- Clinical Study
- Electrolyte Imbalance in Patients with Sheehan's Syndrome
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Chur Hoan Lim, Ji Hyun Han, Joon Jin, Ji Eun Yu, Jin Ook Chung, Dong Hyeok Cho, Dong Jin Chung, Min Young Chung
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Endocrinol Metab. 2015;30(4):502-508. Published online December 31, 2015
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DOI: https://doi.org/10.3803/EnM.2015.30.4.502
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- Background
We investigated the prevalence of electrolyte imbalance and the relationship between serum electrolyte and anterior pituitary hormone levels in patients with Sheehan's syndrome. MethodsIn a retrospective study, we investigated 78 patients with Sheehan's syndrome. We also included 95 normal control subjects who underwent a combined anterior pituitary hormone stimulation test and showed normal hormonal responses. ResultsIn patients with Sheehan's syndrome, the serum levels of sodium, potassium, ionized calcium, magnesium, and inorganic phosphate were significantly lower than those in control subjects. The prevalence of hyponatremia, hypokalemia, hypocalcemia, hypomagnesemia, and hypophosphatemia in patients with Sheehan's syndrome was 59.0% (n=46), 26.9% (n=21), 35.9% (n=28), 47.4% (n=37), and 23.1% (n=18), respectively. Levels of sodium and ionized calcium in serum were positively correlated with levels of all anterior pituitary hormones (all P<0.05). Levels of potassium in serum were positively correlated with adrenocorticotrophic hormone (ACTH) and growth hormone (GH) levels (all P<0.05). Levels of inorganic phosphate in serum were positively correlated with levels of thyroid-stimulating hormone, prolactin, and GH (all P<0.05), and levels of magnesium in serum were positively correlated with delta ACTH (P<0.01). ConclusionElectrolyte imbalance was common in patients with Sheehan's syndrome. Furthermore, the degree of anterior pituitary hormone deficiency relates to the degree of electrolyte disturbance in patients with this disease.
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- Acute parkinsonism in a patient with myxedema crisis: A case report
Rajat Gupta, Shakun Chaudhary, Vivek Sood, Narvir Chauhan, Nidhi Chauhan, Dhiraj Kapoor Medicine International.2024;[Epub] CrossRef - Myopathic syndrome revealing a rare condition: Sheehan syndrome, a case-based review
Elena Gradinaru, Catalin Furculescu, Andreea Trandafir, Daniela Opris-Belinski, Ioana Cristina Saulescu Clinical Rheumatology.2023; 42(6): 1705. CrossRef - Partial Sheehan’s syndrome with abdominal tuberculosis presented with pancytopenia and fluctuating thyroid profile: a case report
Prashant Yadav, Md Anwarul Bari, Akash Saha, Sushmita Yadav, Amzad H. Khan Annals of Medicine & Surgery.2023; 85(3): 548. CrossRef - Acute pituitary crisis after lumbar surgery: A case report
Hui Wang, Xingrui Gong Medicine.2023; 102(48): e36294. CrossRef - Long-term hepatic and cardiac health in patients diagnosed with Sheehan’s syndrome
Liza Das, Jayaprakash Sahoo, Neelam Dahiya, Sunil Taneja, Sanjay Kumar Bhadada, Mohammad Hayat Bhat, Paramjeet Singh, Vanita Suri, Bashir Ahmad Laway, Pinaki Dutta Pituitary.2022; 25(6): 971. CrossRef - Clinical, endocrine, metabolic profile, and bone health in Sheehan's syndrome
Soumita Mandal, Pradip Mukhopadhyay, Mainak Banerjee, Sujoy Ghosh Indian Journal of Endocrinology and Metabolism.2020; 24(4): 338. CrossRef - A rare endocrine cause of electrical storm - a case report
Sunny D Shinde, Girish R Sabnis, Charan P Lanjewar, Prafulla G Kerkar European Heart Journal - Case Reports.2017;[Epub] CrossRef - Sheehan syndrome
Züleyha Karaca, Bashir A. Laway, Hatice S. Dokmetas, Hulusi Atmaca, Fahrettin Kelestimur Nature Reviews Disease Primers.2016;[Epub] CrossRef
- Response: Increased Carotid Intima-Media Thickness Is Associated with Progression of Diabetic Nephropathy in Patients with Type 2 Diabetes.
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Dong Hyeok Cho
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Endocrinol Metab. 2012;27(2):171-172. Published online June 20, 2012
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DOI: https://doi.org/10.3803/EnM.2012.27.2.171
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66,089
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- Morphological Carotid Plaque Area Is Associated With Glomerular Filtration Rate: A Study of South Asian Indian Patients With Diabetes and Chronic Kidney Disease
Anudeep Puvvula, Ankush D. Jamthikar, Deep Gupta, Narendra N. Khanna, Michele Porcu, Luca Saba, Klaudija Viskovic, Janet N. A. Ajuluchukwu, Ajay Gupta, Sophie Mavrogeni, Monika Turk, John R. Laird, Gyan Pareek, Martin Miner, Petros P. Sfikakis, Athanasios Angiology.2020; 71(6): 520. CrossRef
- Increased Carotid Intima-Media Thickness is Associated with Progression of Diabetic Nephropathy in Patients with Type 2 Diabetes.
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Dong Hyeok Cho, Jin Ook Chung, Dong Jin Chung, Min Young Chung
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Endocrinol Metab. 2011;26(4):310-316. Published online December 1, 2011
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DOI: https://doi.org/10.3803/EnM.2011.26.4.310
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- BACKGROUND
Cardiovascular risk is higher among people with diabetic nephropathy than among those with normal renal function. Carotid intima-media thickness (IMT) is an independent predictor of cardiovascular mortality in type 2 diabetic patients. However, the relationship between carotid IMT and diabetic nephropathy is not well known. The aim of our study was to elucidate whether carotid IMT is associated with progression of diabetic nephropathy in type 2 diabetic patients. METHODS: We recruited a total of 354 type 2 diabetic patients with diabetic nephropathy. Renal function was evaluated by serum creatinine levels, estimated glomerular filtration rate (eGFR), and urinary albumin/creatinine ratio (ACR). Carotid IMT was assessed using B-mode ultrasound by measuring generally used parameters. Baseline-to-study end changes in eGFR were calculated, and the yearly change of eGFR (mL/min/yr) was computed. RESULTS: Age, diabetes duration, ACR, and eGFR were significantly correlated with mean or maximal carotid IMT; however, lipid profiles, HbA1c, and blood pressure were not correlated. The mean yearly eGFR change was -4.9 +/- 5.3 mL/min/yr. The yearly eGFR change was negatively correlated with mean and maximal carotid IMT. After adjusting for age and diabetes duration, the mean IMT is an independent predictor of yearly eGFR change. CONCLUSION: Carotid IMT may be a predictor of diabetic nephropathy progression in patients with type 2 diabetes.
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- Cardiovascular disease and stroke risk assessment in patients with chronic kidney disease using integration of estimated glomerular filtration rate, ultrasonic image phenotypes, and artificial intelligence: a narrative review
Ankush D. JAMTHIKAR, Anudeep PUVVULA, Deep GUPTA, Amer M. JOHRI, Vijay NAMBI, Narendra N. KHANNA, Luca SABA, Sophie MAVROGENI, John R. LAIRD, Gyan PAREEK, Martin MINER, Petros P. SFIKAKIS, Athanasios PROTOGEROU, George D. KITAS, Andrew NICOLAIDES, Aditya International Angiology.2021;[Epub] CrossRef - Proteinuria as a significant predictive factor for the progression of carotid artery atherosclerosis in non-albuminuric type 2 diabetes
Young-eun Kim, Minyoung Lee, Yong-ho Lee, Eun Seok Kang, Bong-soo Cha, Byung-Wan Lee Diabetes Research and Clinical Practice.2021; 181: 109082. CrossRef
- Spontaneous Hypoglycemia due to Insulin Antibody after Insulin Treatment of Diabetic Ketoacidosis.
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Jin Ook Chung, Dong Hyeok Cho, Dong Jin Chung, Min Young Chung
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Endocrinol Metab. 2010;25(3):217-220. Published online September 1, 2010
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DOI: https://doi.org/10.3803/EnM.2010.25.3.217
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2,232
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- Hypoglycemia in diabetic patients is usually caused by excessive exogenous insulin or the administration of an insulin secretagogue relative to the prevailing glucose concentration. Thus, the clinical manifestations of hypoglycemia are usually not observed in diabetic patients after either insulin or an oral hypoglycemic agent is discontinued. In contrast, diabetic ketoacidosis results from relative or absolute insulin deficiency. Although about 40% of diabetic patients who inject human insulin have insulin antibodies, these antibodies seldom significantly affect the glycemic control. It has not been reported in the literature that insulin antibody in the setting of human insulin therapy is associated with diabetic ketoacidosis and subsequent hypoglycemia. We describe here a rare case of spontaneous hypoglycemia due to insulin antibody after the improvement of diabetic ketoacidosis in a patient with type 2 diabetes mellitus and who had been treated with human insulin.
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- Type 1 diabetes complicated with cyclic vomiting syndrome and exogenous insulin antibody syndrome: A case report
Leiluo Geng, Xue Diao, Hao Han, Ying Lin, Wei Liang, Aimin Xu Frontiers in Endocrinology.2022;[Epub] CrossRef - Insulin Glulisine May Cause a Disease Resembling Insulin Autoimmune Syndrome: Case Report
Maki Kawasaki, Yoichi Oikawa, Takeshi Katsuki, Yusuke Kabeya, Masuomi Tomita, Mari Okisugi, Akira Shimada Diabetes Care.2013; 36(12): e195. CrossRef - Insulin Autoimmune Syndrome with Diabetic Ketoacidosis
Yeong Geol Jo, Young Il Kim, Su Jin Lee, Ki Won Kim, Sung Wan Chun, Yeo Joo Kim, Sang Jin Kim Journal of Korean Diabetes.2012; 13(2): 105. CrossRef
- Determining the Factors that Influence the Insulin Requirements in Type 2 Diabetic Patients.
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Jin Ook Chung, Dong Hyeok Cho, Dong Jin Chung, Min Young Chung
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Endocrinol Metab. 2010;25(2):110-118. Published online June 1, 2010
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DOI: https://doi.org/10.3803/EnM.2010.25.2.110
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- BACKGROUND
The initial insulin dose is often determined by clinical experience or with a formula using the body weight. However, it may be difficult to determine the initial insulin dose because various factors such as insulin sensitivity and the glycemic status can influence the insulin requirement. The purpose of this study was to assess the factors that influence the initial insulin requirement in insulin naive patients with type 2 diabetes mellitus. METHODS: A total 128 patients who were admitted for glycemic control were investigated. The patients were managed with long-acting insulin glargine and rapid-acting insulin lispro. RESULTS: The basal insulin requirement was positively correlated with waist circumference, body mass index (BMI), the HbA1C, AST, ALT, fasting plasma glucose and 2-hour postprandial glucose levels and the homeostasis model assessment of insulin resistance (HOMA-IR), but it was negatively correlated with age and the stimulated C-peptide level. The daily insulin requirement was positively correlated with waist circumference, BMI, the HbA1C, AST, ALT, triglyceride, fasting plasma glucose and 2-hour postprandial glucose level and HOMA-IR, but it was negatively correlated with age. On the multiple linear regression analysis, the basal insulin requirement was independently associated with BMI (beta = 0.507, p < 0.001), the 2-hour postprandial glucose level (beta = 0.307, p < 0.001), the ALT level (beta = 0.214, P = 0.015) and the meal-stimulated C-peptide level (beta = -0.209, P = 0.010). The daily insulin requirement was independently associated with BMI (beta = 0.508, p < 0.001) and the 2-hour postprandial glucose level (beta = 0.404, p < 0.001). CONCLUSION: Our results show that the BMI and 2-hour postprandial glucose level are useful predictors of the initial insulin requirement in insulin naive type 2 diabetic patients. It may be prudent to consider the other various factors that influence the insulin requirement together when insulin therapy is required.
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- Effects of Sunsik Prepared through Steaming-Drying Cycles on Blood Glucose and Inflammatory Marker in Rats Fed High Fat
Kyung-Hee Hwang Journal of the East Asian Society of Dietary Life.2015; 25(1): 111. CrossRef - The Effects of Chungkukjang Powder Supplements on the Regulation of Blood Glucose and Inflammation in Diabetic Rats
Kyung-Mi Yang Korean journal of food and cookery science.2015; 31(2): 118. CrossRef
- Aortic Intramural Hematoma Associated with Primary Aldosteronism.
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Jin Ook Chung, Dong Hyeok Cho, Dong Jin Chung, Min Young Chung
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J Korean Endocr Soc. 2009;24(3):217-220. Published online September 1, 2009
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DOI: https://doi.org/10.3803/jkes.2009.24.3.217
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- Intramural hematoma of the aorta is a variant of aortic dissection characterized by the absence of direct communication between the false lumen and the true lumen of the aorta. Primary aldosteronism, which is an uncommon cause of hypertension, may direct alter arterial structure through the pleiotropic effects of aldosterone as well as pressure-mediated indirect alterations. There have been several reported cases of aortic dissection in patients with primary aldosteronism, which suggests a causal relationship between the two diagnostic entities. However, intramural hematoma has not been described in a patient with primary aldosteronism. We describe a case of aortic intramural hematoma in a patient with primary aldosteronism and speculate about the causal relationship between these two entities.
- Glucose Counterregulatory Hormone Response During Hypoglycemia due to Endogenous Hyperinsulinemia.
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Jin Ook Chung, Dong Hyeok Cho, Dong Jin Chung, Min Young Chung
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J Korean Endocr Soc. 2009;24(3):174-180. Published online September 1, 2009
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DOI: https://doi.org/10.3803/jkes.2009.24.3.174
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2,091
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- BACKGROUND
In patients with hypoglycemia due to endogenous hyperinsulinemia such as insulinoma or insulin autoimmune syndrome, little is known about the counterregulatory hormone response to spontaneous hypoglycemia. We therefore compared hormone responses during spontaneous hypoglycemia due to endogenous hyperinsulinemia with those at the end of a 72-hour fast. METHODS: We measured glucagon, epinephrine, cortisol, and growth hormone responses during spontaneous hypoglycemia in 8 patients with insulinoma and 18 patients with insulin autoimmune syndrome. We also assessed these responses in 13 normal control subjects who underwent a 72-hour fast. RESULTS: In patients with insulinoma (median serum glucose level, 35.0 mg/dL), plasma glucagon levels (median, 42.9 vs. 76.2 pg/mL, respectively; P < 0.05) were lower than those in control subjects (serum glucose level, 62.5 mg/dL), whereas, there were no statistically significant differences in the other hormone responses between the two groups. In contrast, in the patients with insulin autoimmune syndrome (median serum glucose level, 34.5 mg/dL), plasma glucagon levels (median, 73.7 vs. 76.2 pg/mL, respectively) were lower than those in the control subjects, but there was no statistically significant difference between the two groups. There were no statistically significant differences in counterregulatory hormone responses during spontaneous hypoglycemia between patients with insulinoma and patients with insulin autoimmune syndrome. CONCLUSION: Our results suggest that defective glucagon secretion in patients with insulinoma rather than insulin autoimmune syndrome may contribute to hypoglycemia in addition to hyperinsulinemia.
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Citations
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- Glycogenic hepatopathy in a Korean girl with poorly controlled type 1 diabetes mellitus
Hwal Rim Jeong, Young Seok Shim, Young Bae Kim, Hae Sang Lee, Jin Soon Hwang Annals of Pediatric Endocrinology & Metabolism.2014; 19(1): 49. CrossRef - Glucose Counterregulatory Hormone Response During Hypoglycemia due to Endogenous Hyperinsulinemia
Jung Guk Kim Journal of Korean Endocrine Society.2009; 24(3): 162. CrossRef
- A Case of Slipped Capital Femoral Epiphysis in Association with Panhypopituitarism after Treatment of Craniopharyngioma.
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Jin Ook Chung, Se In Hong, Dong Hyeok Cho, Dong Jin Chung, Min Young Chung
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J Korean Endocr Soc. 2008;23(3):193-198. Published online June 1, 2008
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DOI: https://doi.org/10.3803/jkes.2008.23.3.193
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1,908
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- Craniopharyngioma accounts for 2~5% of all primary intracranial neoplasms. It may present with a variety of manifestations including neurological, visual, and/or hypothalamic-pituitary dysfunction. Treatment options include radical surgery or radiotherapy, or a combination of these modalities. Craniopharyngioma ablation results in anterior and/or posterior pituitary hormone deficits. Slipped capital femoral epiphysis (SCFE), in which the femoral head slips downward and backward on the femoral neck at the epiphyseal plate, most commonly occurs during the rapid growth phase of puberty. Its actual cause is unknown, but the clinical association between SCFE and endocrine disorders is well known. We report a case of an adult male patient who developed SCFE in association with panhypopituitarism after treatment of a craniopharyngioma.
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Citations
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- A Case of Slipped Capital Femoral Epiphysis in Association With Craniopharyngioma
Mehran Soleymanha, Ali Karimi, Seyed Mojtaba Mehrdad Trauma Monthly.2015;[Epub] CrossRef - Panhypopituitarism due to craniopharyngioma with bilateral slipped capital femoral epiphysis
Sun Woo Kim, Young-Jin Song, Eun Jeong Choi, Dong Hee Han, Hyun Yon Jung, Sung Hoon Yu, Hyung Joon Yoo, Jae Myung Yu Yeungnam University Journal of Medicine.2014; 31(1): 61. CrossRef
- A Case of Primary Hyperparathyroidism due to Cystic Parathyroid Adenoma Presenting as Hypercalcemic Crisis Associated with Intracranial Hemorrhage.
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Jin Ook Chung, Gwi Hong Jeong, Se In Hong, Dong Hyeok Cho, Dong Jin Chung, Min Young Chung
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J Korean Endocr Soc. 2007;22(4):292-298. Published online August 1, 2007
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DOI: https://doi.org/10.3803/jkes.2007.22.4.292
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- Most patients with hypercalcemia are asymptomatic or they have non-specific symptoms at diagnosis. Yet hypercalcemic crisis is a potentially fatal complication of hyperparathyroidism. Cystic parathyroid adenoma is a rare cause of primary hyperparathyroidism and hypercalcemic crisis. A 52-year-old woman was transferred to our hospital due to her relapsed drowsy mental state and renal insufficiency that occurred in course of her management for intracranial hemorrhage with manitol. The total serum calcium was 16.2 mg/dL and the intact parathyroid hormone was 546 pg/mL. Neck computed tomography showed a 3.1 x 1.8 cm sized cystic mass on the right thyroid lower pole. 99mTc-labelled sestamibi scintigraphy showed no significant uptake. In addition to prompt saline infusion and loop diuretics, the patient was given pamidronate to lower the serum calcium, and she was improved to an alert mental state with normal renal function. Surgical excision of the parathyroid cyst was performed. A histological examination confirmed a cystic parathyroid adenoma. The levels of plasma PTH and serum calcium were normalized after resection.
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- Can Biochemical Markers and Ultrasonographical Diameters Be Used to Predict Histopathological Diagnosis in Patients with Primary Hyperparathyroidism?
Ahmet Dirikoc, Husniye Baser, Burcak Polat, Cevdet Aydin, Aylin Kilic Yazgan, Mehmet Kilic, Didem Ozdemir, Bekir Cakir Indian Journal of Surgery.2022;[Epub] CrossRef - Preoperative Predictive Factors for Parathyroid Carcinoma in Patients with Primary Hyperparathyroidism
Jae Hyun Bae, Hyung Jin Choi, Yenna Lee, Min Kyong Moon, Young Joo Park, Chan Soo Shin, Do Jun Park, Hak Chul Jang, Seong Yeon Kim, Sang Wan Kim Journal of Korean Medical Science.2012; 27(8): 890. CrossRef
- A Case of Raymond-Cestan Syndrome Caused by Inferior Petrosal Sinus Sampling.
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Dong Hyeok Cho
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J Korean Endocr Soc. 2003;18(1):73-78. Published online February 1, 2003
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- Inferior petrosal sinus sampling (IPSS) plays an important role in the assessment of patients with ACTH-dependent Cushing's syndrome. IPSS has been described as an innocuous, essentially risk-free procedure. Neurological complications associated with IPSS are rare. Previously reported neurological complications include brain stem infraction, pontine hemorrhage and subarachnoid hemorrhage. A 26-year-old woman was admitted to the hospital because of a moon face and a buffalo hump. A MRI showed a suspicious, but uncertain, area on the left side of the sella turcica. IPSS was performed as an appropriate means of providing more information about the side of the ACTH source. Immediately after the procedure, the woman experienced double vision, caused by a complete sixth nerve palsy of the left eye, together with a contralateral hemiparesis. From a clinical point of view, abducens nerve palsy and contralateral hemiparesis corresponded to Raymond-Cestan syndrome. I report a case of Raymond-Cestan syndrome, following petrosal sinus sampling in a female patient with ACTH-dependent Cushing's syndrome. To the best of our knowledge, this complication associated with petrosal sinus sampling has only been described in one previous case report. Although IPSS may provide essential information in the investigation of Cushing's syndrome, the possibility of very occasional but devastating complications should be remembered.
- Papillary Thyroid Cancer Arising in Lateral Aberrant Thyroid Presenting with Multiple Metastases.
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Nam Il Cheon, Chang Hun Lee, Se In Hong, Jin Ook Chung, In Seok Yoon, Dong Hyeok Cho, Ho Cheol Kang, Dong Jin Chung, Min Young Chung
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J Korean Endocr Soc. 2001;16(4-5):494-501. Published online October 1, 2001
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- Carcinoma of the thyroid usually presents as a palpable thyroid mass. However, in rare cases patients with thyroid cancer present with metastases of the cervical lymph node as the initial manifestation. The metastatic papillary tumor in cervical lymph nodes stained positive for thyroglobulin indicates the presence of a thyroid carcinoma, usually in the ipsilateral lobe. We herein report a case of multiple metastases in papillary thyroid carcinoma arising in the lateral aberrant thyroid with no evidence of thyroid carcinoma in the thyroid lobe.
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