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F. Sinem Hocaoglu-Emre  (Hocaoglu-Emre FS) 1 Article
Vascular Cell Adhesion Molecule 1, Intercellular Adhesion Molecule 1, and Cluster of Differentiation 146 Levels in Patients with Type 2 Diabetes with Complications
F. Sinem Hocaoglu-Emre, Devrim Saribal, Guven Yenmis, Guvenc Guvenen
Endocrinol Metab. 2017;32(1):99-105.   Published online March 20, 2017
DOI: https://doi.org/10.3803/EnM.2017.32.1.99
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  • 13 Citations
AbstractAbstract PDFPubReader   CrossRef-TDMCrossref - TDM
Background

Type 2 diabetes mellitus (T2DM) is a multisystemic, chronic disease accompanied by microvascular complications involving various complicated mechanisms. Intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and cluster of differentiation-146 (CD146) are mainly expressed by endothelial cells, and facilitate the adhesion and transmigration of immune cells, leading to inflammation. In the present study, we evaluated the levels of soluble adhesion molecules in patients with microvascular complications of T2DM.

Methods

Serum and whole blood samples were collected from 58 T2DM patients with microvascular complications and 20 age-matched healthy subjects. Levels of soluble ICAM-1 (sICAM-1) and soluble VCAM-1 (sVCAM-1) were assessed using enzyme-linked immunosorbent assay, while flow cytometry was used to determine CD146 levels.

Results

Serum sICAM-1 levels were lower in T2DM patients with microvascular complications than in healthy controls (P<0.05). No significant differences were found in sVCAM-1 and CD146 levels between the study and the control group. Although patients were subdivided into groups according to the type of microvascular complications that they experienced, cell adhesion molecule levels were not correlated with the complication type.

Conclusion

In the study group, most of the patients were on insulin therapy (76%), and 95% of them were receiving angiotensin-converting enzyme (ACE)-inhibitor agents. Insulin and ACE-inhibitors have been shown to decrease soluble adhesion molecule levels via various mechanisms, so we suggest that the decreased or unchanged levels of soluble forms of cellular adhesion molecules in our study group may have resulted from insulin and ACE-inhibitor therapy, as well as tissue-localized inflammation in patients with T2DM.

Citations

Citations to this article as recorded by  
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  • The association of cell adhesion molecules and selectins (VCAM-1, ICAM-1, E-selectin, L-selectin, and P-selectin) with microvascular complications in patients with type 2 diabetes: A follow-up study
    Khalid Siddiqui, Teena P. George, Muhammad Mujammami, Arthur Isnani, Assim A. Alfadda
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
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    Medicni perspektivi.2023; 28(1): 82.     CrossRef
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    International Journal for Vitamin and Nutrition Research.2021; 91(3-4): 315.     CrossRef
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  • Serum netrin and VCAM-1 as biomarker for Egyptian patients with type IΙ diabetes mellitus
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  • Circulating Biomarkers of Inflammation and Endothelial Activation in Diabetic Retinopathy
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    Bionatura.2021; 6(4): 2292.     CrossRef
  • IL-18, VCAM-1 and P-selectin as early biomarkers in normoalbuminuric Type 2 diabetes patients
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    Biomarkers in Medicine.2019; 13(6): 467.     CrossRef
  • miR-146a mediates thymosin β4 induced neurovascular remodeling of diabetic peripheral neuropathy in type-II diabetic mice
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