Skip Navigation
Skip to contents

Endocrinol Metab : Endocrinology and Metabolism

clarivate
OPEN ACCESS
SEARCH
Search

Author index

Page Path
HOME > BROWSE ARTICLES > Author index
Search
Chul Woo Ahn  (Ahn CW) 35 Articles
Diabetes, obesity and metabolism
Study Design and Protocol for a Randomized Controlled Trial to Assess Long-Term Efficacy and Safety of a Triple Combination of Ezetimibe, Fenofibrate, and Moderate-Intensity Statin in Patients with Type 2 Diabetes and Modifiable Cardiovascular Risk Factors (ENSEMBLE)
Nam Hoon Kim, Juneyoung Lee, Suk Chon, Jae Myung Yu, In-Kyung Jeong, Soo Lim, Won Jun Kim, Keeho Song, Ho Chan Cho, Hea Min Yu, Kyoung-Ah Kim, Sang Soo Kim, Soon Hee Lee, Chong Hwa Kim, Soo Heon Kwak, Yong‐ho Lee, Choon Hee Chung, Sihoon Lee, Heung Yong Jin, Jae Hyuk Lee, Gwanpyo Koh, Sang-Yong Kim, Jaetaek Kim, Ju Hee Lee, Tae Nyun Kim, Hyun Jeong Jeon, Ji Hyun Lee, Jae-Han Jeon, Hye Jin Yoo, Hee Kyung Kim, Hyeong-Kyu Park, Il Seong Nam-Goong, Seongbin Hong, Chul Woo Ahn, Ji Hee Yu, Jong Heon Park, Keun-Gyu Park, Chan Ho Park, Kyong Hye Joung, Ohk-Hyun Ryu, Keun Yong Park, Eun-Gyoung Hong, Bong-Soo Cha, Kyu Chang Won, Yoon-Sok Chung, Sin Gon Kim
Endocrinol Metab. 2024;39(5):722-731.   Published online August 22, 2024
DOI: https://doi.org/10.3803/EnM.2024.1995
  • 1,657 View
  • 168 Download
AbstractAbstract PDFPubReader   ePub   
Background
Atherogenic dyslipidemia, which is frequently associated with type 2 diabetes (T2D) and insulin resistance, contributes to the development of vascular complications. Statin therapy is the primary approach to dyslipidemia management in T2D, however, the role of non-statin therapy remains unclear. Ezetimibe reduces cholesterol burden by inhibiting intestinal cholesterol absorption. Fibrates lower triglyceride levels and increase high-density lipoprotein cholesterol (HDL-C) levels via peroxisome proliferator- activated receptor alpha agonism. Therefore, when combined, these drugs effectively lower non-HDL-C levels. Despite this, few clinical trials have specifically targeted non-HDL-C, and the efficacy of triple combination therapies, including statins, ezetimibe, and fibrates, has yet to be determined.
Methods
This is a multicenter, prospective, randomized, open-label, active-comparator controlled trial involving 3,958 eligible participants with T2D, cardiovascular risk factors, and elevated non-HDL-C (≥100 mg/dL). Participants, already on moderate-intensity statins, will be randomly assigned to either Ezefeno (ezetimibe/fenofibrate) addition or statin dose-escalation. The primary end point is the development of a composite of major adverse cardiovascular and diabetic microvascular events over 48 months.
Conclusion
This trial aims to assess whether combining statins, ezetimibe, and fenofibrate is as effective as, or possibly superior to, statin monotherapy intensification in lowering cardiovascular and microvascular disease risk for patients with T2D. This could propose a novel therapeutic approach for managing dyslipidemia in T2D.
Close layer
Diabetes, Obesity and Metabolism
Association of Shift Work with Normal-Weight Obesity in Community-Dwelling Adults
Chul Woo Ahn, Sungjae Shin, Seunghyun Lee, Hye-Sun Park, Namki Hong, Yumie Rhee
Endocrinol Metab. 2022;37(5):781-790.   Published online October 25, 2022
DOI: https://doi.org/10.3803/EnM.2022.1532
  • 4,579 View
  • 205 Download
  • 3 Web of Science
  • 4 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
Shift work is associated with obesity and metabolic syndrome. However, this association in the normal-weight population remains unclear. This study aimed to investigate whether shift work is associated with normal-weight obesity (NWO).
Methods
From the nationally representative Korea National Health and Nutrition Examination Survey (KNHANES) dataset (2008 to 2011), 3,800 full-time workers aged ≥19 years with a body mass index (BMI) ≤25 kg/m2 were analysed. We defined NWO as BMI ≤25 kg/m2 and body fat percentage ≥25% in men and ≥37% in women. Working patterns were classified into “daytime,” “other than daytime,” and “shift.” Multivariable logistic regression analysis was performed to evaluate the relationship between shift work and NWO.
Results
Shift work was associated with higher odds of NWO than daytime work (adjusted odds ratio [aOR], 1.47; 95% confidence interval [CI], 1.04 to 2.09) and night/evening work (aOR, 1.87; 95% CI, 1.11 to 3.14) after adjustment for type of work, working hours, age, sex, BMI, 25-hydroxyvitamin D levels, homeostatic model assessment for insulin resistance, and other sociodemographic factors. In subgroup analyses, the association between shift work and NWO was more robust in those aged ≥60 years and those working ≥56 hours/week.
Conclusion
Shift work was associated with NWO in community-dwelling Korean adults, independent of age, sex, BMI, and other covariates.

Citations

Citations to this article as recorded by  
  • Association of Shift Work, Sociodemographic Variables and Healthy Habits with Obesity Scales
    Javier Tosoratto, Pedro Juan Tárraga López, Ángel Arturo López-González, Daniela Vallejos, Emilio Martínez-Almoyna Rifá, José Ignacio Ramirez-Manent
    Life.2024; 14(11): 1503.     CrossRef
  • Impaired Melatonin Secretion, Oxidative Stress and Metabolic Syndrome in Night Shift Work
    Sorina Hohor, Cristina Mandanach, Andreea Maftei, Corina Aurelia Zugravu, Marina Ruxandra Oțelea
    Antioxidants.2023; 12(4): 959.     CrossRef
  • Normal-Weight Obesity and Metabolic Syndrome in Korean Adults: A Population-Based Cross-Sectional Study
    Jeonghyeon Kim, Seamon Kang, Hyunsik Kang
    Healthcare.2023; 11(16): 2303.     CrossRef
  • You Can’t Avoid Shift Work? Then Focus on Body Fat Rather than Weight
    Eun Kyung Lee
    Endocrinology and Metabolism.2022; 37(5): 756.     CrossRef
Close layer
Clinical Study
Current Management of Type 2 Diabetes Mellitus in Primary Care Clinics in Korea
Da Hea Seo, Shinae Kang, Yong-ho Lee, Jung Yoon Ha, Jong Suk Park, Byoung-Wan Lee, Eun Seok Kang, Chul Woo Ahn, Bong-Soo Cha
Endocrinol Metab. 2019;34(3):282-290.   Published online September 26, 2019
DOI: https://doi.org/10.3803/EnM.2019.34.3.282
  • 6,671 View
  • 94 Download
  • 16 Web of Science
  • 16 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background

This study investigated the overall status of diabetes control and screening for diabetic microvascular complications in patients with type 2 diabetes mellitus attending primary care clinics in Korea.

Methods

In this cross-sectional observational study, 191 primary care clinics were randomly selected across Korea from 2015 to 2016. In total, 3,227 subjects were enrolled in the study.

Results

The patients followed at the primary care clinics were relatively young, with a mean age of 61.4±11.7 years, and had a relatively short duration of diabetes (mean duration, 7.6±6.5 years). Approximately 14% of subjects had diabetic microvascular complications. However, the patients treated at the primary care clinics had suboptimal control of hemoglobin A1c levels, blood pressure, and serum lipid levels, along with a metabolic target achievement rate of 5.9% according to the Korean Diabetes Association guidelines. The screening rates for diabetic nephropathy, retinopathy, and neuropathy within the past 12 months were 28.4%, 23.3%, and 13.3%, respectively.

Conclusion

The overall status of diabetes management, including the frequency of screening for microvascular complications, was suboptimal in the primary care clinics. More efforts should be made and more resources need to be allocated for primary care physicians to promote adequate healthcare delivery, which would result in stricter diabetes control and improved management of diabetic complications.

Citations

Citations to this article as recorded by  
  • Efficacy and Safety of Pioglitazone/Metformin Fixed-Dose Combination Versus Uptitrated Metformin in Patients with Type 2 Diabetes without Adequate Glycemic Control: A Randomized Clinical Trial
    Li-xin Guo, Lian-wei Wang, De-zeng Tian, Feng-mei Xu, Wei Huang, Xiao-hong Wu, Wei Zhu, Jun-Qiu Chen, Xin Zheng, Hai-Yan Zhou, Hong-Mei Li, Zhong-Chen He, Wen-Bo Wang, Li-Zhen Ma, Jun-Ting Duan
    Diabetes Therapy.2024; 15(11): 2351.     CrossRef
  • Risk of Cause-Specific Mortality across Glucose Spectrum in Elderly People: A Nationwide Population-Based Cohort Study
    Joonyub Lee, Hun-Sung Kim, Kee-Ho Song, Soon Jib Yoo, Kyungdo Han, Seung-Hwan Lee
    Endocrinology and Metabolism.2023; 38(5): 525.     CrossRef
  • Comparison of on-Statin Lipid and Lipoprotein Levels for the Prediction of First Cardiovascular Event in Type 2 Diabetes Mellitus
    Ji Yoon Kim, Jimi Choi, Sin Gon Kim, Nam Hoon Kim
    Diabetes & Metabolism Journal.2023; 47(6): 837.     CrossRef
  • Effectiveness of quality of care for patients with type 2 diabetes in China: findings from the Shanghai Integration Model (SIM)
    Chun Cai, Yuexing Liu, Yanyun Li, Yan Shi, Haidong Zou, Yuqian Bao, Yun Shen, Xin Cui, Chen Fu, Weiping Jia
    Frontiers of Medicine.2022; 16(1): 126.     CrossRef
  • Comparison of Health Outcomes by Care Provider Type for Newly Diagnosed Mild Type 2 Diabetes Patients in South Korea: A Retrospective Cohort Study
    Hee-Chung Kang, Jae-Seok Hong
    Healthcare.2022; 10(2): 334.     CrossRef
  • Management Status of Patients with Type 2 Diabetes Mellitus at General Hospitals in Korea: A 5-Year Follow-Up Study
    Jin Hee Jung, Jung Hwa Lee, Hyang Mi Jang, Young Na, Hee Sun Choi, Yeon Hee Lee, Yang Gyo Kang, Na Rae Kim, Jeong Rim Lee, Bok Rye Song, Kang Hee Sim
    The Journal of Korean Diabetes.2022; 23(1): 64.     CrossRef
  • Type 2 Diabetes Mellitus with Early Dry Skin Disorder: A Comparison Study Between Primary and Tertiary Care in Indonesia
    Lili Legiawati, Kusmarinah Bramono, Wresti Indriatmi, Em Yunir, Aditya Indra Pratama
    Current Diabetes Reviews.2022;[Epub]     CrossRef
  • Long-Term Changes in HbA1c According to Blood Glucose Control Status During the First 3 Months After Visiting a Tertiary University Hospital
    Hyunah Kim, Da Young Jung, Seung-Hwan Lee, Jae-Hyoung Cho, Hyeon Woo Yim, Hun-Sung Kim
    Journal of Korean Medical Science.2022;[Epub]     CrossRef
  • Differences in health behavior and nutrient intake status between diabetes-aware and unaware Korean adults based on the Korea national health and nutrition examination survey 2016–18 data: A cross-sectional study
    Anshul Sharma, Chen Lulu, Kee-Ho Song, Hae-Jeung Lee
    Frontiers in Public Health.2022;[Epub]     CrossRef
  • Effects of Diabetes Quality Assessment on Diabetes Management Behaviors Based on a Nationwide Survey
    Chang Kyun Choi, Jungho Yang, Ji-An Jeong, Min-Ho Shin
    International Journal of Environmental Research and Public Health.2022; 19(23): 15781.     CrossRef
  • The Impact of the Indonesian Chronic Disease Management Program (PROLANIS) on Metabolic Control and Renal Function of Type 2 Diabetes Mellitus Patients in Primary Care Setting
    Firas Farisi Alkaff, Fauzan Illavi, Sovia Salamah, Wiwit Setiyawati, Ristra Ramadhani, Elly Purwantini, Dicky L. Tahapary
    Journal of Primary Care & Community Health.2021;[Epub]     CrossRef
  • Questionnaire-based Survey of Demographic and Clinical Characteristics, Health Behaviors, and Mental Health of Young Korean Adults with Early-Onset Diabetes
    Ji In Park, Hyunjeong Baek, Sang-Wook Kim, Ji Yun Jeong, Kee-Ho Song, Ji Hee Yu, Il Sung Nam-Goong, Eun-Hee Cho
    Journal of Korean Medical Science.2021;[Epub]     CrossRef
  • Sodium–Glucose Cotransporter 2 Inhibitors and Risk of Retinal Vein Occlusion Among Patients With Type 2 Diabetes: A Propensity Score–Matched Cohort Study
    Min-Kyung Lee, Bongsung Kim, Kyungdo Han, Jae-Hyuk Lee, Minhee Kim, Mee Kyoung Kim, Ki-Hyun Baek, Ki-Ho Song, Hyuk-Sang Kwon, Young-Jung Roh
    Diabetes Care.2021; 44(10): 2419.     CrossRef
  • Challenges in the Management of Diabetes in Primary Care
    Yeon Kyung Lee
    The Journal of Korean Diabetes.2020; 21(3): 161.     CrossRef
  • Does Diabetes Increase the Risk of Contracting COVID-19? A Population-Based Study in Korea
    Sung-Youn Chun, Dong Wook Kim, Sang Ah Lee, Su Jung Lee, Jung Hyun Chang, Yoon Jung Choi, Seong Woo Kim, Sun Ok Song
    Diabetes & Metabolism Journal.2020; 44(6): 897.     CrossRef
  • Comprehensive Efforts Are Needed to Improve the Quality of Primary Diabetes Care in Korea
    Chan-Hee Jung
    Endocrinology and Metabolism.2019; 34(3): 265.     CrossRef
Close layer
Clinical Study
Triglyceride Glucose Index Is Superior to the Homeostasis Model Assessment of Insulin Resistance for Predicting Nonalcoholic Fatty Liver Disease in Korean Adults
Sang Bae Lee, Min Kyung Kim, Shinae Kang, Kahui Park, Jung Hye Kim, Su Jung Baik, Ji Sun Nam, Chul Woo Ahn, Jong Suk Park
Endocrinol Metab. 2019;34(2):179-186.   Published online May 20, 2019
DOI: https://doi.org/10.3803/EnM.2019.34.2.179
  • 8,989 View
  • 176 Download
  • 92 Web of Science
  • 91 Crossref
AbstractAbstract PDFPubReader   ePub   
Background

Recently, the triglyceride glucose (TyG) index has been considered a surrogate marker of insulin resistance which is a well-known pathogenic factor in nonalcoholic fatty liver disease (NAFLD). However, few studies have investigated the relationship between the TyG index and NAFLD. Thus, we investigated the relationship between the TyG index and NAFLD and the effectiveness of the TyG index compared with the homeostasis model assessment of insulin resistance (HOMA-IR) in identifying NAFLD in Korean adults.

Methods

Participants of 4,986 who underwent ultrasonography in a health promotion center were enrolled. The TyG index was calculated as ln [fasting triglycerides (mg/dL)×fasting glucose (mg/dL)/2], and HOMA-IR was estimated. NAFLD was diagnosed by ultrasonography.

Results

Significant differences were observed in metabolic parameters among the quartiles of the TyG index. The prevalence of NAFLD significantly increased with increment in the TyG index. After adjusting for multiple risk factors, a logistic regression analysis was performed. When the highest and lowest quartiles of the TyG index and HOMA-IR were compared, the odds ratios for the prevalence of NAFLD were 2.94 and 1.93 (95% confidence interval, 2.32 to 3.72 and 1.43 to 2.61; both P for trend <0.01), respectively. According to the receiver operating characteristic analysis, the TyG index was superior to HOMA-IR in predicting NAFLD.

Conclusion

The TyG index and prevalence of NAFLD were significantly related and the TyG index was superior to HOMA-IR in predicting NAFLD in Korean adults.

Citations

Citations to this article as recorded by  
  • Triglyceride-glucose body mass index predicts prognosis in patients with ST-elevation myocardial infarction
    Ming Liu, Jianyuan Pan, Ke Meng, Yuwei Wang, Xueqing Sun, Likun Ma, Xiaofan Yu
    Scientific Reports.2024;[Epub]     CrossRef
  • Triglyceride-glucose index is capable of identifying metabolically obese, normal-weight older individuals
    Bokun Kim, Keisuke Taniguchi, Tomonori Isobe, Sechang Oh
    Journal of Physiological Anthropology.2024;[Epub]     CrossRef
  • Comparison of triglyceride/glucose index and related parameters with Indian Diabetes Risk Score assessment in non-diabetic individuals visiting primary healthcare centre—A community-based cross-sectional study
    Sivapragasam Ramalingam, Amlan Kumar Kar, Rajini Senthil
    Journal of Family Medicine and Primary Care.2024; 13(1): 235.     CrossRef
  • Insulin resistance in NSCLC: unraveling the link between development, diagnosis, and treatment
    Shizhang Zhan, Liu Wang, Wenping Wang, Ruoran Li
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • The association between the triglyceride–glucose index and prognosis in postoperative renal cell carcinoma patients: a retrospective cohort study
    Guoliang Qin, Zhuang Sun, Yuxiang Jin, Xiangguo Ren, Zhaocun Zhang, Shuo Wang, Guanwen Zhou, Kun Huang, Haifeng Zhao, Xianzhou Jiang
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • Profiling triglyceride-glucose index in Filipinos with type 2 diabetes mellitus: a single-center study
    Chastene Christopher Flake, Madonna Morales-Valenzuela, Raphael Enrique Tiongco, Annalyn Navarro
    The Egyptian Journal of Internal Medicine.2024;[Epub]     CrossRef
  • Diagnostic Performance of Insulin Resistance Indices for Identifying Metabolic Dysfunction–Associated Fatty Liver Disease
    A. Lum Han, Hee Kyung Lee, Sae Ron Shin
    Metabolic Syndrome and Related Disorders.2024; 22(5): 402.     CrossRef
  • Metabolic profiling of galectin-1 and galectin-3: a cross-sectional, multi-omics, association study
    Emanuel Fryk, Vagner Ramon Rodrigues Silva, Lena Strindberg, Robin Strand, Håkan Ahlström, Karl Michaëlsson, Joel Kullberg, Lars Lind, Per-Anders Jansson
    International Journal of Obesity.2024; 48(8): 1180.     CrossRef
  • A Study of the Relationship Between the Triglyceride-Glucose Index and Skeletal Muscle Mass in a General Chinese Population
    Yue Liu, Hongwei Chen, Ziyi Wei, Tingting Han, Ningxin Chen, Yurong Weng, Yaomin Hu
    Clinical Medicine Insights: Endocrinology and Diabetes.2024;[Epub]     CrossRef
  • Triglyceride–glucose–alanine aminotransferase index: A noninvasive serum predictor for identifying the severity of pediatric nonalcoholic fatty liver disease
    Eu-Seon Noh, Il Tae Hwang
    Medicine.2024; 103(26): e38241.     CrossRef
  • Association between the C-reactive protein-triglyceride glucose index and erectile dysfunction in US males: results from NHANES 2001–2004
    Yangyang Mei, Yangmeina Li, Bo Zhang, Renfang Xu, Xingliang Feng
    International Journal of Impotence Research.2024;[Epub]     CrossRef
  • Triglyceride glucose index as a predictor for non-alcoholic fatty liver disease: insights from a longitudinal analysis in non-obese individuals
    Qi Ning, Keyang Zheng, Jiafu Yan, Chao Zhu
    Frontiers in Medicine.2024;[Epub]     CrossRef
  • The nutritional metabolic risk index as a predictor of all-cause and cardiovascular mortality: A national cohort study
    Chuanwei Zhao, Yane Yang, Conghao Duan, Chenxuan Gao, Yansi Wang, Huan Ni, Lanping Zhou, Yunfang Xiang, MeiJu Li, Zhao Xu
    Clinical Nutrition ESPEN.2024; 63: 391.     CrossRef
  • Triglyceride Glucose Index is Associated with Ultrasonographic Fatty Liver Indicator in Children and Adolescents with Non-alcoholic Fatty Liver Disease
    Bitgyeol Kim, Hye Young Jin, Jong Seo Yoon, Eu Seon Noh, Il Tae Hwang
    Journal of Clinical Research in Pediatric Endocrinology.2024;[Epub]     CrossRef
  • Triglyceride-glucose index and combined indicators: effective indicators for screening NAFLD in snoring patients
    Yuqing Cai, Jia Chen, Xiaoyu Deng, Biying Wang, Jiefeng Huang, Ningfang Lian
    BMC Pulmonary Medicine.2024;[Epub]     CrossRef
  • Diagnostic and prognostic value of triglyceride glucose index: a comprehensive evaluation of meta-analysis
    Sandeep Samethadka Nayak, Dona Kuriyakose, Lakshmi D. Polisetty, Anjali Avinash Patil, Daniyal Ameen, Rakshita Bonu, Samatha P. Shetty, Pubali Biswas, Micheal T. Ulrich, Negin Letafatkar, Arman Habibi, Mohammad-Hossein Keivanlou, Sara Nobakht, Abdulhadi A
    Cardiovascular Diabetology.2024;[Epub]     CrossRef
  • Relationship between triglyceride-glucose index and endometriosis: a cross-sectional analysis
    Yue Cao, Qian Yang, Qiqing Mai, Jianxiong Wuliu, Kaixian Deng
    BMC Women's Health.2024;[Epub]     CrossRef
  • Association Between Triglyceride-Glucose Index and Lung Function Parameters in the General Population Undergoing Health Examinations
    Yu Yang, Shuqi Wang, Boying Jia, Shuchun Chen
    Diabetes, Metabolic Syndrome and Obesity.2024; Volume 17: 4031.     CrossRef
  • The Triglyceride-Glucose Index is Associated with Vitamin D Status in Metabolic-Associated Fatty Liver Disease
    Zhiping Liu, Wensha Zhang, Zhiwei Zhao, Wenhao Li, Jinhua Zhang
    Diabetes, Metabolic Syndrome and Obesity.2023; Volume 16: 2651.     CrossRef
  • The triglyceride and glucose index and risk of nonalcoholic fatty liver disease: A dose–response meta-analysis
    Qin Ling, Jiawei Chen, Xiao Liu, Yi Xu, Jianyong Ma, Peng Yu, Kai Zheng, Fuwei Liu, Jun Luo
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Triglyceride–Glucose Index as a Potential Indicator of Sarcopenic Obesity in Older People
    Bokun Kim, Gwonmin Kim, Yongkook Lee, Keisuke Taniguchi, Tomonori Isobe, Sechang Oh
    Nutrients.2023; 15(3): 555.     CrossRef
  • Association of insulin resistance with bone mineral density in a nationwide health check-up population in China
    Ming Zhuo, Ze Chen, Mao-Lin Zhong, Fang Lei, Juan-Juan Qin, Shuhua Liu, Ye-Mao Liu, Tao Sun, Xiao-Jing Zhang, Lihua Zhu, Jingjing Cai, Jun-Ming Ye, Erping Yang
    Bone.2023; 170: 116703.     CrossRef
  • Metabolic Dysfunction-Associated Fatty Liver Disease and Mortality: A Population-Based Cohort Study
    Kyung-Soo Kim, Sangmo Hong, Hong-Yup Ahn, Cheol-Young Park
    Diabetes & Metabolism Journal.2023; 47(2): 220.     CrossRef
  • Comparison of the prognostic value of a comprehensive set of predictors in identifying risk of metabolic-associated fatty liver disease among employed adults
    Ze Yang, Bin Yu, Zihang Wang, Zhitao Li, Bo Yang, Honglian Zeng, Shujuan Yang
    BMC Public Health.2023;[Epub]     CrossRef
  • The triglyceride glucose index and CDKAL1 gene rs10946398 SNP are associated with NAFLD in Chinese adults
    Jun ZHU, Dujuan XU, Ruihua YANG, Min LIU, Ying LIU
    Minerva Endocrinology.2023;[Epub]     CrossRef
  • PNPLA3 rs738409 risk genotype decouples TyG index from HOMA2-IR and intrahepatic lipid content
    Ákos Nádasdi, Viktor Gál, Tamás Masszi, Anikó Somogyi, Gábor Firneisz
    Cardiovascular Diabetology.2023;[Epub]     CrossRef
  • Baseline level and change trajectory of the triglyceride-glucose index in relation to the development of NAFLD: a large population-based cohort study
    Yaqin Wang, Jiangang Wang, Lei Liu, Pingting Yang, Shuwen Deng, Xuelian Liu, Linlin Zhao, Changfa Wang, Ying Li
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Assessing temporal differences in the predictive power of baseline TyG-related parameters for future diabetes: an analysis using time-dependent receiver operating characteristics
    Maobin Kuang, Ruijuan Yang, Xin Huang, Chao Wang, Guotai Sheng, Guobo Xie, Yang Zou
    Journal of Translational Medicine.2023;[Epub]     CrossRef
  • Metabolic Score for Insulin Resistance (METS-IR) Predicts Adverse Cardiovascular Events in Patients with Type 2 Diabetes and Ischemic Cardiomyopathy
    Xuehe Zhang, Fen Liu, Wenling Li, Jixin Zhang, Tong Zhang, Xiaolin Yu, Junyi Luo, Qian Zhao, Jinyu Zhang, Binbin Fang, Yining Yang, Xiaomei Li
    Diabetes, Metabolic Syndrome and Obesity.2023; Volume 16: 1283.     CrossRef
  • Prevalence and Risk Factors of Metabolic-Associated Fatty Liver Disease Among Hospital Staff
    Daya Zhang, Lijun Zhang, Shiju Chen, Runxiang Chen, Xiaodong Zhang, Feihu Bai
    Diabetes, Metabolic Syndrome and Obesity.2023; Volume 16: 1221.     CrossRef
  • The metabolic score of insulin resistance is positively correlated with bone mineral density in postmenopausal patients with type 2 diabetes mellitus
    Peng Gu, Bin Pu, Qiao Xin, Dan Yue, LieLiang Luo, JiaSheng Tao, HaiShan Li, Ming Chen, MingHua Hu, XiaoRong Hu, XiaoHui Zheng, ZhanPeng Zeng
    Scientific Reports.2023;[Epub]     CrossRef
  • Prevalence estimates of the insulin resistance and associated prevalence of heart failure among United Status adults
    Xiaozhong Li, Jihong Wang, Liyan Niu, Ziqi Tan, Jianyong Ma, Ling He, Peng Yu, Xiao Liu, Juxiang Li
    BMC Cardiovascular Disorders.2023;[Epub]     CrossRef
  • From NAFLD to HCC: Advances in noninvasive diagnosis
    Qinchen Xu, Maoxiao Feng, Yidan Ren, Xiaoyan Liu, Huiru Gao, Zigan Li, Xin Su, Qin Wang, Yunshan Wang
    Biomedicine & Pharmacotherapy.2023; 165: 115028.     CrossRef
  • Usefulness of two-dimensional shear wave elastography in the assessment of non-alcoholic fatty liver disease in children and adolescents
    Jong Seo Yoon, Kyoung Ja Lim, Il Tae Hwang
    Scientific Reports.2023;[Epub]     CrossRef
  • A non-linear relationship between triglyceride glucose waist circumference and nonalcoholic fatty liver disease in a Japanese population: a secondary analysis
    Xiaojie He, Xinyue Huang, Yafang Qian, Ting Sun
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Neck Circumference as a Predictor of Insulin Resistance in People with Non-alcoholic Fatty Liver Disease
    Da-Hye Son, Jee Hye Han, Jun-Hyuk Lee
    Journal of Obesity & Metabolic Syndrome.2023; 32(3): 214.     CrossRef
  • Prediction and Validation of Metabolic Dysfunction-Associated Fatty Liver Disease Using Insulin Resistance-Related Indices in the Japanese Population
    Kengo Moriyama, Nagamu Inoue, Jin Imai, Yumi Masuda, Chizumi Yamada, Noriaki Kishimoto, Shinji Takashimizu, Akira Kubo, Yasuhiro Nishizaki
    Metabolic Syndrome and Related Disorders.2023; 21(9): 489.     CrossRef
  • Application value of triglyceride-glucose index and triglyceride-glucose body mass index in evaluating the degree of hepatic steatosis in non-alcoholic fatty liver disease
    Mengyuan Wang, Mingxing Chang, Peipu Shen, Wei Wei, Huayao Li, Guifang Shen
    Lipids in Health and Disease.2023;[Epub]     CrossRef
  • Homeostatic Model Assessment of Insulin Resistance as a Potential Screening Test for Non-Alcoholic Fatty Liver Disease in Korean Adults without Diabetes
    Hyejung Lee, Jae-Ho Lee
    Korean Journal of Family Practice.2023; 13(4): 233.     CrossRef
  • Comparison of the Triglyceride Glucose Index and Modified Triglyceride Glucose Indices to Predict Nonalcoholic Fatty Liver Disease in Youths
    Kyungchul Song, Goeun Park, Hye Sun Lee, Myeongseob Lee, Hae In Lee, Han Saem Choi, Junghwan Suh, Ahreum Kwon, Ho-Seong Kim, Hyun Wook Chae
    The Journal of Pediatrics.2022; 242: 79.     CrossRef
  • The triglyceride-glucose index as a clinical useful marker for metabolic associated fatty liver disease (MAFLD): a population-based study among Iranian adults
    Ehsaneh Taheri, Mohammad Amin Pourhoseingholi, Alireza Moslem, Amir Hossein Hassani, Alireza Mousavi Jarrahi, Hamid Asadzadeh Aghdaei, Mohammad Reza Zali, Behzad Hatami
    Journal of Diabetes & Metabolic Disorders.2022; 21(1): 97.     CrossRef
  • Comparison of triglyceride-glucose index and HOMA-IR for predicting prevalence and incidence of metabolic syndrome
    Da-Hye Son, Hye Sun Lee, Yong-Jae Lee, Jun-Hyuk Lee, Jee-Hye Han
    Nutrition, Metabolism and Cardiovascular Diseases.2022; 32(3): 596.     CrossRef
  • Triglycerides/Glucose Index Is Associated with Sperm Parameters and Sperm DNA Fragmentation in Primary Infertile Men: A Cross-Sectional Study
    Federico Belladelli, Luca Boeri, Edoardo Pozzi, Giuseppe Fallara, Christian Corsini, Luigi Candela, Walter Cazzaniga, Daniele Cignoli, Luca Pagliardini, Alessia D’Arma, Paolo Capogrosso, Eugenio Ventimiglia, Francesco Montorsi, Andrea Salonia
    Metabolites.2022; 12(2): 143.     CrossRef
  • Association of triglyceride-glucose index and stroke recurrence among nondiabetic patients with acute ischemic stroke
    Xiaomeng Yang, Guangyao Wang, Jing Jing, Anxin Wang, Xiaoli Zhang, Qian Jia, Xia Meng, Xingquan Zhao, Liping Liu, Hao Li, Yongjun Wang, Yilong Wang
    BMC Neurology.2022;[Epub]     CrossRef
  • The triglycerides and glucose (TyG) index: A new marker associated with nonalcoholic steatohepatitis (NASH) in obese patients
    Benjamin Rivière, Audrey Jaussent, Valérie Macioce, Stéphanie Faure, Nicolas Builles, Patrick Lefebvre, Philippe Géraud, Marie-Christine Picot, Sandra Rebuffat, Eric Renard, Valérie Paradis, Marie-Dominique Servais, Nathalie de Preville, David Nocca, Anne
    Diabetes & Metabolism.2022; 48(4): 101345.     CrossRef
  • Association of triglyceride-glucose with cardiac hemodynamics in type 2 diabetes
    Chenxi Wang, Zhicong Zhao, Xia Deng, Zhensheng Cai, Tian Gu, Lian Li, Chang Guo, Dong Wang, Ling Yang, Li Zhao, Guoyue Yuan
    Diabetes and Vascular Disease Research.2022;[Epub]     CrossRef
  • Comparison of the Modified TyG Indices and Other Parameters to Predict Non-Alcoholic Fatty Liver Disease in Youth
    Kyungchul Song, Hae Won Lee, Han Saem Choi, Goeun Park, Hye Sun Lee, Su Jin Kim, Myeongseob Lee, Junghwan Suh, Ahreum Kwon, Ho-Seong Kim, Hyun Wook Chae
    Biology.2022; 11(5): 685.     CrossRef
  • Triglyceride-Glucose Index for Early Prediction of Nonalcoholic Fatty Liver Disease: A Meta-Analysis of 121,975 Individuals
    Azizullah Beran, Hazem Ayesh, Mohammed Mhanna, Waseem Wahood, Sami Ghazaleh, Ziad Abuhelwa, Wasef Sayeh, Nameer Aladamat, Rami Musallam, Reem Matar, Saif-Eddin Malhas, Ragheb Assaly
    Journal of Clinical Medicine.2022; 11(9): 2666.     CrossRef
  • Triglyceride and Glucose Index as a Screening Tool for Nonalcoholic Liver Disease in Patients with Metabolic Syndrome
    Anca Maria Amzolini, Mircea-Cătălin Forțofoiu, Anca Barău Alhija, Ionela Mihaela Vladu, Diana Clenciu, Adina Mitrea, Maria Forțofoiu, Daniela Matei, Magdalena Diaconu, Marinela Sinziana Tudor, Elena Simona Micu
    Journal of Clinical Medicine.2022; 11(11): 3043.     CrossRef
  • Triglyceride glucose index is superior biomarker for predicting type 2 diabetes mellitus in children and adolescents
    Jong Seo Yoon, Hye Jin Lee, Hwal Rim Jeong, Young Suk Shim, Min Jae Kang, Il Tae Hwang
    Endocrine Journal.2022; 69(5): 559.     CrossRef
  • Triglyceride and glucose index is a simple and easy‐to‐calculate marker associated with nonalcoholic fatty liver disease
    Kyung‐Soo Kim, Sangmo Hong, Hong‐Yup Ahn, Cheol‐Young Park
    Obesity.2022; 30(6): 1279.     CrossRef
  • Evaluating Triglyceride and Glucose Index as a Simple and Easy-to-Calculate Marker for All-Cause and Cardiovascular Mortality
    Kyung-Soo Kim, Sangmo Hong, You-Cheol Hwang, Hong-Yup Ahn, Cheol-Young Park
    Journal of General Internal Medicine.2022; 37(16): 4153.     CrossRef
  • The Role of Insulin Resistance in Fueling NAFLD Pathogenesis: From Molecular Mechanisms to Clinical Implications
    Rossella Palma, Annamaria Pronio, Mario Romeo, Flavia Scognamiglio, Lorenzo Ventriglia, Vittorio Maria Ormando, Antonietta Lamazza, Stefano Pontone, Alessandro Federico, Marcello Dallio
    Journal of Clinical Medicine.2022; 11(13): 3649.     CrossRef
  • Comparison of the diagnostic value between triglyceride-glucose index and triglyceride to high-density lipoprotein cholesterol ratio in metabolic-associated fatty liver disease patients: a retrospective cross-sectional study
    Zhi Liu, He He, Yuzhao Dai, Lidan Yang, Shenling Liao, Zhenmei An, Shuangqing Li
    Lipids in Health and Disease.2022;[Epub]     CrossRef
  • Insulin Resistance Markers to Detect Nonalcoholic Fatty Liver Disease in a Male Hispanic Population
    Maritza Pérez-Mayorga, Jose P. Lopez-Lopez, Maria A. Chacon-Manosalva, Maria G Castillo, Johanna Otero, Daniel Martinez-Bello, Diego Gomez-Arbelaez, Daniel D. Cohen, Patricio Lopez-Jaramillo, Federico Ravaioli
    Canadian Journal of Gastroenterology and Hepatology.2022; 2022: 1.     CrossRef
  • Risk factors and prediction model for nonalcoholic fatty liver disease in northwest China
    Danting Li, Meiyu Zhang, Shengli Wu, Huiwen Tan, Nong Li
    Scientific Reports.2022;[Epub]     CrossRef
  • The triglyceride glucose index is associated with the cerebral small vessel disease in a memory clinic population
    Jiayu Zhang, Ming Hu, Yanqiu Jia, Shicong Zhao, Peiyuan Lv, Mingyue Fan, Yuanyuan Shi, Wei Jin
    Journal of Clinical Neuroscience.2022; 104: 126.     CrossRef
  • Integrating experimental model, LC-MS/MS chemical analysis, and systems biology approach to investigate the possible antidiabetic effect and mechanisms of Matricaria aurea (Golden Chamomile) in type 2 diabetes mellitus
    Yassin Ismail, Dina M. Fahmy, Maivel H. Ghattas, Mai M. Ahmed, Walaa Zehry, Samy M. Saleh, Dina M. Abo-elmatty
    Frontiers in Pharmacology.2022;[Epub]     CrossRef
  • Laboratory data clustering in defining population cohorts: Case study on metabolic indicators
    Ivan Pavicevic, Goran Miljus, Olgica Nedic
    Journal of the Serbian Chemical Society.2022; 87(9): 1025.     CrossRef
  • Association of triglyceride glucose-body mass index with non-small cell lung cancer risk: A case-control study on Chinese adults
    Feifei Wang, Ting He, Guoliang Wang, Tuo Han, Zhongqiang Yao
    Frontiers in Nutrition.2022;[Epub]     CrossRef
  • Association Between Triglyceride-Glucose Index and Risk of Metabolic Dysfunction-Associated Fatty Liver Disease: A Cohort Study
    Ru Zhang, Qing Guan, Mengting Zhang, Yajie Ding, Zongzhe Tang, Hongliang Wang, Wei Zhang, Yue Chen, Rong Jiang, Yan Cui, Jie Wang
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2022; Volume 15: 3167.     CrossRef
  • Association between the triglyceride-glucose (TyG) index and increased blood pressure in normotensive subjects: a population-based study
    Dong-Hwa Lee, Jong Eun Park, So Young Kim, Hyun Jeong Jeon, Jong-Hyock Park
    Diabetology & Metabolic Syndrome.2022;[Epub]     CrossRef
  • Fructose consumption correlates with triglyceride-glucose index and glycemic status in healthy adults
    Eda Keskin, Havvanur Yoldas Ilktac
    Clinical Nutrition ESPEN.2022; 52: 184.     CrossRef
  • Associations Between Type 2 Diabetes Subtypes and Complications: Analysis of the Malaysia National Diabetes Registry
    Rasa Kazlauskaite, Nathan Ellermeier, Carrie Ngongo, Arunah Chandran, Pankaja Desai, Ethan Ritz, Rachel Nugent, Feisul Idzwan Mustapha
    SSRN Electronic Journal .2022;[Epub]     CrossRef
  • Independent and combined effects of triglyceride-glucose index on prehypertension risk: a cross-sectional survey in China
    Hong Xie, Jian Song, Liangliang Sun, Xinxin Xie, Yehuan Sun
    Journal of Human Hypertension.2021; 35(3): 207.     CrossRef
  • Association of Triglyceride-Glucose Index with Bone Mineral Density in Non-diabetic Koreans: KNHANES 2008–2011
    Jee Hee Yoon, A Ram Hong, Wonsuk Choi, Ji Yong Park, Hee Kyung Kim, Ho-Cheol Kang
    Calcified Tissue International.2021; 108(2): 176.     CrossRef
  • Triglyceride‐Glucose Index (TyG) is associated with erectile dysfunction: A cross‐sectional study
    Mehmet Yilmaz, Mustafa Karaaslan, Senol Tonyali, Mecit Celik, Tuncay Toprak, Oner Odabas
    Andrology.2021; 9(1): 238.     CrossRef
  • Triglyceride Glucose Index and Related Parameters (Triglyceride Glucose-Body Mass Index and Triglyceride Glucose-Waist Circumference) Identify Nonalcoholic Fatty Liver and Liver Fibrosis in Individuals with Overweight/Obesity
    Mohammad E. Khamseh, Mojtaba Malek, Rowshanak Abbasi, Hoda Taheri, Maryam Lahouti, Fariba Alaei-Shahmiri
    Metabolic Syndrome and Related Disorders.2021; 19(3): 167.     CrossRef
  • Triglyceride and glucose index and the risk of gestational diabetes mellitus: A nationwide population-based cohort study
    Jung A Kim, Jinsil Kim, Eun Roh, So-hyeon Hong, You-Bin Lee, Sei Hyun Baik, Kyung Mook Choi, Eunjin Noh, Soon Young Hwang, Geum Joon Cho, Hye Jin Yoo
    Diabetes Research and Clinical Practice.2021; 171: 108533.     CrossRef
  • Association of the triglyceride and glucose index with low muscle mass: KNHANES 2008–2011
    Jung A. Kim, Soon Young Hwang, Ji Hee Yu, Eun Roh, So-hyeon Hong, You-Bin Lee, Nam Hoon Kim, Hye Jin Yoo, Ji A. Seo, Nan Hee Kim, Sin Gon Kim, Sei Hyun Baik, Kyung Mook Choi
    Scientific Reports.2021;[Epub]     CrossRef
  • The triglycerides and glucose index is strongly associated with hepatic steatosis in children with overweight or obesity
    Luis E. Simental-Mendía, César Javier Ortega-Pacheco, Elvira García-Guerrero, María Alejandra Sicsik-Aragón, Fernando Guerrero-Romero, Gerardo Martínez-Aguilar
    European Journal of Pediatrics.2021; 180(6): 1755.     CrossRef
  • Triglyceride-glucose index and the risk of stroke and its subtypes in the general population: an 11-year follow-up
    Anxin Wang, Guangyao Wang, Qian Liu, Yingting Zuo, Shuohua Chen, Boni Tao, Xue Tian, Penglian Wang, Xia Meng, Shouling Wu, Yongjun Wang, Yilong Wang
    Cardiovascular Diabetology.2021;[Epub]     CrossRef
  • Association Between Triglyceride Glucose Index and Non-Small Cell Lung Cancer Risk in Chinese Population
    Xin Yan, Yujuan Gao, Jingzhi Tong, Mi Tian, Jinghong Dai, Yi Zhuang
    Frontiers in Oncology.2021;[Epub]     CrossRef
  • Triglyceride Glucose Index Is Associated With Arterial Stiffness and 10-Year Cardiovascular Disease Risk in a Chinese Population
    Wen Guo, Wenfang Zhu, Juan Wu, Xiaona Li, Jing Lu, Pei Qin, Cheng Zhu, Nianzhen Xu, Qun Zhang
    Frontiers in Cardiovascular Medicine.2021;[Epub]     CrossRef
  • An Analysis of the Potential Relationship of Triglyceride Glucose and Body Mass Index With Stroke Prognosis
    Zongyi Hou, Yuesong Pan, Yindong Yang, Xiaofan Yang, Xianglong Xiang, Yilong Wang, Zixiao Li, Xingquan Zhao, Hao Li, Xia Meng, Yongjun Wang
    Frontiers in Neurology.2021;[Epub]     CrossRef
  • Role of Endocrine-Disrupting Chemicals in the Pathogenesis of Non-Alcoholic Fatty Liver Disease: A Comprehensive Review
    Raquel Cano, José Pérez, Lissé Dávila, Ángel Ortega, Yosselin Gómez, Nereida Valero-Cedeño, Heliana Parra, Alexander Manzano, Teresa Véliz Castro, María Albornoz, Gabriel Cano, Joselyn Rojas-Quintero, Maricarmen Chacín, Valmore Bermúdez
    International Journal of Molecular Sciences.2021; 22(9): 4807.     CrossRef
  • Triglyceride glucose (TyG) index and the progression of liver fibrosis: A cross-sectional study
    Helda Tutunchi, Fatemeh Naeini, Majid Mobasseri, Alireza Ostadrahimi
    Clinical Nutrition ESPEN.2021; 44: 483.     CrossRef
  • Newly proposed insulin resistance indexes called TyG-NC and TyG-NHtR show efficacy in diagnosing the metabolic syndrome
    M. Mirr, D. Skrypnik, P. Bogdański, M. Owecki
    Journal of Endocrinological Investigation.2021; 44(12): 2831.     CrossRef
  • Association Between the Triglyceride–Glucose Index and Outcomes of Nonalcoholic Fatty Liver Disease: A Large-Scale Health Management Cohort Study
    Jing Liu, Liying Guan, Meng Zhao, Qihang Li, An Song, Ling Gao, Haiyan Lin, Jiajun Zhao
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2021; Volume 14: 2829.     CrossRef
  • Association between triglyceride-glucose index and thyroid function in euthyroid adults: The Korea National Health and Nutritional Examination Survey 2015
    Wonsuk Choi, Ji Yong Park, A. Ram Hong, Jee Hee Yoon, Hee Kyung Kim, Ho-Cheol Kang, Sun Young Lee
    PLOS ONE.2021; 16(7): e0254630.     CrossRef
  • Triglyceride glucose-waist to height ratio: a novel and effective marker for identifying hepatic steatosis in individuals with type 2 diabetes mellitus
    Mojtaba Malek, Mohammad E. Khamseh, Haleh Chehrehgosha, Sohrab Nobarani, Fariba Alaei-Shahmiri
    Endocrine.2021; 74(3): 538.     CrossRef
  • The association between triglyceride-glucose index, cardio-cerebrovascular diseases, and death in Korean adults: A retrospective study based on the NHIS-HEALS cohort
    Joungyoun Kim, Sang-Jun Shin, Hee-Taik Kang, Claudio Passino
    PLOS ONE.2021; 16(11): e0259212.     CrossRef
  • A population-based study of TyG index distribution and its relationship to cardiometabolic risk factors in children and adolescents
    Jong Seo Yoon, Young Suk Shim, Hae Sang Lee, Il Tae Hwang, Jin Soon Hwang
    Scientific Reports.2021;[Epub]     CrossRef
  • Comparison of several blood lipid-related indexes in the screening of non-alcoholic fatty liver disease in women: a cross-sectional study in the Pearl River Delta region of southern China
    Jingrui Wang, Zhenzhen Su, Yijin Feng, Ruihan Xi, Jiamin Liu, Peixi Wang
    BMC Gastroenterology.2021;[Epub]     CrossRef
  • The value of the triglyceride-glucose index in the diagnosis of insulin resistance in early forms of non-alcoholic fatty liver disease
    A. A. Shipovskaya, N. A. Larina, I. V. Kurbatova, O. P. Dudanova
    Experimental and Clinical Gastroenterology.2021; (10): 43.     CrossRef
  • Triglyceride Glucose-Waist Circumference Is Superior to the Homeostasis Model Assessment of Insulin Resistance in Identifying Nonalcoholic Fatty Liver Disease in Healthy Subjects
    Hwi Seung Kim, Yun Kyung Cho, Eun Hee Kim, Min Jung Lee, Chang Hee Jung, Joong-Yeol Park, Hong-Kyu Kim, Woo Je Lee
    Journal of Clinical Medicine.2021; 11(1): 41.     CrossRef
  • Homeostasis model assessment of insulin resistance and lobular inflammation in nondiabetic patients with nonalcoholic fatty liver disease: methodological considerations
    Denis Monneret, Dominique Bonnefont-Rousselot
    European Journal of Gastroenterology & Hepatology.2020; 32(4): 542.     CrossRef
  • Helicobacter pylori infection may increase the severity of nonalcoholic fatty liver disease via promoting liver function damage, glycometabolism, lipid metabolism, inflammatory reaction and metabolic syndrome
    Chen Chen, Caiyun Zhang, Xuelin Wang, Feijuan Zhang, Ze Zhang, Pengchai Ma, Shuzhi Feng
    European Journal of Gastroenterology & Hepatology.2020; 32(7): 857.     CrossRef
  • Beneficial effect of anti-diabetic drugs for nonalcoholic fatty liver disease
    Kyung-Soo Kim, Byung-Wan Lee
    Clinical and Molecular Hepatology.2020; 26(4): 430.     CrossRef
  • The triglyceride-glucose index is associated with the severity of hepatic steatosis and the presence of liver fibrosis in non-alcoholic fatty liver disease: a cross-sectional study in Chinese adults
    Wen Guo, Jing Lu, Pei Qin, Xiaona Li, Wenfang Zhu, Juan Wu, Nianzhen Xu, Qun Zhang
    Lipids in Health and Disease.2020;[Epub]     CrossRef
  • Association between triglyceride glucose-body mass index and non-alcoholic fatty liver disease in the non-obese Chinese population with normal blood lipid levels: a secondary analysis based on a prospective cohort study
    Yaling Li, Rui Zheng, Jie Li, Shuyi Feng, Li Wang, Zhiming Huang
    Lipids in Health and Disease.2020;[Epub]     CrossRef
Close layer
Clinical Study
Calpain-10 and Adiponectin Gene Polymorphisms in Korean Type 2 Diabetes Patients
Ji Sun Nam, Jung Woo Han, Sang Bae Lee, Ji Hong You, Min Jin Kim, Shinae Kang, Jong Suk Park, Chul Woo Ahn
Endocrinol Metab. 2018;33(3):364-371.   Published online September 18, 2018
DOI: https://doi.org/10.3803/EnM.2018.33.3.364
  • 4,180 View
  • 54 Download
  • 7 Web of Science
  • 6 Crossref
AbstractAbstract PDFPubReader   ePub   
Background

Genetic variations in calpain-10 and adiponectin gene are known to influence insulin secretion and resistance in type 2 diabetes mellitus. Recently, several single nucleotide polymorphisms (SNPs) in calpain-10 and adiponectin gene have been reported to be associated with type 2 diabetes and various metabolic derangements. We investigated the associations between specific calpain-10 and adiponectin gene polymorphisms and Korean type 2 diabetes patients.

Methods

Overall, 249 type 2 diabetes patients and 131 non-diabetic control subjects were enrolled in this study. All the subjects were genotyped for SNP-43 and -63 of calpain-10 gene and G276T and T45G frequencies of the adiponectin gene. The clinical characteristics and measure of glucose metabolism were compared within these genotypes.

Results

Among calpain-10 polymorphisms, SNP-63 T/T were more frequent in diabetes patients, and single SNP-63 increases the susceptibility to type 2 diabetes. However, SNP-43 in calpain-10 and T45G and intron G276T in adiponectin gene were not significantly associated with diabetes, insulin resistance, nor insulin secretion.

Conclusion

Variations in calpain-10, SNP-63 seems to increase the susceptibility to type 2 diabetes in Koreans while SNP-43 and adiponectin SNP-45, -276 are not associated with impaired glucose metabolism.

Citations

Citations to this article as recorded by  
  • Decoding type 2 diabetes mellitus genetic risk variants in Pakistani Pashtun ethnic population using the nascent whole exome sequencing and MassARRAY genotyping: A case-control association study
    Asif Jan, Zakiullah, Sajid Ali, Basir Muhammad, Amina Arshad, Yasar Shah, Haji Bahadur, Hamayun Khan, Fazli Khuda, Rani Akbar, Kiran Ijaz, Giuseppe Novelli
    PLOS ONE.2023; 18(1): e0281070.     CrossRef
  • Silencing LncRNA PVT1 Reverses High Glucose-Induced Regulation of the High Expression of PVT1 in HRMECs by Targeting miR-128-3p
    Xuyang Wang, Wangling Chen, Wei Lao, Yunxin Chen
    Hormone and Metabolic Research.2022; 54(02): 119.     CrossRef
  • Association of CAPN10 (SNP-19) genetic polymorphism and obesity with T2DM: a study on Bengali Hindu caste population
    Pranabesh Sarkar, Diptendu Chatterjee, Arup Ratan Bandyopadhyay
    International Journal of Diabetes in Developing Countries.2021; 41(1): 37.     CrossRef
  • Association of Candidate Gene Polymorphism with Metabolic Syndrome among Mongolian Subjects: A Case-Control Study
    Ariunbold Chuluun-Erdene, Orgil Sengeragchaa, Tsend-Ayush Altangerel, Purevjal Sanjmyatav, Batnaran Dagdan, Solongo Battulga, Lundiamaa Enkhbat, Nyamjav Byambasuren, Munkhzol Malchinkhuu, Munkhtstetseg Janlav
    Medical Sciences.2020; 8(3): 38.     CrossRef
  • Meta-analysis of the association between adiponectin SNP 45, SNP 276, and type 2 diabetes mellitus
    Yuwei Dong, Gongping Huang, Xin Wang, Zhaoming Chu, Jingzhi Miao, Houwen Zhou, Mingqing Xu
    PLOS ONE.2020; 15(10): e0241078.     CrossRef
  • Association of three SNPs in adiponectin gene with lipid traits of Tianzhu Black Muscovy (Cairina moschata)
    Yuan-Yu Qin, Yi-Yu Zhang, Hua-Lun Luo, Lei Wu
    Molecular Biology Reports.2019; 46(1): 325.     CrossRef
Close layer
Effect of 17-beta Estradiol on Adipocyte Lipin-1 Expression in OLETF Rat.
Eun Seok Kang, In Sook Kim, Seok Jin Ko, Chul Hoon Kim, Sung Wan Chun, Chul Woo Ahn, Bong Soo Cha, Hyun Chul Lee
Endocrinol Metab. 2010;25(3):199-205.   Published online September 1, 2010
DOI: https://doi.org/10.3803/EnM.2010.25.3.199
  • 2,337 View
  • 22 Download
  • 1 Crossref
AbstractAbstract PDF
BACKGROUND
17 beta-estradiol is known to play an important role in glucose homeostasis. Lipin-1 is a nuclear protein that is essential in adipocyte differentiation and it is considered to play a role in ectopic fat deposition and the redistribution of fat. The aim of this study was to evaluate the effect of 17 beta-estradiol on the lipin-1 expression in the adipocytes of OLETF rats, which is an animal model of diabetes. METHODS: The OLETF rats were divided into 3 groups, 1) the sham-operation group (SHAM) 2) the castrated group (CAST) and 2) the castrated and estradiol treatment group (EST), and all the rats were at 6 weeks of age. LETO rats were used as a control group (LETO). 0.1 mg of estradiol valerate was injected subcutaneously every 4 weeks in the rats of the EST group. The visceral and subcutaneous tissues were isolated to evaluate the lipin-1 protein expression. The lipin-1 expression was measured in human visceral and subcutaneous preadipocytes. RESULTS: Less body weight gain was observed in the EST group compared with that of the SHAM group. In addition, improvement in the glucose tolerance was observed in the EST group. The lipin-1 expression in visceral fat was decreased in the SHAM and CAST groups, but it was but recovered in the EST group. The lipin-1 expression in the subcutaneous fat was decreased in the SHAM, CAST, and EST groups. CONCLUSION: Long term estradiol treatment in OLETF rats reduces the body weight gain and improves the glucose tolerance. Estradiol enhances the lipin-1 protein expression in the visceral adipocytes, but not in the subcutaneous adipocytes.

Citations

Citations to this article as recorded by  
  • Effect of 17-beta Estradiol on Adipocyte Lipin-1 Expression in OLETF Rat
    Seong-Kyu Lee
    Endocrinology and Metabolism.2010; 25(3): 177.     CrossRef
Close layer
Retraction: Expression of RET in Thyroid Diseases of a Korean Population.
Si Hoon Lee, Soon Won Hong, Woo Chul Moon, Myoung Ryur Oh, Jin Kyung Lee, Bong Soo Cha, Chul Woo Ahn, Kyung Rae Kim, Sung Kil Lim, Hyun Chul Lee
J Korean Endocr Soc. 2008;23(1):70.   Published online February 1, 2008
  • 1,228 View
  • 16 Download
Close layer
Retraction: Contributing Factors to Different Natural Courses of Posttansplantation Diabetes Mellitus in Renal Allograft Recipients.
Kyu Yeon Hur, Myoung Soo Kim, Jae Hyun Nam, Eun Seok Kang, Hyun Joo Lee, So Hun Kim, Bong Soo Cha, Chul Woo Ahn, Soon Il Kim, Yu Seun Kim, Hyun Chul Lee
J Korean Endocr Soc. 2007;22(6):479.   Published online December 1, 2007
DOI: https://doi.org/10.3803/jkes.2007.22.6.479
  • 1,697 View
  • 21 Download
PDF
Close layer
A Case of Turner's Syndrome with Transient Hypopituitarism.
Ji Sun Nam, Min Ho Cho, Jung Min Roh, Hai Jin Kim, Ji Eun Yoon, Han Young Jung, Jong Suk Park, Eun Seok Kang, Chul Woo Ahn, Bong Soo Cha, Eun Jig Lee, Sung Kil Lim, Kyung Rae Kim, Hyun Chul Lee
J Korean Endocr Soc. 2007;22(4):266-271.   Published online August 1, 2007
DOI: https://doi.org/10.3803/jkes.2007.22.4.266
  • 1,925 View
  • 19 Download
AbstractAbstract PDF
Turner's syndrome is characterized by short stature and gonadal dysgenesis, and it is often associated with various systemic manifestations, such as cardiovascular, renal, thyroidal, gastrointestinal, and musculoskeletal disorders. Though very rare, it can also be accompanied by hypopituitarism. It is important to give a meticulous medical attention to short females with gonadal dysgenesis so that neither disease is neglected or gets delayed diagnosis. In this case, Turner's syndrome and hypopituitarism were diagnosed almost simultaneously, but hypopiuitarism was transient, and the normal pituitary function was recovered spontaneously without any treatment. Initial sella MRI showed mild congenital hypoplastic hypopituitarism, and combined pituitary function test was compatible with hypopituitarism, but after 5 years, though growth hormone deficiency was still present, otherwise normal pituitary function was noted without any change in MRI. Herein, we are reporting a case of Turner's syndrome with transient idiopathic hypopituitarism with the review of literature.
Close layer
A Case of Autoimmune Hypoglycemia due to Insulin Antibody in Patient with End Stage Renal Disease.
Ji Ye Jung, Eun Seok Kang, Beom Seok Kim, Sung Wan Chun, Yumie Rhee, Chul Woo Ahn, Bong Soo Cha, Eun Jig Lee, Sung Kil Lim, Hyun Chul Lee
J Korean Endocr Soc. 2006;21(6):536-541.   Published online December 1, 2006
DOI: https://doi.org/10.3803/jkes.2006.21.6.536
  • 1,830 View
  • 18 Download
AbstractAbstract PDF
Fasting hypoglycemia results from several mechanisms. Autoimmune hypoglycemia is one of the rare causes of hypoglycemia, and characterized by hyperinsulinemia, fasting hypoglycemia and the presence of autoantibodies to insulin or insulin receptor. We report here on a 64-year-old male patient with autoimmune hypoglycemia with end stage renal disease. He had no history of diabetes or insulin use. He had experienced several severe hypoglycemic events. The serum C-peptide level was 7.48 ng/mL and the insulin concentration was 115.4 micro U/mL when the fasting plasma glucose level was 88 mg/dL. The insulin to glucose ratio was 5.42, which suggested the presence of insulinoma. Yet the radiologic studies, including magnetic resonance cholangiopancreatography, endoscopic ultrasonography and selective calcium stimulated venous sampling revealed no evidence of insulinoma. The insulin autoantibody level was 62 micro U/mL. Therefore, we could diagnosis the autoimmune hypoglycemia. The hypoglycemia was treated with prednisolone and the patient recovered from this. His insulin level decreased to 21.11 micro U/mL and the insulin autoantibody level decreased to 34 micro U/mL. Hypoglycemia in the hemodialysis patients is not uncommon. One should bear in mind autoimmune hypoglycemia as one of the causes of hypoglycemia in patients with no history of diabetes.
Close layer
Contributing Factors to Different Natural Courses of Posttansplantation Diabetes Mellitus in Renal Allograft Recipients.
Kyu Yeon Hur, Myoung Soo Kim, Jae Hyun Nam, Eun Seok Kang, Hyun Joo Lee, So Hun Kim, Bong Soo Cha, Chul Woo Ahn, Soon Il Kim, Yu Seun Kim, Hyun Chul Lee
J Korean Endocr Soc. 2006;21(5):373-381.   Published online October 1, 2006
DOI: https://doi.org/10.3803/jkes.2006.21.5.373
  • 2,288 View
  • 23 Download
  • 2 Crossref
AbstractAbstract PDF
BACKGROUND
New onset diabetes is a major complication after kidney transplantation. However, the natural course of posttransplantation diabetes mellitus (PTDM) remains unclear. The aim of this study was to demonstrate the detailed natural courses of PTDM according to the onset and persistency of hyperglycemia, and to investigate risk factors for development of different courses of PTDM in renal allograft recipients. METHODS: A total of 77 renal allograft recipients without previously known diabetes were enrolled and performed a serial 75 g oral glucose tolerance test at 0, 1, and 7 years after kidney transplantation. Patients were classified according to the onset and persistency of PTDM: early PTMD (E-PTDM), late PTDM (L-PTDM), persistent PTDM (P-PTDM), transient PTMD (T-PTDM), and non-PTDN (N-PTDM). RESULTS: The incidence of each group was as follows: E-PTDM, 39%; L-PTDM, 11.7%; P-PTDM, 23.4% T-PTDM, 15.6%; N-PTDM, 49.3%. Tacrolimus and female gender were associated with the development of E-PTDM. Among E-PTDM, age at transplantation was a high risk factor for the development of P-PTDM. Higher BMI at year1 was associated with the development of L-PTDM. CONCLUSION: Different risk factors were associated with various natural courses of PTDM. Since old age and female gender are not modifiable risk factors, it may be important to modify immunosuppressive therapy regimens for the prevention of E-PTDM and control of body weight for L-PTDM.

Citations

Citations to this article as recorded by  
  • Efficacy and Safety of Gemigliptin in Post-Transplant Patients With Type 2 Diabetes Mellitus
    Jaehyun Bae, Youjin Kim, Yongin Cho, Minyoung Lee, Ji-Yeon Lee, Yong-ho Lee, Byung-Wan Lee, Bong-Soo Cha, Dong Jin Joo, Kyu Ha Huh, Myoung Soo Kim, Yu Seun Kim, Eun Seok Kang
    Transplantation Proceedings.2019; 51(10): 3444.     CrossRef
  • Post-transplantation Diabetes Mellitus
    Kun-Ho Yoon
    Journal of Korean Endocrine Society.2006; 21(5): 370.     CrossRef
Close layer
The Relationship between the Leptin Concentration and the Small Dense Low Density Lipoprotein Cholesterol Concentration in Korean Type 2 Diabetic Patients.
Wan Sub Shim, Hae Jin Kim, Eun Seok Kang, Yu Mie Rhee, Chul Woo Ahn, Sung Kil Lim, Hyun Chul Lee, Bong Soo Cha
J Korean Endocr Soc. 2006;21(4):319-327.   Published online August 1, 2006
DOI: https://doi.org/10.3803/jkes.2006.21.4.319
  • 2,220 View
  • 22 Download
  • 2 Crossref
AbstractAbstract PDF
BACKGROUND
Leptin has been suggested as a possible cause of atherosclerotic disease. The small dense low-density lipoprotein cholesterol (LDL-C) has also been regarded as a new surrogate marker in atherosclerotic disease. The aim of this study was to evaluate the relationship between the leptin concentration and the small dense LDL-C concentration in Korean type 2 diabetic patients. METHODS: One hundred-ninety one type 2 diabetic patients, who did not use any medication that could affect the concentration of lipid such as statin, fibrate, thiazolidinediones and corticosteroid, were enrolled in this study. We analyzed the relationship between leptin, the small dense LDL-C and the other metabolic parameters. RESULTS: The small dense LDL-C concentrations were higher in the group with the highest tertile of the leptin value, both in males and females than those patients in the group with the lowest tertile of the leptin value. The small dense LDL-C concentrations were also higher in the group with the highest tertile of leptin divided by the BMI value both in males and females than those patients in the group with the lowest tertile of the leptin value. The leptin concentration was positively correlated with the small dense LDL-C, total cholesterol, triglyceride, LDL-C, insulin and HOMAIR values after adjusting for age, gender and BMI. CONCLUSION: The association between leptin and small dense LDL-C could be a factor that explains the association between leptin and cardiovascular disease.

Citations

Citations to this article as recorded by  
  • Relationships among Serum Adiponectin, Leptin and Vitamin D Concentrations and the Metabolic Syndrome in Farmers
    Seo-Eun Yeon, Hee-Ryoung Son, Jung-Sook Choi, Eun-Kyung Kim
    Korean Journal of Community Nutrition.2014; 19(1): 12.     CrossRef
  • The Effect of Visceral Fat Area and Adipocytokines on Acute Myocardial Infarction: A Case-Control Study in Adult Korean Population
    Kang-Kon Lee, Young-Sung Suh, Keun-Sang Yum
    The Korean Journal of Obesity.2012; 21(1): 57.     CrossRef
Close layer
A Case of Patient with Opioid-Induced Adrenocortical Insufficiency and Hypogonadism.
Hai Jin Kim, Chul Sik Kim, Jong Suk Park, Jina Park, Eun Seok Kang, Chul Woo Ahn, Bong Soo Cha, Sung Kil Lim, Kyung Rae Kim, Hyun Chul Lee
J Korean Endocr Soc. 2006;21(3):257-260.   Published online June 1, 2006
DOI: https://doi.org/10.3803/jkes.2006.21.3.257
  • 2,015 View
  • 21 Download
AbstractAbstract PDF
Opioids are known to decrease plasma cortisol and testosterone level in human and other mammals. Nowadays, opioid use is exponentially increasing, but little is known about its side effects. With the help of progressive human science, we can habit longer life and as result, are becoming more avid for healthy life. In this respect, analgesics play important role in maintaining good and healthy quality of life. For this reason, it is important to fully understand its side effects and handle it with special precaution. We are reporting a 22-year-old male who had been taken opioid analgesic for more than six years to relieve chronic, intractable headache. Then, his hormone test revealed hypogonadotropic hypogonadism combined with hypoadrenocorticotropic hypoadrenalism but showed no definite clinical features except for sexual frigidity. After two years of oxycodon discontinuation, we reevaluated that his hormone test, and all other laboratory tests returned to the normal range.
Close layer
Reversible Pituitary Dysfunction in a Patient with Cushing's Syndrome due to Adrenal Adenoma.
Jee Hyun Kong, Kyung Wook Kim, Hei Jin Kim, Ji Sun Nam, Jin A Park, Jong Sook Park, Chul Sik Kim, Byung Soo Moon, Soon Won Hong, Chul Woo Ahn, Kyung Rae Kim
J Korean Endocr Soc. 2006;21(2):146-152.   Published online April 1, 2006
DOI: https://doi.org/10.3803/jkes.2006.21.2.146
  • 1,834 View
  • 23 Download
AbstractAbstract PDF
A 45-year-old woman who complained of weight gain and irregular menstruation was diagnosed as having Cushing's syndrome due to a 3 cm sized left adrenal adenoma. She underwent left adrenalectomy, and she also underwent combined anterior pituitary tests before and 9 months after the surgery. The growth hormone and adrenocorticotropic hormone levels failed to respond to hypoglycemia before the surgery, but their responses recovered after the surgery. Cortisol and thyroid stimulating hormone failed to respond to hypoglycemia and thyrotropin releasing hormone (TRH) before the surgery, respectively, but these were improved after the surgery. Luteinizing hormone, follicle stimulating hormone, and prolactin adequately responded to gonadotropin-releasing hormone and TRH, respectively, before and after the surgery. However, the basal levels of these hormones were higher after adrenalectomy, suggesting that hypercortisolemia had a significant influence on all the pituitary hormones.
Close layer
A Case of Multiple Endocrine Neoplasia Type 1 with Papillary Thyroid Carcinoma.
Hai Jin Kim, Chul Sik Kim, Hyun Chul Je, Jina Park, Jong Suk Park, Jee Hyun Kong, Eun Seok Kang, Chul Woo Ahn, Bong Soo Cha, Sung Kil Lim, Kyung Rae Kim, Hyun Chul Lee, Hang Suk Jang, Soon Won Hong
J Korean Endocr Soc. 2006;21(1):79-84.   Published online February 1, 2006
DOI: https://doi.org/10.3803/jkes.2006.21.1.79
  • 2,062 View
  • 21 Download
  • 1 Crossref
AbstractAbstract PDF
This is the first report of papillary thyroid carcinoma combined with multiple endocrine neoplasia type 1 (MEN 1). It is an hereditary syndrome characterized by neoplastic disorders such as pituitary adenoma, parathyroid adenoma or hyperplasia and pancreatic neuroendocrine tumor, such as gastrinoma just like in our case. But sometimes pheochromocytoma, mucosal ganglioneuromas, lipoma, forgut carcinoid and thyroid disease could be accompany the disease, but coincidental papillary thyroid carcinoma was never reported before in Korea. Herein we represent a 39-year-old woman who manifested typical features of MEN 1 with coincidental papillary thyroid carcinoma. Despite with definite family history of MEN 1, her genetic analysis of DNA had not found any germline mutation in MEN 1 gene. Unidentified culprit gene unable further genetic study of finding LOH (loss of heterogeneity) in 11q13, the possible explanation of papillary thyroid carcinoma as a new component of MEN 1. As we have experienced a case of MEN 1 combined with papillary thyroid carcinoma, we report it with the review of literature.

Citations

Citations to this article as recorded by  
  • A Case of Multiple Endocrine Neoplasia Type I with Atypical Clinical Course
    Yun Sun Choi, Youn Sun Bai, Bon Jeong Ku, Young Suk Jo, Young Kun Kim, Heung Kyu Ro, Minho Shong
    Journal of Korean Endocrine Society.2008; 23(4): 266.     CrossRef
Close layer
A Case of Acromegaly Caused by Double Pituitary Adenomas.
Hai Jin Kim, Chul Sik Kim, Jong Suk Park, Jina Park, Jee Hyun Kong, Ji Sun Nam, Chul Woo Ahn, Bong Soo Cha, Sung Kil Lim, Kyung Rae Kim, Hyun Chul Lee, Soon Won Hong
J Korean Endocr Soc. 2006;21(1):53-57.   Published online February 1, 2006
DOI: https://doi.org/10.3803/jkes.2006.21.1.53
  • 2,153 View
  • 23 Download
AbstractAbstract PDF
Acromegaly is a clinical syndrome, which is caused by an excess of growth hormone (GH), most commonly secreted from a pituitary solitary adenoma. However, our patient had bilateral GH-secreting pituitary tumors, the incidence of which has been reported in only 1.3 to 1.69% of all acromegalic patients. A 59-year-old female, with no family history of pituitary adenomas, demonstrated an increased level of serum insulin-like growth factor-1 (IGF-1), and GH not suppressed after 75 g oral glucose loading. On a preoperative MRI, only one pituitary tumor, measuring 1.1 x 0.7 cm, could be observed using sellar MRI. After surgical resection of the tumor, her headache and myalgia were sustained, and the IGF-1 level was still in a high titer. Therefore, a follow-up sellar MRI was taken, and a 0.6 x 0.7 cm sized newly growing pituitary tumor was found on the other side. With a retrospective review of radiological examinations, the patient was found to have bilateral tumors. The 0.3 cm sized tumor on the left was too small to be detected on the preoperative MRI. As the patient preferred medical treatment after surgery, she was treated with sandostatin analogues. Acromegaly with bilateral GH-secreting pituitary tumors, is a very rare disease, with no previous case having been reported in Korea. Herein, we report the case with a review of the literature.
Close layer
A Case of Acromegaly with Gall Bladder Cancer.
Ji Sun Nam, Chul Sik Kim, Jee Hyun Kong, Hai Jin Kim, Jin A Park, Jong Suk Park, Chul Woo Ahn, Se Joon Lee, Bong Soo Cha, Sung Kil Lim, Kyung Rae Kim, Hyun Chul Lee
J Korean Endocr Soc. 2005;20(4):401-406.   Published online August 1, 2005
DOI: https://doi.org/10.3803/jkes.2005.20.4.401
  • 1,975 View
  • 24 Download
AbstractAbstract PDF
Acromegaly is a systemic endocrine disorder due to an excessive release of growth hormone, which increases the serum levels of insulin-like growth factor-1(IGF-1). Elevated levels of these hormones are assumed to increase the incidence of malignant tumors in patients with acromegaly, due to by stimulating the growth and maturation of cells. In particular, IGF-1 is considered to be closely related with the development of colon polyps and colon cancers. Studies suggest that various malignant tumors, including thyroid cancer, brain tumor and renal cell carcinomas, are also more common in patients with acromegaly. Here, a case of gall bladder cancer in a patient with acromegaly, and the possible relationships between these two disorders, is reported.
Close layer
The Effect of Treatment Modalities on Survival Rates of Patients with Anaplastic Thyroid Carcinoma.
Jae Myoung Choi, Mi Jeong Kim, Seung Won Lee, Kyoung Eun Song, Yoon Sok Chung, Kwan Woo Lee, Dae Jung Kim, Sung Hee Choi, So Hun Kim, Min Ho Cho, Yumie Rhee, Chul Woo Ahn, Sung Kil Lim, Kyung Rae Kim
J Korean Endocr Soc. 2005;20(2):127-133.   Published online April 1, 2005
DOI: https://doi.org/10.3803/jkes.2005.20.2.127
  • 2,033 View
  • 18 Download
  • 1 Crossref
AbstractAbstract PDF
BACKGROUND
Anaplastic thyroid carcinoma represents 2% to 5% of all thyroid cancers and it is one of the most aggressive human cancers. Local extension at the time of diagnosis and distant metastases are almost always the rule. Its lethality is evidenced by a 5-year survival rate of 3.6% and a median survival time of 4 months. We retrospectively reviewed patients with this disease at 4 tertiary referral centers. METHODS: From 1990 to 2003, 19 cases(9 men and 10 women, mean age: 65.1+/-7.1 years) of anaplastic thyroid carcinoma were reviewed via the medical records. The overall survival rates according to the prognostic factors and the treatment modalities were analyzed. RESULTS: The presenting symptoms included rapidly enlarged neck masses in 16 patients, shortness of breath in 3 patients, hoarseness in 4 patients, dysphagia in 2 patients and chest wall pain in 1 patient. The mean diameter of tumor was 7.2cm. Local extension was seen in all of the cases that had undergone surgery. Distant metastases(lung 6, bone 2, abdominal carcinomatosis 2, brain 1 and mediastinum 1) were seen in 9 patients. Surgical treatment was performed in 10 patients. Radiotherapy was performed in 9 patients and chemotherapy was done in 5 patients; radiotherapy was performed alone in 2 patients, combination chemo-radiotherapy was performed in 3 patients, postoperative radiotherapy was performed in 2 patients and postoperative combination chemo-radiotherapy was performed in 2 patients. 4 patients were treated cons ervatively after the confirmative diagnosis. The overall median survival time was 123 days(range: 23~621 days); the median survival time was 129 days in the treatment group(n=15), and 27 days in the no treatment group (n=4), and significantly higher survival rates were observed for the treated patients(p=0.02). According to the treatment modalities, patients who underwent surgical treatment and postoperative radiotherapy and/or chemotherapy were observed to have significantly higher survival rates than patients in the radiotherapy and/or chemotherapy group(p=0.03), and also than those patients in the surgical treatment only group(p=0.04). CONCLUSION: We found that aggressive surgical treatment and postoperative radiotherapy and/or chemotherapy improved the survival rates of patients with anaplastic thyroid carcinoma even though local invasion and distant metastases was generally observed to occur

Citations

Citations to this article as recorded by  
  • Anaplastic Thyroid Carcinoma: Experience of a Single Institute
    Dongbin Ahn, Jin Ho Sohn
    Korean Journal of Otorhinolaryngology-Head and Neck Surgery.2012; 55(1): 37.     CrossRef
Close layer
A Case of Multiple Endocrine Neoplasia Type 1 with Mutation in MENIN Gene.
Se Eun Park, Eun Seok Kang, Hyun Joo Lee, So Hun Kim, Mi Young Do, Shin Ae Kang, Seung Jin Han, Hyeong Jin Kim, Chul Woo Ahn, Bong Soo Cha, Sung Kil Lim, Kyung Rae Kim, Il Jin Kim, Hyun Chul Lee
J Korean Endocr Soc. 2005;20(1):71-77.   Published online February 1, 2005
DOI: https://doi.org/10.3803/jkes.2005.20.1.71
  • 2,423 View
  • 22 Download
  • 6 Crossref
AbstractAbstract PDF
Multiple endocrine neoplasia type 1(MEN 1) is an autosomal dominantly inherited syndrome, characterized by the combined occurrence of tumors of the parathyroid glands, endocrine pancreas, and anterior pituitary gland. The MENIN gene, which is a kind of tumor suppressor gene, is located at the chromosomal locus 11q13. It consists of one untranslated exon and nine exons encoding the menin protein. We report a case of a 22-yearss-old woman with MEN type 1, who was proven to have a mutation in the MENIN gene. The patient was admitted because of repeated hypoglycemia. The fasting plasma glucose level was 32mg/dL. Seventy two hours fasting test showed an the insulin/glucose ratio as 0.33. Endoscopic ultrasonography detected multiple masses on the pancreas. The arterial -stimulated venous sampling(ASVS) with calcium showed sudden step up of insulin at the head and tail portions of the pancreas. The sellar MRI showed a pituitary mass that produced prolactin. Instead of a pathologic diagnosis from operational specimen, the genetic analysis revealed a mutation in the MENIN 1 gene(exon 2, 200~201insAGCCC).

Citations

Citations to this article as recorded by  
  • Genetic and Epigenetic Analysis in Korean Patients with Multiple Endocrine Neoplasia Type 1
    Yoon Jung Chung, Sena Hwang, Jong Ju Jeong, Sun Yong Song, Se Hoon Kim, Yumie Rhee
    Endocrinology and Metabolism.2014; 29(3): 270.     CrossRef
  • A Case of Familial Multiple Endocrine Neoplasia Type 1 with a Novel Mutation in theMEN1Gene
    Min Jung Kim, Eun Hee Kim, Mi-Seon Shin, Joo Hui Kim, Hee Kyung Na, Seong Joon Park, Sang Ah Lee, Eun Hee Koh, Woo Je Lee, Ki Ho Song, Joong-Yeol Park, Ki-Up Lee, Gu-Hwan Kim, Han-Wook Yoo, Min-Seon Kim
    Endocrinology and Metabolism.2011; 26(2): 171.     CrossRef
  • Somatic Mutational Analysis of MEN1 and Phenotypic Correlation in Sporadic Parathyroid Tumors
    Young Su Chae, Hee Jin Kim, Sun Wook Kim, Myung-Chul Chang
    Journal of the Korean Surgical Society.2009; 76(1): 15.     CrossRef
  • Multiple Endocrine Neoplasia Type 1 with Multiple Leiomyomas Linked to a Novel Mutation in the MEN1 Gene
    Heekyoung Choi, Sehyun Kim, Jae-Hoon Moon, Yoon Hee Lee, Yumie Rhee, Eun Seok Kang, Chul Woo Ahn, Bong Soo Cha, Eun Jig Lee, Kyung Rae Kim, Hyun Chul Lee, Seon Yong Jeong, Hyun Ju Kim, Sung-Kil Lim
    Yonsei Medical Journal.2008; 49(4): 655.     CrossRef
  • A Case of Familial Multiple Endocrine Neoplasia Type 1 with MEN1 Gene Mutation
    Young Eun Jo, Yong-Jun Choi, Yun Kyung Kim, Sang Mi Ahn, Sun Hye Jung, Hae Jin Kim, Dae Jung Kim, Kwan Woo Lee, Ji-Hee Hong, Seon-Yong Jeong, Hyon J Kim, Yoon-Sok Chung
    Journal of Korean Endocrine Society.2007; 22(1): 68.     CrossRef
  • A Case of Familial Multiple Endocrine Neoplasia with MEN1 Gene Mutation
    Hye-Young Sung, Yeon-Joo Chun, Hyeug Lee, Bum Jun Kwon, Kun Woo Park, Jung Min Lee, Sung Dae Moon, Sang Ah Chang, Je-Ho Han
    Journal of Korean Endocrine Society.2006; 21(6): 560.     CrossRef
Close layer
Adiponectin Gene Polymorphism and Carotid Artery Intima-Media thickness in Type 2 Diabetes.
Eun Seok Kang, So Young Park, So Hun Kim, Hyun Joo Lee, Kyu Yeon Hur, Seung Jin Han, Se Eun Park, Hyeong Jin Kim, Chul Woo Ahn, Bong Soo Cha, Sung Kil Lim, Kyung Rae Kim, Hyun Chul Lee
J Korean Endocr Soc. 2005;20(1):29-39.   Published online February 1, 2005
DOI: https://doi.org/10.3803/jkes.2005.20.1.29
  • 1,954 View
  • 18 Download
AbstractAbstract PDF
BACKGROUND
The aim of this study was to examine the association between the common polymorphisms of the adiponectin gene(ACDC) and the intima-media thickness(IMT) of the common carotid arteries in type 2 diabetic patients. METHODS: The B mode ultrasound examination of carotid artery was performed on 133 type 2 diabetic patients. The carotid IMT was calculated using the Intimascope computer program. The SNP45 and SNP276 of the ACDC were examined. RESULTS: There was no significant difference in the carotid IMT among the SNP45 genotypes(0.66+/-0.18mm for TT, 0.71+/-0.12mm for TG and 0.64+/-0.15mm for GG, P=NS). Subjects carrying the SNP276 GG genotype had a markedly lower serum adiponectin concentration than those carrying the TT genotype(3.35+/-2.00microgram/mL vs. 4.98+/-2.24microgram/mL, P=0.029) The carotid IMT was significantly higher in patients with the SNP276 GG genotype than those with the TT genotype (0.70+/-0.17mm vs. 0.59+/-0.13mm, P=0.032). Patients with the +45GG/+276GG genotype combination showed significantly higher mean carotid IMT than the other genotype combinations(0.78+/-0.09mm vs. 0.71+/-0.15mm, P=0.013) CONCLUSIONS: These results suggest that the adiponectin gene, SNP276 is associated with the carotid IMT in type 2 diabetic patients. Further studies are will be needed to confirm these genotypephenotype associations.
Close layer
A Case of Follicular Thyroid Carcinoma Developed in Pendred Syndrome.
So Hun Kim, Ji Young Jung, Sung Jae Shin, So Young Park, Si Hoon Lee, Yoo Mee Kim, Yu Mie Rhee, Soon Won Hong, Bong Soo Cha, Chul Woo Ahn, Kyung Rae Kim, Sung Kil Lim, Hyun Chul Lee
J Korean Endocr Soc. 2004;19(4):411-418.   Published online August 1, 2004
  • 1,166 View
  • 22 Download
AbstractAbstract PDF
Pendred syndrome is an autosomal recessive genetic disorder, which is characterized by sensorineural hearing loss, goiter and a positive perchlorate discharge test. It is caused by mutations of the PDS gene, and its clinical characteristics vary widely. The thyroid function in most cases is normal, or shows only mild hypothyroidism. In Pendred syndrome, there is an organification defect that leads to defective thyroid hormone synthesis, followed by chronic TSH stimulation. Herein is reported a case of a follicular thyroid carcinoma associated with Pendred syndrome. To our knowledge, this is the first case reported in Korea. The patient presented with a huge anterior neck mass, sensorineural hearing loss and a positive perchlorate discharge test. Fine needle aspiration cytology suggested malignancy of the thyroid, and a total thyroidectomy, with central compartment node dissection, was performed. The pathology from the thyroid mass showed a poorly differentiated follicular thyroid carcinoma
Close layer
A Case of Hepatomegaly due to Diabetic Glycogenosis Reversed by Glycemic Control.
Jina Park, Dae Hoon Song, Jong Suk Park, Joo Young Nam, Chul Sik Kim, Dol Mi Kim, Chul Woo Ahn, Bong Soo Cha, Sung Kil Lim, Kyung Rae Kim, Hyun Chul Lee, Hae Ryoung Kim, Chan Il Park
J Korean Endocr Soc. 2004;19(2):223-228.   Published online April 1, 2004
  • 1,240 View
  • 24 Download
AbstractAbstract PDF
Diabetes mellitus is well known to be associated with various structural and functional liver abnormalities. If diabetic patients are accompanied by hepatomegaly or abnormal findings from a liver function test, the most common pathological findings are steatosis and glycogenosis. The steatosis is characterized by deposition of macrovesicular fat droplets in the hepatocytes, which is common in obese, type 2 diabetes mellitus. If macrovesicular steatosis is combined with mixed inflammatory infiltrate, without evidence of alcoholic hepatitis, the case could be diagnosed as nonalcoholic steatohepatitis (NASH). NASH has the possibility of progressing to cirrhosis. Secondary glycogenosis is common in uncontrolled type 1 diabetes mellitus, and is completely reversible. A 22-year-old male, with uncontrolled type 1 diabetes mellitus, was admitted with anorexia, nausea and right upper quadrant pain. Hepatomegaly and elevated aminotransferases were noted. He was diagnosed as diabetic glycogenosis using computed tomogram and liver biopsy. The hepato megaly and liver function test abnormalities were markedly improved with glycemic control
Close layer
Relationship with Serum Adiponectin Concentrations and Obesity in Korean Children.
Hyoun Ah Kim, Hyoung Suk Lee, Chul Sik Kim, Chul Woo Ahn, Yoon Sok Chung, Kwan Woo Lee, Kap Bum Huh, Dae Jung Kim
J Korean Endocr Soc. 2003;18(5):473-480.   Published online October 1, 2003
  • 1,302 View
  • 20 Download
AbstractAbstract PDF
BACKGROUND
Adiponectin is an adipocytokine that is highly specific to adipose tissue. In contrast to other adipocytokine, the adiponectin levels are decreased in obesity and/or type 2 diabetes. There are few studies regarding the correlation between the adiponectin concentration and obesity in children. Thus, whether the serum adiponectin concentrations are associated with adiposity in children was investigated. METHODS: One hundred and sixty four subjects were selected from the participants in an ongoing study on the relationship between birth weight and insulin resistance in children. The current weights, heights, body fat percentages, waist circumferences, blood pressures, lipid profiles and insulin resistance, by the HOMA method, were measured in all the subjects. The serum adiponectin concentrations were determined by a validated sandwich ELISA, using a human adiponectin-specific antibody. RESULTS: The serum adiponectin concentration was negatively correlated with the body mass index, waist circumference, systolic blood pressure, insulin resistance by HOMA and serum triglycerides, and positively correlated with the serum HDL cholesterol level. The serum adiponectin concentrations in the boys were significantly lower than in the girls. In a multiple regression analysis, the serum adiponectin concentration was strongly associated with waist circumference and gender. CONCLUSION: It is concluded that there was an inverse relationship between the serum adiponectin concentration and abdominal adiposity in children. However, further studies on independent gender differences on adiponectin are needed.
Close layer
A Case of Riedel's Thyroiditis in a Patient with a History of Subacute Thyroiditis.
Chul Sik Kim, Sung Ju Lee, Jong Suk Park, Joo Young Nam, Dol Mi Kim, Chul Woo Ahn, Bong Soo Cha, Sung Kil Lim, Kyung Rae Kim, Hyun Chul Lee
J Korean Endocr Soc. 2003;18(4):414-419.   Published online August 1, 2003
  • 1,295 View
  • 21 Download
AbstractAbstract PDF
Riedel's thyroiditis is a rare form of chronic thyroiditis, characterized by a fibroinflammatory process which partially destroys the thyroid, often involving surrounding tissues. The relationship of Riedel's thyroiditis to other forms of thyroiditis is not clear. A case of Riedel's thyroiditis in a 51-year-old female patient, admitted with a previous diagnosis of subacute thyroiditis, is reported. She was first diagnosed with subacute thyroiditis based on clinical manifestation and radiologic and laboratory results. She was treated with glucocorticoid for 8 weeks. The follow-up lasted for 12 months. However, three years later she underwent a thyroidectomy operation due to an enlargement of the thyroid nodule and suspicion of malignancy. Histopathologic examination confirmed that she had Riedel's Thyroiditis. Until now, few case of Riedel's thyroiditis in patients with a history of subacute thyroiditis have been reported in the literature. Although the etiology of Riedel's thyroiditis is unknown, it may develop in the course of subacute thyroiditis.
Close layer
A Case of Adrenal Cortical Carcinoma with Liver Metastasis.
Hyun Joo Lee, Myung Soo Kim, Hyo Kyoung Park, Dae Jung Kim, Yu Mie Rhee, Chul Woo Ahn, Jae Hyun Nam, Bong Soo Cha, Young Duk Song, Sang Won Han, Sung Kil Lim, Kyung Rae Kim, Hyun Chul Lee, Kap Bum Huh
J Korean Endocr Soc. 2003;18(2):232-238.   Published online April 1, 2003
  • 1,517 View
  • 20 Download
AbstractAbstract PDF
An adrenal cortical carcinoma is a rare malignancy associated with poor prognosis. On diagnosis, most patients present with large tumor masses, which are often detected at an advanced stage. The most effective treatment is a complete resection, which is the only curative treatment for adrenal cortical carcinomas. The most important prognostic factor is a successful resection of the primary tumor, as long as it is low-grade and has not spread to distant sites. However, with advanced adrenal cortical carcinomas, with distant metastasis, there is no strict effective treatment program, and the prognosis is poor. The case of a 50-year-old female patient, presenting with an adrenal cortical carcinoma and Cushing's syndrome, who had a long-term survival of 78 months, is reported. The mass was completely resected on diagnosis, but 16 months later liver metastasis was discovered. She had received chemotherapy, with cisplatin, etoposide and bleomycin, for the liver metastasis for a period of 15 months, but with no response, furthermore, the size had increased after 10 months. Afterward, she received her 10th session of intrahepatic artery cisplatin chemotherapy and her 3rd hepatic artery embolization. Although the patient had a large degree of liver metastasis, this was tolerated. The tumor mass is presently not aggravated, and she still survives after 78 months.
Close layer
Association between Serum Leptin Concentration and Bone Mineral Density in Healthy Korean Women.
Yumie Rhee, Dae Jung Kim, Se Hwa Kim, Chul Woo Ahn, Bong Soo Cha, Kyung Rae Kim, Hyun Chul Lee, Sung Kil Lim
J Korean Endocr Soc. 2003;18(2):177-183.   Published online April 1, 2003
  • 1,279 View
  • 20 Download
AbstractAbstract PDF
BACKGROUND
Leptin is known to affect bone metabolism both centrally and peripherally. This study was performed to investigate the relationship between leptin and bone mineral density(BMD) in healthy premenopausal and postmenopausal Korean women. METHODS: 140 women were recruited for a routine health check-up. Anthro-pometric and biochemical data were checked as usual. BMDs were measured by dual x-ray absorptiometry of the spine and femur in 67 premenopausal women and 73 postmenopausal women, in addition to their serum leptin levels. RESULTS: Serum leptin level showed no correlation with BMD in premenopausal women, but there was a positive correlation betwen serum leptin and spinal BMD in postmenopausal women(r=0.468, p<0.001). After the correcting for age, body mass index, and duration of menopause, the serum leptin level and BMD still showed a positive correlation(r=0.217, p=0.088) although weak. The women in the lowest quartile of serum leptin level showed significantly lower lumbar and femoral neck BMD. CONCLUSION: Leptin level seems to have a weak relationship with BMD showing different features in premenopausal and postmenopausal women.
Close layer
Expression of RET in Thyroid Diseases of a Korean Population.
Si Hoon Lee, Soon Won Hong, Woo Chul Moon, Myoung Ryur Oh, Jin Kyung Lee, Bong Soo Cha, Chul Woo Ahn, Kyung Rae Kim, Sung Kil Lim, Hyun Chul Lee
J Korean Endocr Soc. 2003;18(2):140-152.   Published online April 1, 2003
  • 1,333 View
  • 22 Download
AbstractAbstract PDF
BACKGROUND
Activation of the RET proto-oncogene, located on the long arms of chromosome 10, contributes to the development of thyroid cancers in two different ways. Somatic rearrangements of RET with variable genes of activation are frequently found in papillary thyroid carcinomas. And Ggerm-line point mutations are responsible for the development of medullary thyroid carcinoma and the multiple endocrine neoplasia type 2(MEN2). There are several conflicting reports on the influences of RET expression and RET/PTC rearrangements on the clinical outcome of thyroid cancer. Therefore, we performed an examination of RET expression and RET/PTC-1, -2, -3 rearrangements in papillary thyroid carcinomas and other thyroid diseases. METHODS: Twenty-six papillary thyroid carcinomas(PTCs), three follicular thyroid carcinomas (FTCs), one anaplastic thyroid carcinoma(ATC), five follicular adenomas(FAs), nineteen hyperplasias, and two normal thyroid tissues were included in this study. RT-PCR and immunohistochemistry analysis were done to identify RET gene, RET/PTC rearrangements, and ret RET protein expression. RESULTS: By RT-PCR, 89.4% of PTCs, 100% of FTCs, and 62.1% of hyperplasias expressed the RET gene, but no RET was observed in ATCs, FAs, and normal thyroid tissues. RET/PTC-1, -2,-3 rearrangements were not detected in any specimens. Immunohistochemical results revealed that 76.9% of PTCs, 50% of FAs, 52.3% of hyperplasias, and 20.6% of normal thyroid tissues expressed the RET ret protein, but FTCs and ATCs did not. Most PTCs showed strong cytoplasmic positivity in RET ret immunostaining, but the positive non- PTCs expressed weak and membranous staining. Overall, the two methods for detecting RET gene, RT-PCR and immunohistochemistry showed similar results. CONCLUSION: The RET gene was highly expressed in PTCs. In contrast to the previous reports of that theRET gene expression of RET gene is being limited to PTCs, RET was also expressed in hyperplasias, Fas, and normal thyroid tissues. However, the pattern and the degree of expression of the RET ret protein in non- PTCs were are different from those in PTCs.
Close layer
A Case of AVP Dependent Bilateral Macronodular Adrenal Hyperplasia.
Hyun Jin Kim, Se Hwa Kim, Yu Mie Rhee, Sung Eun Kim, Chul Woo Ahn, Bong Soo Cha, Kyung Rae Kim, Hyun Chul Lee, Kap Bum Huh, Sung Kil Lim
J Korean Endocr Soc. 2002;17(4):603-609.   Published online August 1, 2002
  • 1,199 View
  • 19 Download
AbstractAbstract PDF
Adrenocorticotropin (ACTH) independent bilateral macronodular adrenal hyperplasia (AIMAH) is a rare form of Cushing's syndrome, in which unique endocrinological, clinical and histopathological features have been described. In AIMAH, cortisol secretion is autonomous and independent of ACTH, thus plasma ACTH levels are persistently suppressed. Various etiological mechanisms have been proposed to explain the development of AIMAH, the development of aberrant adrenal sensitivity to gastric inhibitory polypeptide (GIP), vasopressin, beta-adrenergic receptor agonists or the presence of circulating adrenal stimulating immunoglobulins have been suggested. We report on a 46-year-old female who had Cushing's syndrome, due to AIMAH, with a positive response to vasopressin.
Close layer
A Case of Klinefelter's Syndrome with Rathke's Cleft Cyst.
Hyun Joo Lee, Hyo Kyoung Park, Dae Jung Kim, Yu Mie Rhee, Chul Woo Ahn, Sang Soo Jung, Jae Hyun Nam, Bong Soo Cha, Young Duk Song, Sung Kil Lim, Kyung Rae Kim, Yong Koo Park, Hyun Chul Lee, Kap Bum Huh
J Korean Endocr Soc. 2002;17(4):564-571.   Published online August 1, 2002
  • 1,228 View
  • 24 Download
AbstractAbstract PDF
Klinefelter's syndrome is one of the most common forms of primary hypogonadism presenting with gynecomastia, azospermia and increased follicle-stimulating hormone. It is well known that this syndrome has an increased incidence of neoplasia, especially breast cancer and extragonadal germ cell tumors. However, it is rarely associated with an intracranial tumor of maldevelopmental origin, especially in the suprasellar area. We report, for the first time, a case of Klinefelter's syndrome, with a Rathke's cleft cyst is the patient was a 32-year-old male who was known to have an incidentaloma form brain computed tomography, which was clinically diagnosed as a suprasellar tumor. After operating, the suprasellar mass was confirmed as a Rathke's cleft cyst, and his hormonal abnormality, an elevated level of follicle-stimulating hormone, was not normalized. Therefore, we performed chromosomal analysis, and diagnosed Klinefelter's syndrome with the XXY karyotype.
Close layer
Effects of Tibolone and Active Vitamin D Combined Treatment on Bone Mineral Density in Korean Postmenopausal Women.
Se Hwa Kim, Yu Mie Rhee, Soo Kyung Kim, Dae Jung Kim, Hyeung Jin Kim, Chul Woo Ahn, Bong Soo Cha, Young Duk Song, Kyung Rae Kim, Hyun Chul Lee, Gap Bum Huh, Sung Kil Lim
J Korean Endocr Soc. 2002;17(4):535-543.   Published online August 1, 2002
  • 1,230 View
  • 23 Download
AbstractAbstract PDF
BACKGROUND
Tibolone is a novel synthetic compound with tissue-specific effects in bone, breast tissue and the endometrium. Tibolone, and active vitamin D, effectively prevent bone loss, and the maintain skeletal integrity of postmenopausal women. The aim of the present study was to examine the effect of tibolone, and active vitamin D (1-hydroxyvitamin D3), therapies given alone, or in combination, against bone loss in postmenopausal women. METHODS: One hundred and three postmenopausal women were treated with tibolone (n=40), alphacalcidol (n=27) or both drugs (n=36) for 12 months. All subjects took supplemental calcium carbonate (500 mg daily). The bone mineral densities (BMD) of the lumbar spine and proximal femur were measured by dual-energy x-ray absorptiometry (DXA) at the baseline and after 12 months. RESULTS: Tibolone therapy produced significant increase of 4.1 and 1.8% in the BMD at the lumbar spine (p<0.001) and femoral neck (p=0.009), respectively. The combination of tibolone and active vitamin D increased the BMD by 8.0 and 4.4% (p<0.001) at the spine and femoral neck, respectively. The differences in the change of BMD from the baseline at the lumbar spine was significant (p=0.038) in the combination treatment group compared that in the tibolone alone group. CONCLUSION: Tibolone alone, and in combination with active vitamin D, effectively increased the BMD at all skeletal sites in postmenopausal women. Combination treatment for osteoporosis is emerging as a promising modality in Korean postmenopausal women.
Close layer
A Case of Adult Fanconi's Syndrome with Glomerular Podocyte Foot Process Effacement and osteomalacia Induced by k Light Chain Disease.
Jae Hyun Nam, Gyu Hyun Choi, Ki Hyun Park, Chul Woo Ahn, Young Duk Song, Sung Kil Lim, Hyun Chul Lee, Kap Bum Huh
J Korean Endocr Soc. 2000;15(4-5):627-633.   Published online January 1, 2001
  • 1,013 View
  • 17 Download
AbstractAbstract PDF
The Fanconi's syndrome is characterized by generalized disturbance of proximal tubular function. It leads to excessive losses of amino acids, glucose, phosphate, bicarbonate, and other substrates handled by the proximal tubules. The metabolic consequences are acidosis, hypophosphatemia, hypocalcemia, osteomalacia, osteoporosis, and growth retardation. Adult Fanconi's syndrome is mostly secondary form caused by multiple myeloma, primary amyloidosis, light chain nephropathy, and heavy metal poisoning. We experienced 50-year-old woman with kappa light chain disease whose chief complaints were weakness of both lower extremities and multiple bone pain. This patient had renal glycosuria, hypercalciuria, normal anion gap type metabolic acidosis, osteomalacia and normal distal tubule acidification. Her bone marrow biopsy showed inappropriate proliferation of plasma cell. The patient underwent percutaneous renal biopsy in which was exceptionally observed focal effacement of podocyte foot process. So we report a case of osteomalacia caused by adult Fanconi's syndrome and foot process effacement by kappa -light chain disease.
Close layer
Two Cases of Malignant Lymphoma Involving Bilateral Adrenal Glands as Huge Masses.
Seung Hyeok Han, Jin Seok Kim, Myung Soo Kim, Hye Won Chung, Jae Ho Jung, Young Suck Goo, Chul Woo Ahn, Jae Hyun Nam, Sang Soo Jung, Young Duk Song, Sung Kil Lim, Kyung Rae Kim, Hyun Chul Lee, Kap Bum Huh, Jee Sook Hahn
J Korean Endocr Soc. 2000;15(1):121-127.   Published online January 1, 2001
  • 1,274 View
  • 17 Download
AbstractAbstract PDF
Adrenal gland is a common site of metastatic tumors such as breast cancer, lung cancer, and colon cancer. When adrenal mass is found incidentally, adenoma is the most common among single adrenal masses. But in the case of bilateral adrenal masses, infection, bilateral metastases and hemorrhage are common. Secondary involvement of the adrenal gland is found in 25% of autopsy cases of non-Hodgkin's lymphoma. However, adrenal insufficiency is rare because it becomes apparent only when approximately 90% of adrenal cortex is destructed. We exprienced two cases of malignant lymphoma which involved the adrenal glands bilaterally. One case in which adrenal insufficiency was suspicious, was accompanied by hypovolemic shock and sepsis at the initial presentation. He died of sepsis combined with DIC even though hydrocortisone, intravenous saline infusion, and antibiotics therapy were started immediately. The other one was found incidentally, in which adrenal infiltraion was confirmed by CT scan. Hormonal level was normal and adrenal masses disappeared after chemotherapy.
Close layer
Mutations in Thyroid Hormone Receptor-beta Associated with Patients with Generalized Resistance and Pituitary Resistance to Thyroid Hormone.
Yong Seok Yun, Sung Kkwan Hong, Chul Woo Ahn, Jae Hyun Nam, Seok Won Park, Bong Su Cha, Young Duk Song, Eun Jig Lee, Sung Kil Lim, Kyung Rae Kim, Hyun Chul Lee, Kap Bum Huh
J Korean Endocr Soc. 2000;15(1):113-120.   Published online January 1, 2001
  • 1,055 View
  • 18 Download
AbstractAbstract PDF
We report a point mutation in the TRbeta gene in korean patients with generalized resistance and pituitary resistance to thyroid hormone. One mutation at TRbeta (P453S) were detected in patient with pituitary resistance to thyroid, which showed different phenotype, generalized resistance to thyroid hormone, in her mothers. But, the other (C31Y), did not show clear relations with the disease. Therefore, further study of molecular and cellular basis will be warranted to explain the clear mechanism of the resistance to thyroid hormone.
Close layer
Two Cases of Extensive Pituitary Calcification.
Chul Woo Ahn, Shin Myung Kang, Do Young Kim, Jang Yel Shin, Seok Won Park, Jae Hyun Nam, Young Duk Song, Sung Kil Lim, Kyung Rae Kim, Hyun Chul Lee, Kap Bum Huh
J Korean Endocr Soc. 1999;14(4):739-744.   Published online January 1, 2001
  • 1,444 View
  • 27 Download
AbstractAbstract PDF
Although calcification of such endocrine gland as adrenal or pineal gland is common, extensive calcification of the pituitary gland is unusual. Calcification is a well recognized but uncommon feature of prolactin-secreting, growth hormone-secreting and non-functioning pituitary tumours. The calcification varies in extent, but rarely exceeds a tiny amount histologically or radiologically. Recently, we had the opportunity to investigate two patients with radiologically demonstrated "pituitary stone" (severely calcified pituitary adenoma). The first Patient, a 51 year-old female, initially presented with general weakness, dizziness, visual disturbance, and loss of hair for 2 months. She was suspected to have a pituitary lesion. Decreased secretion of GH, TSH, LH, and FSH was demonstrated by dynamic tests. On CT scan, she was found to have multilobulated calcified sella mass. She was successfully managed by medical treatment. The second patient, a 65 year-old male, presented with general weakness, nausea, vomiting and polyuria for 2 months. Combined pituitary stimulation test showed subnormal response of GH and prolactine. Radiologic studies revealed pituitary stone which was managed with medical treatment of hormone replacement. We suggest that calcific changes in the pituitary adenoma might be common and occur to the extent of pituitary stone formation with the possible alteration of hormonal secretion.
Close layer
SR (Slow-Replase) Lanreotide Treatment in Acromegalic Patients.
Jae Hyun Nam, Sung Kil Lim, Sun Ho Kim, Chul Woo Ahn, Song Chul Lee, Young Duk Song, Kyung Rae Kim, Hyun Chul Lee, Ki Hyun Park, Kap Bum Huh
J Korean Endocr Soc. 1999;14(3):472-482.   Published online January 1, 2001
  • 1,114 View
  • 16 Download
AbstractAbstract PDF
BACKGROUND
Several clinical studies reported the efficacy of the long-acting SRIH analog, octreotide (Octreotide, Sandoz) in the treattnent of acromegaly. Recently, another SRIH analog (BIM 23014, Ipsen Biotech) was shown to decrease plasma GH levels in acromegalic patients. The recent availability of a long-acting formulation of BIM 23014 [slow release (SR) lanreotide] could avoid repeated sc injections or continuous sc infusions. The objective of this study was to determine the tolerability and effectiveness of the slow release (SR) somatostatin analog, SR lanreotide in active acromegaly. METHOD: Between March 1998 and May 1998, 10 patients were recruited in the prospective study carried out at Yonsei University. The effects of 6 weeks of SR lanreotide, given every 14 days at a dosage of 30 mg, im, were analyzed. All the patients completed the 6-week period of therapy. RESULTS: SR lanreotide injection produced 45% suppression of area under the curve of GH levels from the basal value on oral glucose tolerance test(OGTT). GH values on OGTT were normalized (< 2ng/mL) in 30% of patients after 6 weeks, whereas insulin-like growth factor I (IGF-I) levels were normalized in 50% of patients. No correlation was found between pretreatment GH levels and GH response to SR lanreotide or between changes in GH and IGF-I during therapy, The significant differences in response to SR lanreotide were shown between the patients with residual mass and no visible mass. During treatment, there was the significant reduction in the percentage of patients complaining of joint pain, hyperhydrosis, and paresthesias. Changes in soft tissue swelling were documented by a significant decrease in the diameter of fingers. Mild diarrhea and fatigue were the most frequent side-effects (20 30%) when SR lanreotide therapy was started. However, these side effects decreased progressively. Significant changes were noted in carbohydrate tolerance. CONCLUSIONS: These data indicate that SR lanreotide at a dose of 30 mg, im, every 14 days is an effective treatment in most unselected acromegalic patients, especially in patients with no visible mass. Tolerability to SR lanreotide therapy is high. The use of a new sustained release formulation of somatostatin analog is clearly advantageous in improving patient compliance with medical treatment for acromegaly.
Close layer

Endocrinol Metab : Endocrinology and Metabolism
TOP