Adrenal masses are mainly detected unexpectedly by an imaging study performed for reasons unrelated to any suspect of adrenal diseases. Such masses are commonly defined as “adrenal incidentalomas” and represent a public health challenge because they are increasingly recognized in current medical practice. Management of adrenal incidentalomas is currently matter of debate. Although there is consensus on the need of a multidisciplinary expert team evaluation and surgical approach in patients with significant hormonal excess and/or radiological findings suspicious of malignancy demonstrated at the diagnosis or during follow-up, the inconsistency between official guidelines and the consequent diffuse uncertainty on management of small adrenal incidentalomas still represents a considerable problem in terms of clinical choices in real practice. The aim of the present work is to review the proposed strategies on how to manage patients with adrenal incidentalomas that are not candidates to immediate surgery. The recent European Society of Endocrinology/European Network for the Study of Adrenal Tumors guidelines have supported the view to avoid surveillance in patients with clear benign adrenal lesions <4 cm and/or without any hormonal secretion; however, newer prospective studies are needed to confirm safety of this strategy, in particular in younger patients.

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• Adrenal Incidentaloma—Innocent Bystander or Intruder?
  Laurence Amar, Inga Harbuz-Miller, Adina F Turcu
  The Journal of Clinical Endocrinology & Metabolism.2024; 109(3): e1303.     CrossRef
• Mineral metabolism assays and osteoporotic fracture risk evaluation in menopausal population diagnosed with adrenal incidentalomas: a sub-analysis of PRECES study
  Alexandra-Ioana Trandafir, Mihaela Stanciu, Ana Valea, Oana-Claudia Sima, Claudiu Nistor, Mădălina Gabriela Iliescu, Ileana Ciobanu, Florina Ligia Popa, Mara Carsote
  Balneo and PRM Research Journal.2024; 15(Vol.15, no): 692.     CrossRef
• Diagnosing and managing adrenal incidentalomas
  Justine Herndon, Irina Bancos
  JAAPA.2023; 36(5): 12.     CrossRef
• Tumor enlargement in adrenal incidentaloma is related to glaucoma: a new prognostic feature?
  M. Caputo, T. Daffara, A. Ferrero, M. Romanisio, E. Monti, C. Mele, M. Zavattaro, S. Tricca, A. Siani, A. Clemente, C. Palumbo, S. De Cillà, A. Carriero, A. Volpe, P. Marzullo, G. Aimaretti, F. Prodam
  Journal of Endocrinological Investigation.2023; 47(2): 377.     CrossRef
• The Role of Biomarkers in Adrenocortical Carcinoma: A Review of Current Evidence and Future Perspectives
  Maja Mizdrak, Tina Tičinović Kurir, Joško Božić
  Biomedicines.2021; 9(2): 174.     CrossRef
• An Adrenocortical Carcinoma Evolving After Nine Years of Latency From a Small Adrenal Incidentaloma
  Harpreet S Kohli, Sukesh Manthri, Shikha Jain, Rahul Kashyap, Sheng Chen, Thoyaja Koritala, Aysun Tekin, Ramesh Adhikari, Raghavendra Tirupathi, Aram Barbaryan, Simon Zec, Hanyin Wang, Stephanie Welle, Pavan Devulapally, Mack Sheraton, Manpreet Kaur, Vish
  Cureus.2021;[Epub]     CrossRef
• Diagnostic algorithm of the subclinical forms of adrenal neoplasms
  Sofya G. Blyumina, Pavel N. Romashchenko, Igor S. Zheleznyak
  Bulletin of the Russian Military Medical Academy.2021; 23(3): 67.     CrossRef