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Cecilia Jimeno  (Jimeno C) 1 Article
Poorly Differentiated Thyroid Carcinoma: 10-Year Experience in a Southeast Asian Population
Marc Gregory Yu, Jonathan Rivera, Cecilia Jimeno
Endocrinol Metab. 2017;32(2):288-295.   Published online June 23, 2017
DOI: https://doi.org/10.3803/EnM.2017.32.2.288
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  • 12 Web of Science
  • 9 Crossref
AbstractAbstract PDFPubReader   
Background

No previous studies have been published on poorly differentiated thyroid carcinoma (PDTC) in Southeast Asia.

Methods

We included all adult PDTC patients diagnosed using the Turin criteria at the Philippine General Hospital from 2006 to 2015. The data collected included demographics, clinical presentation, histopathology, treatment, and outcomes. Tests of association were employed to compare these data with foreign studies on PDTC, as well as with local studies on well differentiated thyroid carcinoma (WDTC) and anaplastic thyroid carcinoma (ATC).

Results

Eighteen PDTC cases were identified. The median age was 62 years old, with the majority being females. All patients had goiter on presentation, and most were stage IV at the time of diagnosis. In terms of PDTC subtype, insular and trabecular patterns were equally common. Extrathyroidal extension was documented in eight patients, while five patients each had nodal and distant metastasis. All but one patient underwent surgery; however, less than half received adjuvant radioiodine therapy. The 5-year survival rate was 83%. Three patients (16.7%) died at a median of 12 months after diagnosis. Nine (50%) are still alive with persistent and/or recurrent disease at a median of 39 months after diagnosis.

Conclusion

The behavior of PDTC in this Southeast Asian population was found to be similar to patterns observed in other regions, and exhibited intermediate features between WDTC and ATC. Appropriate surgery provided excellent 5-year survival rates, but the role of adjuvant therapy remains unclear. Larger studies are needed to identify prognostic factors in this population.

Citations

Citations to this article as recorded by  
  • Poorly differentiated thyroid carcinomas: conceptual controversy and clinical impact
    Andrés Coca-Pelaz, Juan P. Rodrigo, Abbas Agaimy, Michelle D. Williams, Nabil F. Saba, Sandra Nuyts, Gregory W. Randolph, Fernando López, Vincent Vander Poorten, Luiz P. Kowalski, Francisco J. Civantos, Mark E. Zafereo, Antti A. Mäkitie, Oded Cohen, Iain
    Virchows Archiv.2024;[Epub]     CrossRef
  • I-131 Avid Tumor Thrombus in a Case of Poorly Differentiated Thyroid Cancer
    Sana Munir Gill, Aamna Hassan, Humayun Bashir, Waqas Shafiq
    Molecular Imaging and Radionuclide Therapy.2023; 32(2): 178.     CrossRef
  • Prognostic Impact of Focal Poorly Differentiated Areas in Follicular Differentiated Thyroid Cancer: Is It a Distinct Entity from Poorly Differentiated Thyroid Cancer?
    Ramakanth Bhargav Panchangam, Pradeep Puthenveetil, Sabaretnam Mayilvaganan
    Indian Journal of Surgical Oncology.2022; 13(1): 157.     CrossRef
  • Newly proposed survival staging system for poorly differentiated thyroid cancer: a SEER-based study
    W. Sun, Z. Wang, J. Xiang, Y. Qin, F. Zhang, H. Zhang
    Journal of Endocrinological Investigation.2022; 46(5): 947.     CrossRef
  • Clinicopathological Characteristics and Prognosis of Poorly Differentiated Thyroid Carcinoma Diagnosed According to the Turin Criteria
    Jiapeng Huang, Wei Sun, Qingfu Zhang, Zhihong Wang, Wenwu Dong, Dalin Zhang, Chengzhou Lv, Liang Shao, Ping Zhang, Hao Zhang
    Endocrine Practice.2021; 27(5): 401.     CrossRef
  • Osteopontin Expression in Thyroid Cancer: Deciphering EMT-Related Molecular Mechanisms
    Bruna Prunes Pena Baroni Viana, Amanda Vitória Pampolha Gomes, Etel Rodrigues Pereira Gimba, Luciana Bueno Ferreira
    Biomedicines.2021; 9(10): 1372.     CrossRef
  • Poorly differentiated thyroid carcinoma (PDTC) characteristics and the efficacy of radioactive iodine (RAI) therapy as an adjuvant treatment in a tertiary cancer care center
    Shivakumar Thiagarajan, Aamir Yousuf, Ratan Shetty, Harsh Dhar, Yash Mathur, Deepa Nair, Sandeep Basu, Asawari Patil, Shubadha Kane, Sarbani Ghosh-Laskar, Devendra Chaukar
    European Archives of Oto-Rhino-Laryngology.2020; 277(6): 1807.     CrossRef
  • Major vessel invasion by thyroid cancer: a comprehensive review
    Michael S. Xu, Jennifer Li, Sam M. Wiseman
    Expert Review of Anticancer Therapy.2019; 19(2): 191.     CrossRef
  • Poorly differentiated thyroid carcinoma and poorly differentiated area in differentiated thyroid carcinoma: is there any difference?
    Raouef Ahmed Bichoo, Anjali Mishra, Niraj Kumari, Narendra Krishnani, Gyan Chand, Gaurav Agarwal, Amit Agarwal, Saroj Kanta Mishra
    Langenbeck's Archives of Surgery.2019; 404(1): 45.     CrossRef
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