Skip Navigation
Skip to contents

Endocrinol Metab : Endocrinology and Metabolism

OPEN ACCESS
SEARCH
Search

Author index

Page Path
HOME > BROWSE ARTICLES > Author index
Search
Chan Kwon Jung  (Jung CK) 11 Articles
Thyroid
Frequency of TERT Promoter Mutations in Real-World Analysis of 2,092 Thyroid Carcinoma Patients (Endocrinol Metab 2022;37:652-63, Heera Yang et al.)
Sue Youn Kim, Chan Kwon Jung
Endocrinol Metab. 2022;37(6):947-948.   Published online November 10, 2022
DOI: https://doi.org/10.3803/EnM.2022.1596
  • 636 View
  • 140 Download
PDFPubReader   ePub   CrossRef-TDMCrossref - TDM
Thyroid
Update from the 2022 World Health Organization Classification of Thyroid Tumors: A Standardized Diagnostic Approach
Chan Kwon Jung, Andrey Bychkov, Kennichi Kakudo
Endocrinol Metab. 2022;37(5):703-718.   Published online October 4, 2022
DOI: https://doi.org/10.3803/EnM.2022.1553
  • 5,383 View
  • 813 Download
  • 5 Citations
AbstractAbstract PDFPubReader   ePub   CrossRef-TDMCrossref - TDM
The fifth edition of the World Health Organization (WHO) histologic classification of thyroid neoplasms released in 2022 includes newly recognized tumor types, subtypes, and a grading system. Follicular cell-derived neoplasms are categorized into three families (classes): benign tumors, low-risk neoplasms, and malignant neoplasms. The terms “follicular nodular disease” and “differentiated high-grade thyroid carcinoma” are introduced to account for multifocal hyperplastic/neoplastic lesions and differentiated thyroid carcinomas with high-grade features, respectively. The term “Hürthle cells” is replaced with “oncocytic cells.” Invasive encapsulated follicular and cribriform morular variants of papillary thyroid carcinoma (PTC) are now redefined as distinct tumor types, given their different genetic alterations and clinicopathologic characteristics from other PTC subtypes. The term “variant” to describe a subclass of tumor has been replaced with the term “subtype.” Instead, the term “variant” is reserved to describe genetic alterations. A histologic grading system based on the mitotic count, necrosis, and/or the Ki67 index is used to identify high-grade follicular-cell derived carcinomas and medullary thyroid carcinomas. The 2022 WHO classification introduces the following new categories: “salivary gland-type carcinomas of the thyroid” and “thyroid tumors of uncertain histogenesis.” This review summarizes the major changes in the 2022 WHO classification and their clinical relevance.

Citations

Citations to this article as recorded by  
  • Update on C-Cell Neuroendocrine Neoplasm: Prognostic and Predictive Histopathologic and Molecular Features of Medullary Thyroid Carcinoma
    Chan Kwon Jung, Shipra Agarwal, Jen-Fan Hang, Dong-Jun Lim, Andrey Bychkov, Ozgur Mete
    Endocrine Pathology.2023; 34(1): 1.     CrossRef
  • The 5th edition of WHO classification of tumors of endocrine organs: changes in the diagnosis of follicular-derived thyroid carcinoma
    Fulvio Basolo, Elisabetta Macerola, Anello Marcello Poma, Liborio Torregrossa
    Endocrine.2023;[Epub]     CrossRef
  • Reprogramming of Cellular Metabolism and Its Therapeutic Applications in Thyroid Cancer
    Yuji Nagayama, Koichiro Hamada
    Metabolites.2022; 12(12): 1214.     CrossRef
  • Developments to improve outcomes in thyroid surgery
    Thomas J. Musholt
    Innovative Surgical Sciences.2022; 7(3-4): 77.     CrossRef
  • The relationship of the clinicopathological characteristics and treatment results of post-Chornobyl papillary thyroid microcarcinomas with the latency period and radiation exposure
    Tetiana Bogdanova, Serhii Chernyshov, Liudmyla Zurnadzhy, Tatiana I. Rogounovitch, Norisato Mitsutake, Mykola Tronko, Masahiro Ito, Michael Bolgov, Sergii Masiuk, Shunichi Yamashita, Vladimir A. Saenko
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
Thyroid
Re-Increasing Trends in Thyroid Cancer Incidence after a Short Period of Decrease in Korea: Reigniting the Debate on Ultrasound Screening
Chan Kwon Jung, Ja Seong Bae, Young Joo Park
Endocrinol Metab. 2022;37(5):816-818.   Published online October 11, 2022
DOI: https://doi.org/10.3803/EnM.2022.1586
  • 870 View
  • 136 Download
PDFPubReader   ePub   CrossRef-TDMCrossref - TDM
Thyroid
Diagnostic Performance of Thyroid Core Needle Biopsy Using the Revised Reporting System: Comparison with Fine Needle Aspiration Cytology
Kwangsoon Kim, Ja Seong Bae, Jeong Soo Kim, So Lyung Jung, Chan Kwon Jung
Endocrinol Metab. 2022;37(1):159-169.   Published online February 28, 2022
DOI: https://doi.org/10.3803/EnM.2021.1299
  • 1,858 View
  • 126 Download
  • 1 Citations
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   CrossRef-TDMCrossref - TDM
Background
We aim to validate the diagnostic performance of thyroid core needle biopsy (CNB) for diagnosing malignancy in clinical settings to align with the changes made in recently updated thyroid CNB guidelines.
Methods
We retrospectively analyzed 1,381 thyroid CNB and 2,223 fine needle aspiration (FNA) samples. The FNA and CNB slides were interpreted according to the Bethesda System for Reporting Thyroid Cytopathology and updated practice guidelines for thyroid CNB, respectively.
Results
Compared to FNA, CNB showed lower rates of inconclusive results: categories I (2.8% vs. 11.2%) and III (1.2% vs. 6.2%), and higher rates of categories II (60.9% vs. 50.4%) and IV (17.5% vs. 2.0%). The upper and lower bounds of the risk of malignancy (ROM) for category IV of CNB were 43.2% and 26.6%, respectively. The CNB subcategory IVb with nuclear atypia had a higher ROM than the subcategory without nuclear atypia (40%–62% vs. 23%–36%). In histologically confirmed cases, there was no significant difference in the diagnostic performance between CNB and FNA for malignancy. However, neoplastic diseases were more frequently detected by CNB than by FNA (88.8% vs. 77.6%, P=0.046). In category IV, there was no difference in unnecessary surgery rate between CNB and FNA (4.7% vs. 6.9%, P=0.6361).
Conclusion
Thyroid CNB decreased the rate of inconclusive results and showed a higher category IV diagnostic rate than FNA. The revised guidelines for thyroid CNB proved to be an excellent reporting system for assessing thyroid nodules.

Citations

Citations to this article as recorded by  
  • A Matched-Pair Analysis of Nuclear Morphologic Features Between Core Needle Biopsy and Surgical Specimen in Thyroid Tumors Using a Deep Learning Model
    Faridul Haq, Andrey Bychkov, Chan Kwon Jung
    Endocrine Pathology.2022; 33(4): 472.     CrossRef
Thyroid
Clinicopathological Characteristics and Recurrence-Free Survival of Rare Variants of Papillary Thyroid Carcinomas in Korea: A Retrospective Study
Mijin Kim, Sun Wook Cho, Young Joo Park, Hwa Young Ahn, Hee Sung Kim, Yong Joon Suh, Dughyun Choi, Bu Kyung Kim, Go Eun Yang, Il-Seok Park, Ka Hee Yi, Chan Kwon Jung, Bo Hyun Kim
Endocrinol Metab. 2021;36(3):619-627.   Published online June 10, 2021
DOI: https://doi.org/10.3803/EnM.2021.974
  • 2,951 View
  • 149 Download
  • 3 Citations
AbstractAbstract PDFPubReader   ePub   CrossRef-TDMCrossref - TDM
Background
We aimed to evaluate the clinicopathological features and biological behaviors of Korean thyroid cancer patients with rare variants of papillary thyroid carcinoma (PTC) to address the ambiguity regarding the prognostic consequences of these variants.
Methods
We retrospectively reviewed the medical records of 5,496 patients who underwent thyroid surgery for PTC, between January and December 2012, in nine tertiary hospitals. Rare PTC variants included tall cell (TCV), columnar cell (CCV), diffuse sclerosing (DSV), cribriform-morular (CMV), solid (SV), hobnail, and Warthin-like variants. Recurrence-free survival (RFS) was defined as the time from the date of thyroidectomy until recurrence.
Results
Rare variants accounted for 1.1% (n=63) of the PTC patients; with 0.9% TCV, 0.02% CCV, 0.1% DSV, 0.1% CMV, and 0.1% SV. The mean age of patients and primary tumor size were 42.1±13.1 years and 1.3±0.9 cm, respectively. Extrathyroidal extension and cervical lymph node metastasis were observed in 38 (60.3%) and 37 (58.7%) patients, respectively. Ultrasonographic findings revealed typical malignant features in most cases. During a median follow-up of 7 years, 6.3% of patients experienced a locoregional recurrence. The 5-year RFS rates were 71.4% in patients with DSV or SV, 95.9% for TCV, or CCV, and 100% for other variants. DSV emerged an independent risk factor associated with shorter RFS.
Conclusion
In this multicenter Korean cohort, rare variants accounted for 1.1% of all PTC cases, with TCV being the most frequent subtype. DSV emerged as a significant prognostic factor for RFS.

Citations

Citations to this article as recorded by  
  • Serum thyroglobulin testing after thyroid lobectomy in patients with 1–4 cm papillary thyroid carcinoma
    Ahreum Jang, Meihua Jin, Chae A Kim, Min Ji Jeon, Yu-Mi Lee, Tae-Yon Sung, Tae Yong Kim, Won Bae Kim, Young Kee Shong, Won Gu Kim
    Endocrine.2023;[Epub]     CrossRef
  • A Retrospective Cohort Study with Validation of Predictors of Differentiated Thyroid Cancer Outcomes
    Ayanthi Wijewardene, Anthony J. Gill, Matti Gild, Diana L. Learoyd, Anthony Robert Glover, Mark Sywak, Stan Sidhu, Paul Roach, Geoffrey Schembri, Jeremy Hoang, Bruce Robinson, Lyndal Tacon, Roderick Clifton-Bligh
    Thyroid.2022;[Epub]     CrossRef
  • Clinicopathological Implications of the BRAFV600E Mutation in Papillary Thyroid Carcinoma of Ukrainian Patients Exposed to the Chernobyl Radiation in Childhood: A Study for 30 Years After the Accident
    Liudmyla Zurnadzhy, Tetiana Bogdanova, Tatiana I. Rogounovitch, Masahiro Ito, Mykola Tronko, Shunichi Yamashita, Norisato Mitsutake, Michael Bolgov, Serhii Chernyshov, Sergii Masiuk, Vladimir A. Saenko
    Frontiers in Medicine.2022;[Epub]     CrossRef
Adrenal gland
Diagnosis for Pheochromocytoma and Paraganglioma: A Joint Position Statement of the Korean Pheochromocytoma and Paraganglioma Task Force
Eu Jeong Ku, Kyoung Jin Kim, Jung Hee Kim, Mi Kyung Kim, Chang Ho Ahn, Kyung Ae Lee, Seung Hun Lee, You-Bin Lee, Kyeong Hye Park, Yun Mi Choi, Namki Hong, A Ram Hong, Sang-Wook Kang, Byung Kwan Park, Moon-Woo Seong, Myungshin Kim, Kyeong Cheon Jung, Chan Kwon Jung, Young Seok Cho, Jin Chul Paeng, Jae Hyeon Kim, Ohk-Hyun Ryu, Yumie Rhee, Chong Hwa Kim, Eun Jig Lee
Endocrinol Metab. 2021;36(2):322-338.   Published online April 6, 2021
DOI: https://doi.org/10.3803/EnM.2020.908
  • 4,443 View
  • 332 Download
  • 4 Citations
AbstractAbstract PDFPubReader   ePub   CrossRef-TDMCrossref - TDM
Pheochromocytoma and paraganglioma (PPGLs) are rare catecholamine-secreting neuroendocrine tumors but can be life-threatening. Although most PPGLs are benign, approximately 10% have metastatic potential. Approximately 40% cases are reported as harboring germline mutations. Therefore, timely and accurate diagnosis of PPGLs is crucial. For more than 130 years, clinical, molecular, biochemical, radiological, and pathological investigations have been rapidly advanced in the field of PPGLs. However, performing diagnostic studies to localize lesions and detect metastatic potential can be still challenging and complicated. Furthermore, great progress on genetics has shifted the paradigm of genetic testing of PPGLs. The Korean PPGL task force team consisting of the Korean Endocrine Society, the Korean Surgical Society, the Korean Society of Nuclear Medicine, the Korean Society of Pathologists, and the Korean Society of Laboratory Medicine has developed this position statement focusing on the comprehensive and updated diagnosis for PPGLs.

Citations

Citations to this article as recorded by  
  • KSNM60 in Nuclear Endocrinology: from the Beginning to the Future
    Chae Moon Hong, Young Jin Jeong, Hae Won Kim, Byeong-Cheol Ahn
    Nuclear Medicine and Molecular Imaging.2022; 56(1): 17.     CrossRef
  • Change of Computed Tomography-Based Body Composition after Adrenalectomy in Patients with Pheochromocytoma
    Yousun Ko, Heeryoel Jeong, Seungwoo Khang, Jeongjin Lee, Kyung Won Kim, Beom-Jun Kim
    Cancers.2022; 14(8): 1967.     CrossRef
  • Evaluation and Management of Bone Health in Patients with Thyroid Diseases: a Position Statement from the Korean Thyroid Association
    A Ram Hong, Hwa Young Ahn, Bu Kyung Kim, Seong Hee Ahn, So Young Park, Min-Hee Kim, Jeongmin Lee, Sun Wook Cho, Ho-Cheol Kang
    International Journal of Thyroidology.2022; 15(1): 1.     CrossRef
  • Pheochromocytoma with Retroperitoneal Metastasis: A Case Report
    建新 崔
    Advances in Clinical Medicine.2021; 11(05): 2239.     CrossRef
Clinical Study
Molecular Correlates and Nuclear Features of Encapsulated Follicular-Patterned Thyroid Neoplasms
Chan Kwon Jung, Andrey Bychkov, Dong Eun Song, Jang-Hee Kim, Yun Zhu, Zhiyan Liu, Somboon Keelawat, Chiung-Ru Lai, Mitsuyoshi Hirokawa, Kaori Kameyama, Kennichi Kakudo
Endocrinol Metab. 2021;36(1):123-133.   Published online February 24, 2021
DOI: https://doi.org/10.3803/EnM.2020.860
  • 3,088 View
  • 117 Download
  • 5 Citations
AbstractAbstract PDFPubReader   ePub   CrossRef-TDMCrossref - TDM
Background
Assessing nuclear features is diagnostically challenging in the aspect of thyroid pathology. The aim of this study was to determine whether pathologists could distinguish BRAF-like and RAS-like nuclear features morphologically and identify morphological features to differentiate thyroid tumors with RAS-like mutations from encapsulated papillary thyroid carcinoma (PTC) with predominant follicular growth and BRAFV600E mutation.
Methods
Representative whole slide images of 16 encapsulated thyroid tumors with predominant follicular growth were reviewed by 12 thyroid pathologists using a web browser-based image viewer. Total nuclear score was calculated from semi-quantitatively scored eight nuclear features. The molecular profile of RAS and BRAF genes was determined by Sanger sequencing.
Results
Total nuclear score ranging 0 to 24 could differentiate BRAF-like tumors from RAS-like tumors with a cut-off value of score 14. The interobserver agreement was the highest for the assessment of nuclear pseudoinclusions (NPIs) but the lowest for nuclear elongation and sickle-shaped nuclei. NPIs were found in tumors with BRAFV600E mutation, but not in tumors with RAS-like mutations. Total nuclear scores were significantly higher for tumors with BRAFV600E than for those with RAS-like mutations (P<0.001).
Conclusion
Our results suggest that NPIs and high nuclear scores have diagnostic utility as rule-in markers for differentiating PTC with BRAFV600E mutation from benign or borderline follicular tumors with RAS-like mutations. Relaxation of rigid criteria for nuclear features resulted in an overdiagnosis of PTC. Immunostaining or molecular testing for BRAFV600E mutation is a useful adjunct for cases with high nuclear scores to identify true PTC.

Citations

Citations to this article as recorded by  
  • The Presence of Typical “BRAFV600E-Like” Atypia in Papillary Thyroid Carcinoma is Highly Specific for the Presence of the BRAFV600E Mutation
    John Turchini, Loretta Sioson, Adele Clarkson, Amy Sheen, Leigh Delbridge, Anthony Glover, Mark Sywak, Stan Sidhu, Anthony J. Gill
    Endocrine Pathology.2023; 34(1): 112.     CrossRef
  • Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP): Tumour Entity with a Short History. A Review on Challenges in Our Microscopes, Molecular and Ultrasonographic Profile
    Ivana Kholová, Elina Haaga, Jaroslav Ludvik, David Kalfert, Marie Ludvikova
    Diagnostics.2022; 12(2): 250.     CrossRef
  • Update from the 2022 World Health Organization Classification of Thyroid Tumors: A Standardized Diagnostic Approach
    Chan Kwon Jung, Andrey Bychkov, Kennichi Kakudo
    Endocrinology and Metabolism.2022; 37(5): 703.     CrossRef
  • Different Threshold of Malignancy for RAS-like Thyroid Tumors Causes Significant Differences in Thyroid Nodule Practice
    Kennichi Kakudo
    Cancers.2022; 14(3): 812.     CrossRef
  • The Incidence of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features: A Meta-Analysis Assessing Worldwide Impact of the Reclassification
    Chanchal Rana, Huy Gia Vuong, Thu Quynh Nguyen, Hoang Cong Nguyen, Chan Kwon Jung, Kennichi Kakudo, Andrey Bychkov
    Thyroid.2021;[Epub]     CrossRef
Thyroid
Updates in the Pathologic Classification of Thyroid Neoplasms: A Review of the World Health Organization Classification
Yanhua Bai, Kennichi Kakudo, Chan Kwon Jung
Endocrinol Metab. 2020;35(4):696-715.   Published online December 2, 2020
DOI: https://doi.org/10.3803/EnM.2020.807
  • 12,417 View
  • 1,061 Download
  • 21 Citations
AbstractAbstract PDFPubReader   ePub   CrossRef-TDMCrossref - TDM
Advances in medical sciences and evidence-based medicine have led to momentous changes in classification and management of thyroid neoplasms. Much progress has been made toward avoiding overdiagnosis and overtreatment of thyroid cancers. The new 2017 World Health Organization (WHO) classification of thyroid neoplasms updated the diagnostic criteria and molecular and genetic characteristics reflecting the biology and behavior of the tumors, and newly introduced the category of borderline malignancy or uncertain malignant potential. Some neoplasms were subclassified, renamed, or redefined as a specific entity. This review introduces changes in the fourth edition WHO classification of thyroid tumors and updates the contemporary diagnosis and classification of thyroid tumors. We also discuss several challenges with the proposal of new diagnostic entities, since they have unique histopathologic and molecular features and clinical relevance.

Citations

Citations to this article as recorded by  
  • Genetic analysis and clinicopathologic features of locally advanced papillary thyroid cancers: a prospective observational study
    Zheng Ding, Xuanbin Tao, Xianzhao Deng, Bomin Guo, Jie Kang, Bo Wu, Zhili Yang, Chunyan Chen, Ping Liu, Yingchao Zhang, Youben Fan, Zhiyan Liu
    Journal of Cancer Research and Clinical Oncology.2023;[Epub]     CrossRef
  • The Efficacy of ACR TI-RADS in the Management of Suspected Thyroid Nodules and Its Correlation With the Bethesda Scoring System
    Emrah Karatay, Mirkhalig Javadov, Kinyas Kartal
    Journal of Diagnostic Medical Sonography.2022; 38(4): 309.     CrossRef
  • Systematic evaluation of the anti-tumor effect of Phellinus linteus polysaccharide in thyroid carcinoma in vitro
    Kun Yu, Zhuo Tan, Ying Xin
    Molecular Biology Reports.2022; 49(4): 2785.     CrossRef
  • Clinical Significance of Circulating Tumor Cells (CTCs) and Survivin on Predicting Prognosis in Thyroid Cancer Patients
    Xun Weng, YangYang, Yujiao Cai, Fu Wang
    Disease Markers.2022; 2022: 1.     CrossRef
  • Identification of DPP4/CTNNB1/MET as a Theranostic Signature of Thyroid Cancer and Evaluation of the Therapeutic Potential of Sitagliptin
    Sheng-Yao Cheng, Alexander T. H. Wu, Gaber El-Saber Batiha, Ching-Liang Ho, Jih-Chin Lee, Halimat Yusuf Lukman, Mohammed Alorabi, Abdullah N. AlRasheedi, Jia-Hong Chen
    Biology.2022; 11(2): 324.     CrossRef
  • Retrospective evaluation of radioactive iodine ablation therapy in the Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP) and Thyroid tumors with uncertain malignity potential
    Mehmet Refik GÖKTUĞ, Özen ÖZ GÜL, Soner CANDER
    Turkish Journal of Internal Medicine.2022;[Epub]     CrossRef
  • Extracellular Vesicles as Signal Carriers in Malignant Thyroid Tumors?
    Małgorzata Grzanka, Anna Stachurska-Skrodzka, Anna Adamiok-Ostrowska, Ewa Gajda, Barbara Czarnocka
    International Journal of Molecular Sciences.2022; 23(6): 3262.     CrossRef
  • Thyroid Cancer Detection in a Routine Clinical Setting: Performance of ACR TI-RADS, FNAC, and Molecular Testing in Prospective Cohort Study
    Tereza Grimmichova, Petra Pacesova, Martin Hill, Barbora Pekova, Marketa Vankova, Jitka Moravcova, Jana Vrbikova, Zdenek Novak, Karolina Mastnikova, Eliska Vaclavikova, Josef Vcelak, Bela Bendlova, Jana Drozenova, Vlasta Sykorova
    Biomedicines.2022; 10(5): 954.     CrossRef
  • Advantages of Small Incision Surgery in Thyroid Tumors
    Wen Feng, Yuan Feng, Qixian Diao, Jian Zhou, Zhaoqi Dong
    Evidence-Based Complementary and Alternative Medicine.2022; 2022: 1.     CrossRef
  • Radioactive Iodine Therapy Does not Improve Cancer-specific Survival in Hürthle Cell Carcinoma of the Thyroid
    Xiaofei Wang, Xun Zheng, Jingqiang Zhu, Zhihui Li, Tao Wei
    The Journal of Clinical Endocrinology & Metabolism.2022; 107(11): 3144.     CrossRef
  • Latency Trend Analysis as a Guide to Screening Malignancy Survivors for Second Primary Thyroid Cancer
    Mohammad Hussein, Lauren Mueller, Peter P. Issa, Muhib Haidari, Lily Trinh, Eman Toraih, Emad Kandil
    Biomedicines.2022; 10(8): 1984.     CrossRef
  • Ultrasonographic characteristics of Hürthle cell neoplasms: prediction of malignancy
    Min Je Kim, Jung Hee Shin, Soo Yeon Hahn, Young Lyun Oh, Sun Wook Kim, Tae Hyuk Kim, Yaeji Lim, Sanghyuk Lee
    Ultrasonography.2022; 41(4): 689.     CrossRef
  • Update from the 2022 World Health Organization Classification of Thyroid Tumors: A Standardized Diagnostic Approach
    Chan Kwon Jung, Andrey Bychkov, Kennichi Kakudo
    Endocrinology and Metabolism.2022; 37(5): 703.     CrossRef
  • A Matched-Pair Analysis of Nuclear Morphologic Features Between Core Needle Biopsy and Surgical Specimen in Thyroid Tumors Using a Deep Learning Model
    Faridul Haq, Andrey Bychkov, Chan Kwon Jung
    Endocrine Pathology.2022; 33(4): 472.     CrossRef
  • Clinicopathological features and prognostic factors analysis of multiple synchronous distinct subtypes of primary thyroid carcinoma
    Quanwei Dai, Xinghao Fu, Yalei Ding, Qi He, Xinguang Qiu
    Endocrine.2022; 79(3): 491.     CrossRef
  • Best Achievements in Clinical Thyroidology in 2020
    Eun Kyung Lee, Young Joo Park
    Endocrinology and Metabolism.2021; 36(1): 30.     CrossRef
  • High Prevalence of DICER1 Mutations and Low Frequency of Gene Fusions in Pediatric Follicular-Patterned Tumors of the Thyroid
    Ja-Seong Bae, Seung-Hyun Jung, Mitsuyoshi Hirokawa, Andrey Bychkov, Akira Miyauchi, Sohee Lee, Yeun-Jun Chung, Chan Kwon Jung
    Endocrine Pathology.2021; 32(3): 336.     CrossRef
  • Deep Learning Fast Screening Approach on Cytological Whole Slides for Thyroid Cancer Diagnosis
    Yi-Jia Lin, Tai-Kuang Chao, Muhammad-Adil Khalil, Yu-Ching Lee, Ding-Zhi Hong, Jia-Jhen Wu, Ching-Wei Wang
    Cancers.2021; 13(15): 3891.     CrossRef
  • How to identify indolent thyroid tumors unlikely to recur and cause cancer death immediately after surgery—Risk stratification of papillary thyroid carcinoma in young patients—
    Kennichi Kakudo, Zhiyan Liu, Yanhua Bai, Yaqiong Li, Naomi Kitayama, Shinya Satoh, Masahiro Nakashima, Chan Kwon Jung
    Endocrine Journal.2021; 68(8): 871.     CrossRef
  • Papillary Thyroid Cancer Prognosis: An Evolving Field
    Salvatore Ulisse, Enke Baldini, Augusto Lauro, Daniele Pironi, Domenico Tripodi, Eleonora Lori, Iulia Catalina Ferent, Maria Ida Amabile, Antonio Catania, Filippo Maria Di Matteo, Flavio Forte, Alberto Santoro, Piergaspare Palumbo, Vito D’Andrea, Salvator
    Cancers.2021; 13(21): 5567.     CrossRef
  • Intrasalivary Thymic Carcinoma: A Case Report and Literature Review
    Michał Kunc, Alexandra Kamieniecki, Grzegorz Walczak, Tomasz Nowicki, Bartosz Wasąg, Bogusław Mikaszewski, Dominik Stodulski, Wojciech Biernat
    Head and Neck Pathology.2021; 16(3): 857.     CrossRef
Recent Advances in Core Needle Biopsy for Thyroid Nodules
Chan Kwon Jung, Jung Hwan Baek
Endocrinol Metab. 2017;32(4):407-412.   Published online December 14, 2017
DOI: https://doi.org/10.3803/EnM.2017.32.4.407
  • 4,304 View
  • 62 Download
  • 24 Citations
AbstractAbstract PDFPubReader   CrossRef-TDMCrossref - TDM

Core needle biopsy (CNB) was introduced as an alternative diagnostic tool to fine-needle aspiration (FNA), and is increasingly being used in the preoperative assessment of thyroid nodules. CNB provides a definitive diagnosis in most cases, but it sometimes may be inconclusive. CNB has the advantage of enabling a histologic examination in relation to the surrounding thyroid tissue, immunohistochemistry, and molecular testing that can provide a more accurate assessment than FNA in selected cases. Nevertheless, CNB should be performed only by experienced experts in thyroid interventions to prevent complications because CNB needles are larger in caliber than FNA needles. As recent evidence has accumulated, and with improvements in the technique and devices for thyroid CNB, the Korean Society of Thyroid Radiology released its 2016 thyroid CNB guidelines and the Korean Endocrine Pathology Thyroid Core Needle Biopsy Study Group published a consensus statement on the pathology reporting system for thyroid CNB in 2015. This review presents the current consensus and recommendations regarding thyroid CNB, focusing on indications, complications, and pathologic classification and reporting.

Citations

Citations to this article as recorded by  
  • Utilidad de la biopsia con aguja gruesa ecoguiada en nódulos tiroideos con punción aspirativa con aguja fina no diagnóstica
    R. Cortázar-García, M.D. Martín-Escalante, L. Robles-Cabeza, C. Martínez-Santos
    Radiología.2022; 64(3): 195.     CrossRef
  • Usefulness of ultrasound-guided core biopsy in thyroid nodules with inconclusive fine-needle aspiration biopsy findings
    R. Cortázar-García, M.D. Martín-Escalante, L. Robles-Cabeza, C. Martínez-Santos
    Radiología (English Edition).2022; 64(3): 195.     CrossRef
  • Effectiveness of core needle biopsy in the diagnosis of thyroid lymphoma and anaplastic thyroid carcinoma: A systematic review and meta-analysis
    Vincent Vander Poorten, Nathan Goedseels, Asterios Triantafyllou, Alvaro Sanabria, Paul M. Clement, Oded Cohen, Pawel Golusinski, Orlando Guntinas-Lichius, Cesare Piazza, Gregory W. Randolph, Alessandra Rinaldo, Ohad Ronen, Maria E. Cabanillas, Ashok R. S
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • A Matched-Pair Analysis of Nuclear Morphologic Features Between Core Needle Biopsy and Surgical Specimen in Thyroid Tumors Using a Deep Learning Model
    Faridul Haq, Andrey Bychkov, Chan Kwon Jung
    Endocrine Pathology.2022; 33(4): 472.     CrossRef
  • Intraoperative Assessment of High-Risk Thyroid Nodules Based on Electrical Impedance Measurements: A Feasibility Study
    Jalil Beheshti Firoozabadi, Reihane Mahdavi, Khosro Shamsi, Hossein Ataee, Abdollah Shafiee, Hojat Ebrahiminik, Hossein Chegini, Parisa Hoseinpour, Afshin Moradi, Narges Yousefpour, Faeze Aghaei, Ali Fardoost, Alireza Ghelichli, Hadi Mokhtari Dowlatabad,
    Diagnostics.2022; 12(12): 2950.     CrossRef
  • Assessing the diagnostic performance of thyroid biopsy with recommendations for appropriate interpretation
    Su Min Ha, Jung Hwan Baek, Dong Gyu Na, Chan-Kwon Jung, Chong Hyun Suh, Young Kee Shong, Tae Yon Sung, Dong Eun Song, Jeong Hyun Lee
    Ultrasonography.2021; 40(2): 228.     CrossRef
  • Update on the Evaluation of Thyroid Nodules
    Victor J. Bernet, Ana-Maria Chindris
    Journal of Nuclear Medicine.2021; 62(Supplement): 13S.     CrossRef
  • Poorly Differentiated Thyroid Carcinoma: Single Centre Experience and Review of the Literature
    Maria Bellini, Marco Biffoni, Renato Patrone, Maria Borcea, Maria Costanzo, Tiziana Garritano, Rossella Melcarne, Rosa Menditto, Alessio Metere, Chiara Scorziello, Marco Summa, Luca Ventrone, Vito D’Andrea, Laura Giacomelli
    Journal of Clinical Medicine.2021; 10(22): 5258.     CrossRef
  • Laser Ablation Versus Radiofrequency Ablation for Benign Non-Functioning Thyroid Nodules: Six-Month Results of a Randomized, Parallel, Open-Label, Trial (LARA Trial)
    Roberto Cesareo, Claudio Maurizio Pacella, Valerio Pasqualini, Giuseppe Campagna, Mario Iozzino, Andrea Gallo, Angelo Lauria Pantano, Roberto Cianni, Claudio Pedone, Paolo Pozzilli, Chiara Taffon, Anna Crescenzi, Silvia Manfrini, Andrea Palermo
    Thyroid.2020; 30(6): 847.     CrossRef
  • 2019 Practice guidelines for thyroid core needle biopsy: a report of the Clinical Practice Guidelines Development Committee of the Korean Thyroid Association
    Chan Kwon Jung, Jung Hwan Baek, Dong Gyu Na, Young Lyun Oh, Ka Hee Yi, Ho-Cheol Kang
    Journal of Pathology and Translational Medicine.2020; 54(1): 64.     CrossRef
  • Morphological and Molecular Assessment in Thyroid Cytology Using Cell-Capturing Scaffolds
    Stefania Scarpino, Silvia Taccogna, Giuseppina Pepe, Enrico Papini, Martina D’Angelo, Federica Cascone, Daniele Nicoletti, Rinaldo Guglielmi, Andrea Palermo, Marcella Trombetta, Alberto Rainer, Chiara Taffon, Anna Crescenzi
    Hormone and Metabolic Research.2020; 52(11): 803.     CrossRef
  • European Thyroid Association Survey on Use of Minimally Invasive Techniques for Thyroid Nodules
    Laszlo Hegedüs, Andrea Frasoldati, Roberto Negro, Enrico Papini
    European Thyroid Journal.2020; 9(4): 194.     CrossRef
  • Malignancy risk of initially benign thyroid nodules: validation with various Thyroid Imaging Reporting and Data System guidelines
    Su Min Ha, Jung Hwan Baek, Young Jun Choi, Sae Rom Chung, Tae Yon Sung, Tae Yong Kim, Jeong Hyun Lee
    European Radiology.2019; 29(1): 133.     CrossRef
  • Tumor Volume Doubling Time in Active Surveillance of Papillary Thyroid Carcinoma
    Hye-Seon Oh, Hyemi Kwon, Eyun Song, Min Ji Jeon, Tae Yong Kim, Jeong Hyun Lee, Won Bae Kim, Young Kee Shong, Ki-Wook Chung, Jung Hwan Baek, Won Gu Kim
    Thyroid.2019; 29(5): 642.     CrossRef
  • Risk of Malignancy According to the Sub-classification of Atypia of Undetermined Significance and Suspicious Follicular Neoplasm Categories in Thyroid Core Needle Biopsies
    Sae Rom Chung, Jung Hwan Baek, Jeong Hyun Lee, Yu-Mi Lee, Tae-Yon Sung, Ki-Wook Chung, Suck Joon Hong, Min Ji Jeon, Tae Yong Kim, Young Kee Shong, Won Bae Kim, Won Gu Kim, Dong Eun Song
    Endocrine Pathology.2019; 30(2): 146.     CrossRef
  • Does Radiofrequency Ablation Induce Neoplastic Changes in Benign Thyroid Nodules: A Preliminary Study
    Su Min Ha, Jun Young Shin, Jung Hwan Baek, Dong Eun Song, Sae Rom Chung, Young Jun Choi, Jeong Hyun Lee
    Endocrinology and Metabolism.2019; 34(2): 169.     CrossRef
  • Response: Long-Term Outcomes Following Thermal Ablation of Benign Thyroid Nodules as an Alternative to Surgery: The Importance of Controlling Regrowth (Endocrinol Metab 2019;34:117–23, Jung Suk Sim et al.)
    Jung Suk Sim, Jung Hwan Baek
    Endocrinology and Metabolism.2019; 34(3): 325.     CrossRef
  • A Study on Head and Neck Malignant Lymphoma Diagnosed by Core Needle Biopsy
    Keisuke Yamamoto, Tsuyoshi Okuni, Makoto Kurose, Akira Yorozu, Kizuku Owada, Ryoto Yajima, Ayumi Takahashi, Kazufumi Obata, Atsushi Kondo, Kenichi Takano
    Practica Oto-Rhino-Laryngologica.2019; 112(9): 609.     CrossRef
  • The Role of Core Needle Biopsy for the Evaluation of Thyroid Nodules with Suspicious Ultrasound Features
    Sae Rom Chung, Jung Hwan Baek, Young Jun Choi, Tae-Yon Sung, Dong Eun Song, Tae Yong Kim, Jeong Hyun Lee
    Korean Journal of Radiology.2019; 20(1): 158.     CrossRef
  • Safety and Efficacy of Radiofrequency Ablation for Nonfunctioning Benign Thyroid Nodules in Children and Adolescents in 14 Patients over a 10-Year Period
    Min Ji Hong, Jin Yong Sung, Jung Hwan Baek, Mi Su Je, Dong Whan Choi, Hyunju Yoo, Sae Jeong Yang, Sang Yu Nam, Eun Young Yoo
    Journal of Vascular and Interventional Radiology.2019; 30(6): 900.     CrossRef
  • Reliability of core needle biopsy as a second-line procedure in thyroid nodules with an indeterminate fine-needle aspiration report: a systematic review and meta-analysis
    Pierpaolo Trimboli, Luca Giovanella
    Ultrasonography.2018; 37(2): 121.     CrossRef
  • The Significance of Having an Excellent Patient's Comfort with Thyroid Core Needle Biopsy
    Pierpaolo Trimboli, Luca Giovanella
    Endocrinology and Metabolism.2018; 33(1): 53.     CrossRef
  • Ultrasonographic Echogenicity and Histopathologic Correlation of Thyroid Nodules in Core Needle Biopsy Specimens
    Ji-hoon Kim, Dong Gyu Na, Hunkyung Lee
    Korean Journal of Radiology.2018; 19(4): 673.     CrossRef
  • A Comparison of Ultrasound-Guided Fine Needle Aspiration versus Core Needle Biopsy for Thyroid Nodules: Pain, Tolerability, and Complications
    Eun Ji Jeong, Sae Rom Chung, Jung Hwan Baek, Young Jun Choi, Jae Kyun Kim, Jeong Hyun Lee
    Endocrinology and Metabolism.2018; 33(1): 114.     CrossRef
Revised Korean Thyroid Association Management Guidelines for Patients with Thyroid Nodules and Thyroid Cancer.
Ka Hee Yi, Young Joo Park, Sung Soo Koong, Jung Han Kim, Dong Gyu Na, Jin Sook Ryu, So Yeon Park, In Ae Park, Chung Hwan Baek, Young Kee Shong, Young Don Lee, Jaetae Lee, Jeong Hyun Lee, Jae Hoon Chung, Chan Kwon Jung, Seung Ho Choi, Bo Youn Cho
Endocrinol Metab. 2010;25(4):270-297.   Published online December 1, 2010
DOI: https://doi.org/10.3803/EnM.2010.25.4.270
  • 2,259 View
  • 39 Download
  • 32 Citations
AbstractAbstract PDF
No abstract available.

Citations

Citations to this article as recorded by  
  • Optimization of the design parameters for a thyroid care nuclide monitoring diverging collimator using Monte Carlo simulation
    Dong-Hee Han, Seung-Jae Lee, Jang-Oh Kim, Da-Eun Kwon, Kyung-Hwan Jung, Cheol-Ha Baek
    Journal of the Korean Physical Society.2022; 81(7): 675.     CrossRef
  • Active Surveillance for Papillary Thyroid Microcarcinoma in a Population with Restrictive Diagnostic Workup Strategies
    Ivona Lončar, Sam P.J. van Dijk, Madelon J.H. Metman, Jia Feng Lin, Schelto Kruijff, Robin P. Peeters, Anton F. Engelsman, Tessa M. van Ginhoven
    Thyroid.2021; 31(8): 1219.     CrossRef
  • Decreasing trends in thyroid cancer incidence in South Korea: What happened in South Korea?
    Chang‐Mo Oh, Jiwon Lim, Yuh Seog Jung, Yeol Kim, Kyu‐Won Jung, Seri Hong, Young‐Joo Won
    Cancer Medicine.2021; 10(12): 4087.     CrossRef
  • Efficacy of Differential Diagnosis of Thyroid Nodules by Shear Wave Elastography—the Stiffness Map
    Myung Hi Yoo, Hye Jeong Kim, In Ho Choi, Suyeon Park, Sumi Yun, Hyeong Kyu Park, Dong Won Byun, Kyoil Suh
    Journal of the Endocrine Society.2021;[Epub]     CrossRef
  • Spatial distribution and determinants of thyroid cancer incidence from 1999 to 2013 in Korea
    Jieun Jang, Dae-Sung Yoo, Byung Chul Chun
    Scientific Reports.2021;[Epub]     CrossRef
  • Income differences in screening, incidence, postoperative complications, and mortality of thyroid cancer in South Korea: a national population-based time trend study
    Hee-Yeon Kang, Ikhan Kim, Yeon-Yong Kim, Jinwook Bahk, Young-Ho Khang
    BMC Cancer.2020;[Epub]     CrossRef
  • Differential Diagnosis of Thyroid Follicular Neoplasm from Nodular Hyperplasia by Shear Wave Elastography
    Myung Hi Yoo, Hye Jeong Kim, In Ho Choi, Ji-Oh Mok, Hyeong Kyu Park, Dong Won Byun, Kyoil Suh
    Soonchunhyang Medical Science.2019; 25(1): 10.     CrossRef
  • Diagnostic Performance of Shear Wave Elastography as Add-on Test in Thyroid Nodules: a Systematic Review and Meta-Analysis
    Sun-young Park, Ji Yang Song, Min Jin Lee, Kyung Min Lee, Mi Hye Jeon, Ryeo Jin Ko, Seok-Hyun Kim, Bong Joo Kang
    International Journal of Thyroidology.2018; 11(1): 31.     CrossRef
  • Structural Equation Modeling on Health-related Quality of Life among Patients with Thyroid Cancer
    Seon Young Lee, Hyun Kyung Kim
    Korean Journal of Adult Nursing.2018; 30(2): 171.     CrossRef
  • Prevalence and Annual Incidence of Thyroid Disease in Korea from 2006 to 2015: A Nationwide Population-Based Cohort Study
    Hyemi Kwon, Jin-hyung Jung, Kyung-Do Han, Yong-Gyu Park, Jung-Hwan Cho, Da Young Lee, Ji Min Han, Se Eun Park, Eun-Jung Rhee, Won-Young Lee
    Endocrinology and Metabolism.2018; 33(2): 260.     CrossRef
  • Ten Years of the Korean Thyroid Association: Achievement and Future
    Young Joo Park, Young Shin Song, Ka Hee Yi
    International Journal of Thyroidology.2018; 11(1): 1.     CrossRef
  • Prediction of Contralateral Occult Malignant Nodule in Patients with Unilaterally Confined Papillary Thyroid Carcinomas
    Sang Wook Jo, Ha Kyoung Park, Tae Kwun Ha
    Journal of Endocrine Surgery.2018; 18(3): 191.     CrossRef
  • Surgical Treatment Guidelines for Patients with Differentiated Thyroid Cancer: The Korean Association of Thyroid and Endocrine Surgeons (KATES) Guidelines Taskforce
    Jin-Woo Park, Ki-Wook Chung, Ji-Sup Yun, Hyungju Kwon, Hoon Yub Kim, Kee Hyun Nam, Kyoung Sik Park, Min Ho Park, Ja Sung Bae, Hyun Jo Youn, Kyu Eun Lee, Chi Young Lim, Jin Hyang Jung, Jun-Ho Choe, Lee Su Kim, Su Jung Lee, Jung Han Yoon
    Korean Journal of Endocrine Surgery.2017; 17(1): 1.     CrossRef
  • Thyroid fine-needle aspiration biopsy positively correlates with increased diagnosis of thyroid cancer in South Korean patients
    Yoon Jae Cho, Do Young Kim, Eun-Cheol Park, Kyu-Tae Han
    BMC Cancer.2017;[Epub]     CrossRef
  • Current trends of practical issues concerning micropapillary thyroid carcinoma
    Yoon Se Lee, Byung-Joo Lee, Hyun Joon Hong, Kang-Dae Lee
    Medicine.2017; 96(45): e8596.     CrossRef
  • The Use of the Bethesda System for Reporting Thyroid Cytopathology in Korea: A Nationwide Multicenter Survey by the Korean Society of Endocrine Pathologists
    Mimi Kim, Hyo Jin Park, Hye Sook Min, Hyeong Ju Kwon, Chan Kwon Jung, Seoung Wan Chae, Hyun Ju Yoo, Yoo Duk Choi, Mi Ja Lee, Jeong Ja Kwak, Dong Eun Song, Dong Hoon Kim, Hye Kyung Lee, Ji Yeon Kim, Sook Hee Hong, Jang Sihn Sohn, Hyun Seung Lee, So Yeon Pa
    Journal of Pathology and Translational Medicine.2017; 51(4): 410.     CrossRef
  • Does the Risk of Metabolic Syndrome Increase in Thyroid Cancer Survivors?
    Min-Hee Kim, Jin-young Huh, Dong-jun Lim, Moo-Il Kang
    Thyroid.2017; 27(7): 936.     CrossRef
  • Surgical Treatment Guidelines for Patients with Differentiated Thyroid Cancer: The Korean Association of Thyroid and Endocrine Surgeons (KATES) Guidelines Taskforce
    Jin-Woo Park, Ki-Wook Chung, Ji-Sup Yun, Hyungju Kwon, Hoon Yub Kim, Kee Hyun Nam, Kyoung Sik Park, Min Ho Park, Ja Sung Bae, Hyun Jo Youn, Kyu Eun Lee, Chi Young Lim, Jin Hyang Jung, Jun-Ho Choe, Lee Su Kim, Su Jung Lee, Jung Han Yoon
    Korean Journal of Endocrine Surgery.2017; 17(1): 1.     CrossRef
  • Incidental Detection of Struma Ovarii on the Whole Body Scan in a Differentiated Thyroid Cancer Patient
    Hye-Seon Oh, Eyun Song, Dong Eun Song, Won Bae Kim
    International Journal of Thyroidology.2016; 9(2): 180.     CrossRef
  • The Experience of Receiving Radioactive Iodine Therapy among Thyroid Cancer Patients
    Kyung Ok Kang, Hyun Kyung Kim, Ji Young Kim, Seok Tae Lim
    Journal of East-West Nursing Research.2016; 22(2): 148.     CrossRef
  • Comparison of two- and three-dimensional sonography for the prediction of the extrathyroidal extension of papillary thyroid carcinomas
    Yang Seon Yi, Sang Soo Kim, Won Jin Kim, Min Jung Bae, Ji Hyun Kang, Bo Gwang Choi, Yun Kyung Jeon, Bo Hyun Kim, Byung Joo Lee, Soo Geun Wang, In Joo Kim, Yong Ki Kim
    The Korean Journal of Internal Medicine.2016; 31(2): 313.     CrossRef
  • Changing trends in the management of well-differentiated thyroid carcinoma in Korea
    Yong Sang Lee, Hang-Seok Chang, Cheong Soo Park
    Endocrine Journal.2016; 63(6): 515.     CrossRef
  • Low Dose versus High Dose Radioiodine Therapy
    Kyoung Sook Won
    Journal of Korean Thyroid Association.2015; 8(1): 14.     CrossRef
  • History of Korean Thyroid Association and Recent Debates on Diagnosis and Treatment of Thyroid Cancer in Korea
    Kwang Woo Lee
    Journal of Korean Thyroid Association.2015; 8(1): 36.     CrossRef
  • Lowered cutoff of lymph node fine-needle aspiration thyroglobulin in thyroid cancer patients with serum anti-thyroglobulin antibody
    Kwanhoon Jo, Min-Hee Kim, Yejee Lim, So-Lyung Jung, Ja-Seong Bae, Chan-Kwon Jung, Moo-Il Kang, Bong-Yun Cha, Dong-Jun Lim
    European Journal of Endocrinology.2015; 173(4): 489.     CrossRef
  • Time Trends Analysis of Characteristics of Patients with Thyroid Cancer in a Single Medical Center
    Hyung Seo Jung, Min Ji Jeon, Dong Eun Song, Suck Joon Hong, Won Gu Kim, Tae Yong Kim, Young Kee Shong, Won Bae Kim
    Journal of Korean Thyroid Association.2014; 7(2): 159.     CrossRef
  • Unfounded Reports on Thyroid Cancer
    Jae Hoon Chung
    Journal of Korean Medical Science.2014; 29(8): 1033.     CrossRef
  • Regional Lymph Node Metastasis in Papillary Thyroid Cancer
    Jae Hyun Park, Kang San Lee, Keum-Seok Bae, Seong Joon Kang
    Journal of Korean Thyroid Association.2014; 7(2): 129.     CrossRef
  • Methods and Clinical Efficacy of Dosimetry-Based Treatment in Radioiodine Therapy of Thyroid Cancer
    Jin Chul Paeng, June-Key Chung
    Journal of Korean Thyroid Association.2013; 6(1): 43.     CrossRef
  • Two Cases of Non-Small Cell Lung Cancer Masquerading as Metastatic Papillary Thyroid Cancer
    Ju Hee Lee, Se-Hoon Lee, Hye Sook Min, Ji-hoon Kim, Do Joon Park, Young Joo Park
    Journal of Korean Thyroid Association.2012; 5(2): 157.     CrossRef
  • Diagnostic Dilemma of a Follicular Lesions/Neoplasm in Thyroid Fine Needle Aspiration Cytology
    Chan Kwon Jung
    Journal of Korean Thyroid Association.2012; 5(2): 104.     CrossRef
  • Updated guidelines for the diagnosis and management of thyroid nodules
    Ka Hee Yi
    Journal of the Korean Medical Association.2011; 54(6): 629.     CrossRef
A Patient with Concurrent Medullary and Papillary Carcinoma of the Thyroid.
Seung Hee Yoo, Keun Joon Lim, Seung Hwan Lee, Ji Hyun Kim, Soon Hwa Hong, Jae Hyoung Cho, Chan Kwon Jung, Hyuk Sang Kwon, Kun Ho Yoon, Min Sik Kim, Bong Yun Cha, Ho Young Son
J Korean Endocr Soc. 2007;22(3):235-240.   Published online June 1, 2007
DOI: https://doi.org/10.3803/jkes.2007.22.3.235
  • 1,434 View
  • 18 Download
  • 1 Citations
AbstractAbstract PDF
The origin of medullary thyroid carcinoma and papillary thyroid carcinoma are embryogenically different, so these tumors have been thought to be independent of each other. We experienced a case of concurrent medullary and papillary thyroid carcinoma in one patient. The patient underwent total thyroidectomy and both two tumors were located at different lobes, respectively. Both tumors showed their own characteristic pathologic and immunohistochemical findings. The patient's elevated calcitonin level returned to the normal range after operation and there has been no evidence of recurrence. It is still controversial whether the concurrency is just coincidental or it arises from activation of a common tumorigenic pathway.

Citations

Citations to this article as recorded by  
  • A Case of Concurrent Papillary and Medullary Thyroid Carcinomas Detected as Recurrent Medullary Carcinoma after Initial Surgery for Papillary Carcinoma
    Dongbin Ahn, Jin Ho Sohn, Ji Young Park
    Journal of Korean Thyroid Association.2013; 6(1): 80.     CrossRef

Endocrinol Metab : Endocrinology and Metabolism