- Clinical Study
- Effect of Lactobacillus sakei, a Probiotic Derived from Kimchi, on Body Fat in Koreans with Obesity: A Randomized Controlled Study
-
Soo Lim, Ji Hye Moon, Chol Min Shin, Dahye Jeong, Bongjoon Kim
-
Endocrinol Metab. 2020;35(2):425-434. Published online June 24, 2020
-
DOI: https://doi.org/10.3803/EnM.2020.35.2.425
-
-
10,104
View
-
284
Download
-
38
Web of Science
-
41
Crossref
-
Abstract
PDFPubReader ePub
- Background
The increased prevalence of obesity has led to increases in the prevalence of chronic diseases worldwide. There is interest whether probiotics have an effect on obesity, but the effectiveness and safety of only a few probiotics for the treatment of obesity have been reported. The purpose of this study was to investigate whether ingestion of Lactobacillus sakei (CJLS03) derived from kimchi causes weight loss in people with obesity.
Methods This randomized, double-blind, placebo-controlled, clinical trial involved 114 adults with a body mass index (BMI) ≥25 kg/m2 who were assigned randomly to a CJLS03 or placebo group. The groups received two allocations of either 5×109 colony-forming units of CJLS03/allocation or the equivalent vehicle for 12 weeks. Demographic and biochemical parameters, and body composition including fat and muscle mass were measured at baseline and after 12 weeks. Changes in body fat, weight, and waist circumference were compared between the two treatment groups. Adverse events were monitored during study period.
Results Body fat mass decreased by 0.2 kg in the CJLS03 group and increased by 0.6 kg in the placebo group (0.8 kg difference, P=0.018). After the 12 weeks, waist circumference was 0.8 cm smaller in the CJLS03 group than in the placebo group (P=0.013). BMI and body weight did not change after the 12 weeks. Adverse events were mild and did not differ between the two groups.
Conclusion These data suggest that L. sakei (CJLS03) might help people with obesity reduce body fat mass without serious side effects (ClinicalTrials.gov: NCT03248414).
-
Citations
Citations to this article as recorded by
-
Latilactobacillus sakei
: a candidate probiotic with a key role in food fermentations and health promotion
Leilei Yu, Ying Chen, Hui Duan, Nanzhen Qiao, Gang Wang, Jianxin Zhao, Qixiao Zhai, Fengwei Tian, Wei Chen Critical Reviews in Food Science and Nutrition.2024; 64(4): 978. CrossRef - Beneficial effects of the probiotics and synbiotics supplementation on anthropometric indices and body composition in adults: A systematic review and meta‐analysis
Saeede Saadati, Kaveh Naseri, Omid Asbaghi, Mohsen Yousefi, Elnaz Golalipour, Barbora de Courten Obesity Reviews.2024;[Epub] CrossRef - Spore-forming probiotics Weizmannia coagulans isolated from human breast milk improves on the flavor development using micro-cheese platform
Hyejin Choi, Daye Mun, Sangdon Ryu, Min-Jin Kwak, Bum-Keun Kim, Dong-Jun Park, Do-Youn Jeong, Wonseo Park, Sangnam Oh, Younghoon Kim Food Bioscience.2024; 57: 103550. CrossRef - Latilactobacillus sakei as a starter culture to ferment pepper fruits
Emma Mani-López, Nelly Ramírez-Corona, Aurelio López-Malo Food and Humanity.2024; 2: 100233. CrossRef - Association between kimchi consumption and obesity based on BMI and abdominal obesity in Korean adults: a cross-sectional analysis of the Health Examinees study
Hyein Jung, Ye-Rang Yun, Sung Wook Hong, Sangah Shin BMJ Open.2024; 14(2): e076650. CrossRef - Adjunctive administration of parabiotic Lactobacillus sakei CVL-001 ameliorates drug-induced toxicity and pulmonary inflammation during antibiotic treatment for tuberculosis
Hagyu Kim, Eun-Jung Song, Eunsol Choi, Kee Woong Kwon, Jong-Hwan Park, Sung Jae Shin International Immunopharmacology.2024; 132: 111937. CrossRef - Anti-obesogenic effects of plant natural products: A focus on Korean traditional foods
Gitishree Das, Luis Alfonso Jiménez Ortega, Sandra Gonçalves, J. Basilio Heredia, Maria de Lourdes Gomes Pereira, Anabela Romano, Han-Seung Shin, Jayanta Kumar Patra Trends in Food Science & Technology.2024; 148: 104470. CrossRef - Efficacy of Lactococcus lactis subsp. lactis LY-66 and Lactobacillus plantarum PL-02 in Enhancing Explosive Strength and Endurance: A Randomized, Double-Blinded Clinical Trial
Mon-Chien Lee, Yi-Ju Hsu, Mu-Tsung Chen, Yi-Wei Kuo, Jia-Hung Lin, Yu-Chieh Hsu, Yen-Yu Huang, Ching-Min Li, Shin-Yu Tsai, Ko-Chiang Hsia, Hsieh-Hsun Ho, Chi-Chang Huang Nutrients.2024; 16(12): 1921. CrossRef - Improvement and application of recommended food score for hypertension in Korean adults: the Korean Genome and Epidemiology Study
Jiyoung Hwang, Jeongsu Kim, Hyesook Kim Frontiers in Nutrition.2024;[Epub] CrossRef - Use of probiotics in preventing and treating excess weight and obesity. A systematic review
Belén Torres, María C. Sánchez, Leire Virto, Arancha Llama‐Palacios, María J. Ciudad, Luis Collado Obesity Science & Practice.2024;[Epub] CrossRef - Association between dietary patterns and obesity: a longitudinal prospective cohort study
L.-J. Tan, S.-J. Oh, B. Nasan-Ulzii, W. Lee, S.W. Hong, S. Shin Public Health.2024; 234: 217. CrossRef - Health Benefits of Kimchi, Sauerkraut, and Other Fermented Foods of the Genus Brassica
Sabina Fijan, Polona Fijan, Lei Wei, Maria L. Marco Applied Microbiology.2024; 4(3): 1165. CrossRef - The Skin Histopathology of Pro- and Parabiotics in a Mouse Model of Atopic Dermatitis
Hun Hwan Kim, Se Hyo Jeong, Min Yeong Park, Pritam Bhagwan Bhosale, Abuyaseer Abusaliya, Jeong Doo Heo, Hyun Wook Kim, Je Kyung Seong, Tae Yang Kim, Jeong Woo Park, Byeong Soo Kim, Gon Sup Kim Nutrients.2024; 16(17): 2903. CrossRef - Effects of Kimchi Intake on the Gut Microbiota and Metabolite Profiles of High-Fat-Induced Obese Rats
Dong-Wook Kim, Quynh-An Nguyen, Saoraya Chanmuang, Sang-Bong Lee, Bo-Min Kim, Hyeon-Jeong Lee, Gwang-Ju Jang, Hyun-Jin Kim Nutrients.2024; 16(18): 3095. CrossRef - The effect of probiotic and synbiotic supplementation on lipid parameters among patients with cardiometabolic risk factors: a systematic review and meta-analysis of clinical trials
Zeinab Ghorbani, Asma Kazemi, Theda U.P. Bartolomaeus, Fahimeh Martami, Morvarid Noormohammadi, Arsalan Salari, Ulrike Löber, Heydar Ali Balou, Sofia K. Forslund, Marjan Mahdavi-Roshan Cardiovascular Research.2023; 119(4): 933. CrossRef - Impact of probiotics on muscle mass, muscle strength and lean mass: a systematic review and meta‐analysis of randomized controlled trials
Konstantinos Prokopidis, Panagiotis Giannos, Richard Kirwan, Theocharis Ispoglou, Francesco Galli, Oliver C. Witard, Konstantinos K. Triantafyllidis, Konstantinos S. Kechagias, Jordi Morwani‐Mangnani, Andrea Ticinesi, Masoud Isanejad Journal of Cachexia, Sarcopenia and Muscle.2023; 14(1): 30. CrossRef - Anti-obesity potential of heat-killed Lactiplantibacillus plantarum K8 in 3T3-L1 cells and high-fat diet mice
Kyoung Ok Jang, Jung Seo Choi, Kyeong Hun Choi, Seongjae Kim, Hangeun Kim, Dae Kyun Chung Heliyon.2023; 9(1): e12926. CrossRef - Effect of Lactobacillus plantarum LMT1-48 on Body Fat in Overweight Subjects: A Randomized, Double-Blind, Placebo-Controlled Trial
Minji Sohn, Hyeyoung Jung, Woo Shun Lee, Tai Hoon Kim, Soo Lim Diabetes & Metabolism Journal.2023; 47(1): 92. CrossRef - Effect of kimchi intake on body weight of general community dwellers: a prospective cohort study
Li-Juan Tan, Ye-Rang Yun, Sung Wook Hong, Sangah Shin Food & Function.2023; 14(4): 2162. CrossRef - Effects of Probiotics on Intermediate Cardiovascular Outcomes in Patients with Overweight or Obesity: A Systematic Review and Meta-Analysis
Frank Mayta-Tovalino, Carlos Diaz-Arocutipa, Alejandro Piscoya, Adrian V. Hernandez Journal of Clinical Medicine.2023; 12(7): 2554. CrossRef - Effects of kimchi on human health: a scoping review of randomized controlled trials
Eunhye Song, Lin Ang, Hye Won Lee, Myung-Sunny Kim, You Jin Kim, Daija Jang, Myeong Soo Lee Journal of Ethnic Foods.2023;[Epub] CrossRef - Randomized controlled trials reporting the effects of probiotics in individuals with overweight and obesity: A critical review of the interventions and body adiposity parameters
Marcella Rodrigues Guedes, Karine Scanci da Silva Pontes, Maria Inês Barreto Silva, Mario Fritsch Neves, Márcia Regina Simas Torres Klein Clinical Nutrition.2023; 42(6): 835. CrossRef - Roles of the gut microbiome in weight management
Rachel N. Carmody, Jordan E. Bisanz Nature Reviews Microbiology.2023; 21(8): 535. CrossRef - Does gut microbiota affect the success of weight loss? Evidence and speculation
Małgorzata Moszak, Marta Pelczyńska, Agnieszka Wesołek, Dominika Stenclik, Paweł Bogdański Nutrition.2023; 116: 112111. CrossRef - Certain Fermented Foods and Their Possible Health Effects with a Focus on Bioactive Compounds and Microorganisms
Gülsüm Deveci, Elif Çelik, Duygu Ağagündüz, Elena Bartkiene, João Miguel F. Rocha, Fatih Özogul Fermentation.2023; 9(11): 923. CrossRef - The gut microbiome in the fight against obesity: The potential of dietary factors
Jamil Ahmad, Imran Khan, Gokhan Zengin, Mohamad Fawzi Mahomoodally The FASEB Journal.2023;[Epub] CrossRef - Effect of Continuous Ingestion of Bifidobacteria and Inulin on Reducing Body Fat: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Comparison Study
Yuhei Baba, Yasuo Saito, Mei Kadowaki, Naoki Azuma, Daisuke Tsuge Nutrients.2023; 15(24): 5025. CrossRef - A Review of the Health Benefits of Kimchi Functional Compounds and Metabolites
Hyun Ju Kim, Min Sung Kwon, Hyelyeon Hwang, Ha-Sun Choi, WooJe Lee, Sang-Pil Choi, Haeun Jo, Sung Wook Hong Microbiology and Biotechnology Letters.2023; 51(4): 353. CrossRef - Efficacy and Safety of Lactobacillus plantarum K50 on Lipids in Koreans With Obesity: A Randomized, Double-Blind Controlled Clinical Trial
Minji Sohn, Ga Yoon Na, Jaeryang Chu, Hyunchae Joung, Byung-Kook Kim, Soo Lim Frontiers in Endocrinology.2022;[Epub] CrossRef - Changes in systolic blood pressure, postprandial glucose, and gut microbial composition following mango consumption in individuals with overweight and obesity
Justine Keathley, Michèle Kearney, Véronique Garneau, Juan de Toro-Martín, Thibault V. Varin, Geneviève Pilon, Patrick Couture, André Marette, Marie-Claude Vohl, Charles Couillard Applied Physiology, Nutrition, and Metabolism.2022; 47(5): 565. CrossRef - Host—microbial interactions in metabolic diseases: from diet to immunity
Ju-Hyung Lee, Joo-Hong Park Journal of Microbiology.2022; 60(6): 561. CrossRef - Effect of MED-02 Containing Two Probiotic Strains, Limosilactobacillus fermentum MG4231 and MG4244, on Body Fat Reduction in Overweight or Obese Subjects: A Randomized, Multicenter, Double-Blind, Placebo-Controlled Study
Young Gyu Cho, Yun Jun Yang, Yeong Sook Yoon, Eon Sook Lee, Jun Hyung Lee, Yulah Jeong, Chang Ho Kang Nutrients.2022; 14(17): 3583. CrossRef - Evaluation of metabolic activities and probiotic characteristics of two Latilactobacillus sakei strains isolated from pastırma
Emine Dincer, Merih Kivanc World Journal of Microbiology and Biotechnology.2022;[Epub] CrossRef - Correlation between autochthonous microbial communities and flavor profiles during the fermentation of mustard green paocai (Brassica juncea Coss.), a typical industrial-scaled salted fermented vegetable
Dongdong Wang, Gong Chen, Yao Tang, Jiayi Li, Runqiu Huang, Meizuo Ye, Jianying Ming, Yalong Wu, Fei Xu, Xingyue Lai, Qisheng Zhang, Wenxue Zhang LWT.2022; 172: 114212. CrossRef - Therapeutic and Improving Function of Lactobacilli in the Prevention and Treatment of Cardiovascular-Related Diseases: A Novel Perspective From Gut Microbiota
Xin Zhao, Xinqin Zhong, Xiao Liu, Xiaoying Wang, Xiumei Gao Frontiers in Nutrition.2021;[Epub] CrossRef - Don’t Worry, Heavy Moms; Just Eat Your Broccoli (or Kimchi)!
Sun-Kyung Lee Molecules and Cells.2021; 44(6): 422. CrossRef - Effects of probiotics on body adiposity and cardiovascular risk markers in individuals with overweight and obesity: A systematic review and meta-analysis of randomized controlled trials
Karine Scanci da Silva Pontes, Marcella Rodrigues Guedes, Michelle Rabello da Cunha, Samanta de Souza Mattos, Maria Inês Barreto Silva, Mario Fritsch Neves, Bianca Cristina Antunes Alves Marques, Márcia Regina Simas Torres Klein Clinical Nutrition.2021; 40(8): 4915. CrossRef - Health-Promoting Constituents and Selected Quality Parameters of Different Types of Kimchi: Fermented Plant Products
Anna Korus, Emilia Bernaś, Jarosław Korus, Eduard Hernández International Journal of Food Science.2021; 2021: 1. CrossRef - Effects of Probiotics and Synbiotics on Weight Loss in Subjects with Overweight or Obesity: A Systematic Review
Valentina Álvarez-Arraño, Sandra Martín-Peláez Nutrients.2021; 13(10): 3627. CrossRef - ADJUVANT AND BENEFICIAL PROBIOTIC THERAPY FOR WOMEN HEALTH
Igori Balta, Eugenia Butucel, Valentyn Mohylyuk Romanian Archives of Microbiology and Immunology.2021; 80(2): 151. CrossRef - Nrf2-interacting nutrients and COVID-19: time for research to develop adaptation strategies
Jean Bousquet, Jean-Paul Cristol, Wienczyslawa Czarlewski, Josep M. Anto, Adrian Martineau, Tari Haahtela, Susana C. Fonseca, Guido Iaccarino, Hubert Blain, Alessandro Fiocchi, G. Walter Canonica, Joao A. Fonseca, Alain Vidal, Hak-Jong Choi, Hyun Ju Kim, Clinical and Translational Allergy.2020;[Epub] CrossRef
|