- Thyroid
- Deiodinases and the Three Types of Thyroid Hormone Deiodination Reactions
-
Laura Sabatino, Cristina Vassalle, Cristina Del Seppia, Giorgio Iervasi
-
Endocrinol Metab. 2021;36(5):952-964. Published online October 21, 2021
-
DOI: https://doi.org/10.3803/EnM.2021.1198
-
-
3,102
View
-
160
Download
-
14
Citations
-
 Abstract
 PDF PubReader  ePub  Crossref - TDM
- Thyroid hormone (TH) signaling is strictly regulated by iodothyronine deiodinase activity, which both preserves the circulating levels of the biologically active triiodothyronine (T3) and regulates TH homeostasis at the local level, in a cell- and time-dependent manner. Three deiodinases have been identified—namely iodothyronine deiodinase 1 (DIO1), DIO2, and DIO3—that differ in their catalytic properties and tissue distribution. The deiodinases represent a dynamic system that changes in the different stages of life according to their functions and roles in various cell types and tissues. Deiodinase activity at the tissue level permits cell-targeted fine regulation of TH homeostasis, mediating the activation (DIO1 and DIO2) and inactivation (DIO3) of THs. Deiodinase homeostasis is the driving force that leads T3-target cells towards customized TH signaling, which takes into account both the hormonal circulating levels and the tissue-specific response. This review analyzes the complex role of deiodinases in physiological and pathological contexts, exploring new challenges and opportunities deriving from a deeper knowledge of the dynamics underlying their roles and functions.
-
Citations
Citations to this article as recorded by  - Selenoprotein Gene mRNA Expression Evaluation During Renal Ischemia–Reperfusion Injury in Rats and Ebselen Intervention Effects
Yikun Wu, Hua Shi, Yuangao Xu, Rao Wen, Maodi Gong, Guangyi Hong, Shuxiong Xu
Biological Trace Element Research.2023; 201(4): 1792. CrossRef - Acute exposure to microcystins affects hypothalamic-pituitary axes of male rats
Ting Shi, Lin-Lin Xu, Liang Chen, Jun He, Ye-Ke Wang, Feng Chen, Yang Chen, John P. Giesy, Yu-Ting Wang, Qian-Hui Wu, Wen-Li Xu, Jun Chen, Ping Xie
Environmental Pollution.2023; 318: 120843. CrossRef - Thyroid hormone Beta receptor agonists for treatment of kidney disease: A promising agent?
Sidar Copur, Furkan Yavuz, Mehmet Kanbay
European Journal of Clinical Investigation.2023;[Epub] CrossRef - The ratio of free triiodothyronine to free thyroxine is regulated differently in patients with type 2 diabetes mellitus treated and not treated with sodium glucose cotransporter 2 inhibitors
Shuichi Okada, Atsushi Isoda, Hiroto Hoshi, Junichi Okada, Kazuya Okada, Eijiro Yamada, Tsugumichi Saito, Takuya Watanabe, Koji Kikkawa, Kihachi Ohshima
Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2023; 17(1): 102704. CrossRef - WITHDRAWN: The effect of deiodinase type-3 gene on the therapeutic response to levothyroxine in a sample of Iraqi hypothyroidism patients
Alaa Hashim Mohmmed, Suzanne Jubair, Ban Hoshi
Human Gene.2023; : 201142. CrossRef - Subclinical hypothyroidism, outcomes and management guidelines: a narrative review and update of recent literature
Bogumila Urgatz, Salman Razvi
Current Medical Research and Opinion.2023; 39(3): 351. CrossRef - DIO1 Gene Polymorphism Is Associated with Thyroid Profiles and Reproductive Performance in Dairy Cows
Olga V. Kostyunina, Olga S. Mityashova, Nikolay V. Bardukov, Olga V. Aleynikova, Irina Y. Lebedeva
Agriculture.2023; 13(2): 398. CrossRef - Embryonic thermal manipulation leads growth inhibition and reduced hepatic insulin-like growth factor1 expression due to promoter DNA hypermethylation in broilers
Wei Cong, Wanwan Han, Jie Liu, Ruqian Zhao, Lei Wu
Poultry Science.2023; 102(4): 102562. CrossRef - Drug Repurposing Patent Applications October–December 2022
Hermann A.M. Mucke
ASSAY and Drug Development Technologies.2023; 21(2): 80. CrossRef - Insights on the Association between Thyroid Diseases and Colorectal Cancer
Federica Gagliardi, Enke Baldini, Eleonora Lori, Silvia Cardarelli, Daniele Pironi, Augusto Lauro, Domenico Tripodi, Piergaspare Palumbo, Eleonora D’Armiento, Giuseppe Cavallaro, Andrea Polistena, Valerio D’Orazi, Simone Sibio, Poupak Fallahi, Alessandro
Journal of Clinical Medicine.2023; 12(6): 2234. CrossRef - Thyroid Dysfunction and COVID-19: The Emerging Role of Selenium in This Intermingled Relationship
Francesca Gorini, Laura Sabatino, Alessio Coi, Giorgio Iervasi, Cristina Vassalle
International Journal of Environmental Research and Public Health.2022; 19(11): 6912. CrossRef - Associations of bisphenol exposure with thyroid hormones in pregnant women: a prospective birth cohort study in China
Huishen Huang, Jun Liang, Peng Tang, Chuanxiang Yu, Haoran Fan, Qian Liao, Jinghua Long, Dongxiang Pan, Xiaoyun Zeng, Shun Liu, Dongping Huang, Xiaoqiang Qiu
Environmental Science and Pollution Research.2022; 29(58): 87170. CrossRef - Selenium in Bodily Homeostasis: Hypothalamus, Hormones, and Highways of Communication
Pamela Toh, Jessica L. Nicholson, Alyssa M. Vetter, Marla J. Berry, Daniel J. Torres
International Journal of Molecular Sciences.2022; 23(23): 15445. CrossRef - Does clinical hypothyroidism occur in obesity? here is what the lab rats may be telling us about hope on the horizon
Orien L Tulp, Frantz Sainvil, Andrew Scrianka, Rolando Branly, Aftab R Awan, George P Einstein
International Journal of Family & Community Medicine.2022; 6(6): 338. CrossRef
|
KES
