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Cecilia Alegado Jimeno  (Jimeno CA) 3 Articles
Clinical Study
Risk Factors Associated with Disease Recurrence among Patients with Low-Risk Papillary Thyroid Cancer Treated at the University of the Philippines-Philippine General Hospital
Maria Cristina Magracia Jauculan, Myrna Buenaluz-Sedurante, Cecilia Alegado Jimeno
Endocrinol Metab. 2016;31(1):113-119.   Published online March 16, 2016
DOI: https://doi.org/10.3803/EnM.2016.31.1.113
  • 3,711 View
  • 40 Download
  • 5 Web of Science
  • 6 Crossref
AbstractAbstract PDFPubReader   
Background

The management of papillary thyroid carcinoma (PTC) in high-risk patients is well-standardized. However, this is not the case for low-risk patients. Filipinos show a high incidence of recurrence of thyroid cancer. Thus, the identification of risk factors for recurrence in this population could potentially identify individuals for whom radioactive iodine (RAI) therapy might be beneficial.

Methods

We reviewed the medical records of adult Filipinos with low-risk PTC who underwent near-total or total thyroidectomy at the University of the Philippines-Philippine General Hospital. Multivariate logistic regression analysis was used to determine risk factors for recurrence.

Results

Recurrence was documented in 51/145 of patients (35.17%) included in this study. Possible risk factors such as age, sex, family history, smoking history, tumor size, multifocality, prophylactic lymph node dissection, initial thyroglobulin (Tg) level, initial anti-thyroglobulin (anti-Tg) antibody concentration, suppression of thyroid stimulating hormone production, and RAI therapy were analyzed. Multivariate analysis revealed that a tumor diameter 2 to 4 cm (odds ratio [OR], 9.17; 95% confidence interval [CI], 1.62 to 51.88; P=0.012), a tumor diameter >4 cm (OR, 16.46; 95% CI, 1.14 to 237.31; P=0.04), and a family history of PTC (OR, 67.27; 95% CI, 2.03 to 2228.96; P=0.018) were significant predictors of recurrence. In addition, RAI therapy (OR, 0.026; 95% CI, 0.01 to 0.023; P≤0.005), an initial Tg level ≤2 ng/mL (OR, 0.049; 95% CI, 0.01 to 0.23; P≤0.005), and an anti-Tg antibody level ≤50 U/mL (OR, 0.087; 95% CI, 0.011 to 0.67; P=0.019) were significant protective factors.

Conclusion

A tumor diameter ≥2 cm and a family history of PTC are significant predictors of recurrence. RAI therapy and low initial titers of Tg and anti-Tg antibody are significant protective factors against disease recurrence among low-risk PTC patients.

Citations

Citations to this article as recorded by  
  • Identifying and analyzing the key genes shared by papillary thyroid carcinoma and Hashimoto’s thyroiditis using bioinformatics methods
    Ting-ting Liu, De-tao Yin, Nan Wang, Na Li, Gang Dong, Meng-fan Peng
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Risk Stratification of Differentiated Thyroid Cancer at King Abdullah Specialized Children's Hospital Endocrinology Clinic in Riyadh, Saudi Arabia
    Raed Al-Dahash, Abdullah Alsohaim, Ziyad N Almutairi , Khaled Z Almutairi , Abdulkarim Alharbi, Sulaiman Alayed, Abdullah Almuhanna, Rayan Alotaibi
    Cureus.2023;[Epub]     CrossRef
  • Behaviour and epidemiology of differentiated thyroid cancer among filipinos in and outside the Philippines: Comparison between Qatar, Canada and Philippines
    Mohamed Said Ghali, Walid El Ansari, Abdelrahman Abdelaal, Mohamed S. Al Hassan
    Annals of Medicine and Surgery.2022; 81: 104202.     CrossRef
  • Recurrent Papillary Thyroid Carcinoma to the Cervical Lymph Nodes: Outcomes of Compartment‐Oriented Lymph Node Resection
    Carlos Gustavo Rivera‐Robledo, David Velázquez‐Fernández, Juan Pablo Pantoja, Mauricio Sierra, Bernardo Pérez‐Enriquez, Raul Rivera‐Moscoso, Mónica Chapa, Miguel F. Herrera
    World Journal of Surgery.2019; 43(11): 2842.     CrossRef
  • Thyrotropin Suppressive Therapy for Low-Risk Small Thyroid Cancer: A Propensity Score–Matched Cohort Study
    Suyeon Park, Won Gu Kim, Minkyu Han, Min Ji Jeon, Hyemi Kwon, Mijin Kim, Tae-Yon Sung, Tae Yong Kim, Won Bae Kim, Suck Joon Hong, Young Kee Shong
    Thyroid.2017; 27(9): 1164.     CrossRef
  • Articles inEndocrinology and Metabolismin 2016
    Won-Young Lee
    Endocrinology and Metabolism.2017; 32(1): 62.     CrossRef
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Thyroid
Anaplastic Thyroid Cancer: Experience of the Philippine General Hospital
Tom Edward Lo, Cecilia Alegado Jimeno, Elizabeth Paz-Pacheco
Endocrinol Metab. 2015;30(2):195-200.   Published online June 30, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.2.195
  • 3,260 View
  • 40 Download
  • 4 Web of Science
  • 4 Crossref
AbstractAbstract PDFPubReader   
Background

Anaplastic thyroid cancer (ATC) is a rare type of thyroid malignancy and one of the most aggressive solid tumors, responsible for between 14% and 50% of the total annual mortality associated with thyroid cancer.

Methods

A retrospective study was made of all ATC cases diagnosed by biopsy in the Philippine General Hospital between 2008 and 2013.

Results

A total of 15 patients were identified, with a median age at diagnosis of 63 years. All tumors were at least 6 cm in size upon diagnosis. All patients had a previous history of thyroid pathology, presenting with an average duration of 11 years. Eleven patients presented with cervical lymphadenopathies, whereas seven exhibited signs of distant metastases, for which the lungs appeared to be the most common site. More than 70% of the patients presented with a rapidly growing neck mass, leading to airway obstruction. Only three patients were treated using curative surgery; the majority received palliative and supportive forms of treatment. In addition, only three patients were offered radiotherapy. Chemotherapy was not offered to any patient. Only two patients were confirmed to still be alive during the study period. The median survival time for the other patients was 3 months; in the majority of cases the patient died within the first year following diagnosis.

Conclusion

Our experience with ATC demonstrated concordance with other institutions with respect to current clinical profile, presentation, and prognosis. An absence of distant metastases and lymph node involvement was associated with improved survival outcomes, whereas age at diagnosis and tumor size did not affect survival. Curative surgery offers the most effective means of prolonging survival. Radiotherapy and chemotherapy in combination with surgery represents a promising treatment strategy.

Citations

Citations to this article as recorded by  
  • Prior Thyroid and Nonthyroid Cancer History Do Not Significantly Alter Overall Survival in Patients Diagnosed with Anaplastic Thyroid Cancer
    Yu Han Chen, Maria Cabanillas, Jared Sperling, Li Xu, Maitrayee Goswami, Anastasios Maniakas, Michelle D. Williams, Stephen Y. Lai, Naifa Busaidy, Ramona Dadu, Mark E. Zafereo, Jennifer Rui Wang
    Thyroid.2023; 33(3): 321.     CrossRef
  • Clinical Outcome and Toxicity in the Treatment of Anaplastic Thyroid Cancer in Elderly Patients
    Teresa Augustin, Dmytro Oliinyk, Viktoria Florentine Koehler, Josefine Rauch, Claus Belka, Christine Spitzweg, Lukas Käsmann
    Journal of Clinical Medicine.2020; 9(10): 3231.     CrossRef
  • Poorly Differentiated Thyroid Carcinoma: 10-Year Experience in a Southeast Asian Population
    Marc Gregory Yu, Jonathan Rivera, Cecilia Jimeno
    Endocrinology and Metabolism.2017; 32(2): 288.     CrossRef
  • Macrophage Densities Correlated with CXC Chemokine Receptor 4 Expression and Related with Poor Survival in Anaplastic Thyroid Cancer
    Dae In Kim, Eunyoung Kim, Young A Kim, Sun Wook Cho, Jung Ah Lim, Young Joo Park
    Endocrinology and Metabolism.2016; 31(3): 469.     CrossRef
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Thyroid
Clinicopathological, Biochemical, and Sonographic Features of Thyroid Nodule Predictive of Malignancy among Adult Filipino Patients in a Tertiary Hospital in the Philippines
Edwin Jadulco Cañete, Cherrie Mae Sison-Peña, Cecilia Alegado Jimeno
Endocrinol Metab. 2014;29(4):489-497.   Published online December 29, 2014
DOI: https://doi.org/10.3803/EnM.2014.29.4.489
  • 4,365 View
  • 36 Download
  • 13 Web of Science
  • 8 Crossref
AbstractAbstract PDFPubReader   
Background

Thyroid nodules may harbor cancer in 5% to 15% of cases. Specific clinical and sonographic features predictive of malignancy have been investigated in various populations, but due to differences in epidemiology, risk factors and iodine nutrition status, these predictors may not be valid in the Philippines. This study determined the clinicopathological, biochemical, and sonographic features of thyroid nodules predictive of malignancy among adult Filipino patients at the University of the Philippines-Philippine General Hospital (UP-PGH).

Methods

We reviewed the medical records of Filipino patients ≥19 years of age who underwent thyroid surgery in UP-PGH from 2008 to 2011.

Results

A total of 837 of 1,670 patients (50.1%) were enrolled in the study, which included 417 benign and 420 malignant tumors. The mean age at diagnosis was 38±11 years, with female predominance. Multiple logistic regression analysis showed that the presence of a hard or firm nodule (odds ratio [OR], 58.8, P<0.001; OR, 12.8, P<0.001), presence of microcalcifications (OR, 11.1; P<0.001), irregular margins on ultrasound (OR, 4.5; P<0.001), and absence of associated symptoms (OR, 2.3; P<0.002) increased significantly the likelihood of thyroid malignancy.

Conclusion

Similar to international data, the absence of associated symptoms, firm to hard thyroid nodules, and the presence of microcalcifications and irregular margins were significant predictors of thyroid malignancy.

Citations

Citations to this article as recorded by  
  • Detection of Thyroid Nodule Prevalence and Associated Risk Factors in Southwest China: A Study of 45,023 Individuals Undergoing Physical Examinations
    Yi Liang, Xiaohong Li, Fang Wang, Zongting Yan, Yuhuan Sang, Yuan Yuan, Yun Qin, Xuefei Zhang, Mei Ju
    Diabetes, Metabolic Syndrome and Obesity.2023; Volume 16: 1697.     CrossRef
  • Diagnostic performance of the EU TI‐RADS and ACR TI‐RADS scoring systems in predicting thyroid malignancy
    Hiba‐Allah Chatti, Ibtissem Oueslati, Aymen Azaiez, Jihen Marrakchi, Seif Boukriba, Habiba Mizouni, Slim Haouet, Ghazi Besbes, Meriem Yazidi, Melika Chihaoui
    Endocrinology, Diabetes & Metabolism.2023;[Epub]     CrossRef
  • Behaviour and epidemiology of differentiated thyroid cancer among filipinos in and outside the Philippines: Comparison between Qatar, Canada and Philippines
    Mohamed Said Ghali, Walid El Ansari, Abdelrahman Abdelaal, Mohamed S. Al Hassan
    Annals of Medicine and Surgery.2022; 81: 104202.     CrossRef
  • Association Between Thyroid Nodules and Volume and Metabolic Syndrome in an Iodine-Adequate Area: A Large Community-Based Population Study
    Yue Su, Yan-ling Zhang, Meng Zhao, Hai-qing Zhang, Xu Zhang, Qing-bo Guan, Chun-xiao Yu, Shan-shan Shao, Jin Xu
    Metabolic Syndrome and Related Disorders.2019; 17(4): 217.     CrossRef
  • Accuracy of ultrasonography-guided fine needle aspiration cytology and significance of non-diagnostic cytology in the preoperative detection of thyroid malignancy
    JSL Chieng, CH Lee, AA Karandikar , JPN Goh, SSS Tan
    Singapore Medical Journal.2019; 60(4): 193.     CrossRef
  • Thyroid Fine-Needle Aspiration Practice in the Philippines
    Agustina D. Abelardo
    Journal of Pathology and Translational Medicine.2017; 51(6): 555.     CrossRef
  • An Epidemiological Study of Risk Factors of Thyroid Nodule and Goiter in Chinese Women
    Lei Zheng, Wenhua Yan, Yue Kong, Ping Liang, Yiming Mu
    International Journal of Environmental Research and Public Health.2015; 12(9): 11608.     CrossRef
  • Articles in 'Endocrinology and Metabolism' in 2014
    Won-Young Lee
    Endocrinology and Metabolism.2015; 30(1): 47.     CrossRef
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