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Hail Kim 3 Articles
Diabetes, Obesity and Metabolism
Serotonergic Regulation of Hepatic Energy Metabolism
Jiwon Park, Wooju Jeong, Chahyeon Yun, Hail Kim, Chang-Myung Oh
Endocrinol Metab. 2021;36(6):1151-1160.   Published online December 16, 2021
DOI: https://doi.org/10.3803/EnM.2021.1331
  • 5,871 View
  • 218 Download
  • 7 Web of Science
  • 7 Crossref
AbstractAbstract PDFPubReader   ePub   
The liver is a vital organ that regulates systemic energy metabolism and many physiological functions. Nonalcoholic fatty liver disease (NAFLD) is the commonest cause of chronic liver disease and end-stage liver failure. NAFLD is primarily caused by metabolic disruption of lipid and glucose homeostasis. Serotonin (5-hydroxytryptamine [5-HT]) is a biogenic amine with several functions in both the central and peripheral systems. 5-HT functions as a neurotransmitter in the brain and a hormone in peripheral tissues to regulate systemic energy homeostasis. Several recent studies have proposed various roles of 5-HT in hepatic metabolism and inflammation using tissue-specific knockout mice and 5-HT-receptor agonists/antagonists. This review compiles the most recent research on the relationship between 5-HT and hepatic metabolism, and the role of 5-HT signaling as a potential therapeutic target in NAFLD.

Citations

Citations to this article as recorded by  
  • Maternal nutrient metabolism in the liver during pregnancy
    Hongxu Fang, Qingyang Li, Haichao Wang, Ying Ren, Leying Zhang, Ling Yang
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • Metabolic and Molecular Response to High-Fat Diet Differs between Rats with Constitutionally High and Low Serotonin Tone
    Petra Baković, Maja Kesić, Darko Kolarić, Jasminka Štefulj, Lipa Čičin-Šain
    International Journal of Molecular Sciences.2023; 24(3): 2169.     CrossRef
  • Roles of gut microbes in metabolic-associated fatty liver disease
    Chun-Yao Chen, Han-Chen Ho
    Tzu Chi Medical Journal.2023; 35(4): 279.     CrossRef
  • Imidazoles as Serotonin Receptor Modulators for Treatment of Depression: Structural Insights and Structure–Activity Relationship Studies
    Kapil Kumar Goel, Somesh Thapliyal, Rajeev Kharb, Gaurav Joshi, Arvind Negi, Bhupinder Kumar
    Pharmaceutics.2023; 15(9): 2208.     CrossRef
  • Serotonin in the regulation of systemic energy metabolism
    Joon Ho Moon, Chang‐Myung Oh, Hail Kim
    Journal of Diabetes Investigation.2022; 13(10): 1639.     CrossRef
  • Involvement of the liver-gut peripheral neural axis in nonalcoholic fatty liver disease pathologies via hepatic HTR2A
    Takashi Owaki, Kenya Kamimura, Masayoshi Ko, Itsuo Nagayama, Takuro Nagoya, Osamu Shibata, Chiyumi Oda, Shinichi Morita, Atsushi Kimura, Takeki Sato, Toru Setsu, Akira Sakamaki, Hiroteru Kamimura, Takeshi Yokoo, Shuji Terai
    Disease Models & Mechanisms.2022;[Epub]     CrossRef
  • Non-alcoholic fatty liver disease (NAFLD) and mental illness: Mechanisms linking mood, metabolism and medicines
    Anwesha Gangopadhyay, Radwa Ibrahim, Karli Theberge, Meghan May, Karen L. Houseknecht
    Frontiers in Neuroscience.2022;[Epub]     CrossRef
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Miscellaneous
Erratum: Correction of Figure. Serotonin Regulates De Novo Lipogenesis in Adipose Tissues through Serotonin Receptor 2A
Ko Eun Shong, Chang-Myung Oh, Jun Namkung, Sangkyu Park, Hail Kim
Endocrinol Metab. 2020;35(3):672.   Published online August 6, 2020
DOI: https://doi.org/10.3803/EnM.2020.307
Corrects: Endocrinol Metab 2020;35(2):470
  • 3,914 View
  • 84 Download
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Endocrine Research
Serotonin Regulates De Novo Lipogenesis in Adipose Tissues through Serotonin Receptor 2A
Ko Eun Shong, Chang-Myung Oh, Jun Namkung, Sangkyu Park, Hail Kim
Endocrinol Metab. 2020;35(2):470-479.   Published online June 24, 2020
DOI: https://doi.org/10.3803/EnM.2020.35.2.470
Correction in: Endocrinol Metab 2020;35(3):672
  • 8,410 View
  • 261 Download
  • 21 Web of Science
  • 20 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
Obesity is defined as excessive fat mass and is a major cause of many chronic diseases such as diabetes, cardiovascular disease, and cancer. Increasing energy expenditure and regulating adipose tissue metabolism are important targets for the treatment of obesity. Serotonin (5-hydroxytryptophan [5-HT]) is a monoamine metabolite of the essential amino acid tryptophan. Here, we demonstrated that 5-HT in mature adipocytes regulated energy expenditure and lipid metabolism.
Methods
Tryptophan hydroxylase 1 (TPH1) is the rate-limiting enzyme during 5-HT synthesis in non-neural peripheral tissues. We generated adipose tissue-specific Tph1 knockout (Tph1 FKO) mice and adipose tissue-specific serotonin receptor 2A KO (Htr2a FKO) mice and analyzed their phenotypes during high-fat diet (HFD) induced obesity.
Results
Tph1 FKO mice fed HFD exhibited reduced lipid accumulation, increased thermogenesis, and resistance to obesity. In addition, Htr2a FKO mice fed HFD showed reduced lipid accumulation in white adipose tissue and resistance to obesity.
Conclusion
These data suggest that the inhibition of serotonin signaling might be an effective strategy in obesity.

Citations

Citations to this article as recorded by  
  • Gut microbiota dysbiosis and decreased levels of acetic and propionic acid participate in glucocorticoid-induced glycolipid metabolism disorder
    Qin Zhang, Gaopeng Guan, Jie Liu, Wenmu Hu, Ping Jin, Yung-Fu Chang
    mBio.2024;[Epub]     CrossRef
  • The Chain-Mediating Effect of Obesity, Depressive Symptoms on the Association between Dietary Quality and Cardiovascular Disease Risk
    Shuai Zhang, Limei E, Zhonghai Lu, Yingying Yu, Xuebin Yang, Yao Chen, Xiubo Jiang
    Nutrients.2023; 15(3): 629.     CrossRef
  • Metabolic and Molecular Response to High-Fat Diet Differs between Rats with Constitutionally High and Low Serotonin Tone
    Petra Baković, Maja Kesić, Darko Kolarić, Jasminka Štefulj, Lipa Čičin-Šain
    International Journal of Molecular Sciences.2023; 24(3): 2169.     CrossRef
  • Linking serotonin homeostasis to gut function: Nutrition, gut microbiota and beyond
    Lili Jiang, Dandan Han, Youling Hao, Zhuan Song, Zhiyuan Sun, Zhaolai Dai
    Critical Reviews in Food Science and Nutrition.2023; : 1.     CrossRef
  • Serotonin transporter-deficient mice display enhanced adipose tissue inflammation after chronic high-fat diet feeding
    Johannes Hoch, Niklas Burkhard, Shanshan Zhang, Marina Rieder, Timoteo Marchini, Vincent Geest, Krystin Krauel, Timm Zahn, Nicolas Schommer, Muataz Ali Hamad, Carolina Bauer, Nadine Gauchel, Daniela Stallmann, Claus Normann, Dennis Wolf, Rüdiger Eberhard
    Frontiers in Immunology.2023;[Epub]     CrossRef
  • The role of serotonin in prenatal ontogenesis
    Inna I. Evsyukova
    Journal of obstetrics and women's diseases.2023; 72(4): 81.     CrossRef
  • Genome-wide survey and functional analysis reveal TCF21 promotes chicken preadipocyte differentiation by directly upregulating HTR2A
    Xinyang Zhang, Bohan Cheng, Yanyan Ma, Yumeng Liu, Ning Wang, Hui Zhang, Yumao Li, Yuxiang Wang, Peng Luan, Zhiping Cao, Hui Li
    Biochemical and Biophysical Research Communications.2022; 587: 131.     CrossRef
  • Maternal Metabolic State and Fetal Sex and Genotype Modulate Methylation of the Serotonin Receptor Type 2A Gene (HTR2A) in the Human Placenta
    Marina Horvatiček, Maja Perić, Ivona Bečeheli, Marija Klasić, Maja Žutić, Maja Kesić, Gernot Desoye, Sandra Nakić Radoš, Marina Ivanišević, Dubravka Hranilovic, Jasminka Štefulj
    Biomedicines.2022; 10(2): 467.     CrossRef
  • Synthesis and biological evaluation of tyrosine derivatives as peripheral 5HT2A receptor antagonists for nonalcoholic fatty liver disease
    Minhee Kim, Wonil Choi, Jihyeon Yoon, Byung-kwan Jeong, Suvarna H. Pagire, Haushabhau S. Pagire, Jungsun Park, Jung Eun Nam, Chang Joo Oh, Jae-Han Jeon, Seong Soon Kim, Byung Hoi Lee, Jin Sook Song, Myung Ae Bae, In-Kyu Lee, Hail Kim, Jin Hee Ahn
    European Journal of Medicinal Chemistry.2022; 239: 114517.     CrossRef
  • Serotonin in the regulation of systemic energy metabolism
    Joon Ho Moon, Chang‐Myung Oh, Hail Kim
    Journal of Diabetes Investigation.2022; 13(10): 1639.     CrossRef
  • Traumatic brain injury alters the gut-derived serotonergic system and associated peripheral organs
    Natosha M. Mercado, Guanglin Zhang, Zhe Ying, Fernando Gómez-Pinilla
    Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2022; 1868(11): 166491.     CrossRef
  • Modulation of adipose tissue metabolism by microbial-derived metabolites
    Wenyun Liu, Ge Yang, Pinyi Liu, Xin Jiang, Ying Xin
    Frontiers in Microbiology.2022;[Epub]     CrossRef
  • Risperidone Exacerbates Glucose Intolerance, Nonalcoholic Fatty Liver Disease, and Renal Impairment in Obese Mice
    Hsiao-Pei Tsai, Po-Hsun Hou, Frank-Chiahung Mao, Chia-Chia Chang, Wei-Cheng Yang, Ching-Feng Wu, Huei-Jyuan Liao, Tzu-Chun Lin, Lan-Szu Chou, Li-Wei Hsiao, Geng-Ruei Chang
    International Journal of Molecular Sciences.2021; 22(1): 409.     CrossRef
  • Pancreatic Sirtuin 3 Deficiency Promotes Hepatic Steatosis by Enhancing 5-Hydroxytryptamine Synthesis in Mice With Diet-Induced Obesity
    Xing Ming, Arthur C.K. Chung, Dandan Mao, Huanyi Cao, Baoqi Fan, Willy K.K. Wong, Chin Chung Ho, Heung Man Lee, Kristina Schoonjans, Johan Auwerx, Guy A. Rutter, Juliana C.N. Chan, Xiao Yu Tian, Alice P.S. Kong
    Diabetes.2021; 70(1): 119.     CrossRef
  • Peripheral Selective Oxadiazolylphenyl Alanine Derivatives as Tryptophan Hydroxylase 1 Inhibitors for Obesity and Fatty Liver Disease
    Eun Jung Bae, Won Gun Choi, Haushabhau S. Pagire, Suvarna H. Pagire, Saravanan Parameswaran, Jun-Ho Choi, Jihyeon Yoon, Won-il Choi, Ji Hun Lee, Jin Sook Song, Myung Ae Bae, Mijin Kim, Jae-Han Jeon, In-Kyu Lee, Hail Kim, Jin Hee Ahn
    Journal of Medicinal Chemistry.2021; 64(2): 1037.     CrossRef
  • A Systems Biology Approach to Investigating the Interaction between Serotonin Synthesis by Tryptophan Hydroxylase and the Metabolic Homeostasis
    Suhyeon Park, Yumin Kim, Jibeom Lee, Jeong Yun Lee, Hail Kim, Sunjae Lee, Chang-Myung Oh
    International Journal of Molecular Sciences.2021; 22(5): 2452.     CrossRef
  • Metabolic Disturbances in Rat Sublines with Constitutionally Altered Serotonin Homeostasis
    Maja Kesić, Petra Baković, Ranko Stojković, Jasminka Štefulj, Lipa Čičin-Šain
    International Journal of Molecular Sciences.2021; 22(10): 5400.     CrossRef
  • The Mechanism of Secretion and Metabolism of Gut-Derived 5-Hydroxytryptamine
    Ning Liu, Shiqiang Sun, Pengjie Wang, Yanan Sun, Qingjuan Hu, Xiaoyu Wang
    International Journal of Molecular Sciences.2021; 22(15): 7931.     CrossRef
  • Inhibiting serotonin signaling through HTR2B in visceral adipose tissue improves obesity-related insulin resistance
    Won Gun Choi, Wonsuk Choi, Tae Jung Oh, Hye-Na Cha, Inseon Hwang, Yun Kyung Lee, Seung Yeon Lee, Hyemi Shin, Ajin Lim, Dongryeol Ryu, Jae Myoung Suh, So-Young Park, Sung Hee Choi, Hail Kim
    Journal of Clinical Investigation.2021;[Epub]     CrossRef
  • Serotonergic Regulation of Hepatic Energy Metabolism
    Jiwon Park, Wooju Jeong, Chahyeon Yun, Hail Kim, Chang-Myung Oh
    Endocrinology and Metabolism.2021; 36(6): 1151.     CrossRef
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Endocrinol Metab : Endocrinology and Metabolism