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Borami Kang  (Kang B) 1 Article
Thyroid
Cholestyramine Use for Rapid Reversion to Euthyroid States in Patients with Thyrotoxicosis
Jeonghoon Ha, Kwanhoon Jo, Borami Kang, Min-Hee Kim, Dong-Jun Lim
Endocrinol Metab. 2016;31(3):476-479.   Published online July 26, 2016
DOI: https://doi.org/10.3803/EnM.2016.31.3.476
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  • 6 Web of Science
  • 7 Crossref
AbstractAbstract PDFPubReader   

Cholestyramine (CS) is an ion exchange resin, which binds to iodothyronines and would lower serum thyroid hormone level. The use of CS added to conventional antithyroid drugs to control thyrotoxicosis has been applied since 1980's, and several studies indicate that using CS in combination with methimazole (MZ) produces a more rapid decline in serum thyroid hormones than with only MZ treatment. Our recent retrospective review of five patients taking high dose MZ and CS, compared to age-, gender-, initial free thyroxine (T4) level-, and MZ dose-matched 12 patients with MZ use only, showed more rapid decline of both free T4 and triiodothyronine levels without more adverse events. CS could be safely applicable short-term adjunctive therapy when first-line antithyroid medications are not enough to adequately control severe thyrotoxicosis or side effects of antithyroid drug would be of great concern.

Citations

Citations to this article as recorded by  
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    Frontiers in Cardiovascular Medicine.2020;[Epub]     CrossRef
  • Propylthiouracil-induced agranulocytosis as a rare complication of antithyroid drugs in a patient with Graves’ disease
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  • Notes on Trauma-Related Thyroid Storm in the Emergency Department
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    The Journal of Emergency Medicine.2018; 54(2): e35.     CrossRef
  • Risk of embryopathies with use of antithyroidal medications
    Stine L. Andersen
    Current Opinion in Endocrinology, Diabetes & Obesity.2017; 24(5): 364.     CrossRef
  • Thiamazole

    Reactions Weekly.2017; 1644(1): 291.     CrossRef
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