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Abigail Uy Canto  (Canto AU) 1 Article
Clinical Study
Risk Factors for Recurrence in Filipinos with Well-Differentiated Thyroid Cancer
Tom Edward Ngo Lo, Abigail Uy Canto, Patricia Deanna D. Maningat
Endocrinol Metab. 2015;30(4):543-550.   Published online December 31, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.4.543
  • 3,570 View
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  • 11 Web of Science
  • 10 Crossref
AbstractAbstract PDFPubReader   
Background

The incidence of well-differentiated thyroid cancer (WDTC) has increased in recent years. Despite its excellent prognosis, increasing morbidity from recurrent diseases continues to affect long-term outcomes. Among at-risk populations, Filipinos have the highest incidence of thyroid cancer worldwide, characterized by a highly aggressive and recurrent form of disease. Here, we sought to identify risk factors associated with disease recurrence among Filipinos with WDTC.

Methods

This retrospective cohort study examined 723 patients diagnosed with WDTC seen at Philippine General Hospital. Affected individuals were classified based on the presence or absence of disease recurrence. Multivariate logistic regression analyses were used to determine significant predictors of recurrence.

Results

Multiple risk factors, including age >45 years (odds ratio [OR], 1.44), multifocality of cancer (OR, 1.43), nodal involvement (OR, 4.0), and distant metastases at presentation (OR, 2.78), were significantly associated with a recurrence of papillary thyroid cancer (PTC). In contrast, follicular variant histology (OR, 0.60) and postsurgical radioactive iodine therapy (OR, 0.31) were protective for PTC recurrence. Distant metastases at presentation (OR, 19.4) and postsurgical radioactive iodine therapy (OR, 0.41) were associated with follicular thyroid cancer (FTC) recurrence.

Conclusion

Lymph node metastases at presentation was the strongest predictor of recurrence in PTC, whereas distant metastases at presentation was the strongest for FTC recurrence. Among Filipinos, stratification of WDTC patients based on recurrence risk factors identified in this study will be helpful in guiding the intensity of treatment strategies and long-term thyroid cancer surveillance.

Citations

Citations to this article as recorded by  
  • Characterization of mortality and high-risk characteristics of thyroid cancer in Filipinos using the California Cancer Registry
    Robert Hsu, Kai-Ya Tsai, Krithika Chennapan, Katherine Y. Wojcik, Alice W. Lee, Jorge J. Nieva, Lihua Liu
    Frontiers in Public Health.2023;[Epub]     CrossRef
  • Behaviour and epidemiology of differentiated thyroid cancer among filipinos in and outside the Philippines: Comparison between Qatar, Canada and Philippines
    Mohamed Said Ghali, Walid El Ansari, Abdelrahman Abdelaal, Mohamed S. Al Hassan
    Annals of Medicine and Surgery.2022; 81: 104202.     CrossRef
  • Risk Factors for Recurrence of Follicular Thyroid Cancer: A Systematic Review
    Mathias Peter Grønlund, Jakob Schmidt Jensen, Christoffer Holst Hahn, Christian Grønhøj, Christian von Buchwald
    Thyroid.2021;[Epub]     CrossRef
  • Differential Expression of Non-Coding RNA Signatures in Thyroid Cancer between Two Ethnic Groups
    Kristiana Rood, Khodeza Begum, Hanmin Wang, Yan C. Wangworawat, Ryan Davis, Celina R. Yamauchi, Mia C. Perez, Alfred A. Simental, Ria T. Laxa, Charles Wang, Sourav Roy, Salma Khan
    Current Oncology.2021; 28(5): 3610.     CrossRef
  • Dynamic Risk Stratification for Predicting Treatment Response in Differentiated Thyroid Cancer
    Evanthia Giannoula, Christos Melidis, Nikitas Papadopoulos, Panagiotis Bamidis, Vasilios Raftopoulos, Ioannis Iakovou
    Journal of Clinical Medicine.2020; 9(9): 2708.     CrossRef
  • Overall Survival of Papillary Thyroid Carcinoma Patients: A Single‐Institution Long‐Term Follow‐Up of 5897 Patients
    Yasuhiro Ito, Akira Miyauchi, Minoru Kihara, Mitsuhiro Fukushima, Takuya Higashiyama, Akihiro Miya
    World Journal of Surgery.2018; 42(3): 615.     CrossRef
  • Prognostic value of the 8th edition of the tumor-node-metastasis classification for patients with papillary thyroid carcinoma: a single-institution study at a high-volume center in Japan
    Yasuhiro Ito, Akira Miyauchi, Mitsuyoshi Hirokawa, Masatoshi Yamamoto, Hitomi Oda, Hiroo Masuoka, Hisanori Sasai, Mitsuhiro Fukushima, Takuya Higashiyama, Minoru Kihara, Akihiro Miya
    Endocrine Journal.2018; 65(7): 707.     CrossRef
  • The correlations between DNA methylation and polymorphisms in the promoter region of the human telomerase reverse transcriptase (hTERT) gene with postoperative recurrence in patients with thyroid carcinoma (TC)
    Jian-Jun Li, Ping Chen Jue-Ru Zheng, Yao-Zong Wang
    World Journal of Surgical Oncology.2017;[Epub]     CrossRef
  • Differentiated Thyroid Cancer in Asians
    Bo Hyun Kim
    Endocrinology and Metabolism.2016; 31(1): 62.     CrossRef
  • Meta-analysis of radiofrequency ablation for treating the local recurrence of thyroid cancers
    Q. Zhao, G. Tian, D. Kong, T. Jiang
    Journal of Endocrinological Investigation.2016; 39(8): 909.     CrossRef
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