- Miscellaneous
- Toward Systems-Level Metabolic Analysis in Endocrine Disorders and Cancer
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Aliya Lakhani, Da Hyun Kang, Yea Eun Kang, Junyoung O. Park
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Endocrinol Metab. 2023;38(6):619-630. Published online November 21, 2023
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DOI: https://doi.org/10.3803/EnM.2023.1814
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 Abstract
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- Metabolism is a dynamic network of biochemical reactions that support systemic homeostasis amidst changing nutritional, environmental, and physical activity factors. The circulatory system facilitates metabolite exchange among organs, while the endocrine system finely tunes metabolism through hormone release. Endocrine disorders like obesity, diabetes, and Cushing’s syndrome disrupt this balance, contributing to systemic inflammation and global health burdens. They accompany metabolic changes on multiple levels from molecular interactions to individual organs to the whole body. Understanding how metabolic fluxes relate to endocrine disorders illuminates the underlying dysregulation. Cancer is increasingly considered a systemic disorder because it not only affects cells in localized tumors but also the whole body, especially in metastasis. In tumorigenesis, cancer-specific mutations and nutrient availability in the tumor microenvironment reprogram cellular metabolism to meet increased energy and biosynthesis needs. Cancer cachexia results in metabolic changes to other organs like muscle, adipose tissue, and liver. This review explores the interplay between the endocrine system and systems-level metabolism in health and disease. We highlight metabolic fluxes in conditions like obesity, diabetes, Cushing’s syndrome, and cancers. Recent advances in metabolomics, fluxomics, and systems biology promise new insights into dynamic metabolism, offering potential biomarkers, therapeutic targets, and personalized medicine.
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Citations
Citations to this article as recorded by  - Editorial: Tumor metabolism and programmed cell death
Dan-Lan Pu, Qi-Nan Wu
Frontiers in Endocrinology.2024;[Epub] CrossRef - Molecular subtypes of clear cell renal carcinoma based on PCD-related long non-coding RNAs expression: insights into the underlying mechanisms and therapeutic strategies
Han Wang, Yang Liu, Aifa Tang, Xiansheng Zhang
European Journal of Medical Research.2024;[Epub] CrossRef
- Thyroid
- Propylthiouracil-Induced Antineutrophil Cytoplasmic Antibody-Positive Vasculitis and Agranulocytosis: A Rare Case with Life-Threatening Multiple Systemic Manifestations
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Da Hyun Kang, Mi-Kyung Song, Sang-Hyeon Ju, Song-I Lee, Yea Eun Kang
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Endocrinol Metab. 2023;38(2):282-284. Published online March 13, 2023
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DOI: https://doi.org/10.3803/EnM.2022.1643
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Citations
Citations to this article as recorded by - An organotypic atlas of human vascular cells
Sam N. Barnett, Ana-Maria Cujba, Lu Yang, Ana Raquel Maceiras, Shuang Li, Veronika R. Kedlian, J. Patrick Pett, Krzysztof Polanski, Antonio M. A. Miranda, Chuan Xu, James Cranley, Kazumasa Kanemaru, Michael Lee, Lukas Mach, Shani Perera, Catherine Tudor,
Nature Medicine.2024; 30(12): 3468. CrossRef - Vascular cells of blood vessels and organs across the human body
Nature Medicine.2024; 30(12): 3431. CrossRef - Methylprednisolone/propylthiouracil
Reactions Weekly.2023; 1962(1): 264. CrossRef
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