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Endocrinol Metab : Endocrinology and Metabolism


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Ghada El-Kannishy  (El-Kannishy G) 1 Article
Clinical Study
Impact of Subtotal Parathyroidectomy on Clinical Parameters and Quality of Life in Hemodialysis Patients with Secondary Hyperparathyroidism
Mohamed Mimi Abd Elgawwad El-kholey, Ghada El-said Ibrahim, Osama Ibrahim Elshahat, Ghada El-Kannishy
Endocrinol Metab. 2019;34(4):367-373.   Published online December 23, 2019
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  • 3 Crossref
AbstractAbstract PDFPubReader   ePub   

Impairment of quality of life (QOL) is a key clinical characteristic of patients with end-stage renal disease (ESRD), and can be especially severe in the presence of secondary hyperparathyroidism (SHPT). Despite the proven success of parathyroidectomy (PTX) in controlling biochemical parameters in patients with severe SHPT, evidence is lacking regarding the effects of PTX on various clinical outcomes, including QOL.


Twenty ESRD patients on maintenance hemodialysis with SHPT who underwent subtotal PTX were included in an observational longitudinal study. All studied patients underwent history-taking, clinical examinations, and laboratory investigations, including a complete blood count and measurements of serum calcium, phosphorus, magnesium, parathyroid hormone (PTH), and albumin levels preoperatively and at 3 months postoperatively. QOL was assessed before surgery and at 3 months after surgery using the Kidney Disease Quality of Life 36-Item Short-Form instrument.


After PTX, significant decreases in serum PTH and phosphorus levels were observed, as well as a significant increase in serum magnesium levels. Significant weight gain and improvements of QOL were also detected postoperatively.


Subtotal PTX seems to be an efficient alternative to medical management in uncontrolled cases of SHPT, as it is capable of controlling the biochemical derangements that occur in hyperparathyroidism. Furthermore, PTX had a beneficial effect on clinical outcomes, as shown by weight gain and improvements in all QOL scales.


Citations to this article as recorded by  
  • Abnormalities of serum magnesium levels in dialysis patients undergoing parathyroidectomy
    Chi-Yu Kuo, Chung-Hsin Tsai, Jie-Jen Lee, Shih-Ping Cheng
    Updates in Surgery.2024;[Epub]     CrossRef
  • Effect of Parathyroidectomy on Quality of Life Among Patients Undergoing Dialysis
    Lin Wang, Ming-Hui Xin, Yan Ma, Yu Wang, Meng-Yuan Hu, Qiang-Qiang Liu, Jin-Bor Chen
    International Journal of General Medicine.2022; Volume 15: 1185.     CrossRef
  • Paricalcitol versus Calcitriol + Cinacalcet for the Treatment of Secondary Hyperparathyroidism in Chronic Kidney Disease in China: A Cost-Effectiveness Analysis
    Zhuolin Zhang, Lele Cai, Hong Wu, Xinglu Xu, Wenqing Fang, Xuan He, Xiao Wang, Xin Li
    Frontiers in Public Health.2021;[Epub]     CrossRef
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