Skip Navigation
Skip to contents

Endocrinol Metab : Endocrinology and Metabolism

clarivate
OPEN ACCESS
SEARCH
Search

Author index

Page Path
HOME > BROWSE ARTICLES > Author index
Search
Ae-Rin Baek  (Baek AR) 1 Article
Obesity and Metabolism
Association between Cardiac Autonomic Neuropathy, Diabetic Retinopathy and Carotid Atherosclerosis in Patients with Type 2 Diabetes
Chan-Hee Jung, Ae-Rin Baek, Kyu-Jin Kim, Bo-Yeon Kim, Chul-Hee Kim, Sung-Koo Kang, Ji-Oh Mok
Endocrinol Metab. 2013;28(4):309-319.   Published online December 12, 2013
DOI: https://doi.org/10.3803/EnM.2013.28.4.309
  • 4,491 View
  • 38 Download
  • 22 Crossref
AbstractAbstract PDFPubReader   
Background

It is not clear whether microangiopathies are associated with subclinical atherosclerosis in type 2 diabetes mellitus (T2DM). We investigated the relation of cardiac autonomic neuropathy (CAN) and other microangiopathies with carotid atherosclerosis in T2DM.

Methods

A total of 131 patients with T2DM were stratified by mean carotid intima-media thickness (CIMT) ≥ or <1.0 mm and the number of carotid plaques. CAN was assessed by the five standard cardiovascular reflex tests according to the Ewing's protocol. CAN was defined as the presence of at least two abnormal tests or an autonomic neuropathy points ≥2. Diabetic microangiopathies were assessed.

Results

Patients with CAN comprised 77% of the group with mean CIMT ≥1.0 mm, while they were 29% of the group with CIMT <1.0 mm (P=0.016). Patients with diabetic retinopathy (DR) comprised 68% of the group with CIMT ≥1.0 mm, while they were 28% of the group without CIMT thickening (P=0.003). Patients with CAN comprised 51% of the group with ≥2 carotid plaques, while they were 23% of the group with ≤1 carotid plaque (P=0.014). In multivariable adjusted logistic regression analysis, the patients who presented with CAN showed an odds ratio [OR] of 8.6 (95% confidence interval [CI], 1.6 to 44.8) for CIMT thickening and an OR of 2.9 (95% CI, 1.1 to 7.5) for carotid plaques. Furthermore, patients with DR were 3.8 times (95% CI, 1.4 to 10.2) more likely to have CIMT thickening.

Conclusion

These results suggest that CAN is associated with carotid atherosclerosis, represented as CIMT and plaques, independent of the traditional cardiovascular risk factors in T2DM. CAN or DR may be a determinant of subclinical atherosclerosis in T2DM.

Citations

Citations to this article as recorded by  
  • Common carotid artery intima media thickness (CIMT) in patients with prediabetes and newly diagnosed type 2 diabetes mellitus
    Antoaneta Gateva, Yavor Assyov, Vera Karamfilova, Zdravko Kamenov
    Journal of Diabetes and its Complications.2024; 38(7): 108766.     CrossRef
  • Carotid atherosclerosis: An independent risk factor for small fiber nerve dysfunction in patients with type 2 diabetes mellitus
    Simin Guo, Yali Jing, Chenxi Li, Dalong Zhu, Weimin Wang
    Journal of Diabetes Investigation.2023; 14(2): 289.     CrossRef
  • Evaluating Diagnostic Ultrasound of the Vagus Nerve as a Surrogate Marker for Autonomic Neuropathy in Diabetic Patients
    Bianka Heiling, Adriana Karl, Nadin Fedtke, Nicolle Müller, Christof Kloos, Alexander Grimm, Hubertus Axer
    Medicina.2023; 59(3): 525.     CrossRef
  • Albuminuria but not low eGFR is closely associated with atherosclerosis in patients with type 2 diabetes: an observational study
    Jun-Wei Wang, Jiang-Feng Ke, Zhi-Hui Zhang, Jun-Xi Lu, Lian-Xi Li
    Diabetology & Metabolic Syndrome.2022;[Epub]     CrossRef
  • Predictive Value of the Advanced Lipoprotein Profile and Glycated Proteins on Diabetic Retinopathy
    Josep Julve, Joana Rossell, Eudald Correig, Marina Idalia Rojo-Lopez, Nuria Amigó, Marta Hernández, Alicia Traveset, Marc Carbonell, Nuria Alonso, Didac Mauricio, Esmeralda Castelblanco
    Nutrients.2022; 14(19): 3932.     CrossRef
  • The relationship between carotid disease and retinopathy in diabetes: a systematic review
    Jocelyn J. Drinkwater, Timothy M. E. Davis, Wendy A. Davis
    Cardiovascular Diabetology.2020;[Epub]     CrossRef
  • Carotid Disease and Retinal Optical Coherence Tomography Angiography Parameters in Type 2 Diabetes: The Fremantle Diabetes Study Phase II
    Jocelyn J. Drinkwater, Fred K. Chen, Alison M. Brooks, Brad T. Davis, Angus W. Turner, Timothy M.E. Davis, Wendy A. Davis
    Diabetes Care.2020; 43(12): 3034.     CrossRef
  • Diabetic foot – invalidating complication of diabetes mellitus
    Oana Manuela Spălăţelu, Sergiu Chirila, Leonard Gurgas, Vasile Sârbu
    Medic.ro.2019; 3(129): 40.     CrossRef
  • Clinical factors associated with the recovery of cardiovascular autonomic neuropathy in patients with type 2 diabetes mellitus
    Ji Eun Jun, Seung-Eun Lee, Min Sun Choi, Sung Woon Park, You-Cheol Hwang, Jae Hyeon Kim
    Cardiovascular Diabetology.2019;[Epub]     CrossRef
  • Association of carotid intima-media thickness with exercise tolerance test in type 2 diabetic patients
    Ali Momeni, Abdolmajid Taheri, Maryam Mansuri, Ali Bazdar, Morteza Sedehi, Masoud Amiri
    IJC Heart & Vasculature.2018; 21: 74.     CrossRef
  • Cardiac autonomic neuropathy may play a role in pathogenesis of atherosclerosis in type 1 diabetes mellitus
    Sarka Mala, Veronika Potockova, Lucie Hoskovcova, Pavlina Pithova, Marek Brabec, Jaroslava Kulhankova, Radan Keil, Lucie Riedlbauchova, Jan Broz
    Diabetes Research and Clinical Practice.2017; 134: 139.     CrossRef
  • Cardio-Ankle Vascular Index and Indices of Diabetic Polyneuropathy in Patients with Type 2 Diabetes
    Akihiko Ando, Michiaki Miyamoto, Kazuhiko Kotani, Kenta Okada, Shoichiro Nagasaka, Shun Ishibashi
    Journal of Diabetes Research.2017; 2017: 1.     CrossRef
  • Cardiac Involvement in Peripheral Neuropathies
    Ahmet Z. Burakgazi, Soufian AlMahameed
    Journal of Clinical Neuromuscular Disease.2016; 17(3): 120.     CrossRef
  • The relationship between vitamin D status and cardiac autonomic neuropathy in patients with type 2 diabetes mellitus
    Chan-Hee Jung, Sang-Hee Jung, Kyu-Jin Kim, Bo-Yeon Kim, Chul-Hee Kim, Sung-Koo Kang, Ji-Oh Mok
    Diabetes and Vascular Disease Research.2015; 12(5): 342.     CrossRef
  • Atorvastatin Treatment for Carotid Intima-Media Thickness in Chinese Patients With Type 2 Diabetes
    Na Fang, Wei Han, Dandan Gong, Zou Chen, Yu Fan
    Medicine.2015; 94(44): e1920.     CrossRef
  • Cardiovascular complications in patients with autonomic failure
    Valeria Milazzo, Cristina Di Stefano, Alberto Milan, Agnese Ravera, Gabriele Sobrero, Luca Sabia, Franco Veglio, Simona Maule
    Clinical Autonomic Research.2015; 25(3): 133.     CrossRef
  • Association of heart rate with albuminuria in a general adult population: the 2011 Korea National Health and Nutrition Examination Survey
    H. S. Choi, J. W. Hong, J. H. Lee, J. H. Noh, D. J. Kim
    Internal Medicine Journal.2015; 45(4): 428.     CrossRef
  • Type 2 diabetes-associated carotid plaque burden is increased in patients with retinopathy compared to those without retinopathy
    Núria Alonso, Alicia Traveset, Esther Rubinat, Emilio Ortega, Nuria Alcubierre, Jordi Sanahuja, Marta Hernández, Angels Betriu, Carmen Jurjo, Elvira Fernández, Didac Mauricio
    Cardiovascular Diabetology.2015;[Epub]     CrossRef
  • Letter: Association between Cardiac Autonomic Neuropathy, Diabetic Retinopathy and Carotid Atherosclerosis in Patients with Type 2 Diabetes (Endocrinol Metab 2013;28:309-19, Chan-Hee Jung et al.)
    Hyun-Kyung Chung
    Endocrinology and Metabolism.2014; 29(1): 101.     CrossRef
  • Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
    Won-Young Lee
    Endocrinology and Metabolism.2014; 29(3): 251.     CrossRef
  • Clinical utility of serum beta-2-microglobulin as a predictor of diabetic complications in patients with type 2 diabetes without renal impairment
    M.K. Kim, K.-J. Yun, H.J. Chun, E.-H. Jang, K.-D. Han, Y.-M. Park, K.-H. Baek, K.-H. Song, B.-Y. Cha, C.S. Park, H.-S. Kwon
    Diabetes & Metabolism.2014; 40(6): 459.     CrossRef
  • Association between Brachial-Ankle pulse wave velocity and cardiac autonomic neuropathy in type 2 diabetes
    Nan Wu, Xiaoling Cai, Kuanping Ye, Yintao Li, Min He, Weiwei Zhao, Renming Hu
    Diabetology & Metabolic Syndrome.2014;[Epub]     CrossRef
Close layer

Endocrinol Metab : Endocrinology and Metabolism