lee, Iksun Hong, Yoonkyung Chang, Tae-Jin Song, Mohamed El-Sayed Abdel-Wanis
    PLOS ONE.2023; 18(6): e0277452.     CrossRef
  • Gamma-glutamyl-transferase is associated with incident hip fractures in women and men ≥ 50 years: a large population-based cohort study
    W. Brozek, H. Ulmer, A. Pompella, G. Nagel, A. Leiherer, O. Preyer, H. Concin, E. Zitt
    Osteoporosis International.2022; 33(6): 1295.     CrossRef
  • Elevated gamma-glutamyl transpeptidase level is associated with an increased risk of hip fracture in postmenopausal women
    Kyoung Jin Kim, Namki Hong, Min Heui Yu, Seunghyun Lee, Sungjae Shin, Sin Gon Kim, Yumie Rhee
    Scientific Reports.2022;[Epub]     CrossRef
  • Elevated serum γ-glutamyl transferase is associated with low muscle function in adults independent of muscle mass
    Seunghyun Lee, Dawon Song, Sungjae Shin, Namki Hong, Yumie Rhee
    Nutrition.2022; 103-104: 111813.     CrossRef
  • A fluorine-18 labeled radiotracer for PET imaging of γ-glutamyltranspeptidase in living subjects
    Dingyao Gao, Yinxing Miao, Siqin Ye, Chunmei Lu, Gaochao Lv, Ke Li, Chunjing Yu, Jianguo Lin, Ling Qiu
    RSC Advances.2021; 11(31): 18738.     CrossRef
  • The dark side of gamma-glutamyltransferase (GGT): Pathogenic effects of an ‘antioxidant’ enzyme
    Alessandro Corti, Eugenia Belcastro, Silvia Dominici, Emilia Maellaro, Alfonso Pompella
    Free Radical Biology and Medicine.2020; 160: 807.     CrossRef
  • Clinical and body composition predictors of bone turnover and mineral content in obese postmenopausal women
    Rim Cherif, Feten Mahjoub, Hela Sahli, Elhem Cheour, Mohsen Sakly, Nebil Attia
    Clinical Rheumatology.2019; 38(3): 739.     CrossRef
  • Association between liver enzymes and bone mineral density in Koreans: a cross-sectional study
    Ho Jeong Do, Joon-Shik Shin, Jinho Lee, Yoon Jae Lee, Me-riong Kim, Dongwoo Nam, Eun-Jung Kim, Yeoncheol Park, Kristin Suhr, In-Hyuk Ha
    BMC Musculoskeletal Disorders.2018;[Epub]     CrossRef
  • Articles inEndocrinology and Metabolismin 2016
    Won-Young Lee
    Endocrinology and Metabolism.2017; 32(1): 62.     CrossRef
Close layer
Bone Metabolism
Efficacy of a Once-Monthly Pill Containing Ibandronate and Cholecalciferol on the Levels of 25-Hydroxyvitamin D and Bone Markers in Postmenopausal Women with Osteoporosis
In-Jin Cho, Ho-Yeon Chung, Sung-Woon Kim, Jae-Won Lee, Tae-Won Lee, Hye-Soon Kim, Sin-Gon Kim, Han Seok Choi, Sung-Hee Choi, Chan Soo Shin, Ki-Won Oh, Yong-Ki Min, Jung-Min Koh, Yumie Rhee, Dong-Won Byun, Yoon-Sok Chung, Jeong Hyun Park, Dong Jin Chung, Minho Shong, Eun-Gyoung Hong, Chang Beom Lee, Ki Hyun Baek, Moo-Il Kang
Endocrinol Metab. 2015;30(3):272-279.   Published online December 9, 2014
DOI: https://doi.org/10.3803/EnM.2015.30.3.272
  • 4,294 View
  • 45 Download
  • 4 Web of Science
  • 5 Crossref
AbstractAbstract PDFPubReader   
Background

The present study evaluated the efficacy of a combination of ibandronate and cholecalciferol on the restoration of the levels of 25-hydroxyvitamin D (25[OH]D) and various bone markers in postmenopausal women with osteoporosis.

Methods

This was a randomized, double-blind, active-controlled, prospective 16-week clinical trial conducted in 20 different hospitals. A total of 201 postmenopausal women with osteoporosis were assigned randomly to one of two groups: the IBN group, which received a once-monthly pill containing 150 mg ibandronate (n=99), or the IBN+ group, which received a once-monthly pill containing 150 mg ibandronate and 24,000 IU cholecalciferol (n=102). Serum levels of 25(OH)D, parathyroid hormone (PTH), and various bone markers were assessed at baseline and at the end of a 16-week treatment period.

Results

After 16 weeks of treatment, the mean serum levels of 25(OH)D significantly increased from 21.0 to 25.3 ng/mL in the IBN+ group but significantly decreased from 20.6 to 17.4 ng/mL in the IBN group. Additionally, both groups exhibited significant increases in mean serum levels of PTH but significant decreases in serum levels of bone-specific alkaline phosphatase and C-telopeptide of type 1 collagen (CTX) at 16 weeks; no significant differences were observed between the groups. However, in subjects with a vitamin D deficiency, IBN+ treatment resulted in a significant decrease in serum CTX levels compared with IBN treatment.

Conclusion

The present findings demonstrate that a once-monthly pill containing ibandronate and cholecalciferol may be useful for the amelioration of vitamin D deficiency in patients with postmenopausal osteoporosis. Moreover, this treatment combination effectively decreased serum levels of resorption markers, especially in subjects with a vitamin D deficiency, over the 16-week treatment period.

Citations

Citations to this article as recorded by  
  • Effect of vitamin D supplementation or fortification on bone turnover markers in women: a systematic review and meta-analysis
    Nasrin Nasimi, Sanaz Jamshidi, Aida Askari, Nazanin Zolfaghari, Erfan Sadeghi, Mehran Nouri, Nick Bellissimo, Shiva Faghih
    British Journal of Nutrition.2024; : 1.     CrossRef
  • Quality of life and patient satisfaction with raloxifene/cholecalciferol combination therapy in postmenopausal women
    Dong-Yun Lee, Yoon-Sok Chung
    Scientific Reports.2022;[Epub]     CrossRef
  • Efficacy of risedronate with cholecalciferol on bone mineral density in Korean patients with osteoporosis
    So Young Park, Moo-Il Kang, Hyung Moo Park, Yumie Rhee, Seong Hwan Moon, Hyun Koo Yoon, Jung-Min Koh, Jae Suk Chang, In Joo Kim, Ye Yeon Won, Ye Soo Park, Hoon Choi, Chan Soo Shin, Taek Rim Yoon, Sung-Cheol Yun, Ho-Yeon Chung
    Archives of Osteoporosis.2020;[Epub]     CrossRef
  • Efficacy and safety of vitamin D3 B.O.N intramuscular injection in Korean adults with vitamin D deficiency
    Han Seok Choi, Yoon-Sok Chung, Yong Jun Choi, Da Hea Seo, Sung-Kil Lim
    Osteoporosis and Sarcopenia.2016; 2(4): 228.     CrossRef
  • Pharmacologic treatment of osteoporosis
    Yong-Ki Min
    Journal of the Korean Medical Association.2016; 59(11): 847.     CrossRef
Close layer
Obesity and Metabolism
Letter: The Relationship of Body Composition and Coronary Artery Calcification in Apparently Healthy Korean Adults (Endocrinol Metab 2013;28:33-40, Jung-Hee Yu et al.)
Han Seok Choi
Endocrinol Metab. 2013;28(2):153-154.   Published online June 18, 2013
DOI: https://doi.org/10.3803/EnM.2013.28.2.153
  • 2,480 View
  • 23 Download
PDFPubReader   
Close layer
Bone Metabolism
Vitamin D Status in Korea
Han Seok Choi
Endocrinol Metab. 2013;28(1):12-16.   Published online March 25, 2013
DOI: https://doi.org/10.3803/EnM.2013.28.1.12
  • 4,329 View
  • 30 Download
  • 35 Web of Science
  • 42 Crossref
AbstractAbstract PDFPubReader   

The majority of the vitamin D in our body is produced by cutaneous synthesis in response to sunlight. As more and more people live in cities and spend the bulk of their time indoors, it can be difficult to get sufficient sun exposure for adequate cutaneous production of vitamin D. Therefore, vitamin D insufficiency has become a very common health problem worldwide. The Korea National Health and Nutrition Examination Survey IV 2008 showed that the prevalence of vitamin D insufficiency, defined as a serum 25-hydroxyvitamin D [25(OH)D] level below 50 nmol/L, was 47.3% in males and 64.5% in females. Only 13.2% of males and 6.7% of females had a serum 25(OH)D level of greater than 75 nmol/L. In Korea, vitamin D insufficiency was more prevalent in young adults than in elderly people, likely due to the indoor lifestyle of younger people. Compared with the United States and Canada, Korea has a lower mean 25(OH)D level and a higher prevalence of vitamin D insufficiency. To improve the vitamin D status of the Korean population, more aggressive policies on food fortification and vitamin D supplementation are needed.

Citations

Citations to this article as recorded by  
  • Bone mineral density and lipid profiles in older adults: a nationwide cross-sectional study
    Jinyoung Kim, Jeonghoon Ha, Chaiho Jeong, Jeongmin Lee, Yejee Lim, Kwanhoon Jo, Mee Kyoung Kim, Hyuk-Sang Kwon, Ki-Ho Song, Ki-Hyun Baek
    Osteoporosis International.2023; 34(1): 119.     CrossRef
  • Exploring optimal supplementation for people with vitamin D deficiency
    Han Seok Choi
    Osteoporosis and Sarcopenia.2023; 9(1): 38.     CrossRef
  • Association between Serum Vitamin D Level and Sleep Quality in Shift-Workers
    Seunghyun Kim, Jaeho Choi, Jiwon Min, Hyerhan Park, Ki Hyun Park, Booyoon Cheung, Soohyoung Lee
    Korean Journal of Family Practice.2022; 12(1): 41.     CrossRef
  • Sodium–glucose cotransporter 2 inhibitors do not increase the risk of fractures in real‐world clinical practice in Korea: A national observational cohort study
    Kyoung Hwa Ha, Dae Jung Kim, Yong Jun Choi
    Journal of Diabetes Investigation.2022; 13(6): 986.     CrossRef
  • Seasonal Changes in Vitamin D Levels of Healthy Children in Mid-Latitude, Asian Urban Area
    Jong Woo Won, Seong Kwan Jung, In Ah Jung, Yoon Lee
    Pediatric Gastroenterology, Hepatology & Nutrition.2021; 24(2): 207.     CrossRef
  • Risk Allele Frequency Analysis of Single-Nucleotide Polymorphisms for Vitamin D Concentrations in Different Ethnic Group
    Byung-Woo Yoon, Hyun-Tae Shin, Jehyun Seo
    Genes.2021; 12(10): 1530.     CrossRef
  • Comparison of Two Strategies to Increase Serum Vitamin D Levels in a Real-World Setting: Sunlight Exposure and Oral Supplementation
    Su Hwan CHO, Jae Moon YUN, Ji Eun LEE, Hyejin LEE, Hee-Kyung JOH, Belong CHO
    Journal of Nutritional Science and Vitaminology.2021; 67(6): 384.     CrossRef
  • Vitamin D Deficiency at Mid-Pregnancy Is Associated with a Higher Risk of Postpartum Glucose Intolerance in Women with Gestational Diabetes Mellitus
    Kyung-Soo Kim, Seok Won Park, Yong-Wook Cho, Soo-Kyung Kim
    Endocrinology and Metabolism.2020; 35(1): 97.     CrossRef
  • Preoperative vitamin D level does not affect the short-term functional outcome after total knee arthroplasty in elderly women
    Il Yeong Hwang, Ki Bong Park, Sung Who Chang, Sung Do Cho, Yoon Seok Youm
    Knee Surgery & Related Research.2020;[Epub]     CrossRef
  • Serum and aqueous humor vitamin D levels in patients with diabetic macular edema
    Kyoung Lae Kim, Su Young Moon, Hye-Mi Noh, Sung Pyo Park, Yong-Kyu Kim
    Graefe's Archive for Clinical and Experimental Ophthalmology.2019; 257(6): 1191.     CrossRef
  • Vitamin D deficiency predicts severe acute pancreatitis
    Ji Hye Huh, Jae Woo Kim, Kyong Joo Lee
    United European Gastroenterology Journal.2019; 7(1): 90.     CrossRef
  • The Effect of Vitamin D Supplementation in Patients with Acute Traumatic Brain Injury
    Jong Min Lee, Sung Woo Jeong, Myoung Young Kim, Jun Bum Park, Min Soo Kim
    World Neurosurgery.2019; 126: e1421.     CrossRef
  • Association of serum 25-hydroxyvitamin D and diabetes-related factors in Korean adults without diabetes: The Fifth Korea National Health and Nutrition Examination Survey 2010–2012
    Hyunah Kim, Hyunyong Lee, Hyeon Woo Yim, Hun-Sung Kim
    Primary Care Diabetes.2018; 12(1): 59.     CrossRef
  • Vitamin D deficiency: What does it mean for chronic obstructive pulmonary disease (COPD)? a compherensive review for pulmonologists
    Nurdan Kokturk, Ayse Baha, Yeon‐Mok Oh, Jung Young Ju, Paul W. Jones
    The Clinical Respiratory Journal.2018; 12(2): 382.     CrossRef
  • A comparative analysis of maternal and fetal 25-hydroxyvitamin D in pregnant women with and without gestational diabetes mellitus
    Hee-Sun Kim, Han-Sung Hwang, Han-Sung Kwon, Ji-Young Lim, In-Sook Sohn
    The Journal of Maternal-Fetal & Neonatal Medicine.2018; 31(20): 2748.     CrossRef
  • Effects of 25‐hydroxyvitamin D and vitamin D‐binding protein on bone mineral density and disease activity in Malaysian patients with rheumatoid arthritis
    Tze Hao Wong, Esha Das Gupta, Ammu K. Radhakrishnan, Suk Chyn Gun, Gandhi Chembalingam, Swan Sim Yeap
    International Journal of Rheumatic Diseases.2018; 21(5): 992.     CrossRef
  • Vitamin D Status and Vitamin D Receptor Gene Polymorphisms Are Associated with Pelvic Floor Disorders in Women
    Jae Hyung Ahn, Yoo Hun Noh, Kyung Joo Um, Hyo Sun Kim, Sook Cho
    Journal of Menopausal Medicine.2018; 24(2): 119.     CrossRef
  • Vitamin D status in South Korean population
    Ju-Hyun Park, In Young Hong, Jae Woo Chung, Han Seok Choi
    Medicine.2018; 97(26): e11032.     CrossRef
  • Vitamin D deficiency affects thyroid autoimmunity and dysfunction in iodine-replete area: Korea national health and nutrition examination survey
    Mijin Kim, Eyun Song, Hye-Seon Oh, Suyeon Park, Hyemi Kwon, Min Ji Jeon, Won Gu Kim, Won Bae Kim, Young Kee Shong, Tae Yong Kim
    Endocrine.2017; 58(2): 332.     CrossRef
  • Serum vitamin D3 levels are not associated with thyroid cancer prevalence in euthyroid subjects without autoimmune thyroid disease
    Yun Mi Choi, Won Gu Kim, Tae Yong Kim, Sung Jin Bae, Hong-Kyu Kim, Eun Kyung Jang, Min Ji Jeon, Ji Min Han, Young Kee Shong, Won Bae Kim
    The Korean Journal of Internal Medicine.2017; 32(1): 102.     CrossRef
  • Low dietary intake of n-3 fatty acids, niacin, folate, and vitamin C in Korean patients with schizophrenia and the development of dietary guidelines for schizophrenia
    Eun Jin Kim, So Young Lim, Hee Jae Lee, Ju-Yeon Lee, Seunggi Choi, Seon-Young Kim, Jae-Min Kim, Il-Seon Shin, Jin-Sang Yoon, Soo Jin Yang, Sung-Wan Kim
    Nutrition Research.2017; 45: 10.     CrossRef
  • Risk Factors for Vitamin D, Zinc, and Selenium Deficiencies in Korean Patients with Inflammatory Bowel Disease
    Yoo Min Han, Hyuk Yoon, Soo Lim, Mi-Kyung Sung, Cheol Min Shin, Young Soo Park, Nayoung Kim, Dong Ho Lee, Joo Sung Kim
    Gut and Liver.2017; 11(3): 363.     CrossRef
  • Relationship between Serum 25-hydroxy-vitamin D Concentration and Risk of Metabolic Syndrome in Patients with Fatty Liver
    Hee-Sook Lim, Tae-Hee Kim, Hae-Hyeog Lee, Soon-Kyung Kim, Bora Lee, Yoon-Hyung Park
    Journal of Bone Metabolism.2017; 24(4): 223.     CrossRef
  • Decrement of Serum Vitamin D Level After Stroke
    Kiyoung Kim, Kye Hee Cho, Sang Hee Im, Jaewoo Choi, Junghoon Yu, MinYoung Kim
    Annals of Rehabilitation Medicine.2017; 41(6): 944.     CrossRef
  • Association of serum calcium concentrations with fibrinogen and homocysteine in nondiabetic Korean subjects
    Hyun Sun Cho, Sung Won Lee, Juyoung Shin, Sung Dae Moon, Je Ho Han, Bong Yun Cha, Eun Sook Kim
    Medicine.2016; 95(24): e3899.     CrossRef
  • Relationship between vitamin D status and vascular complications in patients with type 2 diabetes mellitus
    Chan-Hee Jung, Kyu-Jin Kim, Bo-Yeon Kim, Chul-Hee Kim, Sung Koo Kang, Ji-Oh Mok
    Nutrition Research.2016; 36(2): 117.     CrossRef
  • Efficacy and safety of vitamin D3 B.O.N intramuscular injection in Korean adults with vitamin D deficiency
    Han Seok Choi, Yoon-Sok Chung, Yong Jun Choi, Da Hea Seo, Sung-Kil Lim
    Osteoporosis and Sarcopenia.2016; 2(4): 228.     CrossRef
  • Analysis of 25‐Hydroxyvitamin D Status According to Age, Gender, and Seasonal Variation
    Hui‐Jin Yu, Min‐Jung Kwon, Hee‐Yeon Woo, Hyosoon Park
    Journal of Clinical Laboratory Analysis.2016; 30(6): 905.     CrossRef
  • Efficacy of a Once-Monthly Pill Containing Ibandronate and Cholecalciferol on the Levels of 25-Hydroxyvitamin D and Bone Markers in Postmenopausal Women with Osteoporosis
    In-Jin Cho, Ho-Yeon Chung, Sung-Woon Kim, Jae-Won Lee, Tae-Won Lee, Hye-Soon Kim, Sin-Gon Kim, Han Seok Choi, Sung-Hee Choi, Chan Soo Shin, Ki-Won Oh, Yong-Ki Min, Jung-Min Koh, Yumie Rhee, Dong-Won Byun, Yoon-Sok Chung, Jeong Hyun Park, Dong Jin Chung, M
    Endocrinology and Metabolism.2015; 30(3): 272.     CrossRef
  • Relationship of vitamin D status with lung function and exercise capacity in COPD
    Ji Ye Jung, Young Sam Kim, Se Kyu Kim, Ha Yan Kim, Yeon Mok Oh, Sang Min Lee, Joon Beom Seo, Sang‐Do Lee
    Respirology.2015; 20(5): 782.     CrossRef
  • Lifestyle and Dietary Factors Associated with Serum 25-Hydroxyvitamin D Levels in Korean Young Adults
    Hee-Kyung Joh, Chun Soo Lim, BeLong Cho
    Journal of Korean Medical Science.2015; 30(8): 1110.     CrossRef
  • Vitamin D Deficiency Is Highly Concomitant but Not Strong Risk Factor for Mortality in Patients Aged 50 Year and Older with Hip Fracture
    Gyeong-Hak Lee, Jung-Won Lim, Yong-Gum Park, Yong-Chan Ha
    Journal of Bone Metabolism.2015; 22(4): 205.     CrossRef
  • Calcium and Vitamin D Supplementations: 2015 Position Statement of the Korean Society for Bone and Mineral Research
    Kyoung Min Kim, Han Seok Choi, Mi-Ja Choi, Ho Yeon Chung
    Journal of Bone Metabolism.2015; 22(4): 143.     CrossRef
  • Vitamin D level is not a predictor of hypocalcemia after total thyroidectomy
    Guk Haeng Lee, Yun Hyi Ku, Hong Il Kim, Myung-Chul Lee, Min Joo Kim
    Langenbeck's Archives of Surgery.2015; 400(5): 617.     CrossRef
  • Associations between serum 25-hydroxyvitamin D and bone mineral density and proximal femur geometry in Koreans: the Korean National Health and Nutrition Examination Survey (KNHANES) 2008–2009
    S. Hwang, H. S. Choi, K. M. Kim, Y. Rhee, S. K. Lim
    Osteoporosis International.2015; 26(1): 163.     CrossRef
  • Association between serum calcium and phosphorus concentrations with non‐alcoholic fatty liver disease in Korean population
    Ju Young Shin, Min Ji Kim, Eun Sook Kim, Eun Young Mo, Sung Dae Moon, Je Ho Han, Bong Yeon Cha
    Journal of Gastroenterology and Hepatology.2015; 30(4): 733.     CrossRef
  • The Prevalence of Vitamin D Deficiency among Cancer Survivors in a Nationwide Survey of the Korean Population
    Myueng Guen Oh, Mi Ah Han, Jong Park, So Yeon Ryu, Seong-Woo Choi, Andrzej T Slominski
    PLOS ONE.2015; 10(6): e0129901.     CrossRef
  • The relationship between vitamin D status and cardiac autonomic neuropathy in patients with type 2 diabetes mellitus
    Chan-Hee Jung, Sang-Hee Jung, Kyu-Jin Kim, Bo-Yeon Kim, Chul-Hee Kim, Sung-Koo Kang, Ji-Oh Mok
    Diabetes and Vascular Disease Research.2015; 12(5): 342.     CrossRef
  • Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
    Won-Young Lee
    Endocrinology and Metabolism.2014; 29(3): 251.     CrossRef
  • Low Serum 25 Hydroxyvitamin D Is Associated with Poor Clinicopathologic Characteristics in Female Patients with Papillary Thyroid Cancer
    Ji Ryang Kim, Bo Hyun Kim, Sang Mi Kim, Min Young Oh, Won Jin Kim, Yun Kyung Jeon, Sang Soo Kim, Byung Joo Lee, Yong Ki Kim, In Ju Kim
    Thyroid.2014; 24(11): 1618.     CrossRef
  • Vitamin D status and associated occupational factors in Korean wage workers: data from the 5th Korea national health and nutrition examination survey (KNHANES 2010–2012)
    Harin Jeong, Sujin Hong, Yunjeong Heo, Hosun Chun, Daeseong Kim, Jongtae Park, Mo-yeol Kang
    Annals of Occupational and Environmental Medicine.2014;[Epub]     CrossRef
  • Diabetes and Vitamin D
    Jin Hee Park, Mee Kyoung Kim
    The Journal of Korean Diabetes.2013; 14(4): 190.     CrossRef
Close layer
1-34 PTH Could Reverse Impaired Bone Mineralization Induced By the Overdose of Bisphosphonate.
Kyeong Hye Park, Kwang Joon Kim, Han Seok Choi, Kyoung Min Kim, Eun Young Lee, Seonhui Han, Hyun Sil Kim, Daham Kim, Hannah Seok, Eun Yeong Choe, Yumie Rhee, Sung Kil Lim
Endocrinol Metab. 2012;27(3):247-250.   Published online September 19, 2012
DOI: https://doi.org/10.3803/EnM.2012.27.3.247
  • 12,613 View
  • 27 Download
AbstractAbstract PDF
Bisphosphonates are the mainstay of osteoporosis treatment. Despite the fact that bisphosphonates have a relatively good safety record and are tolerated well by the majority of patients, serious adverse events have been associated with their use. A 41-year-old man had been diagnosed with osteoporosis and had taken etidronate 200 mg/day daily for 2 years due to the judgmental error. He was referred for the management of refractory bone pain and generalized muscle ache. Serum calcium, phosphate, 25-hydroxy-vitamin D (25(OH)D), and immunoreactive parathyroid hormone (iPTH) were within normal range. Plain X-ray showed multiple fractures. Whole body bone scan confirmed multiple sites of increased bone uptakes. Tetracycline-labeled bone biopsy showed typical findings of osteomalacia. He was diagnosed with iatrogenic, etidronate-induced osteomalacia. The patient received daily parathyroid hormone (PTH) injection for 18 months. PTH effectively reverses impaired bone mineralization caused by etidronate misuse. Currently, he is doing well without bone pain. Bone mineral density significantly increased, and the increased bone uptake was almost normalized after 18 months. This case seems to suggest that human PTH (1-34) therapy, possibly in association with calcium and vitamin D, is associated with important clinical improvements in patients with impaired bone mineralization due to the side effect of bisphosphonate.
Close layer

Endocrinol Metab : Endocrinology and Metabolism