- Thyroid
- Deiodinases and the Three Types of Thyroid Hormone Deiodination Reactions
-
Laura Sabatino, Cristina Vassalle, Cristina Del Seppia, Giorgio Iervasi
-
Endocrinol Metab. 2021;36(5):952-964. Published online October 21, 2021
-
DOI: https://doi.org/10.3803/EnM.2021.1198
-
-
9,152
View
-
328
Download
-
50
Web of Science
-
58
Crossref
-
Abstract
PDFPubReader ePub
- Thyroid hormone (TH) signaling is strictly regulated by iodothyronine deiodinase activity, which both preserves the circulating levels of the biologically active triiodothyronine (T3) and regulates TH homeostasis at the local level, in a cell- and time-dependent manner. Three deiodinases have been identified—namely iodothyronine deiodinase 1 (DIO1), DIO2, and DIO3—that differ in their catalytic properties and tissue distribution. The deiodinases represent a dynamic system that changes in the different stages of life according to their functions and roles in various cell types and tissues. Deiodinase activity at the tissue level permits cell-targeted fine regulation of TH homeostasis, mediating the activation (DIO1 and DIO2) and inactivation (DIO3) of THs. Deiodinase homeostasis is the driving force that leads T3-target cells towards customized TH signaling, which takes into account both the hormonal circulating levels and the tissue-specific response. This review analyzes the complex role of deiodinases in physiological and pathological contexts, exploring new challenges and opportunities deriving from a deeper knowledge of the dynamics underlying their roles and functions.
-
Citations
Citations to this article as recorded by
- Understanding the Roles of Selenium on Thyroid Hormone-Induced Thermogenesis in Adipose Tissue
Yasmin Anissa R. Ruswandi, Ronny Lesmana, Aziiz Mardanarian Rosdianto, Julia Windi Gunadi, Hanna Goenawan, Felix Zulhendri Biological Trace Element Research.2024; 202(6): 2419. CrossRef - Noncatalytic Reductive Deiodination of Thyroid Hormones. Electrochemistry and Quantum Chemical Calculations
Piotr P. Romańczyk, Stefan S. Kurek ChemElectroChem.2024;[Epub] CrossRef - Comparison of in vitro thyroxine (T4) metabolism between Wistar rat and human hepatocyte cultures
Audrey Baze, Lucille Wiss, Liliia Horbal, Klaus Biemel, Laure Asselin, Lysiane Richert Toxicology in Vitro.2024; 96: 105763. CrossRef - Thyroxine Levels Predict the Development of Brain Failure in Patients With Cirrhosis in Indian Population
Anand V. Kulkarni, Moiz Vora, Ramyasri Ramagundam, Mithun Sharma, D. Nageshwar Reddy, P.N. Rao, S. Iyengar, D. Gujjarlapudi, A. Gupta, M. Alla, S. Venishetty, R. Gupta Gastro Hep Advances.2024; 3(1): 55. CrossRef - Arsenic-Induced Thyroid Hormonal Alterations and Their Putative Influence on Ovarian Follicles in Balb/c Mice
Nandheeswari K, Jayapradha P, Sree Vaishnavi Nalla, Itishree Dubey, Sapana Kushwaha Biological Trace Element Research.2024; 202(9): 4087. CrossRef - Embryonic thermal manipulation reduces hatch time, increases hatchability, thermotolerance, and liver metabolism in broiler embryos
Sadid Al Amaz, Md Ahosanul Haque Shahid, Ajay Chaudhary, Rajesh Jha, Birendra Mishra Poultry Science.2024; 103(4): 103527. CrossRef - Factors and Mechanisms of Thyroid Hormone Activity in the Brain: Possible Role in Recovery and Protection
Laura Sabatino, Dominga Lapi, Cristina Del Seppia Biomolecules.2024; 14(2): 198. CrossRef - Association between per- and polyfluoroalkyl substances exposure and thyroid function biomarkers among females attending a fertility clinic
Yu Zhang, Vicente Mustieles, T.I.M. Korevaar, Leah Martin, Yang Sun, Zainab Bibi, Nicole Torres, Ayanna Coburn-Sanderson, Olivia First, Irene Souter, John C. Petrozza, Maarten A.C. Broeren, Julianne C. Botelho, Antonia M. Calafat, Yi-Xin Wang, Carmen Mess Environmental Pollution.2024; 346: 123513. CrossRef - Correlation between a low serum free triiodothyronine level and mortality of severe pulmonary tuberculosis patients
Yan Yang, Xiaoqing Huang BMC Infectious Diseases.2024;[Epub] CrossRef - Investigating open access new approach methods (NAM) to assess biological points of departure: A case study with 4 neurotoxic pesticides
Marilyn H. Silva Current Research in Toxicology.2024; 6: 100156. CrossRef - A regulatory element associated to NAFLD in the promoter of DIO1 controls LDL-C, HDL-C and triglycerides in hepatic cells
Casimiro Castillejo-López, José Ramón Bárcenas-Walls, Marco Cavalli, Anders Larsson, Claes Wadelius Lipids in Health and Disease.2024;[Epub] CrossRef - Thyroid dysfunction and Alzheimer's disease, a vicious circle
Zhaoqing Li, Jia Liu Frontiers in Endocrinology.2024;[Epub] CrossRef - Male-transmitted transgenerational effects of the herbicide linuron on DNA methylation profiles in Xenopus tropicalis brain and testis
Mauricio Roza, Andreas N.M. Eriksson, Sofie Svanholm, Cecilia Berg, Oskar Karlsson Science of The Total Environment.2024; 923: 170949. CrossRef - Endoplasmic reticulum-resident selenoproteins and their roles in glucose and lipid metabolic disorders
Zhan Shi, Ziyu Han, Jingyi Chen, Ji-Chang Zhou Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2024; 1870(6): 167246. CrossRef - Effects of penthiopyrad on the hypothalamic-pituitary-thyroid (HPT) axis in zebrafish
Le Qian, Yikai Zhang, Xuheng Gao, Jia Jiang, Shengming Liu, Chengju Wang Pesticide Biochemistry and Physiology.2024; 202: 105961. CrossRef - Thyroid under siege: Unravelling the toxic impact of real-life metal mixture exposures in Wistar rats
Đurđica Marić, Katarina Baralić, Dragana Vukelić, Ivan Milošević, Anja Nikolić, Biljana Antonijević, Danijela Đukić-Ćosić, Zorica Bulat, Michael Aschner, Aleksandra Buha Djordjevic Chemosphere.2024; 360: 142441. CrossRef - Sex-specific transgenerational effects on murine thyroid gland imposed by ancestral exposure to neonicotinoid thiacloprid
Mariam Diba Lahmidi, Morgane Le Noc, Ouzna Dali, Pierre-Yves Kernanec, Pierre-Etienne Merret, Christian Jaulin, Fatima Smagulova Scientific Reports.2024;[Epub] CrossRef - Effects of Combined Hypothyroidism and Selenium Deficiency on Selenoenzyme Glutathione Peroxidase Activity in Rats
Svetlana Milanović, Olivera Valčić, Danijela Kirovski, Darko Marinković, Sanja Vranješ-Đurić, Dragan Gvozdić, Ivan B. Jovanović Acta Veterinaria.2024; 74(2): 261. CrossRef - Exploring the Link between Oxidative Stress, Selenium Levels, and Obesity in Youth
Teofana Otilia Bizerea-Moga, Laura Pitulice, Otilia Bizerea-Spiridon, Tudor Voicu Moga International Journal of Molecular Sciences.2024; 25(13): 7276. CrossRef - Cardiovascular toxicity of chemotherapy and thyroid status of patients with gastric and colon cancer: Current state of the problem. A review
Irina V. Stanoevich, Vitaliy A. Ioutsi, Natalya L. Lysovolenko, Ilya E. Alekseev, Alina D. Kondrashkina, Maksim B. Polianskii, Ekaterina V. Pis'mennaia Journal of Modern Oncology.2024; 26(2): 224. CrossRef - Mass spectrometry in measurement of thyroid biomarkers
Qiang Zhao, Dan Song, Huanyu Ju, Wenjing Xing, Jian Ma, Peng Xiao Clinica Chimica Acta.2024; 562: 119872. CrossRef - Long‐term safety and efficacy of glucagon‐like peptide‐1 receptor agonists in individuals with obesity and without type 2 diabetes: A global retrospective cohort study
Yu‐Nan Huang, Wen‐Ling Liao, Jing‐Yang Huang, Yu‐Jung Lin, Shun‐Fa Yang, Chieh‐Chen Huang, Chung‐Hsing Wang, Pen‐Hua Su Diabetes, Obesity and Metabolism.2024;[Epub] CrossRef - Medium-Chain Chlorinated Paraffins Trigger Thyroid Hormone Synthesis and Interfere with Mitochondrial Function in the Thyroid Gland
Lin Cheng, Shuangshuang Chen, Yun Luo, Yuan Gao, Yan Ren, Haijun Zhang, Jiping Chen, Ningbo Geng Environmental Science & Technology.2024; 58(35): 15428. CrossRef - Changes in Central Sensitivity to Thyroid Hormones vs. Urine Iodine during Pregnancy
Ioannis Ilias, Charalampos Milionis, Maria Alexiou, Ekaterini Michou, Chrysi Karavasili, Evangelia Venaki, Kostas Markou, Irini Mamali, Eftychia Koukkou Medical Sciences.2024; 12(4): 50. CrossRef - Modular Polymerase Synthesis and Internal Protein Domain Swapping via Dual Opposed Frameshifts in the Ebola Virus L Gene
David B. Stubbs, Jan A. Ruzicka, Ethan W. Taylor Pathogens.2024; 13(10): 829. CrossRef - Thyroid Endocrine Disruption and Mechanism of the Marine Antifouling Pollutant 4,5-Dichloro-2-n-octyl-4-isothiazolin-3-one
Mengyuan Liu, Chenyan Hu, Jiali Li, Bingsheng Zhou, Paul K.S. Lam, Lianguo Chen Environmental Science & Technology.2024;[Epub] CrossRef - Selenoprotein Gene mRNA Expression Evaluation During Renal Ischemia–Reperfusion Injury in Rats and Ebselen Intervention Effects
Yikun Wu, Hua Shi, Yuangao Xu, Rao Wen, Maodi Gong, Guangyi Hong, Shuxiong Xu Biological Trace Element Research.2023; 201(4): 1792. CrossRef - Acute exposure to microcystins affects hypothalamic-pituitary axes of male rats
Ting Shi, Lin-Lin Xu, Liang Chen, Jun He, Ye-Ke Wang, Feng Chen, Yang Chen, John P. Giesy, Yu-Ting Wang, Qian-Hui Wu, Wen-Li Xu, Jun Chen, Ping Xie Environmental Pollution.2023; 318: 120843. CrossRef - Thyroid hormone Beta receptor agonists for treatment of kidney disease: A promising agent?
Sidar Copur, Furkan Yavuz, Mehmet Kanbay European Journal of Clinical Investigation.2023;[Epub] CrossRef - The ratio of free triiodothyronine to free thyroxine is regulated differently in patients with type 2 diabetes mellitus treated and not treated with sodium glucose cotransporter 2 inhibitors
Shuichi Okada, Atsushi Isoda, Hiroto Hoshi, Junichi Okada, Kazuya Okada, Eijiro Yamada, Tsugumichi Saito, Takuya Watanabe, Koji Kikkawa, Kihachi Ohshima Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2023; 17(1): 102704. CrossRef - WITHDRAWN: The effect of deiodinase type-3 gene on the therapeutic response to levothyroxine in a sample of Iraqi hypothyroidism patients
Alaa Hashim Mohmmed, Suzanne Jubair, Ban Hoshi Human Gene.2023; : 201142. CrossRef - Subclinical hypothyroidism, outcomes and management guidelines: a narrative review and update of recent literature
Bogumila Urgatz, Salman Razvi Current Medical Research and Opinion.2023; 39(3): 351. CrossRef - DIO1 Gene Polymorphism Is Associated with Thyroid Profiles and Reproductive Performance in Dairy Cows
Olga V. Kostyunina, Olga S. Mityashova, Nikolay V. Bardukov, Olga V. Aleynikova, Irina Y. Lebedeva Agriculture.2023; 13(2): 398. CrossRef - Embryonic thermal manipulation leads growth inhibition and reduced hepatic insulin-like growth factor1 expression due to promoter DNA hypermethylation in broilers
Wei Cong, Wanwan Han, Jie Liu, Ruqian Zhao, Lei Wu Poultry Science.2023; 102(4): 102562. CrossRef - Drug Repurposing Patent Applications October–December 2022
Hermann A.M. Mucke ASSAY and Drug Development Technologies.2023; 21(2): 80. CrossRef - Insights on the Association between Thyroid Diseases and Colorectal Cancer
Federica Gagliardi, Enke Baldini, Eleonora Lori, Silvia Cardarelli, Daniele Pironi, Augusto Lauro, Domenico Tripodi, Piergaspare Palumbo, Eleonora D’Armiento, Giuseppe Cavallaro, Andrea Polistena, Valerio D’Orazi, Simone Sibio, Poupak Fallahi, Alessandro Journal of Clinical Medicine.2023; 12(6): 2234. CrossRef - Combining In Vitro and In Silico New Approach Methods to Investigate Type 3 Iodothyronine Deiodinase Chemical Inhibition Across Species
Sally A. Mayasich, Michael R. Goldsmith, Kali Z. Mattingly, Carlie A. LaLone Environmental Toxicology and Chemistry.2023; 42(5): 1032. CrossRef - Thyrotoxic Cardiomyopathy: State of the Art
Juan Eduardo Quiroz-Aldave, María del Carmen Durand-Vásquez, Carlos Jhonatan Lobato-Jeri, Juan-Manuel Muñoz-Moreno, Diana Carolina Deutz Gómez Condori, Sofía Pilar Ildefonso-Najarro, Felipe Contreras-Yametti, Francisca Zavaleta-Gutiérrez, Luis Concepción- European Endocrinology.2023; 19(1): 78. CrossRef - Bisphenol A-Induced Endocrine Dysfunction and its Associated Metabolic Disorders
Meenu Maniradhan, Latchoumycandane Calivarathan Endocrine, Metabolic & Immune Disorders - Drug Targets.2023; 23(4): 515. CrossRef - Dose- and Time-Dependent Effects of Radiofrequency Electromagnetic Field on Adipose Tissue: Implications of Thermoregulation and Mitochondrial Signaling
Jennifer Maalouf, Amandine Pelletier, Aurélie Corona, Jérôme Gay-Quéheillard, Véronique Bach, René de Seze, Brahim Selmaoui International Journal of Molecular Sciences.2023; 24(13): 10628. CrossRef - Critically ill patients: Histopathological evidence of thyroid dysfunction
Dipti Saha, Saurabh Chattopadhyay, Sayak Sovan Dutta, Anup Kumar Roy Journal of Critical Care.2023; 78: 154384. CrossRef - Primary Hypothyroidism and Alzheimer’s Disease: A Tale of Two
Faisal Holil AlAnazi, Hayder M. Al-kuraishy, Athanasios Alexiou, Marios Papadakis, Mohamed H. Mazhar Ashour, Saud A. Alnaaim, Omnya Elhussieny, Hebatallah M. Saad, Gaber El-Saber Batiha Cellular and Molecular Neurobiology.2023; 43(7): 3405. CrossRef - Genetically predicted thyroid function and risk of colorectal cancer: a bidirectional Mendelian randomization study
Qiang Du, Zhaoyang Zheng, Yong Wang, Lie Yang, Zongguang Zhou Journal of Cancer Research and Clinical Oncology.2023; 149(15): 14015. CrossRef - SARS-CoV-2 infection and thyroid dysfunction in children
K. V. Kozak, H. A. Pavlyshyn, I. Y. Avramenko, O. M. Dyvonyak, O. O. Shevchuk, K. T. Hlushko The Ukrainian Biochemical Journal.2023; 95(3): 12. CrossRef - Nongenomic roles of thyroid hormones and their derivatives in adult brain: are these compounds putative neurotransmitters?
Joseph V. Martin, Pradip K. Sarkar Frontiers in Endocrinology.2023;[Epub] CrossRef - Drug Repurposing Patent Applications April–June 2023
Hermann A.M. Mucke ASSAY and Drug Development Technologies.2023; 21(6): 288. CrossRef - Deiodinase Types 1 and 3 and Proinflammatory Cytokine Values May Discriminate Depressive Disorder Patients from Healthy Controls
Elżbieta Małujło-Balcerska, Tadeusz Pietras Journal of Clinical Medicine.2023; 12(19): 6163. CrossRef - Thyroid Dysfunction Induced by Fungicide Famoxadone Exposure Contributes to Nonalcoholic Fatty Liver Disease in Male Mice: In Vivo, In Vitro, and In Silico Studies
Shouchun Xiao, Jingna Cui, Aisong Chen, Haonan Hou, Jianing Yao, Yue Cao, Yaofeng Fang, Xueke Liu, Zhiqiang Zhou, Donghui Liu, Peng Wang Environmental Science & Technology.2023; 57(40): 14881. CrossRef -
In-silico
studies of
Brassica oleracea
active compounds and their role in thyroid peroxidase activity
Haritha Kalath, Abel John Koshy, Bhavya Banjan, Sowmya Soman, Gururaja Hosadevasthana, Rajesh Raju, Niyas Rehman, Amjesh Revikumar Journal of Biomolecular Structure and Dynamics.2023; : 1. CrossRef - Advances and Perspectives of Selenocompounds as Dietary Supplements to Ameliorate Obesity Biomarkers: From Field to Market
Frineth de la Luz Limón Aguilera, Sayra N. Serrano Sandoval, Mauricio Graciano-Palacios, Janet A. Gutiérrez-Uribe, Anayansi Escalante-Aburto Food Reviews International.2023; : 1. CrossRef - Deiodinase Type 3 Polymorphism (rs1190716) Affects Therapeutic Response to Levothyroxine
Alaa Hashim MOHMMED, Ban HOSHI, Suzanne JUBAIR Turkish Journal of Pharmaceutical Sciences.2023; 20(5): 335. CrossRef - Polycystic Ovary Syndrome and Oxidative Stress—From Bench to Bedside
Natalia Zeber-Lubecka, Michał Ciebiera, Ewa E. Hennig International Journal of Molecular Sciences.2023; 24(18): 14126. CrossRef - Thyroid hormone action and liver disease, a complex interplay
Luigi Marino, Adam Kim, Bin Ni, Francesco S. Celi Hepatology.2023;[Epub] CrossRef - Type 2 amiodarone-induced thyrotoxicosis: prevalence, time and predictors of development
A. S. Ermolaeva, V. V. Fadeev Problems of Endocrinology.2023; 70(3): 9. CrossRef - Thyroid Dysfunction and COVID-19: The Emerging Role of Selenium in This Intermingled Relationship
Francesca Gorini, Laura Sabatino, Alessio Coi, Giorgio Iervasi, Cristina Vassalle International Journal of Environmental Research and Public Health.2022; 19(11): 6912. CrossRef - Associations of bisphenol exposure with thyroid hormones in pregnant women: a prospective birth cohort study in China
Huishen Huang, Jun Liang, Peng Tang, Chuanxiang Yu, Haoran Fan, Qian Liao, Jinghua Long, Dongxiang Pan, Xiaoyun Zeng, Shun Liu, Dongping Huang, Xiaoqiang Qiu Environmental Science and Pollution Research.2022; 29(58): 87170. CrossRef - Selenium in Bodily Homeostasis: Hypothalamus, Hormones, and Highways of Communication
Pamela Toh, Jessica L. Nicholson, Alyssa M. Vetter, Marla J. Berry, Daniel J. Torres International Journal of Molecular Sciences.2022; 23(23): 15445. CrossRef - Does clinical hypothyroidism occur in obesity? here is what the lab rats may be telling us about hope on the horizon
Orien L Tulp, Frantz Sainvil, Andrew Scrianka, Rolando Branly, Aftab R Awan, George P Einstein International Journal of Family & Community Medicine.2022; 6(6): 338. CrossRef
|