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Endocrinol Metab : Endocrinology and Metabolism


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Edwin Jadulco Cañete  (Cañete EJ) 1 Article
Clinicopathological, Biochemical, and Sonographic Features of Thyroid Nodule Predictive of Malignancy among Adult Filipino Patients in a Tertiary Hospital in the Philippines
Edwin Jadulco Cañete, Cherrie Mae Sison-Peña, Cecilia Alegado Jimeno
Endocrinol Metab. 2014;29(4):489-497.   Published online December 29, 2014
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  • 13 Web of Science
  • 8 Crossref
AbstractAbstract PDFPubReader   

Thyroid nodules may harbor cancer in 5% to 15% of cases. Specific clinical and sonographic features predictive of malignancy have been investigated in various populations, but due to differences in epidemiology, risk factors and iodine nutrition status, these predictors may not be valid in the Philippines. This study determined the clinicopathological, biochemical, and sonographic features of thyroid nodules predictive of malignancy among adult Filipino patients at the University of the Philippines-Philippine General Hospital (UP-PGH).


We reviewed the medical records of Filipino patients ≥19 years of age who underwent thyroid surgery in UP-PGH from 2008 to 2011.


A total of 837 of 1,670 patients (50.1%) were enrolled in the study, which included 417 benign and 420 malignant tumors. The mean age at diagnosis was 38±11 years, with female predominance. Multiple logistic regression analysis showed that the presence of a hard or firm nodule (odds ratio [OR], 58.8, P<0.001; OR, 12.8, P<0.001), presence of microcalcifications (OR, 11.1; P<0.001), irregular margins on ultrasound (OR, 4.5; P<0.001), and absence of associated symptoms (OR, 2.3; P<0.002) increased significantly the likelihood of thyroid malignancy.


Similar to international data, the absence of associated symptoms, firm to hard thyroid nodules, and the presence of microcalcifications and irregular margins were significant predictors of thyroid malignancy.


Citations to this article as recorded by  
  • Detection of Thyroid Nodule Prevalence and Associated Risk Factors in Southwest China: A Study of 45,023 Individuals Undergoing Physical Examinations
    Yi Liang, Xiaohong Li, Fang Wang, Zongting Yan, Yuhuan Sang, Yuan Yuan, Yun Qin, Xuefei Zhang, Mei Ju
    Diabetes, Metabolic Syndrome and Obesity.2023; Volume 16: 1697.     CrossRef
  • Diagnostic performance of the EU TI‐RADS and ACR TI‐RADS scoring systems in predicting thyroid malignancy
    Hiba‐Allah Chatti, Ibtissem Oueslati, Aymen Azaiez, Jihen Marrakchi, Seif Boukriba, Habiba Mizouni, Slim Haouet, Ghazi Besbes, Meriem Yazidi, Melika Chihaoui
    Endocrinology, Diabetes & Metabolism.2023;[Epub]     CrossRef
  • Behaviour and epidemiology of differentiated thyroid cancer among filipinos in and outside the Philippines: Comparison between Qatar, Canada and Philippines
    Mohamed Said Ghali, Walid El Ansari, Abdelrahman Abdelaal, Mohamed S. Al Hassan
    Annals of Medicine and Surgery.2022; 81: 104202.     CrossRef
  • Association Between Thyroid Nodules and Volume and Metabolic Syndrome in an Iodine-Adequate Area: A Large Community-Based Population Study
    Yue Su, Yan-ling Zhang, Meng Zhao, Hai-qing Zhang, Xu Zhang, Qing-bo Guan, Chun-xiao Yu, Shan-shan Shao, Jin Xu
    Metabolic Syndrome and Related Disorders.2019; 17(4): 217.     CrossRef
  • Accuracy of ultrasonography-guided fine needle aspiration cytology and significance of non-diagnostic cytology in the preoperative detection of thyroid malignancy
    JSL Chieng, CH Lee, AA Karandikar , JPN Goh, SSS Tan
    Singapore Medical Journal.2019; 60(4): 193.     CrossRef
  • Thyroid Fine-Needle Aspiration Practice in the Philippines
    Agustina D. Abelardo
    Journal of Pathology and Translational Medicine.2017; 51(6): 555.     CrossRef
  • An Epidemiological Study of Risk Factors of Thyroid Nodule and Goiter in Chinese Women
    Lei Zheng, Wenhua Yan, Yue Kong, Ping Liang, Yiming Mu
    International Journal of Environmental Research and Public Health.2015; 12(9): 11608.     CrossRef
  • Articles in 'Endocrinology and Metabolism' in 2014
    Won-Young Lee
    Endocrinology and Metabolism.2015; 30(1): 47.     CrossRef
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