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Duk Kyu Kim  (Kim DK) 8 Articles
Clinical Study
Glucose-Dependent Insulinotropic Peptide Level Is Associated with the Development of Type 2 Diabetes Mellitus
Sunghwan Suh, Mi Yeon Kim, Soo Kyoung Kim, Kyu Yeon Hur, Mi Kyoung Park, Duk Kyu Kim, Nam H. Cho, Moon-Kyu Lee
Endocrinol Metab. 2016;31(1):134-141.   Published online March 16, 2016
DOI: https://doi.org/10.3803/EnM.2016.31.1.134
  • 3,632 View
  • 42 Download
  • 7 Web of Science
  • 6 Crossref
AbstractAbstract PDFPubReader   
Background

Incretin hormone levels as a predictor of type 2 diabetes mellitus have not been fully investigated. Therefore, we measured incretin hormone levels to examine the relationship between circulating incretin hormones, diabetes, and future diabetes development in this study.

Methods

A nested case-control study was conducted in a Korean cohort. The study included the following two groups: the control group (n=149), the incident diabetes group (n=65). Fasting total glucagon-like peptide-1 (GLP-1) and total glucose-dependent insulinotropic peptide (GIP) levels were measured and compared between these groups.

Results

Fasting total GIP levels were higher in the incident diabetes group than in the control group (32.64±22.68 pmol/L vs. 25.54±18.37 pmol/L, P=0.034). There was no statistically significant difference in fasting total GLP-1 levels between groups (1.14±1.43 pmol/L vs. 1.39±2.13 pmol/L, P=0.199). In multivariate analysis, fasting total GIP levels were associated with an increased risk of diabetes (odds ratio, 1.005; P=0.012) independent of other risk factors.

Conclusion

Fasting total GIP levels may be a risk factor for the development of type 2 diabetes mellitus. This association persisted even after adjusting for other metabolic parameters such as elevated fasting glucose, hemoglobin A1c, and obesity in the pre-diabetic period.

Citations

Citations to this article as recorded by  
  • Mendelian randomization analyses suggest a causal role for circulating GIP and IL-1RA levels in homeostatic model assessment-derived measures of β-cell function and insulin sensitivity in Africans without type 2 diabetes
    Karlijn A. C. Meeks, Amy R. Bentley, Themistocles L. Assimes, Nora Franceschini, Adebowale A. Adeyemo, Charles N. Rotimi, Ayo P. Doumatey
    Genome Medicine.2023;[Epub]     CrossRef
  • Glucose- and Bile Acid-Stimulated Secretion of Gut Hormones in the Isolated Perfused Intestine Is Not Impaired in Diet-Induced Obese Mice
    Jenna E. Hunt, Jens J. Holst, Sara L. Jepsen
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Combined treatment with a gastric inhibitory polypeptide receptor antagonist and a peptidyl peptidase-4 inhibitor improves metabolic abnormalities in diabetic mice
    Fei Yang, Shan Dang, Hongjun LV, Bingyin Shi
    Journal of International Medical Research.2021; 49(1): 030006052098566.     CrossRef
  • Elevated levels of fasting serum GIP may be protective factors for diabetic retinopathy in type 2 diabetes mellitus
    LingHong Huang, JingXiong Zhou, Bo Liang, HuiBin Huang, LiangYi Li
    International Journal of Diabetes in Developing Countries.2021; 41(4): 543.     CrossRef
  • Enteroendocrine K and L cells in healthy and type 2 diabetic individuals
    Tina Jorsal, Nicolai A. Rhee, Jens Pedersen, Camilla D. Wahlgren, Brynjulf Mortensen, Sara L. Jepsen, Jacob Jelsing, Louise S. Dalbøge, Peter Vilmann, Hazem Hassan, Jakob W. Hendel, Steen S. Poulsen, Jens J. Holst, Tina Vilsbøll, Filip K. Knop
    Diabetologia.2018; 61(2): 284.     CrossRef
  • Articles inEndocrinology and Metabolismin 2016
    Won-Young Lee
    Endocrinology and Metabolism.2017; 32(1): 62.     CrossRef
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Thyroid
Subclinical Hypothyroidism and Cardiovascular Disease
Sunghwan Suh, Duk Kyu Kim
Endocrinol Metab. 2015;30(3):246-251.   Published online August 4, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.3.246
  • 4,511 View
  • 56 Download
  • 31 Web of Science
  • 29 Crossref
AbstractAbstract PDFPubReader   

Subclinical hypothyroidism (SCH) is a common disorder that is characterized by elevated thyroid-stimulating hormone levels in conjunction with free thyroxine concentrations within the normal reference range. Thyroid hormones are known to affect the heart and vasculature and, as a result, the impact of SCH on the cardiovascular (CV) system has recently become an important topic of research. Strong evidence points to a link between SCH and CV risk factors such as alterations in blood pressure, lipid levels, and atherosclerosis. Additionally, accumulating evidence indicates that SCH is associated with metabolic syndrome and heart failure. The present review proposes that SCH may be a potentially modifiable risk factor of CV disease and mortality. However, large-scale clinical trials with appropriate power investigating the risks and benefits of SCH treatment are required to determine whether these benefits can be achieved with levothyroxine therapy.

Citations

Citations to this article as recorded by  
  • Prognostic implications of thyroid disease in patients with atrial fibrillation
    Anthi Vasilopoulou, Vasiliki Patsiou, Alexandra Bekiaridou, Andreas S. Papazoglou, Dimitrios V. Moysidis, Marina Spaho, Martha Zergioti, Dimitrios Kostakakis, Maria-Eirini Kyriakideli, Chrysanthi-Ioanna Lampropoulou, Anastasios Kartas, Athanasios Samaras,
    Heart and Vessels.2024; 39(2): 185.     CrossRef
  • A Comparative Study of Iron Status in Subclinical Hypothyroid and Euthyroid Subjects in a Tertiary Care Hospital
    Thokati G Swapnika, S S Sabitha Rani, Satish Dipankar, Afreen Begum H Itagi, Immadi S Vamshidhar
    Cureus.2024;[Epub]     CrossRef
  • The influence of hypothyroidism on the course of coronary artery disease in patients with reduced left ventricular ejection fraction
    M.V. Kucheriava, G.B. Mankovskyi
    INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine).2023; 19(3): 161.     CrossRef
  • Correlation between Subclinical Hypothyroidism and Metabolic Syndrome: A Retrospective Study
    SalhahSaleh Alsulami, Mukhtiar Baig, AtheerHameed Albeladi, ShahadBandar Alyoubi, ShahadAlhumaidi Alsubaie, SamahAbdulsalam Albeladi, KholoudAlawi Ghamri, AbeerMohammed Saeed Alraiqi, SafaMobarak Alyoubi, WesamAied Almutairi
    Saudi Journal of Medicine and Medical Sciences.2023; 11(3): 250.     CrossRef
  • Low awareness and under-diagnosis of hypothyroidism
    Ulrike Gottwald-Hostalek, Barbara Schulte
    Current Medical Research and Opinion.2022; 38(1): 59.     CrossRef
  • Mean platelet volume (MPV) levels in subclinical hypothyroidism and its relation to serum lipid levels
    Zafer ERCAN, Mehmet Emin DEMİR
    Anatolian Current Medical Journal.2022; 4(3): 234.     CrossRef
  • The impact of subclinical hypothyroidism on long-term outcomes in older patients undergoing percutaneous coronary intervention
    Yong-Sheng Liu, Mei Wei, Le Wang, Gang Liu, Guo-Ping Ma, Katsushige Ono, Ze-Long Cao, Man Yang, Ming-Qi Zheng
    BMC Endocrine Disorders.2021;[Epub]     CrossRef
  • Subclinical Hypothyroidism in Geriatric Population and Its Association With Heart Failure
    Priyanka Panday, Ana P Arcia Franchini, Beshoy Iskander, Fatima Anwer, Federico Oliveri, Fotios Kakargias , Pousette Hamid
    Cureus.2021;[Epub]     CrossRef
  • The Effect of Thyroxine Therapy on Cardiovascular Risk Factors in Patients with Subclinical Hypothyroidism
    Selvihan BEYSEL, Mahmut APAYDIN, Mustafa ÇALIŞKAN, Mustafa ÖZBEK, Erman ÇAKAL
    Düzce Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi.2021;[Epub]     CrossRef
  • Pathophysiological aspects of development myocardial infarction type 2 in subclinical hypothyroidism
    A. A. Ivannikov, A. A. Kanibolotsky, Kh. G. Alidzhanova, I. V. Bratischev
    Medical alphabet.2021; (42): 34.     CrossRef
  • Unknown Subclinical Hypothyroidism and In-Hospital Outcomes and Short- and Long-Term All-Cause Mortality among ST Segment Elevation Myocardial Infarction Patients Undergoing Percutaneous Coronary Intervention
    Elena Izkhakov, David Zahler, Keren-Lee Rozenfeld, Dor Ravid, Shmuel Banai, Yan Topilsky, Naftali Stern, Yona Greenman, Yacov Shacham
    Journal of Clinical Medicine.2020; 9(12): 3829.     CrossRef
  • Evaluation of left atrial volume and functions by real time three‐dimensional echocardiography in patients with subclinical hypothyroidism before and after levothyroxine therapy
    Seçkin Dereli, Adil Bayramoğlu, Nurtaç Özer, Ahmet Kaya, Muhammet Özbilen
    Echocardiography.2019; 36(5): 916.     CrossRef
  • The impact of thyroid hormone dysfunction on ischemic heart disease
    Madalena von Hafe, João Sergio Neves, Catarina Vale, Marta Borges-Canha, Adelino Leite-Moreira
    Endocrine Connections.2019; 8(5): R76.     CrossRef
  • Association High-Iodine-Containing Seaweed Soup Consumption after Birth and Subclinical Hypothyroidism in Korean Women: Korea National Health and Nutrition Examination Survey IV (2013–2015)
    Hyunsam Kim, Ha Ni Lee, Jeonghoon Ha
    International Journal of Thyroidology.2019; 12(2): 105.     CrossRef
  • Association between subclinical hypothyroidism and metabolic disorders: A retrospective chart review study in an emerging university hospital
    Khaled Aldossari, Sameer Al‐Ghamdi, Jamaan Al‐Zahrani, Anwar Al Jammah, Bader Alanazi, Abdulilah Al‐Briek, Mohammad Alanazi
    Journal of Clinical Laboratory Analysis.2019;[Epub]     CrossRef
  • Thyroid replacement therapy, thyroid stimulating hormone concentrations, and long term health outcomes in patients with hypothyroidism: longitudinal study
    Rasiah Thayakaran, Nicola J Adderley, Christopher Sainsbury, Barbara Torlinska, Kristien Boelaert, Dana Šumilo, Malcolm Price, G Neil Thomas, Konstantinos A Toulis, Krishnarajah Nirantharakumar
    BMJ.2019; : l4892.     CrossRef
  • Visceral Adiposity Index Levels in Patients with Hypothyroidism
    Selma Pekgor, Cevdet Duran, Ruhuşen Kutlu, Ibrahim Solak, Ahmet Pekgor, Mehmet Ali Eryilmaz
    Journal of the National Medical Association.2018; 110(6): 606.     CrossRef
  • Diagnosis and Management of Hypothyroidism: Addressing the Knowledge–Action Gaps
    Sanjay Kalra, A. K. Das, Sarita Bajaj, Banshi Saboo, Deepak Khandelwal, Mangesh Tiwaskar, Navneet Agarwal, Pritam Gupta, Rakesh Sahay, Sameer Aggarwal, Sujoy Ghosh, Vijay Negalur, A. G. Unnikrishnan, Ganapathi Bantwal, Rashmi Aggarwal, Harshal Chaudhari,
    Advances in Therapy.2018; 35(10): 1519.     CrossRef
  • DYNAMICS OF EXCHANGE PARAMETERS OF ULTRASONIC HEART RESEARCH IN PATIENTS WITH CLIMACTERIC SYNDROME ASSOCIATED WITH HYPOTHYROIDISM UNDER THE INFLUENCE OF COMPLEX THERAPY
    M. O. Pavlovska, V. P. Vakaluk, E. I. Deltsova
    World of Medicine and Biology.2018; 14(63): 056.     CrossRef
  • Risk factors for cardiovascular disease in subclinical hypothyroidism
    F. Decandia
    Irish Journal of Medical Science (1971 -).2018; 187(1): 39.     CrossRef
  • New levothyroxine formulation meeting 95–105% specification over the whole shelf-life: results from two pharmacokinetic trials
    Ulrike Gottwald-Hostalek, Wolfgang Uhl, Peter Wolna, George J. Kahaly
    Current Medical Research and Opinion.2017; 33(2): 169.     CrossRef
  • Subclinical thyroid dysfunction and risk of carotid atherosclerosis
    Hosu Kim, Tae Hyuk Kim, Hye In Kim, So Young Park, Young Nam Kim, Seonwoo Kim, Min-Ji Kim, Sang-Man Jin, Kyu Yeon Hur, Jae Hyeon Kim, Moon-Kyu Lee, Yong-Ki Min, Jae Hoon Chung, Mira Kang, Sun Wook Kim, Tatsuo Shimosawa
    PLOS ONE.2017; 12(7): e0182090.     CrossRef
  • Effect of Marijuana Use on Thyroid Function and Autoimmunity
    Sonali Malhotra, Rubina A. Heptulla, Peter Homel, Roja Motaghedi
    Thyroid.2017; 27(2): 167.     CrossRef
  • Modified Low-Dose Triiodo-L-thyronine Therapy Safely Improves Function Following Myocardial Ischemia-Reperfusion Injury
    Viswanathan Rajagopalan, Youhua Zhang, Christine Pol, Clifford Costello, Samantha Seitter, Ann Lehto, Olga V. Savinova, Yue-feng Chen, A. Martin Gerdes
    Frontiers in Physiology.2017;[Epub]     CrossRef
  • Myocardial Performance Index for Patients with Overt and Subclinical Hypothyroidism
    Aziz Karabulut, Abdullah Doğan, Alpaslan Kemal Tuzcu
    Medical Science Monitor.2017; 23: 2519.     CrossRef
  • CARDIOVASCULAR MANIFESTATIONS IN PATIENTS OF HYPOTHYROIDISM- RESULTS OF A SINGLE CENTRE STUDY
    Rohit Vasant Deshpande, Swati Harish Sharma, Swapnil Sahebrao Walke, Mayur Ramakrishnarao Hedau, Bharat Sing Rathod, Amol Raghunath Bhore, Hitesh Lotan Mahale
    Journal of Evolution of Medical and Dental Sciences.2017; 6(45): 3514.     CrossRef
  • The Association of Thyroid Hormones and Tsh with the Metabolic Syndrome in Euthyroid Taiwanese Individuals
    Chun-Yuan Huang, Lee-Ching Hwang
    Endocrine Practice.2016; 22(11): 1303.     CrossRef
  • Potential harmful correlation between homocysteine and low-density lipoprotein cholesterol in patients with hypothyroidism
    Xuejie Dong, Zhi Yao, Yanjin Hu, Ning Yang, Xia Gao, Yuan Xu, Guang Wang
    Medicine.2016; 95(29): e4291.     CrossRef
  • Impaired Hemorheological Parameters and Increased Carotid Intima-Media Thickness in Children with Subclinical Hypothyroidism
    Yasemin Isik-Balci, Sebahat Agladioglu, Kadir Agladioglu, Emine Kilic-Toprak, Ozgen Kilic-Erkek, Bayram Ozhan, Aziz Polat, Melek Bor-Kucukatay
    Hormone Research in Paediatrics.2016; 85(4): 250.     CrossRef
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Obesity and Metabolism
Sex Factors in the Metabolic Syndrome as a Predictor of Cardiovascular Disease
Sunghwan Suh, Jongha Baek, Ji Cheol Bae, Kyoung-Nyoun Kim, Mi Kyoung Park, Duk Kyu Kim, Nam H. Cho, Moon-Kyu Lee
Endocrinol Metab. 2014;29(4):522-529.   Published online December 29, 2014
DOI: https://doi.org/10.3803/EnM.2014.29.4.522
  • 4,381 View
  • 37 Download
  • 16 Web of Science
  • 17 Crossref
AbstractAbstract PDFPubReader   
Background

Metabolic syndrome (MetS) is a condition characterized by a cluster of metabolic disorders and is associated with increased risk of cardiovascular disease (CVD). This study analyzed data from the Korean Health and Genome Study to examine the impact of MetS on CVD.

Methods

A total of 8,898 subjects (4,241 males and 4,657 females), 40 to 69 years of age, were enrolled and evaluated for the development of new onset CVD from 2001 to 2012 (median 8.1 years of follow-up).

Results

The prevalence of MetS at baseline was 22.0% (932/4,241) and 29.7% (1,383/4,657) in males and females, respectively. MetS was associated with increased risk of coronary heart disease (CHD; hazard ratio [HR], 1.818; 95% confidence interval [CI], 1.312 to 2.520 in males; HR, 1.789; 95% CI, 1.332 to 2.404 in females) and CVD (HR, 1.689; 95% CI, 1.295 to 2.204 in males; HR, 1.686; 95% CI, 1.007 to 2.192 in females). Specifically, MetS was associated with risk of future stroke in females only (HR, 1.486; 95% CI, 1.007 to 2.192). Among MetS components, abdominal obesity and hypertension were independent predictors of both CHD and CVD. In addition, a higher number of MetS components correlated with higher CVD risk.

Conclusion

MetS is a significant risk factor for the development of CVD although its impact varies between sexes.

Citations

Citations to this article as recorded by  
  • Cardiovascular age of workers with different employment categories
    Byung-Kook Lee, Jaeouk Ahn, Nam-Soo Kim, Jungsun Park, Yangho Kim
    Archives of Environmental & Occupational Health.2022; 77(3): 243.     CrossRef
  • Effects of Anthocyanin-rich Berries on the Risk of Metabolic Syndrome: A Systematic Review and Meta-analysis
    Mikkel Roulund Wilken, Max Norman Tandrup Lambert, Christine Bodelund Christensen, Per Bendix Jeppesen
    Review of Diabetic Studies.2022; 18(1): 42.     CrossRef
  • Rate and risk factors of metabolic components and component combinations according to hypertension status in Tibetans in a cross-sectional study
    Jihong Hu, Brian Thompson, Shuxia Wang, Minhao Guo, Chunjuan Yan, Fengfeng Ding, Peng Guo, Li Chen, Zhuoma Cao, Jianzong Wang
    Medicine.2022; 101(43): e31320.     CrossRef
  • Gender differences in changes in metabolic syndrome status and its components and risk of cardiovascular disease: a longitudinal cohort study
    Azra Ramezankhani, Fereidoun Azizi, Farzad Hadaegh
    Cardiovascular Diabetology.2022;[Epub]     CrossRef
  • The Association of Metabolic Syndrome with the development of cardiovascular disease among Kazakhs in remote rural areas of Xinjiang, China: a cohort study
    Wenwen Yang, Shuxia Guo, Haixia Wang, Yu Li, Xianghui Zhang, Yunhua Hu, Heng Guo, Kui Wang, Yizhong Yan, Jingyu Zhang, Jiaolong Ma, Lei Mao, Lati Mu, Jiaming Liu, Yanpeng Song, Changjing Li, Zhuo Ma, Rulin Ma, Jia He
    BMC Public Health.2021;[Epub]     CrossRef
  • Serum Arylsulfatase and Acid Phosphatase Activity in Patients with Metabolic Syndrome as a Result of Oxidative Damage to Lysosomes
    Dorota M. Olszewska-Słonina
    Protein & Peptide Letters.2021; 28(11): 1246.     CrossRef
  • Validation of Risk Prediction Models for Atherosclerotic Cardiovascular Disease in a Prospective Korean Community-Based Cohort
    Jae Hyun Bae, Min Kyong Moon, Sohee Oh, Bo Kyung Koo, Nam Han Cho, Moon-Kyu Lee
    Diabetes & Metabolism Journal.2020; 44(3): 458.     CrossRef
  • The Prevalence of Obesity and Metabolic Syndrome in the Korean Military Compared with the General Population
    Jung Hwan Lee, Da Hea Seo, Min Jung Nam, Geon Hui Lee, Dong Hee Yang, Min Joo Lee, Ung-Rim Choi, Seongbin Hong
    Journal of Korean Medical Science.2018;[Epub]     CrossRef
  • Relationship between serum bilirubin levels and cardiovascular disease
    Sunghwan Suh, Young Rak Cho, Mi Kyoung Park, Duk Kyu Kim, Nam H. Cho, Moon-Kyu Lee, Christian Herder
    PLOS ONE.2018; 13(2): e0193041.     CrossRef
  • Comparison Between Metabolic Syndrome and the Framingham Risk Score as Predictors of Cardiovascular Diseases Among Kazakhs in Xinjiang
    Wenwen Yang, Rulin Ma, Xianghui Zhang, Heng Guo, Jia He, Lei Mao, Lati Mu, Yunhua Hu, Yizhong Yan, Jiaming Liu, Jiaolong Ma, Shugang Li, Yusong Ding, Mei Zhang, Jingyu Zhang, Shuxia Guo
    Scientific Reports.2018;[Epub]     CrossRef
  • Impact of interactions among metabolic syndrome components on the development of cardiovascular disease among Kazakhs in Xinjiang
    Wenwen Yang, Xiang Gao, Xianghui Zhang, Yunhua Hu, Heng Guo, Kui Wang, Yizhong Yan, Jia He, Jingyu Zhang, Jiaolong Ma, Lei Mao, Lati Mu, Jiaming Liu, Shugang Li, Yusong Ding, Mei Zhang, Rulin Ma, Shuxia Guo, Mahesh Narayan
    PLOS ONE.2018; 13(10): e0205703.     CrossRef
  • Prediction of cardiovascular disease in Korean population: based on health risk appraisal of national health screening program
    Jae Moon Yun, Tae Gon Yoo, Seung-Won Oh, Be Long Cho, Eunyoung Kim, Insob Hwang
    Journal of the Korean Medical Association.2017; 60(9): 746.     CrossRef
  • Metabolic Syndrome Is a Strong Risk Factor for Minor Ischemic Stroke and Subsequent Vascular Events
    Guang-Sheng Wang, Dao-Ming Tong, Xiao-Dong Chen, Tong-Hui Yang, Ye-Ting Zhou, Xiao-Bo Ma, Gianpaolo Reboldi
    PLOS ONE.2016; 11(8): e0156243.     CrossRef
  • Metabolic syndrome related to cardiovascular events in a 10-year prospective study
    Laura Kazlauskienė, Jūratė Butnorienė, Antanas Norkus
    Diabetology & Metabolic Syndrome.2015;[Epub]     CrossRef
  • Articles in 'Endocrinology and Metabolism' in 2014
    Won-Young Lee
    Endocrinology and Metabolism.2015; 30(1): 47.     CrossRef
  • Impact of Cadmium Exposure on the Association between Lipopolysaccharide and Metabolic Syndrome
    Seung Han, Kyoung Ha, Ja Jeon, Hae Kim, Kwan Lee, Dae Kim
    International Journal of Environmental Research and Public Health.2015; 12(9): 11396.     CrossRef
  • Heat Killed Lactobacillus reuteri GMNL-263 Reduces Fibrosis Effects on the Liver and Heart in High Fat Diet-Hamsters via TGF-β Suppression
    Wei-Jen Ting, Wei-Wen Kuo, Dennis Hsieh, Yu-Lan Yeh, Cecilia-Hsuan Day, Ya-Hui Chen, Ray-Jade Chen, Viswanadha Padma, Yi-Hsing Chen, Chih-Yang Huang
    International Journal of Molecular Sciences.2015; 16(10): 25881.     CrossRef
Close layer
A Case of Graves' Disease Presented as Generalized Seizure Attack.
So Young Park, Su Kyoung Park, Sung Hwan Suh, Duk Kyu Kim, Sang Ho Kim, Mi Kyoung Park, Song Yee Han, Seung Hee Ryu, Su Mi Woo, Sung Woo Lee, Neul Bom Yoon
Endocrinol Metab. 2012;27(2):142-146.   Published online June 20, 2012
DOI: https://doi.org/10.3803/EnM.2012.27.2.142
  • 23,378 View
  • 30 Download
AbstractAbstract PDF
Hyperthyroidism is diagnosed when a patient is presented with typical symptoms, such as weight loss, palpitation, and hand tremor. However, early diagnosis is difficult in elders, because they have no typical symptoms, but only cardiovascular or muscular symptoms. In hyperthyroidism, there are often with neurologic changes, leading to various neurologic symptoms. Generalized or focal seizures are rarely reported in thyrotoxicosis and thyrotoxic crisis. Further, cases of hyperthyroidism presented as generalized seizure attack are extremely rare. We report a case of hyperthyroidism. A patient is presented at the hospital with mental change, as well as generalized seizure, who was finally diagnosed to have Graves' disease. A 56-year-old male was admitted to the hospital because of mental change with generalized seizure attack. Initial neurologic evaluations, including a brain magnetic resonance imaging and electroencephalogram proved to be normal. But, thyroid function test showed abnormal results. We diagnosed him as Graves' disease and prescribed anti-thyroid drug. Thereafter, there has been no recurrence of neurologic symptoms for 12 months.
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A Case of Primary Hyperparathyroidism with Rapid Regression of a Brown Tumor after Parathyroidectomy.
Ji Young Mok, Ha Yeon Kim, Hsing Chien Ter, Sang Ock Kim, Dong Kyun Kim, Ji Sun Han, So Young Park, Sa Rah Lee, Mi Kyoung Park, Duk Kyu Kim
J Korean Endocr Soc. 2010;25(1):50-55.   Published online March 1, 2010
DOI: https://doi.org/10.3803/jkes.2010.25.1.50
  • 1,751 View
  • 30 Download
AbstractAbstract PDF
Primary hyperparathyroidism is mainly caused by parathyroid adenoma (85%) and is characterized by hypercalcemia, osteoporosis, renal stones, and gastrointestinal and neurological disorders. Because of improvements in blood analysis over the last two decades, primary hyperparathyroidism is typically diagnosed early and asymptomatically. A rare clinical manifestations of primary hyperparathyroidism, brown tumors (osteitis fibrosa cystica), are osteolytic lesions resulting from long-term hyperparathyroidism. Radiologically, it is difficult to distinguish a brown tumor from plasmacytoma, multiple myeloma, or bone metastasis. We report a case of a 44-year-old man with primary hyperparathyroidism that caused a large brown tumor (11 x 5 x 8 cm) that mimicked plasmacytoma or cancer metastasis on pelvic magnetic resonance imaging. After a bone biopsy report that was highly suggestive of a brown tumor, serum calcium and intact parathyroid hormone levels were determined. The lesion was ultimately diagnosed as a brown tumor and a parathyroidectomy was performed. After 1 year, the lesion has nearly regressed by follow up of the anteroposterior view of the pelvis and bone mineral density has improved. The present case highlights the importance of considering brown tumors in the evaluation of patients presenting with hypercalcemia and osteolytic lesions without definite primary neoplasm.
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The Effect of Fenofibrate and Exercise on Metabolic Syndrome and Hepatic Steatosis in OLETF Rats.
Kyung II Lee, Ji Min Kim, Ja Young Park, Ja Won Kim, Ji Young Mok, Mi Kyoung Park, Hye Jeong Lee, Sook Hee Hong, Wenjun Li, Duk Kyu Kim
J Korean Endocr Soc. 2007;22(3):192-202.   Published online June 1, 2007
DOI: https://doi.org/10.3803/jkes.2007.22.3.192
  • 2,040 View
  • 22 Download
  • 1 Crossref
AbstractAbstract PDF
BACKGROUND
The aim of this study is to verify the effects of fenofibrate monotherapy and fenofibrate combined with exercise for improving metabolic syndrome and hepatic steatosis. METHODS: Thirty-four weeks old OLETF rats (Otsuka Long-Evans Tokushima Fatty Rats, n = 20) were divided four groups: the regular diet group (n = 5, DD group), the exercise group (n = 5, DE group), the fenofibrate (100 mg/kg) treated group (n = 5, DF group) and the combination treatment group {fenofibrate and exercise (n = 5, EF group)}. After 5 weeks of treatment, blood was drawn for measuring the blood glucose, insulin, lipid and leptin levels. All the subjects were sacrificed for assessment of their body adiposity and hepatic steatosis. RESULTS: The total amount of food intake, body weight and total body weight of the rat were significantly decreased in the EF and DF groups compared to the DD group. The plasma triglyceride and glucose levels were significantly decreased in the EF and DF groups compared to the DD group. The HOMA-IR of EF, DF and DE groups were significantly decreased compared with that of the DD group. The plasma leptin levels of the EF and DF groups were significantly decreased compared with those of the DD and DE groups. The hepatic steatosis index was significantly decreased in the EF and DF groups compared to the DD and DE groups. CONCLUSION: Fenofibrate monotherapy was effective to control three major components (obesity, hypertriglyceridemia and hyperglycemia) of metabolic syndrome and hepatic steatosis in OLETF rats. Exercise combined with fenofibrate treatment showed an additional effect compared to that of fenofibrate monotherapy.

Citations

Citations to this article as recorded by  
  • Effect of Fenofibrate and Exercise on Metabolic Syndrome and Hepatic Steatosis
    Bong Soo Cha, Jae Hyuk Lee
    Journal of Korean Endocrine Society.2007; 22(3): 188.     CrossRef
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A Case of Malignant Insulinoma Resistant to Octreotide and Combination Chemotherapy.
Duk Kyu Kim, Hyuk Chan Kwon, Ju Il Lee, Do Young Kang, Jae Seok Kim, Hyo Jin Kim, Jong Seong Kim
J Korean Endocr Soc. 1994;10(3):300-305.   Published online November 6, 2019
  • 909 View
  • 17 Download
AbstractAbstract PDF
Insulinoma is insulin-secreting tumor that almost all originate in the pancreas and cause symptoms related to hypoglycemia. The documentation of metastatic lesions by imaging studies, is only accurate mean of diagnosing malignant insulinoma before surgical exploration. We experienced a case of malignant insulinoma with liver, adrenal glands, regional lymph nodes and multiple bone metastasis. Abdominal ultrasonography, computed tomography and liver, bone scanning were used to evaluate the disease. Tissue diagnosis was obtained by percutaneous needle biopsy of liver metastasis. The patient was treated with Octreotide therapy and combination chemotherapy(Streptozocin and 5-FU), but she did not respond to these regimen. Now, we present this case with the brief review of literatures.
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Quantitative Changes of Apoprotein Levels in Non - Insulin Dependent Diabetics.
Do Young Kang, Duk Kyu Kim
J Korean Endocr Soc. 1994;10(2):105-114.   Published online November 6, 2019
  • 733 View
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The aim of this study was to evaluate the quantitative changes of apoprotein levels in non-insulin dependent diabetics.As the subjects of this study, 37 patients were selected among non-insulin dependent diabetics admitted to Dong-A University Hospital between March 1990 and February 1994. They were divided into two groups. One group(n=20) had the diabetic dyslipidemia(Group DD) and the other group(n=17) had no diabetic dyslipidemia(Group D). For the control, normal healthy persons(n=17) were studied.Plasma lipid and apoprotein levels of all the subjects were measured. The results were as follows;1) Apoprotein AI & AII levels were significantly decreased in Group DD compared with both Group D and Control, but there was no significant difference between Group D and Control.2) Apoprotein B levels were significantly decreased in both Group DD and Group D compared with Control, but there was no significant difference between Group DD and Group D. 3) Apoprotein CII levels were significantly increased in both Group DD and Group D compared with Control, but there was no significant difference between Group DD and Group D. 4) Apoprotein CIII levels were significantly increased in Group D compared with both Group DD and Control, but there was no significant difference between Group DD and Control. 5) Apoprotein E levels were not significantly different among three groups.These results suggest that NIDDM itself causes the level of apoprotein B to decrease and the level of apoprotein CII to increase, regardless of the associated diabetic dyslipidemia.
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Endocrinol Metab : Endocrinology and Metabolism