Papillary thyroid carcinoma (PTC) is a common affliction of the thyroid gland, accounting for 70% to 80% of all thyroid cancers, whereas mucosa-associated lymphoid tissue (MALT) lymphoma of the thyroid gland is uncommon. The simultaneous occurrence of both malignancies is extremely rare. We report the case of a patient with both PTC and MALT lymphoma in the setting of Hashimoto thyroiditis. An 81-year-old female patient was first admitted with goiter and hoarseness, which was attributed to an ultrasonographic thyroid nodule. Subsequent fine-needle aspirate, interpreted as suspicious of papillary thyroid cancer, prompted total thyroidectomy. MALT lymphoma was an incidental postsurgical finding, coexisting with PTC in the setting of Hashimoto thyroiditis. Although the development of MALT lymphoma is very rare, patients with longstanding Hashimoto thyroiditis should undergo careful surveillance for both malignancies.

Citations

Citations to this article as recorded by  

• Two lymphoma histotypes and papillary thyroid carcinoma coexisting on Hashimoto ground: a case report and review of the literature
  Igor Iskra, Maja Ilić Tomaš, Tatjana Bogović Crnčić, Edvin Kukić, Ita Hadžisejdić, Manuela Avirović, Neva Girotto
  Diagnostic Pathology.2024;[Epub]     CrossRef
• Thyroid papillary carcinoma combined with primary follicular lymphoma: a case report
  Ting Xu, Li Wu, Hua Ye, Shuai Luo, Jinjing Wang
  Diagnostic Pathology.2024;[Epub]     CrossRef
• Thyroid Mucosa-associated Lymphoid Tissue Lymphoma Presenting as Intermediate-risk Thyroid Nodule with Positive KRAS Mutation
  Nipith Charoenngam, Mehmet Sercan Marangoz, Simon Lamothe, Benjamin C. James
  AACE Clinical Case Reports.2023; 9(2): 44.     CrossRef
• Coexistence of tuberculosis and extranodal marginal zone lymphoma of the thyroid gland: Case report and literature review
  Sami Akbulut, Khaled Demyati, Ridvan Yavuz, Nilgun Sogutcu, Emine Turkmen Samdanci, Yusuf Yagmur
  Annals of Medicine and Surgery.2022; 78: 103861.     CrossRef
• Hashimoto's thyroiditis: An update on pathogenic mechanisms, diagnostic protocols, therapeutic strategies, and potential malignant transformation
  Massimo Ralli, Diletta Angeletti, Marco Fiore, Vittorio D'Aguanno, Alessandro Lambiase, Marco Artico, Marco de Vincentiis, Antonio Greco
  Autoimmunity Reviews.2020; 19(10): 102649.     CrossRef
• Mucosa-Associated Lymphoid Tissue Lymphoma of the Thyroid Gland: A Systematic Review of the Literature
  Evangelos Karvounis, Ioannis Kappas, Anna Angelousi, Georgios-Marios Makris, Eva Kassi
  European Thyroid Journal.2020; 9(1): 11.     CrossRef
• Primary thyroid MALToma– a rare diagnosis of an unassuming thyroid nodule
  Pragya Shrestha, Kimberly Aderhold, Sharon Swierczynski, Catherine Lin, Ronald Herb
  Journal of Community Hospital Internal Medicine Perspectives.2018; 8(1): 42.     CrossRef
• Coexistence of diffuse large B-cell lymphoma and papillary thyroid carcinoma in a patient affected by Hashimoto's thyroiditis
  Maria Trovato, Giuseppe Giuffrida, Antonino Seminara, Simone Fogliani, Vittorio Cavallari, Rosaria Maddalena Ruggeri, Alfredo Campennì
  Archives of Endocrinology and Metabolism.2017; 61(6): 643.     CrossRef
• Pathology Verified Concomitant Papillary Thyroid Carcinoma in the Sonographically Suspected Thyroid Lymphoma: A Case Report
  Qiong Wu, Yu-xin Jiang, Jun-chao Guo, Yu Xiao, Xiao Yang, Rui-na Zhao, Xing-jian Lai, Shen-ling Zhu, Xiao-yan Zhang, Bo Zhang
  Chinese Medical Sciences Journal.2016; 31(1): 54.     CrossRef
• Coexistence of papillary thyroid microcarcinoma and mucosa-associated lymphoid tissue lymphoma in a context of Hashimoto's thyroiditis
  Saul Levy-Blitchtein, Stefany Plasencia-Rebata, Domingo Morales Luna, Juana del Valle Mendoza
  Asian Pacific Journal of Tropical Medicine.2016; 9(8): 812.     CrossRef
• Synchronous Occurrence of Papillary Thyroid Carcinoma and Mucosa-Associated Lymphoid Tissue Lymphoma: a Single Case Report
  Jun Suk Byun, Hye Yoon Lee, Ki Won Chun, Dae Sung Yoon
  International Journal of Thyroidology.2016; 9(2): 195.     CrossRef
• Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
  Won-Young Lee
  Endocrinology and Metabolism.2014; 29(3): 251.     CrossRef
• Primary mucosa-associated lymphoid tissue lymphoma of the thyroid with concomitant papillary carcinoma
  Shaakir Hasan, Aruna Turaka
  Journal of Radiotherapy in Practice.2014; 13(4): 490.     CrossRef
• G Protein-Coupled Estrogen Receptor-1 Is Involved in the Protective Effect of Protocatechuic Aldehyde against Endothelial Dysfunction
  Byung Soo Kong, Yoon Hee Cho, Eun Jig Lee, Rajesh Mohanraj
  PLoS ONE.2014; 9(11): e113242.     CrossRef