Skip Navigation
Skip to contents

Endocrinol Metab : Endocrinology and Metabolism

clarivate
OPEN ACCESS
SEARCH
Search

Author index

Page Path
HOME > BROWSE ARTICLES > Author index
Search
F. Sinem Hocaoglu-Emre  (Hocaoglu-Emre FS) 1 Article
Vascular Cell Adhesion Molecule 1, Intercellular Adhesion Molecule 1, and Cluster of Differentiation 146 Levels in Patients with Type 2 Diabetes with Complications
F. Sinem Hocaoglu-Emre, Devrim Saribal, Guven Yenmis, Guvenc Guvenen
Endocrinol Metab. 2017;32(1):99-105.   Published online March 20, 2017
DOI: https://doi.org/10.3803/EnM.2017.32.1.99
  • 4,556 View
  • 79 Download
  • 19 Web of Science
  • 17 Crossref
AbstractAbstract PDFPubReader   
Background

Type 2 diabetes mellitus (T2DM) is a multisystemic, chronic disease accompanied by microvascular complications involving various complicated mechanisms. Intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and cluster of differentiation-146 (CD146) are mainly expressed by endothelial cells, and facilitate the adhesion and transmigration of immune cells, leading to inflammation. In the present study, we evaluated the levels of soluble adhesion molecules in patients with microvascular complications of T2DM.

Methods

Serum and whole blood samples were collected from 58 T2DM patients with microvascular complications and 20 age-matched healthy subjects. Levels of soluble ICAM-1 (sICAM-1) and soluble VCAM-1 (sVCAM-1) were assessed using enzyme-linked immunosorbent assay, while flow cytometry was used to determine CD146 levels.

Results

Serum sICAM-1 levels were lower in T2DM patients with microvascular complications than in healthy controls (P<0.05). No significant differences were found in sVCAM-1 and CD146 levels between the study and the control group. Although patients were subdivided into groups according to the type of microvascular complications that they experienced, cell adhesion molecule levels were not correlated with the complication type.

Conclusion

In the study group, most of the patients were on insulin therapy (76%), and 95% of them were receiving angiotensin-converting enzyme (ACE)-inhibitor agents. Insulin and ACE-inhibitors have been shown to decrease soluble adhesion molecule levels via various mechanisms, so we suggest that the decreased or unchanged levels of soluble forms of cellular adhesion molecules in our study group may have resulted from insulin and ACE-inhibitor therapy, as well as tissue-localized inflammation in patients with T2DM.

Citations

Citations to this article as recorded by  
  • INFLUENCE OF FACTORS OF THE PROGRESSION OF DIABETIC RETINOPATHY ON THE CONTENT OF BLOOD SERUM CLUSTER OF DIFFERENTIATION CHEMOKINE CD54 IN THE OF PATIENTS WITH TYPE 2 DIABETES
    O.V. Rybachuk
    Medical Science of Ukraine (MSU).2024; 20(2): 3.     CrossRef
  • Immunity status and expression of molecular markers (ICAM-1, CD5, CD25, CD95) on lymphocytes of patients with recurrent anterior uveitis complicated by macular edema
    Natalia I. Khramenko, Natalia V. Konovalova, Volodymyr Ya. Usov, Liudmyla M. Velychko, Olexandra V. Bogdanova
    Graefe's Archive for Clinical and Experimental Ophthalmology.2023; 261(5): 1423.     CrossRef
  • The association of cell adhesion molecules and selectins (VCAM-1, ICAM-1, E-selectin, L-selectin, and P-selectin) with microvascular complications in patients with type 2 diabetes: A follow-up study
    Khalid Siddiqui, Teena P. George, Muhammad Mujammami, Arthur Isnani, Assim A. Alfadda
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Vascular cell adhesion molecule‑1 levels in patients with coronary artery disease with type 2 diabetes mellitus
    S.A. Serik, N.R. Mavrycheva
    Medicni perspektivi.2023; 28(1): 82.     CrossRef
  • Diabetic Endothelial Cell Glycogen Synthase Kinase 3β Activation Induces VCAM1 Ectodomain Shedding
    Masuma Akter Brishti, Somasundaram Raghavan, Kennedy Lamar, Udai P. Singh, Daniel M. Collier, M. Dennis Leo
    International Journal of Molecular Sciences.2023; 24(18): 14105.     CrossRef
  • Evaluation of cell adhesion molecules (LFA-1 and L-selectin) in ankylosing spondylitis patients after treatment with β-D-mannuronic acid (M2000)
    MohammadJavad Fattahi, BerndH A. Rehm, Hidenori Matsuo, Salvatore Cuzzocrea, Fahimeh Jafarnezhad-Ansariha, Hossein Ahmadi, Farzaneh Tofighi-Zavareh, Mona Oraei, Zahra Aghazadeh, Abbas Mirshafiey
    Indian Journal of Medical Research.2023; 157(5): 453.     CrossRef
  • Circulating Cell Adhesion Molecules Level in Type 2 Diabetes Mellitus and Its Correlation with Glycemic Control and Metabolic Syndrome
    Reber Ali Abdullah, Ibtesam Salih Abdulrahman
    Medical Journal of Babylon.2023; 20(1): 64.     CrossRef
  • Coenzyme Q10 administration has no effect on sICAM-1 and metabolic parameters of pediatrics with type 1 diabetes mellitus
    Heba Serag, Lamia El Wakeel, Amira Adly
    International Journal for Vitamin and Nutrition Research.2021; 91(3-4): 315.     CrossRef
  • Diabetes induced renal complications by leukocyte activation of nuclear factor κ-B and its regulated genes expression
    Noura M. Darwish, Yousif M. Elnahas, Fatmah S. AlQahtany
    Saudi Journal of Biological Sciences.2021; 28(1): 541.     CrossRef
  • Effect of French maritime pine bark extract supplementation on metabolic status and serum vascular cell adhesion molecule-1 levels in patients with type 2 diabetes and microalbuminuria
    Elham Navval-Esfahlan, Maryam Rafraf, Somayyeh Asghari, Hossein Imani, Mohammad Asghari-Jafarabadi, Sanaz Karimi-Avval
    Complementary Therapies in Medicine.2021; 58: 102689.     CrossRef
  • Dysregulation of Leukocyte Trafficking in Type 2 Diabetes: Mechanisms and Potential Therapeutic Avenues
    Laleh Pezhman, Abd Tahrani, Myriam Chimen
    Frontiers in Cell and Developmental Biology.2021;[Epub]     CrossRef
  • Regulatory effects of IL-1β in the interaction of GBM and tumor-associated monocyte through VCAM-1 and ICAM-1
    Ching-Kai Shen, Bor-Ren Huang, Wei-Lan Yeh, Chao-Wei Chen, Yu-Shu Liu, Sheng-Wei Lai, Wen-Pei Tseng, Dah-Yuu Lu, Cheng-Fang Tsai
    European Journal of Pharmacology.2021; 905: 174216.     CrossRef
  • Serum netrin and VCAM-1 as biomarker for Egyptian patients with type IΙ diabetes mellitus
    Maher M. Fadel, Faten R. Abdel Ghaffar, Shimaa K. Zwain, Hany M. Ibrahim, Eman AE. badr
    Biochemistry and Biophysics Reports.2021; 27: 101045.     CrossRef
  • Circulating Biomarkers of Inflammation and Endothelial Activation in Diabetic Retinopathy
    Federica Storti, Jennifer Pulley, Pascal Kuner, Markus Abt, Ulrich F. O. Luhmann
    Translational Vision Science & Technology.2021; 10(12): 8.     CrossRef
  • Estimation of Vascular Cell Adhesion Molecule 1 (VCAM-1) Levels In Type 1 Diabetic Mellitus Patients
    Ousamha Akram Saterr, Abeer J. Hassan, Qahtan Adnan Rasheed
    Bionatura.2021; 6(4): 2292.     CrossRef
  • Il-18, Vcam-1 and P-Selectin As Early Biomarkers in Normoalbuminuric Type 2 Diabetes Patients
    Khalid Al-Rubeaan, Shaik S Nawaz, Amira M Youssef, Mohammed Al Ghonaim, Khalid Siddiqui
    Biomarkers in Medicine.2019; 13(6): 467.     CrossRef
  • miR-146a mediates thymosin β4 induced neurovascular remodeling of diabetic peripheral neuropathy in type-II diabetic mice
    Lei Wang, Michael Chopp, XueRong Lu, Alexandra Szalad, LongFei Jia, Xian Shuang Liu, Kuan-Han Wu, Mei Lu, Zheng Gang Zhang
    Brain Research.2019; 1707: 198.     CrossRef
Close layer

Endocrinol Metab : Endocrinology and Metabolism
TOP