Endocrinology and Metabolism

Fereidoun Azizi (Azizi F)

5 Articles

Thyroid
Efficacy and Safety of Long-Term Methimazole versus Radioactive Iodine in the Treatment of Toxic Multinodular Goiter: Fereidoun Azizi, Navid Saadat, Mir Alireza Takyar, Hengameh Abdi, Ladan Mehran, Atieh Amouzegar; Endocrinol Metab. 2022;37(6):861-869. Published online November 23, 2022; DOI: https://doi.org/10.3803/EnM.2022.1476

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Background
This study compared the degree of sustained control of hyperthyroidism in patients with toxic multinodular goiter (TMNG) treated with long-term methimazole (LT-MMI) or radioactive iodine (RAI).
Methods
In this clinical trial, 130 untreated patients with TMNG were randomized to either LT-MMI or RAI treatment. Both groups were followed for 108 to 148 months, with median follow-up durations of 120 and 132 months in the LT-MMI and RAI groups, respectively. Both groups of patients were followed every 1 to 3 months in the first year and every 6 months thereafter.
Results
After excluding patients in whom the treatment modality was changed and those who were lost to follow-up, 53 patients in the LT-MMI group and 54 in the RAI group completed the study. At the end of the study period, 50 (96%) and 25 (46%) patients were euthyroid, and two (4%) and 25 (46%) were hypothyroid in LT-MMI and RAI groups, respectively. In the RAI group, four (8%) patients had subclinical hyperthyroidism. The mean time to euthyroidism was 4.3±1.3 months in LT-MMI patients and 16.3± 15.0 months in RAI recipients (P<0.001). Patients treated with LT-MMI spent 95.8%±5.9% of the 12-year study period in a euthyroid state, whereas this proportion was 72.4%±14.8% in the RAI-treated patients (P<0.001). No major treatment-related adverse events were observed in either group.
Conclusion
In patients with TMNG, LT-MMI therapy is superior to RAI treatment, as shown by the earlier achievement of euthyroidism and the longer duration of sustained normal serum thyrotropin.

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Control rate of hyperthyroidism and its associated factors after prolonged use of anti-thyroid drugs in a hospital setting, Northwest Ethiopia
Seyoum Mengesha, Abilo Tadesse, Biruk Mulat Worku, Kifle Alamrew, Tesfaye Yesuf, Yonas Gedamu
Medicine.2024; 103(23): e38201. CrossRef
Approach to the Patient Considering Long-term Antithyroid Drug Therapy for Graves’ Disease
Fereidoun Azizi, Ladan Mehran, Hengameh Abdi, Atieh Amouzegar
The Journal of Clinical Endocrinology & Metabolism.2024; 109(10): e1881. CrossRef
Mechanism of Huatan Sanjie Fang in improving goiter in Graves' disease mice based on the Hippo signaling pathway
Huimin Yuan, Wenxin Ma, Yifei Song, Hang Wang, Shuxin Yan, Silan Hao, Xiaoyun Zhu, Yang Tang
Journal of Traditional Chinese Medical Sciences.2023; 10(3): 289. CrossRef

Obesity and Metabolism
Helicobacter pylori Stool Antigen Levels and Serological Biomarkers of Gastric Inflammation are Associated with Cardio-Metabolic Risk Factors in Type 2 Diabetic Patients: Zahra Bahadoran, Parvin Mirmiran, Maryam Zarif-yeaganeh, Homayoun Zojaji, Fereidoun Azizi; Endocrinol Metab. 2015;30(3):280-287. Published online May 18, 2015; DOI: https://doi.org/10.3803/EnM.2015.30.3.280

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Background

Helicobacter pylori infection and subsequent gastric inflammation have been proposed as risk factors for the development of insulin resistance and cardiovascular disease. In this study we assessed the possible association of H. pylori bacterial load, and serum biomarker of gastric inflammation with cardiometabolic risk factors in diabetic patients.

Methods

In this cross-sectional study, 84 H. pylori-infected type 2 diabetic patients were assessed for anthropometrics, biochemical and clinical measurements. Pearson correlation test, linear, and logarithmic regression curve estimation models were used to assess the association of H. pylori stool antigen (HpSAg) levels, and pepsinogen I (PGI) to pepsinogen II (PGII) ratio with fasting serum glucose, insulin, serum lipid and lipoprotein parameters, malondialdehyde, high-sensitive C-reactive protein (hs-CRP), systolic and diastolic blood pressure, body weight, waist circumference and lipid accumulation product (LAP) index.

Results

The mean age of participants was 54±10 years, and 44% were men. Mean HpSAg levels and PGI/PGII ratio were 0.24±0.23 µg/mL and 9.9±9.0, respectively. Higher HpSAg as well as lower PGI/PGII was correlated with higher anthropometric measures and LAP. A significant negative correlation between PGI/PGII ratio and blood pressure (r=-0.21 and r=-0.22, systolic and diastolic, respectively, P<0.05), serum insulin (r=-0.17, P=0.05), and hs-CRP (r=-0.17, P=0.05) was observed. A significant linear association between PGI/PGII ratio with serum triglycerides (β=-0.24, P<0.05), serum high density lipoprotein cholesterol (HDL-C; β=0.43, P<0.01), and triglycerides/HDL-C ratio (β=-0.28, P<0.05) were observed.

Conclusion

Higher H. pylori bacterial load and lower PGI/PGII ratio was associated with higher levels of cardiometabolic risk factors in H. pylori infected type 2 diabetic patients.

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Cardiovascular and Neurological Diseases and Association with Helicobacter Pylori Infection—An Overview
Vlad Pădureanu, Dalia Dop, Daniel Cosmin Caragea, Dumitru Rădulescu, Rodica Pădureanu, Mircea-Cătălin Forțofoiu
Diagnostics.2024; 14(16): 1781. CrossRef
Both diet and Helicobacter pylori infection contribute to atherosclerosis in pre- and postmenopausal cynomolgus monkeys
Traci L. Testerman, Cristina Semino-Mora, Jennifer A. Cann, Beidi Qiang, Edsel A. Peña, Hui Liu, Cara H. Olsen, Haiying Chen, Susan E. Appt, Jay R. Kaplan, Thomas C. Register, D. Scott Merrell, Andre Dubois, Xianwu Cheng
PLOS ONE.2019; 14(9): e0222001. CrossRef
Associations of Helicobacter pylori infection and peptic disease with diabetic mellitus: Results from a large population-based study
Saeda Haj, Gabriel Chodick, Rotem Refaeli, Sophy Goren, Varda Shalev, Khitam Muhsen, David M. Ojcius
PLOS ONE.2017; 12(8): e0183687. CrossRef
Helicobacter Pylori Infection Is Associated with Dyslipidemia and Increased Levels of Oxidized LDL in Type-2 Diabetes Mellitus
Mohamed Hasan Mukhtar, Wesam Ahmed Nasif, Abdullatif Taha Babakr
Journal of Diabetes Mellitus.2016; 06(03): 185. CrossRef
Update on prevention and treatment of Helicobacter pylori infection
Zhao-Chun Chi
World Chinese Journal of Digestology.2016; 24(16): 2454. CrossRef

Obesity and Metabolism
Sugar-Sweetened Beverage Consumption Is Associated with Metabolic Syndrome in Iranian Adults: Tehran Lipid and Glucose Study: Hanieh-Sadat Ejtahed, Zahra Bahadoran, Parvin Mirmiran, Fereidoun Azizi; Endocrinol Metab. 2015;30(3):334-342. Published online May 18, 2015; DOI: https://doi.org/10.3803/EnM.2015.30.3.334

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Background

Metabolic syndrome (MetS), a cluster of multiple metabolic abnormalities, is one of the major public health challenges worldwide. The current study was conducted to evaluate the association between sugar-sweetened beverage (SSB) consumption and MetS and its components in Iranian adults.

Methods

This cross-sectional study was conducted among 5,852 men and women, aged 19 to 70 years, who participated in the fourth phase (2009 to 2011) of the Tehran Lipid and Glucose Study. Demographics, anthropometrics, biochemical measurements, and blood pressure (BP) were assessed and MetS was defined by National Cholesterol Education Program Adult Treatment Panel III definition. Frequency and quantity of SSB intakes including carbonated drinks and synthetic fruit juices were collected using a validated semiquantitative food frequency questionnaire.

Results

Mean age of participants (43%, men) was 40.6±12.9 years. Significant positive associations between SSBs and waist circumference, triglyceride level, systolic and diastolic BP in the third and fourth quartile of SSBs were observed, after adjustment for all potential confounding variables. The odds of MetS in the third and fourth quartiles compared to the first quartile category of SSBs was 1.21 (95% confidence interval [CI], 1.01 to 1.45) and 1.30 (95% CI, 1.06 to 1.58), respectively (P for trend=0.03). The odds of MetS, abdominal obesity, low high density lipoprotein cholesterol and elevated BP had increasing trends across increasing of SSB consumption (P for trend <0.05).

Conclusion

Higher intake of SSBs was associated with the higher odds of MetS in adults. It is suggested that reducing consumption of SSBs could be a practical approach to prevent metabolic abnormalities.

Citations

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Exploring the effect of sedentary behavior on increased adiposity in middle-aged adults
Nayeli Macías, Eric Monterrubio-Flores, Jorge Salmerón, Joacim Meneses-León, Yvonne N. Flores, Alejandra Jáuregui, Deborah Salvo, Umberto Villa, Armando G. Olvera, Katia Gallegos-Carrillo
BMC Public Health.2024;[Epub] CrossRef
Association between Sugar-Sweetened Beverage Consumption and the Risk of the Metabolic Syndrome: A Systematic Review and Meta-Analysis
Ainara Muñoz-Cabrejas, Pilar Guallar-Castillón, Martín Laclaustra, Helena Sandoval-Insausti, Belén Moreno-Franco
Nutrients.2023; 15(2): 430. CrossRef
Relationship between Coffee, Tea, and Carbonated Beverages and Cardiovascular Risk Factors
Hye-Ji An, Yejin Kim, Young-Gyun Seo
Nutrients.2023; 15(4): 934. CrossRef
The Association between the Consumption of Sugar-Sweetened Beverages and Metabolic Syndrome Components in Young Rural Adults in South Africa
Mohlago Ablonia Seloka, Moloko Matshipi, Peter Modupi Mphekgwana, Kotsedi Daniel Monyeki
Applied Sciences.2022; 12(6): 3015. CrossRef
A comparison between body mass index and waist circumference for identifying continuous metabolic syndrome risk score components in Iranian school-aged children using a structural equation modeling approach: the CASPIAN-V study
Hanieh-Sadat Ejtahed, Zohreh Mahmoodi, Mostafa Qorbani, Pooneh Angoorani, Mohammad Esmaeil Motlagh, Shirin Hasani-Ranjbar, Hasan Ziaodini, Majzoubeh Taheri, Ramin Heshmat, Roya Kelishadi
Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity.2021; 26(5): 1609. CrossRef
Dietary Intake and Health Status of Elderly Patients With Type 2 Diabetes Mellitus: Cross-sectional Study Using a Mobile App in Primary Care
Joane Diomara Coleone, Ericles Andrei Bellei, Mateus Klein Roman, Vanessa Ramos Kirsten, Ana Carolina Bertoletti De Marchi
JMIR Formative Research.2021; 5(8): e27454. CrossRef
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Azad Fatahi, Amin Doosti-Irani, Zahra Cheraghi
International Journal of Preventive Medicine.2020; 11(1): 64. CrossRef
Sugar-sweetened beverages consumption in relation to hypertension among Iranian university students: the MEPHASOUS study
Masoume Mansouri, Farshad Sharifi, Hamid Yaghubi, Mehdi Varmaghani, Yousef Moghadas Tabrizi, Morteza Nasiri, Omid Sadeghi
Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity.2020; 25(4): 973. CrossRef
Sugary beverages are associated with cardiovascular risk factors in diabetic patients
Razieh Anari, Reza Amani, Masoud Veissi
Journal of Diabetes & Metabolic Disorders.2019; 18(1): 7. CrossRef
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Danielle Cristina Guimarães da Silva, Wellington Segheto, Fernanda Cristina da Silva Amaral, Nínive de Almeida Reis, Ghéssica Santana Silva Veloso, Milene Cristine Pessoa, Juliana Farias de Novaes, Giana Zarbato Longo
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The amounts and contributions of total drinking fluids and water from food to total water intake of young adults in Baoding, China
Jianfen Zhang, Na Zhang, Shuxin Liang, Yan Wang, Shuzhuo Liu, Shufang Liu, Songming Du, Hairong He, Yifan Xu, Hao Cai, Xiaohui Guo, Lixin Ma, Guansheng Ma
European Journal of Nutrition.2019; 58(7): 2669. CrossRef
The association of glycemic index and glycemic load with elevated blood pressure in Iranian women
Seyedeh Forough Sajjadi, Alireza Milajerdi, Leila Azadbakht
Journal of Cardiovascular and Thoracic Research.2019; 11(4): 272. CrossRef
Utility of waist circumference‐to‐height ratio as a screening tool for generalized and central obesity among Iranian children and adolescents: The CASPIAN‐V study
Hanieh‐Sadat Ejtahed, Roya Kelishadi, Mostafa Qorbani, Mohammad Esmaeil Motlagh, Shirin Hasani‐Ranjbar, Pooneh Angoorani, Shaghayegh Beshtar, Hasan Ziaodini, Majzoubeh Taheri, Ramin Heshmat
Pediatric Diabetes.2019;[Epub] CrossRef
Discriminatory ability of visceral adiposity index as an indicator for modeling cardio-metabolic risk factors in pediatric population: the CASPIAN-V study
Hanieh-Sadat Ejtahed, Roya Kelishadi, Shirin Hasani-Ranjbar, Pooneh Angoorani, Mohammad Esmaeil Motlagh, Gita Shafiee, Hasan Ziaodini, Majzoubeh Taheri, Mostafa Qorbani, Ramin Heshmat
Journal of Cardiovascular and Thoracic Research.2019; 11(4): 280. CrossRef
The Association between Various Lifestyle Patterns and the Body Mass Index in Adolescents
Irina-Bianca Kosovski, Dana-Valentina Ghiga, Monica Tarcea, Cristina Nicoleta Ciurea, Ana Ioana Savin, Anca Bacârea
Acta Medica Marisiensis.2019; 65(3): 111. CrossRef
Sugar-Sweetened Beverages Consumption Positively Associated with the Risks of Obesity and Hypertriglyceridemia Among Children Aged 7–18 Years in South China
Baoting He, Weiqing Long, Xiuhong Li, Wenhan Yang, Yajun Chen, Yanna Zhu
Journal of Atherosclerosis and Thrombosis.2018; 25(1): 81. CrossRef
Nutrition and Cardio-Metabolic Risk Factors: 20 Years of the Tehran Lipid and Glucose Study Findings
Firoozeh Hosseini-Esfahani, Somaye Hosseinipour, Golaleh Asghari, Zahra Bahadoran, Nazanin Moslehi, Mahdieh Golzarand, Hanieh Ejtahed, Parvin Mirmiran, Fereidoun Azizi
International Journal of Endocrinology and Metabolism.2018;[Epub] CrossRef
Are non-high–density lipoprotein fractions associated with pediatric metabolic syndrome? The CASPIAN-V study
Pooneh Angoorani, Majid Khademian, Hanieh-Sadat Ejtahed, Ramin Heshmat, Mohammad Esmaeil Motlagh, Mahya Vafaeenia, Gita Shafiee, Armita Mahdivi-Gorabi, Mostafa Qorbani, Roya Kelishadi
Lipids in Health and Disease.2018;[Epub] CrossRef
Sugar-sweetened beverages consumption is associated with abdominal obesity risk in diabetic patients
Razieh Anari, Reza Amani, Masoud Veissi
Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2017; 11: S675. CrossRef
Prevalence of metabolic syndrome and health-related quality of life in war-related bilateral lower limb amputees
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Journal of Diabetes & Metabolic Disorders.2017;[Epub] CrossRef
Soft drink intake and the risk of metabolic syndrome: A systematic review and meta-analysis
Aditya Narain, Chun Shing Kwok, Mamas A. Mamas
International Journal of Clinical Practice.2017; 71(2): e12927. CrossRef
Long-term consumption of sugar-sweetened beverage during the growth period promotes social aggression in adult mice with proinflammatory responses in the brain
Jung-Yun Choi, Mi-Na Park, Chong-Su Kim, Young-Kwan Lee, Eun Young Choi, Woo Young Chun, Dong-Mi Shin
Scientific Reports.2017;[Epub] CrossRef
Frequent Consumption of Sugar- and Artificially Sweetened Beverages and Natural and Bottled Fruit Juices Is Associated with an Increased Risk of Metabolic Syndrome in a Mediterranean Population at High Cardiovascular Disease Risk
Cíntia Ferreira-Pêgo, Nancy Babio, Maira Bes-Rastrollo, Dolores Corella, Ramon Estruch, Emilio Ros, Montserrat Fitó, Lluís Serra-Majem, Fernando Arós, Miguel Fiol, José Manuel Santos-Lozano, Carlos Muñoz-Bravo, Xavier Pintó, Miguel Ruiz-Canela, Jordi Sala
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The effect of interaction between Melanocortin-4 receptor polymorphism and dietary factors on the risk of metabolic syndrome
Gelareh Koochakpoor, Maryam S. Daneshpour, Parvin Mirmiran, Seyed Ahmad Hosseini, Firoozeh Hosseini-Esfahani, Bahareh Sedaghatikhayat, Fereidoun Azizi
Nutrition & Metabolism.2016;[Epub] CrossRef

Obesity and Metabolism
Associations between Dietary Acid-Base Load and Cardiometabolic Risk Factors in Adults: The Tehran Lipid and Glucose Study: Zahra Bahadoran, Parvin Mirmiran, Hadise Khosravi, Fereidoun Azizi; Endocrinol Metab. 2015;30(2):201-207. Published online June 30, 2015; DOI: https://doi.org/10.3803/EnM.2015.30.2.201

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Background

In this study we investigated the associations of dietary acid-base load, identified by potential renal acid load (PRAL) and protein to potassium (Pro:K) ratio, with cardiometabolic risk factors in Tehranian adults.

Methods

A cross-sectional study was conducted within the framework of the fourth phase of the Tehran Lipid and Glucose Study (2009 to 2011) on 5,620 men and women aged 19 to 70 years. Dietary data were collected by a trained dietitian using a validated, 147-food item, semi-quantitative food frequency questionnaire, and dietary PRAL and Pro:K ratio were calculated. Multiple linear regression models with adjustment for potential confounding variables were used to evaluate the associations of dietary acid-base load with anthropometric measures, blood pressure, serum triglycerides, high density lipoprotein cholesterol (HDL-C), serum creatinine, and fasting blood glucose.

Results

The mean±SD age of the participants was 39.8±12.8 years and 54% of participants were women. Mean±SD PRAL was -22.0±29.1; mean PRAL was -15.6 in men and -26.8 in women. Dietary PRAL was associated with weight (β=0.098, P<0.001), waist circumference (β=0.062, P<0.01), serum triglycerides (β=0.143, P<0.01), HDL-C (β=-0.11, P<0.01), diastolic blood pressure (β=0.062, P<0.01), and serum creatinine (β=0.142, P<0.001). Pro:K ratio was associated with weight (β=0.055, P<0.001), waist circumference (β=0.04, P<0.01), serum HDL-C (β=-0.06, P<0.01), serum triglycerides (β=0.03, P<0.05), diastolic blood pressure (β=0.026, P<0.05), and serum creatinine (β=0.07, P<0.01).

Conclusion

A more acidic dietary acid-base load may be a risk factor for the development of metabolic disorders.

Citations

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A high dietary acid load can potentially exacerbate cardiometabolic risk factors: An updated systematic review and meta-analysis of observational studies
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Mahdieh Abbasalizad Farhangi, Leila Nikniaz, Zeinab Nikniaz, Raffaele Serra
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Higher dietary acid load is associated with higher likelihood of peripheral arterial disease among American adults
Mohsen Mazidi, Dimitri P. Mikhailidis, Maciej Banach
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Nutrition and Cardio-Metabolic Risk Factors: 20 Years of the Tehran Lipid and Glucose Study Findings
Firoozeh Hosseini-Esfahani, Somaye Hosseinipour, Golaleh Asghari, Zahra Bahadoran, Nazanin Moslehi, Mahdieh Golzarand, Hanieh Ejtahed, Parvin Mirmiran, Fereidoun Azizi
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Association between Dietary Acid Load and Insulin Resistance: Tehran Lipid and Glucose Study
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Preventive Nutrition and Food Science.2016; 21(2): 104. CrossRef

Obesity and Metabolism
Lipid Accumulation Product Is Associated with Insulin Resistance, Lipid Peroxidation, and Systemic Inflammation in Type 2 Diabetic Patients: Parvin Mirmiran, Zahra Bahadoran, Fereidoun Azizi; Endocrinol Metab. 2014;29(4):443-449. Published online December 29, 2014; DOI: https://doi.org/10.3803/EnM.2014.29.4.443

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Background

Lipid accumulation product (LAP) is a novel biomarker of central lipid accumulation related to risk of diabetes and cardiovascular disease. In this study, we assessed the association of LAP with glucose homeostasis, lipid and lipid peroxidation, and subclinical systemic inflammation in diabetic patients.

Methods

Thirty-nine male and 47 female type 2 diabetic patients were assessed for anthropometrics and biochemical measurements. LAP was calculated as [waist circumference (cm)-65]×[triglycerides (mmol/L)] in men, and [waist circumference (cm)-58]×[triglycerides (mmol/L)] in women. Associations of LAP with fasting glucose, insulin, insulin resistance index, lipid and lipoprotein levels, malondialdehyde, and high-sensitive C-reactive protein (hs-CRP) were assessed.

Results

Mean age and LAP index were 53.6±9.6 and 51.9±31.2 years, respectively. After adjustments for age, sex and body mass index status, a significant positive correlation was observed between LAP index and fasting glucose (r=0.39, P<0.001), and homeostasis model assessment of insulin resistance (r=0.31, P<0.05). After additional adjustment for fasting glucose levels, antidiabetic and antilipidemic drugs, the LAP index was also correlated to total cholesterol (r=0.45, P<0.001), high density lipoprotein cholesterol (HDL-C) levels (r=-0.29, P<0.05), triglycerides to HDL-C ratio (r=0.89, P<0.001), malondialdehyde (r=0.65, P<0.001), and hs-CRP levels (r=0.27, P<0.05).

Conclusion

Higher central lipid accumulation in diabetic patients was related to higher insulin resistance, oxidative stress and systemic inflammation.

Citations

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