- Clinical Study
- Prevalence of Reduced Kidney Function by Estimated Glomerular Filtration Rate Using an Equation Based on Creatinine and Cystatin C in Metabolic Syndrome and Its Components in Korean Adults
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Yang Ho Kang, Dong Wook Jeong, Seok Man Son
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Endocrinol Metab. 2016;31(3):446-453. Published online August 2, 2016
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DOI: https://doi.org/10.3803/EnM.2016.31.3.446
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Abstract
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- Background
It is known that metabolic syndrome (MetS) is associated with chronic kidney disease. We evaluated and compared the prevalence of reduced kidney function in MetS and its components by estimated glomerular filtration rate (eGFR) using an equation based on creatinine (eGFRcr), cystatin C (eGFRcys), and combined creatinine-cystatin C (eGFRcr-cys) in Korean adults. MethodsWe analyzed data from 3,649 adults who participated in a comprehensive health examination. ResultsMean values of eGFRcys were higher compared with mean values of eGFRcr (96.1±18.2 mL/min/1.73 m2 vs. 91.2±13.6 mL/min/1.73 m2) in total subjects. The prevalence of reduced kidney function increased with age (9.6% for eGFRcys vs. 5.8% for eGFRcr-cys vs. 4.9% for eGFRcr, in subjects aged ≥60 years), and significantly increased with MetS, abdominal obesity, hypertension, high triglyceride, low high density lipoprotein (HDL), and high insulin resistance. The prevalence of MetS, abdominal obesity, hypertension, high insulin resistance, low HDL, and hepatic steatosis was significantly increased in subjects with reduced kidney function. This increased prevalence and the odds ratio of reduced kidney function for prevalence of MetS was highest for eGFRcys, followed by those of eGFRcr-cys, and eGFRcr. ConclusionThe prevalence of reduced kidney function by eGFR was significantly increased in subjects with MetS and its related components. eGFRcys and eGFRcr-cys were superior to eGFRcr in detecting reduced kidney function.
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Yarong Ding, Zhe Xu, Yuesong Pan, Xia Meng, Xianglong Xiang, Hao Li, Liping Liu, Yongjun Wang Frontiers in Neurology.2021;[Epub] CrossRef - Long-term effects of various types of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on changes in glomerular filtration rate in Korea
Seo Yeon Baik, Hyunah Kim, So Jung Yang, Tong Min Kim, Seung-Hwan Lee, Jae Hyoung Cho, Hyunyong Lee, Hyeon Woo Yim, Kun-Ho Yoon, Hun-Sung Kim Frontiers of Medicine.2019; 13(6): 713. CrossRef - Gender specific association of parathyroid hormone and vitamin D with metabolic syndrome in population with preserved renal function
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- Obesity and Metabolism
- Comparison of Serum Ferritin and Vitamin D in Association with the Severity of Nonalcoholic Fatty Liver Disease in Korean Adults
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Dong Wook Jeong, Hye Won Lee, Young Hye Cho, Dong Won Yi, Sang Yeoup Lee, Seok Man Son, Yang Ho Kang
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Endocrinol Metab. 2014;29(4):479-488. Published online December 29, 2014
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DOI: https://doi.org/10.3803/EnM.2014.29.4.479
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5,326
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Abstract
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- Background
Increased serum ferritin and decreased vitamin D levels associated with nonalcoholic fatty liver disease (NAFLD). However, their association with the severity of NAFLD has not been fully evaluated. The aim of this study was to compare the association of serum ferritin and 25(OH)D3 levels with the severity of ultrasonographically detected NAFLD (US-NAFLD) and hepatic steatosis defined by fatty liver index (FLI) in Korean adults. MethodsA cross-sectional analysis of clinical and anthropometric data, including serum ferritin and 25(OH)D3, from men (n=295) and women (n=263) who underwent a routine health check-up in 2012. ResultsIn men, with an increase in the quartile of serum ferritin level, the incidences of subjects with metabolic syndrome (P=0.002), US-NAFLD (P=0.041), and FLI ≥60 (P=0.010) were significantly elevated. In women, the incidence of subjects with US-NAFLD was also significantly elevated with increases in the serum ferritin quartile (P=0.012). Regarding 25(OH)D3, no statistical differences were observed among the different quartiles in either gender. Serum ferritin level significantly increased as the severity of US-NAFLD increased (P<0.001); however, no significant differences in 25(OH)D3 level were observed in men. No significant differences in either serum ferritin or 25(OH)D3 level were observed among women with different levels of severity of US-NAFLD. ConclusionIncreased serum ferritin level showed a closer association with severity of NAFLD compared with level of serum vitamin D, suggesting that serum ferritin level may be a better marker than vitamin D level for predicting the severity of US-NAFLD and hepatic steatosis in a clinical setting.
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Xin Su, Danping Zhang, Zhe Chen, Xu Han, Peichen Xia, Minhao Yin, Hong Zhu SSRN Electronic Journal .2022;[Epub] CrossRef - Ferritin as a key risk factor for nonalcoholic fatty liver disease in children with obesity
Junfeng Zhang, Jiajia Cao, Hui Xu, Guanping Dong, Ke Huang, Wei Wu, Jingjing Ye, Junfen Fu Journal of Clinical Laboratory Analysis.2021;[Epub] CrossRef - Serum ferritin level as a noninvasive marker for detection and staging of hepatocellular injury, liver fibrosis, and steatosis in children and adolescents with nonalcoholic fatty liver disease
Ahmed A. Hassan, Mohiee E.-D.A. El-Aziz Awad, Hanan H. Soliman, Reda A.F. Usef, Dina S. Ata Alexandria Journal of Pediatrics.2021; 34(3): 253. CrossRef - Low vitamin D level was associated with metabolic syndrome and high leptin level in subjects with nonalcoholic fatty liver disease: a community-based study
Li-Wei Chen, Cheng-Hung Chien, Sheng-Fong Kuo, Chia-Ying Yu, Chih-Lang Lin, Rong-Nan Chien BMC Gastroenterology.2019;[Epub] CrossRef - Association between Vitamin D Levels and Nonalcoholic Fatty Liver Disease: Potential Confounding Variables
Lucia Pacifico, John F. Osborn, Enea Bonci, Pasquale Pierimarchi, Claudio Chiesa Mini-Reviews in Medicinal Chemistry.2019; 19(4): 310. CrossRef - The association between serum ferritin and 25-hydroxyvitamin D and metabolic syndrome in Korean women: the Korea National Health and Nutrition Examination Survey 2010–2012
Hyun Yoon, Nan Young Bae, Mi Young Gi, Bu Yeon Park, Jeong Min Seong Journal of Clinical Biochemistry and Nutrition.2017; 61(1): 60. CrossRef - Gender difference in relationship between serum ferritin and 25-hydroxyvitamin D in Korean adults
Jeong Min Seong, Yo Sang Yoon, Kyu Su Lee, Nan Young Bae, Mi Young Gi, Hyun Yoon, Andrzej T Slominski PLOS ONE.2017; 12(5): e0177722. CrossRef - The Association of Serum Ferritin and Metabolic Syndrome and Metabolic Syndrome Score in Korean Adults
Hyun Yoon, Jae Seong Go, Kang Uk Kim, Keon Woo Lee The Korean Journal of Clinical Laboratory Science.2016; 48(4): 287. CrossRef - AMP-activated protein kinase suppresses the expression of LXR/SREBP-1 signaling-induced ANGPTL8 in HepG2 cells
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