Endocrinology and Metabolism

A Ram Hong (Hong AR)

21 Articles

Thyroid
Active Surveillance for Low-Risk Papillary Thyroid Carcinoma as an Acceptable Management Option with Additional Benefits: A Comprehensive Systematic Review: Jee Hee Yoon, Wonsuk Choi, Ji Yong Park, A Ram Hong, Hee Kyung Kim, Ho-Cheol Kang; Endocrinol Metab. 2024;39(1):152-163. Published online January 22, 2024; DOI: https://doi.org/10.3803/EnM.2023.1794

2,659 View
124 Download
1 Web of Science
2 Crossref

Abstract PDF Supplementary Material PubReader ePub

Background
Active surveillance (AS) has been introduced as a management strategy for low-risk papillary thyroid carcinoma (PTC) due to its typically indolent nature. Despite this, the widespread adoption of AS has encountered several challenges. The aim of this systematic review was to evaluate the safety of AS related to disease progression and its benefits compared with immediate surgery (IS).
Methods
Studies related to AS in patients with low-risk PTC were searched through the Ovid MEDLINE, Embase, Cochrane Library, and KoreaMed databases. Studies on disease progression, surgical complication, quality of life (QoL), and cost-effectiveness were separately analyzed and narratively synthesized.
Results
In the evaluation of disease progression, the proportions of cases with tumor growth ≥3 mm and a volume increase >50% were 2.2%–10.8% and 16.0%–25.5%, respectively. Newly detected lymph node metastasis was identified in 0.0%–1.4% of patients. No significant difference was found between IS and delayed surgery in surgical complications, including vocal cord paralysis and postoperative hypoparathyroidism. AS was associated with better QoL than IS. Studies on the cost-effectiveness of AS reported inconsistent data, but AS was more cost-effective when quality-adjusted life years were considered.
Conclusion
AS is an acceptable management option for patients with low-risk PTC based on the low rate of disease progression and the absence of an increased mortality risk. AS has additional benefits, including improved QoL and greater QoL-based cost-effectiveness.

Citations

Citations to this article as recorded by

It Is Time to Understand the Additional Benefits of Active Surveillance for Low-Risk Papillary Thyroid Carcinoma
Kyeong Jin Kim
Endocrinology and Metabolism.2024; 39(1): 95. CrossRef
Thyroid Nodules: Past, Present, and Future
Alan A. Parsa, Hossein Gharib
Endocrine Practice.2024;[Epub] CrossRef

Thyroid
Evaluation and Management of Bone Health in Patients with Thyroid Diseases: A Position Statement of the Korean Thyroid Association: A Ram Hong, Ho-Cheol Kang; Endocrinol Metab. 2023;38(2):175-189. Published online April 27, 2023; DOI: https://doi.org/10.3803/EnM.2023.1701

6,025 View
307 Download
3 Web of Science
5 Crossref

Abstract PDF PubReader ePub

Thyroid hormones play an important physiological role in maintaining adult bone structure and strength. Consequently, thyroid dysfunction is related to skeletal outcomes. Overt hyperthyroidism is an established cause of high bone turnover with accelerated bone loss, leading to osteoporosis and increased fracture risk. Hyperthyroidism induced by thyroid-stimulating hormone-suppressive therapy in patients with differentiated thyroid cancer is a cause of secondary osteoporosis. In contrast, there is a lack of evidence on the negative impact of hypothyroidism on bone health. Considering the clinical updates on the importance of bone health in thyroid dysfunction, the Task Force from the Clinical Practice Guidelines Development Committee of the Korean Thyroid Association recently developed a position statement on the evaluation and management of bone health of patients with thyroid diseases, particularly focused on endogenous hyperthyroidism and thyroid-stimulating hormone-suppressive therapy-associated hyperthyroidism in patients with differentiated thyroid cancer. Herein, we review the Korean Thyroid Association’s position statement on the evaluation and management of bone health associated with thyroid diseases.

Citations

Citations to this article as recorded by

Diagnosis and therapeutic approach to bone health in patients with hypopituitarism
Justyna Kuliczkowska-Płaksej, Aleksandra Zdrojowy-Wełna, Aleksandra Jawiarczyk-Przybyłowska, Łukasz Gojny, Marek Bolanowski
Reviews in Endocrine and Metabolic Disorders.2024; 25(3): 513. CrossRef
Osteoporosis, Osteoarthritis, and Subchondral Insufficiency Fracture: Recent Insights
Shunichi Yokota, Hotaka Ishizu, Takuji Miyazaki, Daisuke Takahashi, Norimasa Iwasaki, Tomohiro Shimizu
Biomedicines.2024; 12(4): 843. CrossRef
Acute hypercalcemic crisis: A narrative review with a focus on pregnancy
Nadia Sabbah
Annales d'Endocrinologie.2024;[Epub] CrossRef
Review on the protective activity of osthole against the pathogenesis of osteoporosis
Jincai Chen, Xiaofei Liao, Juwen Gan
Frontiers in Pharmacology.2023;[Epub] CrossRef
Estudio comparativo tras la cirugía tiroidea y otras variables asociadas al desarrollo de osteoporosis en una cohorte latinoamericana
María Paula Ciliberti Artavia, Juan Sebastián Theran León, Jaime Alberto Gómez Ayala, Valentina Cabrera Peña, Rafael Guillermo Parales Strauch, Edgar Camilo Blanco Pimiento, Luis Andres Dulcey Sarmiento, Juan Camilo Martínez, Juan Camilo Mayorca, María Al
Revista Salud y Desarrollo.2023; 7(2): e605. CrossRef

Thyroid Thyroid Cancer Screening
A Comprehensive Assessment of the Harms of Fine-Needle Aspiration Biopsy for Thyroid Nodules: A Systematic Review: Ji Yong Park, Wonsuk Choi, A Ram Hong, Jee Hee Yoon, Hee Kyung Kim, Ho-Cheol Kang; Endocrinol Metab. 2023;38(1):104-116. Published online February 27, 2023; DOI: https://doi.org/10.3803/EnM.2023.1669

6,481 View
204 Download
6 Web of Science
10 Crossref

Abstract PDF Supplementary Material PubReader ePub

Background
There have concerns related with the potential harms of fine-needle aspiration biopsy (FNAB). We aimed to summarize the clinical complications and evaluate the safety of FNAB.
Methods
Studies related with the harms of FNAB were searched on MEDLINE, Embase, Cochrane library, and KoreaMed from 2012 to 2022. Also, studies reviewed in the previous systematic reviews were evaluated. Included clinical complications were postprocedural pain, bleeding events, neurological symptoms, tracheal puncture, infections, post-FNAB thyrotoxicosis, and needle tract implantation of thyroid cancers.
Results
Twenty-three cohort studies were included in this review. Nine studies which were related with FNAB-related pain showed that most of the subjects had no or mild discomfort. The 0% to 6.4% of the patients had hematoma or hemorrhage after FNAB, according to 15 studies. Vasovagal reaction, vocal cord palsy, and tracheal puncture have rarely described in the included studies. Needle tract implantation of thyroid malignancies was described in three studies reporting 0.02% to 0.19% of the incidence rate.
Conclusion
FNAB is considered to be a safe diagnostic procedure with rare complications, which are mainly minor events. Thorough assessement of the patients’ medical condition when deciding to perform FNABs would be advisable to lower potential complications.

Citations

Citations to this article as recorded by

A Narrative Review of the 2023 Korean Thyroid Association Management Guideline for Patients with Thyroid Nodules
Eun Kyung Lee, Young Joo Park, Chan Kwon Jung, Dong Gyu Na
Endocrinology and Metabolism.2024; 39(1): 61. CrossRef
Fine-needle aspiration cytology for neck lesions in patients with antithrombotic/anticoagulant medications: systematic review and meta-analysis
Dongbin Ahn, Ji Hye Kwak, Gill Joon Lee, Jin Ho Sohn
European Radiology.2024; 34(10): 6843. CrossRef
2023 Update of the Korean Thyroid Association Guidelines for the Management of Thyroid Nodules
Eun Kyung Lee, Young Joo Park
Clinical Thyroidology®.2024; 36(4): 153. CrossRef
Korean Thyroid Association Guidelines on the Management of Differentiated Thyroid Cancers; Part II. Follow-up Surveillance after Initial Treatment 2024
Mijin Kim, Ji-In Bang, Ho-Cheol Kang, Sun Wook Kim, Dong Gyu Na, Young Joo Park, Youngduk Seo, Young Shin Song, So Won Oh, Sang-Woo Lee, Eun Kyung Lee, Ji Ye Lee, Dong-Jun Lim, Ari Chong, Yun Jae Chung, Chae Moon Hong, Min Kyoung Lee, Bo Hyun Kim
International Journal of Thyroidology.2024; 17(1): 115. CrossRef
Needle size for thyroid fine needle aspiration cytology. A single institution experience
Pasquale Cianci, Rocco Tumolo, Ivana Conversano, Damiano Travaglia, Giuseppe Trigiante, Giuliano Lantone, Vincenzo Lizzi, Miriam Cappiello, Marco Montagna, Fabio Pio Curci, Enrico Restini
Frontiers in Surgery.2024;[Epub] CrossRef
Important Role of Ultrasonography Immediately After Fine-Needle Aspiration Biopsy of Thyroid Nodules to Detect Acute Transient Thyroid Swelling
Kouichi Yoshimoto, Shinya Satoh, Hisakazu Shindo, Kento Katsuyama, Daisuke Tatsushima, Takashi Fukuda, Seigo Tachibana, Yusuke Mori, Hiroshi Takahashi, Yuji Nagayama, Hiroyuki Yamashita
Cureus.2024;[Epub] CrossRef
To Screen or Not to Screen?
Do Joon Park
Endocrinology and Metabolism.2023; 38(1): 69. CrossRef
Thyroid Cancer Screening: How to Maximize Its Benefits and Minimize Its Harms
Jung Hwan Baek
Endocrinology and Metabolism.2023; 38(1): 75. CrossRef
Evaluation of the Appropriateness of Thyroid Fine-Needle Aspiration
Lairce Cristina Ribeiro Brito, Iara Beatriz De Carvalho Botêlho, Lanna Matos Silva Fernandes, Nayze Lucena Sangreman Aldeman, Uziel Nunes Silva
International Journal for Innovation Education and Research.2023; 11(6): 8. CrossRef
A Retrospective Analysis of Ultrasound-Guided Fine-Needle Aspiration Biopsy for Thyroid Diseases Indicating Ciliated Columnar Epithelium
Yoshiyuki SAITO, Wataru KITAGAWA, Ryohei KATOH, Takashi AMANO, Ai MATSUI, Yoko KUGA, Chie MASAKI, Junko AKAISHI, Ritsuko OKAMURA, Akifumi SUZUKI, Kenichi MATSUZU, Mitsuji NAGAHAMA, Kiminori SUGINO, Koichi ITO
Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association).2023; 84(12): 1835. CrossRef

Miscellaneous
Corrigendum: Correction of Acknowledgments. Transformation of Mature Osteoblasts into Bone Lining Cells and RNA Sequencing-Based Transcriptome Profiling of Mouse Bone during Mechanical Unloading: A Ram Hong, Kwangsoo Kim, Ji Yeon Lee, Jae-Yeon Yang, Jung Hee Kim, Chan Soo Shin, Sang Wan Kim; Endocrinol Metab. 2021;36(6):1314. Published online November 18, 2021; DOI: https://doi.org/10.3803/EnM.2021.601; Corrects: Endocrinol Metab 2020;35(2):456

4,168 View
86 Download

PDF PubReader ePub

Thyroid
Clinical Characteristics and Prognosis of Coexisting Thyroid Cancer in Patients with Graves’ Disease: A Retrospective Multicenter Study: Jee Hee Yoon, Meihua Jin, Mijin Kim, A Ram Hong, Hee Kyung Kim, Bo Hyun Kim, Won Bae Kim, Young Kee Shong, Min Ji Jeon, Ho-Cheol Kang; Endocrinol Metab. 2021;36(6):1268-1276. Published online November 26, 2021; DOI: https://doi.org/10.3803/EnM.2021.1227

5,673 View
193 Download
11 Web of Science
14 Crossref

Abstract PDF Supplementary Material PubReader ePub

Background
The association between Graves’ disease (GD) and co-existing thyroid cancer is still controversial and most of the previously reported data have been based on surgically treated GD patients. This study investigated the clinicopathological findings and prognosis of concomitant thyroid cancer in GD patients in the era of widespread application of ultrasonography.
Methods
Data of GD patients who underwent thyroidectomy for thyroid cancer between 2010 and 2019 in three tertiary hospitals in South Korea (Asan Medical Center, Chonnam National University Hwasun Hospital, and Pusan National University Hospital) were collected and analyzed retrospectively. In the subgroup analysis, aggressiveness and clinical outcomes of thyroid cancer were compared nodular GD and non-nodular GD groups according to the presence or absence of the thyroid nodules other than thyroid cancer (index nodules).
Results
Of the 15,159 GD patients treated at the hospitals during the study period, 262 (1.7%) underwent thyroidectomy for coexisting thyroid cancer. Eleven patients (4.2%) were diagnosed with occult thyroid cancer and 182 patients (69.5%) had microcarcinomas. No differences in thyroid cancer aggressiveness, ultrasonographic findings, or prognosis were observed between the nodular GD and non-nodular GD groups except the cancer subtype. In the multivariate analysis, only lymph node (LN) metastasis was an independent prognostic factor for recurrent/persistent disease of thyroid cancer arising in GD (P=0.020).
Conclusion
The prevalence of concomitant thyroid cancer in GD patients was considerably lower than in previous reports. The clinical outcomes of thyroid cancer in GD patients were also excellent but, more cautious follow-up is necessary for patients with LN metastasis in the same way as for thyroid cancer in non-GD patients.

Citations

Citations to this article as recorded by

Comparison of Surgical Outcomes of Transoral Versus Open Thyroidectomy for Graves Disease
Suo-Hsien Wang, Wu-Po Chao, Ta-You Lo, Soh-Ching Ng, Yu-Hsien Chen
Surgical Laparoscopy, Endoscopy & Percutaneous Techniques.2024; 34(2): 150. CrossRef
Characterization of Immune Infiltrate Along the Leading Edge of Differentiated Thyroid Cancer
Anupam Kotwal, Krysten Vance, Kemal Hajric, Ana Yuil-Valdes, Benjamin Swanson, Ernesto Martinez Duarte, Oleg Shats, Michael Hollingsworth, Hamid Band, Whitney Goldner
Thyroid®.2024; 34(8): 999. CrossRef
The Role of Risk Factors for the Progression of Patients with T1b-T2 Papillary Thyroid Carcinoma (PC) during Long-Term Follow-Up
Andrea Marongiu, Susanna Nuvoli, Andrea De Vito, Antonio Mura, Sonia Vargiu, Angela Spanu, Giuseppe Madeddu
Journal of Clinical Medicine.2024; 13(18): 5373. CrossRef
Outcomes of Surgical Treatment for Graves’ Disease: A Single-Center Experience of 216 Cases
Hanxing Sun, Hui Tong, Xiaohui Shen, Haoji Gao, Jie Kuang, Xi Chen, Qinyu Li, Weihua Qiu, Zhuoran Liu, Jiqi Yan
Journal of Clinical Medicine.2023; 12(4): 1308. CrossRef
Cancer and Mortality Risks of Graves’ Disease in South Korea Based on National Data from 2010 to 2019
Young Ju Choi, Kyungdo Han, Won Kyoung Cho, Min Ho Jung, Byung-Kyu Suh
Clinical Epidemiology.2023; Volume 15: 535. CrossRef
Risk and Prognosis of Thyroid Cancer in Patients with Graves’ Disease: An Umbrella Review
Marco Palella, Francesca Maria Giustolisi, Adriana Modica Fiascaro, Martina Fichera, Antonella Palmieri, Rossella Cannarella, Aldo E. Calogero, Margherita Ferrante, Maria Fiore
Cancers.2023; 15(10): 2724. CrossRef
Characteristics, staging and outcomes of differentiated thyroid cancer in patients with and without Graves’ disease
Chaitra Gopinath, Hanna Crow, Sujata Panthi, Leonidas Bantis, Kenneth D. Burman, Chitra Choudhary
Journal of Clinical & Translational Endocrinology.2023; 33: 100321. CrossRef
Prevalence, Treatment Status, and Comorbidities of Hyperthyroidism in Korea from 2003 to 2018: A Nationwide Population Study
Hwa Young Ahn, Sun Wook Cho, Mi Young Lee, Young Joo Park, Bon Seok Koo, Hang-Seok Chang, Ka Hee Yi
Endocrinology and Metabolism.2023; 38(4): 436. CrossRef
Hashimoto’s Thyroiditis and Papillary Thyroid Carcinoma: A Follow-Up Study in Patients with Absence of Aggressive Risk Factors at the Surgery of the Primary Tumor
Andrea Marongiu, Susanna Nuvoli, Andrea De Vito, Sonia Vargiu, Angela Spanu, Giuseppe Madeddu
Diagnostics.2023; 13(19): 3068. CrossRef
Table of Contents

Clinical Thyroidology.2022; 34(2): 48. CrossRef
Predisposition to and Prognosis of Thyroid Cancer May Not Be Affected by Graves’ Disease, But Some Questions Still Remain
Yanrui Huang, Haixia Guan
Clinical Thyroidology.2022; 34(2): 59. CrossRef
A Comparative Follow-Up Study of Patients with Papillary Thyroid Carcinoma Associated or Not with Graves’ Disease
Andrea Marongiu, Susanna Nuvoli, Andrea De Vito, Maria Rondini, Angela Spanu, Giuseppe Madeddu
Diagnostics.2022; 12(11): 2801. CrossRef
An unusual case of papillary thyroid carcinoma presenting as Graves’ disease
Pooja Tiwari, Uma Kaimal Saikia, Abhamoni Baro, Ashok Krishna Bhuyan
Thyroid Research and Practice.2022; 19(1): 47. CrossRef
An unusual case of papillary thyroid carcinoma presenting as Graves’ disease
Pooja Tiwari, Uma Kaimal Saikia, Abhamoni Baro, Ashok Krishna Bhuyan
Thyroid Research and Practice.2021; 18(3): 129. CrossRef

Adrenal Gland
Metabolic Subtyping of Adrenal Tumors: Prospective Multi-Center Cohort Study in Korea: Eu Jeong Ku, Chaelin Lee, Jaeyoon Shim, Sihoon Lee, Kyoung-Ah Kim, Sang Wan Kim, Yumie Rhee, Hyo-Jeong Kim, Jung Soo Lim, Choon Hee Chung, Sung Wan Chun, Soon-Jib Yoo, Ohk-Hyun Ryu, Ho Chan Cho, A Ram Hong, Chang Ho Ahn, Jung Hee Kim, Man Ho Choi; Endocrinol Metab. 2021;36(5):1131-1141. Published online October 21, 2021; DOI: https://doi.org/10.3803/EnM.2021.1149

6,330 View
227 Download
12 Web of Science
11 Crossref

Abstract PDF Supplementary Material PubReader ePub

Background
Conventional diagnostic approaches for adrenal tumors require multi-step processes, including imaging studies and dynamic hormone tests. Therefore, this study aimed to discriminate adrenal tumors from a single blood sample based on the combination of liquid chromatography-mass spectrometry (LC-MS) and machine learning algorithms in serum profiling of adrenal steroids.
Methods
The LC-MS-based steroid profiling was applied to serum samples obtained from patients with nonfunctioning adenoma (NFA, n=73), Cushing’s syndrome (CS, n=30), and primary aldosteronism (PA, n=40) in a prospective multicenter study of adrenal disease. The decision tree (DT), random forest (RF), and extreme gradient boost (XGBoost) were performed to categorize the subtypes of adrenal tumors.
Results
The CS group showed higher serum levels of 11-deoxycortisol than the NFA group, and increased levels of tetrahydrocortisone (THE), 20α-dihydrocortisol, and 6β-hydroxycortisol were found in the PA group. However, the CS group showed lower levels of dehydroepiandrosterone (DHEA) and its sulfate derivative (DHEA-S) than both the NFA and PA groups. Patients with PA expressed higher serum 18-hydroxycortisol and DHEA but lower THE than NFA patients. The balanced accuracies of DT, RF, and XGBoost for classifying each type were 78%, 96%, and 97%, respectively. In receiver operating characteristics (ROC) analysis for CS, XGBoost, and RF showed a significantly greater diagnostic power than the DT. However, in ROC analysis for PA, only RF exhibited better diagnostic performance than DT.
Conclusion
The combination of LC-MS-based steroid profiling with machine learning algorithms could be a promising one-step diagnostic approach for the classification of adrenal tumor subtypes.

Citations

Citations to this article as recorded by

Treating Primary Aldosteronism-Induced Hypertension: Novel Approaches and Future Outlooks
Nathan Mullen, James Curneen, Padraig T Donlon, Punit Prakash, Irina Bancos, Mark Gurnell, Michael C Dennedy
Endocrine Reviews.2024; 45(1): 125. CrossRef
Steroid profiling in adrenal disease
Danni Mu, Dandan Sun, Xia Qian, Xiaoli Ma, Ling Qiu, Xinqi Cheng, Songlin Yu
Clinica Chimica Acta.2024; 553: 117749. CrossRef
Plasma Steroid Profiling Combined With Machine Learning for the Differential Diagnosis in Mild Autonomous Cortisol Secretion From Nonfunctioning Adenoma in Patients With Adrenal Incidentalomas
Danni Mu, Xia Qian, Yichen Ma, Xi Wang, Yumeng Gao, Xiaoli Ma, Shaowei Xie, Lian Hou, Qi Zhang, Fang Zhao, Liangyu Xia, Liling Lin, Ling Qiu, Jie Wu, Songlin Yu, Xinqi Cheng
Endocrine Practice.2024; 30(7): 647. CrossRef
Mild autonomous cortisol secretion: pathophysiology, comorbidities and management approaches
Alessandro Prete, Irina Bancos
Nature Reviews Endocrinology.2024; 20(8): 460. CrossRef
Plasma Steroid Profiling Between Patients With and Without Diabetes Mellitus in Nonfunctioning Adrenal Incidentalomas
Yui Nakano, Maki Yokomoto-Umakoshi, Kohta Nakatani, Hironobu Umakoshi, Hiroshi Nakao, Masamichi Fujita, Hiroki Kaneko, Norifusa Iwahashi, Tatsuki Ogasawara, Tazuru Fukumoto, Yayoi Matsuda, Ryuichi Sakamoto, Yoshihiro Izumi, Takeshi Bamba, Yoshihiro Ogawa
Journal of the Endocrine Society.2024;[Epub] CrossRef
Serum and hair steroid profiles in patients with nonfunctioning pituitary adenoma undergoing surgery: A prospective observational study
Seung Shin Park, Yong Hwy Kim, Ho Kang, Chang Ho Ahn, Dong Jun Byun, Man Ho Choi, Jung Hee Kim
The Journal of Steroid Biochemistry and Molecular Biology.2023; 230: 106276. CrossRef
Recent Updates on the Management of Adrenal Incidentalomas
Seung Shin Park, Jung Hee Kim
Endocrinology and Metabolism.2023; 38(4): 373. CrossRef
LC-MS based simultaneous profiling of adrenal hormones of steroids, catecholamines, and metanephrines
Jongsung Noh, Chaelin Lee, Jung Hee Kim, Seung Woon Myung, Man Ho Choi
Journal of Lipid Research.2023; 64(11): 100453. CrossRef
2023 Korean Endocrine Society Consensus Guidelines for the Diagnosis and Management of Primary Aldosteronism
Jeonghoon Ha, Jung Hwan Park, Kyoung Jin Kim, Jung Hee Kim, Kyong Yeun Jung, Jeongmin Lee, Jong Han Choi, Seung Hun Lee, Namki Hong, Jung Soo Lim, Byung Kwan Park, Jung-Han Kim, Kyeong Cheon Jung, Jooyoung Cho, Mi-kyung Kim, Choon Hee Chung
Endocrinology and Metabolism.2023; 38(6): 597. CrossRef
Toward Systems-Level Metabolic Analysis in Endocrine Disorders and Cancer
Aliya Lakhani, Da Hyun Kang, Yea Eun Kang, Junyoung O. Park
Endocrinology and Metabolism.2023; 38(6): 619. CrossRef
Prevalence and Characteristics of Adrenal Tumors in an Unselected Screening Population
Ying Jing, Jinbo Hu, Rong Luo, Yun Mao, Zhixiao Luo, Mingjun Zhang, Jun Yang, Ying Song, Zhengping Feng, Zhihong Wang, Qingfeng Cheng, Linqiang Ma, Yi Yang, Li Zhong, Zhipeng Du, Yue Wang, Ting Luo, Wenwen He, Yue Sun, Fajin Lv, Qifu Li, Shumin Yang
Annals of Internal Medicine.2022; 175(10): 1383. CrossRef

Adrenal Gland
Contralateral Suppression at Adrenal Venous Sampling Is Associated with Renal Impairment Following Adrenalectomy for Unilateral Primary Aldosteronism: Ye Seul Yang, Seung Hun Lee, Jung Hee Kim, Jee Hee Yoo, Jung Hyun Lee, Seo Young Lee, A Ram Hong, Dong-Hwa Lee, Jung-Min Koh, Jae Hyeon Kim, Sang Wan Kim; Endocrinol Metab. 2021;36(4):875-884. Published online August 11, 2021; DOI: https://doi.org/10.3803/EnM.2021.1047

5,817 View
160 Download
7 Web of Science
7 Crossref

Abstract PDF Supplementary Material PubReader ePub

Background
Adrenal venous sampling (AVS) is performed to distinguish the subtype of primary aldosteronism (PA). The clinical implication of contralateral suppression (CS; aldosterone/cortisol_nondominantperipheral) at AVS remains unclear. We aimed to investigate the clinical significance of CS and its impact on postoperative outcomes after unilateral adrenalectomy.
Methods
In this retrospective observational multi-center study, we analyzed PA patients who underwent both successful adrenocorticotropin hormone-stimulated AVS and unilateral adrenalectomy. Successful cannulation was defined as the selectivity index (cortisol_adrenal/ cortisol_peripheral) ≥3. Clinical and biochemical outcomes after unilateral adrenalectomy were evaluated based on the international Primary Aldosteronism Surgical Outcome consensus.
Results
Among 263 patients analyzed, 247 had CS (93.9%). Patients with CS had lower serum potassium levels, higher plasma aldosterone concentration, higher aldosterone-to-renin ratio (ARR), and larger adenoma size than those without CS. Those with CS showed significantly higher lateralization index than those without CS (P<0.001). Although postoperative blood pressure and ARR significantly decreased in those with CS, clinical and biochemical outcomes were comparable in both groups. When the cut-off value of age was determined using receiver operating characteristic (ROC) analysis, patients aged ≥50 years old with contralateral suppression index (CSI; the ratio between aldosterone/cortisol_nondominant and aldosterone/cortisol_peripheral) ≤0.26 had greater odds ratio (6.43; 95% confidence interval, 1.30 to 31.69) of incident chronic kidney disease than those aged <50 years with CSI >0.26 after adjusting for other factors.
Conclusion
CS may not predict postoperative clinical and biochemical outcomes in subjects with unilateral aldosterone excess, but it is associated with postsurgical deterioration of renal function in subjects over 50 years with CSI ≤0.26.

Citations

Citations to this article as recorded by

Treatment decision based on unilateral index from nonadrenocorticotropic hormone-stimulated and adrenocorticotropic hormone-stimulated adrenal vein sampling in primary aldosteronism
Xizi Zhang, Xiaoyu Shu, Feifei Wu, Jun Yang, Qingfeng Cheng, Zhipeng Du, Ying Song, Yi Yang, Jinbo Hu, Yue Wang, Qifu Li, Shumin Yang
Journal of Hypertension.2024; 42(3): 450. CrossRef
Correlation of Histopathologic Subtypes of Primary Aldosteronism with Clinical Phenotypes and Postsurgical Outcomes
Chang Ho Ahn, You-Bin Lee, Jae Hyeon Kim, Young Lyun Oh, Jung Hee Kim, Kyeong Cheon Jung
The Journal of Clinical Endocrinology & Metabolism.2024; 109(8): e1582. CrossRef
Prognostic value of contralateral suppression on kidney function after surgery in patients with primary aldosteronism
Nathalie Voss, Sara Mørup, Caroline Clausen, Claus larsen Feltoft, Jan Viberg Jepsen, Mads Hornum, Mikkel Andreassen, Jesper Krogh
Clinical Endocrinology.2023; 98(3): 306. CrossRef
Factors Predicting Long-term Estimated Glomerular Filtration Rate Decrease, a Reliable Indicator of Renal Function After Adrenalectomy in Primary Aldosteronism
Qiyu He, Zhimin Tan, Yu Liu, Liang Zhou
Endocrine Practice.2023; 29(3): 199. CrossRef
Prognostic value of contralateral suppression for remission after surgery in patients with primary aldosteronism
Sara Mørup, Nathalie Voss, Caroline Clausen, Claus Larsen Feltoft, Mikkel Andreassen, Jesper Krogh
Clinical Endocrinology.2022; 96(6): 793. CrossRef
Contralateral Suppression at Adrenal Venous Sampling Is Associated with Renal Impairment Following Adrenalectomy for Unilateral Primary Aldosteronism (Endocrinol Metab 2021;36:875-84, Ye Seul Yang et al.)
Zhimin Tan, Qiyu He, Liang Zhou
Endocrinology and Metabolism.2022; 37(6): 951. CrossRef
Contralateral Suppression at Adrenal Venous Sampling Is Associated with Renal Impairment Following Adrenalectomy for Unilateral Primary Aldosteronism (Endocrinol Metab 2021;36:875-84, Ye Seul Yang et al.)
Ye Seul Yang, Sang Wan Kim
Endocrinology and Metabolism.2022; 37(6): 953. CrossRef

Thyroid
Programmed Cell Death-Ligand 1 (PD-L1) gene Single Nucleotide Polymorphism in Graves’ Disease and Hashimoto’s Thyroiditis in Korean Patients: Jee Hee Yoon, Min-ho Shin, Hee Nam Kim, Wonsuk Choi, Ji Yong Park, A Ram Hong, Hee Kyung Kim, Ho-Cheol Kang; Endocrinol Metab. 2021;36(3):599-606. Published online June 2, 2021; DOI: https://doi.org/10.3803/EnM.2021.965

4,587 View
124 Download
2 Web of Science
2 Crossref

Abstract PDF Supplementary Material PubReader ePub

Background
Programmed cell death-ligand 1 (PD-L1) has an important role in regulating immune reactions by binding to programmed death 1 (PD-1) on immune cells, which could prevent the exacerbation of autoimmune thyroid disease (AITD). The aim of this study was to evaluate the association of PD-L1 polymorphism with AITD, including Graves’ disease (GD) and Hashimoto’s thyroiditis (HT).
Methods
A total of 189 GD patients, 234 HT patients, and 846 healthy age- and sex-matched controls were enrolled in this study. We analyzed PD-L1 single nucleotide polymorphism (SNP) (rs822339) and investigated the associations with clinical disease course and outcome.
Results
Genotype frequency at the PD-L1 marker RS822339 in GD (P=0.219) and HT (P=0.764) patients did not differ from that among healthy controls. In patients with GD, the A/G or G/G genotype group demonstrated higher TBII titer (20.6±20.5 vs. 28.0± 25.8, P=0.044) and longer treatment duration (39.0±40.4 months vs. 62.4±65.0 months, P=0.003) compared to the A/A genotype group. Among patients in whom anti-thyroid peroxidase (TPO) antibody was measured after treatment of GD, post-treatment antiTPO positivity was higher in the A/G or G/G genotype group compared to the A/A genotype group (48.1% vs. 69.9%, P=0.045). Among patients with HT, there was no significant difference of anti-TPO antibody positivity (79.4% vs. 68.6%, P=0.121), anti-thyroglobulin antibody positivity (80.9% vs. 84.7%, P=0.661), or development to overt hypothyroidism (68.0% vs. 71.1%, P=0.632) between the A/A genotype group and the A/G or G/G genotype group.
Conclusion
The genotype frequency of PD-L1 (rs822339) is not different in patients with AITD compared with healthy controls. The intact PD-1/PD-L1 pathway in GD and HT might be important to maintain chronicity of AITD by protecting immune tolerance. However, the PD-L1 SNP could be associated with difficulty in achieving remission in patients with GD, which may be helpful to predict the possibility of longer treatment. Further studies are required to investigate the complex immune tolerance system in patients with AITD.

Citations

Citations to this article as recorded by

Synergistic effects of BTN3A1, SHP2, CD274, and STAT3 gene polymorphisms on the risk of systemic lupus erythematosus: a multifactorial dimensional reduction analysis
Yang-Yang Tang, Wang-Dong Xu, Lu Fu, Xiao-Yan Liu, An-Fang Huang
Clinical Rheumatology.2024; 43(1): 489. CrossRef
Relationship between CD274 gene polymorphism and systemic lupus erythematosus risk in a Chinese Han population
Lu‐Qi Yang, Zhen Qin, Lu Fu, Wang‐Dong Xu
International Journal of Rheumatic Diseases.2024;[Epub] CrossRef

Clinical Study
Characteristics of Immune-Related Thyroid Adverse Events in Patients Treated with PD-1/PD-L1 Inhibitors: Jee Hee Yoon, A Ram Hong, Hee Kyung Kim, Ho-Cheol Kang; Endocrinol Metab. 2021;36(2):413-423. Published online April 6, 2021; DOI: https://doi.org/10.3803/EnM.2020.906

6,733 View
235 Download
26 Web of Science
26 Crossref

Abstract PDF Supplementary Material PubReader ePub

Background
Thyroid immune-related adverse events (IRAEs) have been reported in patients treated with programmed cell death protein-1 (PD-1) and programmed cell death protein-ligand 1 (PD-L1) inhibitors. We investigated the incidence and clinical course of PD-1/PD-L1 inhibitor-induced thyroid IRAEs, and identified predictable clinical risk factors of thyroid IRAEs, in particular, overt hypothyroidism (OH).
Methods
We retrospectively reviewed the medical records of 325 cancer patients receiving PD-1/PD-L1 inhibitor in a tertiary referral center.
Results
A total of 50.5% (164/325) of patients experienced at least one abnormal thyroid function following PD-1/PD-L1 inhibitor. Eighty-four patients (51.2%) of them recovered to normal thyroid function during follow-up. In overall population, 25 patients (7.7%) required thyroid hormone replacement therapy due to PD-1/PD-L1 inhibitor-induced OH. Patients who progressed to OH showed significantly higher baseline thyroid stimulating hormone level and longer duration of PD-1/PD-L1 inhibitor therapy than those without thyroid dysfunction or OH (both P<0.001). Median time interval to the development of OH was 3 months after the therapy. OH was significantly associated with positive anti-thyroid peroxidase antibody at baseline and anti-thyroglobulin antibody during the therapy than those without thyroid dysfunction or OH (P=0.015 and P=0.005, respectively). We observed no patients with OH who were able to stop levothyroxine replacement after the cessation of PD-1/PD-L1 inhibitor therapy.
Conclusion
PD-1/PD-L1 inhibitor-induced thyroid dysfunctions are considerably reversible; however, OH is irreversible requiring levothyroxine replacement even after stopping the therapy. Positive thyroid autoantibodies may predict the progression to OH.

Citations

Citations to this article as recorded by

Thyroid Dysfunction after Atezolizumab and Bevacizumab Is Associated with Favorable Outcomes in Hepatocellular Carcinoma
Young Shin Song, Hannah Yang, Beodeul Kang, Jaekyung Cheon, Ilhwan Kim, Hyeyeong Kim, Won Suk Lee, Yun Beom Sang, Sanghoon Jung, Ho Yeong Lim, Vincent E. Gaillard, Chan Kim, Hong Jae Chon
Liver Cancer.2024; 13(1): 89. CrossRef
Thyroid dysfunction (TD) induced by PD-1/PD-L1 inhibitors in advanced lung cancer
Yanling Wang, Xiaoxuan Yang, Jia Ma, Shenglan Chen, Ping Gong, Ping Dai
Heliyon.2024; 10(5): e27077. CrossRef
Non-Invasive Predictive Biomarkers for Immune-Related Adverse Events Due to Immune Checkpoint Inhibitors
Ben Ponvilawan, Abdul Wali Khan, Janakiraman Subramanian, Dhruv Bansal
Cancers.2024; 16(6): 1225. CrossRef
Changes in TgAb and TPOAb titers are greater in thyrotoxicosis than isolated hypothyroidism induced by PD-1 blockade
Ayana Yamagami, Shintaro Iwama, Tomoko Kobayashi, Xin Zhou, Yoshinori Yasuda, Takayuki Okuji, Masaaki Ito, Tetsushi Izuchi, Masahiko Ando, Takeshi Onoue, Takashi Miyata, Mariko Sugiyama, Daisuke Hagiwara, Hidetaka Suga, Ryoichi Banno, Hiroshi Arima
Endocrine Journal.2024; 71(5): 515. CrossRef
Autoantibody-positivity before and seroconversion during treatment with anti-PD-1 is associated with immune-related adverse events in patients with melanoma
Jessica S W Borgers, Tineke J van Wesemael, Kyra A Gelderman, Theo Rispens, Els M E Verdegaal, Dirk J A R Moes, Catharina M Korse, Ellen Kapiteijn, Marij J P Welters, Sjoerd H van der Burg, Winan J van Houdt, Johannes V van Thienen, John B A G Haanen, Dia
Journal for ImmunoTherapy of Cancer.2024; 12(6): e009215. CrossRef
Development and Validation of a Prediction Model for Thyroid Dysfunction in Patients During Immunotherapy
Qian Wang, Tingting Wu, Ru Zhao, Yuanqin Li, Xuetao Chen, Shanmei Shen, Xiaowen Zhang
Endocrine Practice.2024; 30(10): 943. CrossRef
Perioperative toripalimab plus neoadjuvant chemotherapy might improve outcomes in resectable esophageal cancer: an interim analysis of a phase III randomized clinical trial
Yan Zheng, Guanghui Liang, Dongfeng Yuan, Xianben Liu, Yufeng Ba, Zimin Qin, Sining Shen, Zhenxuan Li, Haibo Sun, Baoxing Liu, Quanli Gao, Peng Li, Zongfei Wang, Shilei Liu, Jianping Zhu, Haoran Wang, Haibo Ma, Zhenzhen Liu, Fei Zhao, Jun Zhang, He Zhang,
Cancer Communications.2024;[Epub] CrossRef
Implication of the Gut Microbiome and Microbial-Derived Metabolites in Immune-Related Adverse Events: Emergence of Novel Biomarkers for Cancer Immunotherapy
David Dora, Syeda Mahak Zahra Bokhari, Kenan Aloss, Peter Takacs, Juliane Zsuzsanna Desnoix, György Szklenárik, Patrick Deniz Hurley, Zoltan Lohinai
International Journal of Molecular Sciences.2023; 24(3): 2769. CrossRef
Immune checkpoint inhibitor-associated toxicity in advanced non-small cell lung cancer: An updated understanding of risk factors
Xiangxiao Hu, Lina Wang, Bin Shang, Junren Wang, Jian Sun, Bin Liang, Lili Su, Wenjie You, Shujuan Jiang
Frontiers in Immunology.2023;[Epub] CrossRef
Immune-related adverse events induced by programmed death protein-1 inhibitors from the perspective of lymphoma immunotherapy
Yong-Zhe Hou, Qin Zhang, Hai Bai, Tao Wu, Ya-Jie Chen
World Journal of Clinical Cases.2023; 11(7): 1458. CrossRef
Predictive Biomarkers for Checkpoint Inhibitor Immune-Related Adverse Events
Iñigo Les, Mireia Martínez, Inés Pérez-Francisco, María Cabero, Lucía Teijeira, Virginia Arrazubi, Nuria Torrego, Ana Campillo-Calatayud, Iñaki Elejalde, Grazyna Kochan, David Escors
Cancers.2023; 15(5): 1629. CrossRef
Immune-related thyroid dysfunctions during anti PD-1/PD-L1 inhibitors: new evidence from a single centre experience
Alice Nervo, Matteo Ferrari, Giovanni Gruosso, Enrica Migliore, Sara Basile, Valentina D’Angelo, Anna Roux, Alessandro Piovesan, Emanuela Arvat
Clinical and Experimental Medicine.2023; 23(8): 4817. CrossRef
RNA Sequencing Reveals Unique Transcriptomic Signatures of the Thyroid in a Murine Lung Cancer Model Treated with PD-1 and PD-L1 Antibodies
Rena Pollack, Joshua Stokar, Natan Lishinsky, Irina Gurt, Naomi Kaisar-Iluz, Merav E. Shaul, Zvi G. Fridlender, Rivka Dresner-Pollak
International Journal of Molecular Sciences.2023; 24(13): 10526. CrossRef
Immune‐related adverse events after immune check point inhibitors: Understanding the intersection with autoimmunity
Namrata Singh, Anne M. Hocking, Jane H. Buckner
Immunological Reviews.2023; 318(1): 81. CrossRef
Endocrine Side Effects in Patients Treated with Immune Checkpoint Inhibitors: A Narrative Review
Nicia I. Profili, Roberto Castelli, Antonio Gidaro, Alessandro Merella, Roberto Manetti, Giuseppe Palmieri, Margherita Maioli, Alessandro P. Delitala
Journal of Clinical Medicine.2023; 12(15): 5161. CrossRef
Incidence of Endocrine-Related Dysfunction in Patients Treated with New Immune Checkpoint Inhibitors: A Meta-Analysis and Comprehensive Review
Won Sang Yoo, Eu Jeong Ku, Eun Kyung Lee, Hwa Young Ahn
Endocrinology and Metabolism.2023; 38(6): 750. CrossRef
PD-1/PD-L1 Inhibitors in Patients With Preexisting Autoimmune Diseases
Ke Zhang, Xiangyi Kong, Yuan Li, Zhongzhao Wang, Lin Zhang, Lixue Xuan
Frontiers in Pharmacology.2022;[Epub] CrossRef
Association between the type of thyroid dysfunction induced by immune checkpoint inhibitors and prognosis in cancer patients
Han-sang Baek, Chaiho Jeong, Kabsoo Shin, Jaejun Lee, Heysun Suh, Dong-Jun Lim, Moo Il Kang, Jeonghoon Ha
BMC Endocrine Disorders.2022;[Epub] CrossRef
A Successful Case of Hepatocellular Carcinoma Treated with Atezolizumab Plus Bevacizumab with Multisystem Immune-related Adverse Events
Hidemi Hayashi, Koji Sawada, Takumu Hasebe, Shunsuke Nakajima, Jun Sawada, Yuri Takiyama, Yumi Takiyama, Toshikatsu Okumura, Mikihiro Fujiya
Internal Medicine.2022; 61(23): 3497. CrossRef
Immune Related Adverse Events of the Thyroid – A Narrative Review
Christopher A. Muir, Venessa H. M. Tsang, Alexander M. Menzies, Roderick J. Clifton-Bligh
Frontiers in Endocrinology.2022;[Epub] CrossRef
Thyroid-related adverse events induced by immune checkpoint inhibitors
Alexandra Chera, Andreea Lucia Stancu, Octavian Bucur
Frontiers in Endocrinology.2022;[Epub] CrossRef
Risk Factors and Biomarkers for Immune-Related Adverse Events: A Practical Guide to Identifying High-Risk Patients and Rechallenging Immune Checkpoint Inhibitors
Adithya Chennamadhavuni, Laith Abushahin, Ning Jin, Carolyn J. Presley, Ashish Manne
Frontiers in Immunology.2022;[Epub] CrossRef
Case 5: A 41-Year-Old Woman With Palpitation
Jiwon Yang, Kabsoo Shin, Jeongmin Lee, Jeonghoon Ha, Dong-Jun Lim, Han-Sang Baek
Journal of Korean Medical Science.2022;[Epub] CrossRef
Immune Checkpoint Inhibitors and Endocrine Disorders: A Position Statement from the Korean Endocrine Society
Hyemi Kwon, Eun Roh, Chang Ho Ahn, Hee Kyung Kim, Cheol Ryong Ku, Kyong Yeun Jung, Ju Hee Lee, Eun Heui Kim, Sunghwan Suh, Sangmo Hong, Jeonghoon Ha, Jun Sung Moon, Jin Hwa Kim, Mi-kyung Kim
Endocrinology and Metabolism.2022; 37(6): 839. CrossRef
Management of Endocrine and Metabolic Toxicities of Immune-Checkpoint Inhibitors: From Clinical Studies to a Real-Life Scenario
Calogera Claudia Spagnolo, Giuseppe Giuffrida, Salvatore Cannavò, Tindara Franchina, Nicola Silvestris, Rosaria Maddalena Ruggeri, Mariacarmela Santarpia
Cancers.2022; 15(1): 246. CrossRef
Antineoplastics

Reactions Weekly.2021; 1874(1): 31. CrossRef

Adrenal gland
Diagnosis for Pheochromocytoma and Paraganglioma: A Joint Position Statement of the Korean Pheochromocytoma and Paraganglioma Task Force: Eu Jeong Ku, Kyoung Jin Kim, Jung Hee Kim, Mi Kyung Kim, Chang Ho Ahn, Kyung Ae Lee, Seung Hun Lee, You-Bin Lee, Kyeong Hye Park, Yun Mi Choi, Namki Hong, A Ram Hong, Sang-Wook Kang, Byung Kwan Park, Moon-Woo Seong, Myungshin Kim, Kyeong Cheon Jung, Chan Kwon Jung, Young Seok Cho, Jin Chul Paeng, Jae Hyeon Kim, Ohk-Hyun Ryu, Yumie Rhee, Chong Hwa Kim, Eun Jig Lee; Endocrinol Metab. 2021;36(2):322-338. Published online April 6, 2021; DOI: https://doi.org/10.3803/EnM.2020.908

9,100 View
654 Download
9 Web of Science
14 Crossref

Abstract PDF PubReader ePub

Pheochromocytoma and paraganglioma (PPGLs) are rare catecholamine-secreting neuroendocrine tumors but can be life-threatening. Although most PPGLs are benign, approximately 10% have metastatic potential. Approximately 40% cases are reported as harboring germline mutations. Therefore, timely and accurate diagnosis of PPGLs is crucial. For more than 130 years, clinical, molecular, biochemical, radiological, and pathological investigations have been rapidly advanced in the field of PPGLs. However, performing diagnostic studies to localize lesions and detect metastatic potential can be still challenging and complicated. Furthermore, great progress on genetics has shifted the paradigm of genetic testing of PPGLs. The Korean PPGL task force team consisting of the Korean Endocrine Society, the Korean Surgical Society, the Korean Society of Nuclear Medicine, the Korean Society of Pathologists, and the Korean Society of Laboratory Medicine has developed this position statement focusing on the comprehensive and updated diagnosis for PPGLs.

Citations

Citations to this article as recorded by

A Prospective Comparative Study of 18F-FDOPA PET/CT Versus 123I-MIBG Scintigraphy With SPECT/CT for the Diagnosis of Pheochromocytoma and Paraganglioma
Changhwan Sung, Hyo Sang Lee, Dong Yun Lee, Yong-il Kim, Jae Eun Kim, Sang Ju Lee, Seung Jun Oh, Tae-Yon Sung, Yu-Mi Lee, Young Hoon Kim, Beom-Jun Kim, Jung-Min Koh, Seung Hun Lee, Jin-Sook Ryu
Clinical Nuclear Medicine.2024; 49(1): 27. CrossRef
Preoperative prediction of metastatic pheochromocytoma and paraganglioma using clinical, genetic, and biochemical markers: A cohort study
Seung Shin Park, Chang Ho Ahn, Seunghoo Lee, Woochang Lee, Won Woong Kim, Yu‐Mi Lee, Su Jin Kim, Tae‐Yon Sung, Kyu Eun Lee, Jung Hee Kim, Seung Hun Lee, Jung‐Min Koh
Journal of Internal Medicine.2024; 296(1): 68. CrossRef
Germline Mutations and Phenotypic Associations in Korean Patients With Pheochromocytoma and Paraganglioma: A Multicenter Study and Literature Review
Kwan Hoon Jo, Jaewoong Lee, Jaeeun Yoo, Hoon Seok Kim, Eun Sook Kim, Je Ho Han, Yi Sun Jang, Jae-Seung Yun, Jang Won Son, Soon Jib Yoo, Seung Hwan Lee, Dong Jun Lim, Hyuk-Sang Kwon, Seungok Lee, Sungdae Moon, Myungshin Kim
Annals of Laboratory Medicine.2024; 44(6): 591. CrossRef
Raccomandazioni della lista del GdS-Endocrinologia e Malattie del Metabolismo SIPMeL-Choosing wisely: tiroide, anticorpi anti-tiroide, cortisolo, surrene, vitamina D: aggiornamento 2024
Romolo M. DORIZZI, Vincenzo BRESCIA, Marina VITILLO, Ottavia PORZIO, Federica D’AURIZIO
La Rivista Italiana della Medicina di Laboratorio.2024;[Epub] CrossRef
Screening and treatment of endocrine hypertension focusing on adrenal gland disorders: a narrative review
Seung Min Chung
Journal of Yeungnam Medical Science.2024; 41(4): 269. CrossRef
Evaluation and Management of Bone Health in Patients with Thyroid Diseases: A Position Statement of the Korean Thyroid Association
A Ram Hong, Ho-Cheol Kang
Endocrinology and Metabolism.2023; 38(2): 175. CrossRef
Lesion-based indicators predict long-term outcomes of pheochromocytoma and paraganglioma– SIZEPASS
Helena Hanschell, Salvador Diaz-Cano, Alfredo Blanes, Nadia Talat, Gabriele Galatá, Simon Aylwin, Klaus Martin Schulte
Frontiers in Endocrinology.2023;[Epub] CrossRef
Interleukin-6-producing paraganglioma as a rare cause of systemic inflammatory response syndrome: a case report
Yin Young Lee, Seung Min Chung
Journal of Yeungnam Medical Science.2023; 40(4): 435. CrossRef
(Extremely rare intrapericardial location of paraganglioma)
Jaroslav Zajíc, Aleš Mokráček, Ladislav Pešl, Jiří Haniš, Dita Schaffelhoferová
Cor et Vasa.2023; 65(4): 692. CrossRef
A Case of Von Hippel-Lindau Disease With Recurrence of Paraganglioma and No Other Associated Symptoms: The Importance of Genetic Testing and Establishing Follow-Up Policies
Naoki Okada, Akihiro Shioya, Sumihito Togi, Hiroki Ura, Yo Niida
Cureus.2023;[Epub] CrossRef
KSNM60 in Nuclear Endocrinology: from the Beginning to the Future
Chae Moon Hong, Young Jin Jeong, Hae Won Kim, Byeong-Cheol Ahn
Nuclear Medicine and Molecular Imaging.2022; 56(1): 17. CrossRef
Change of Computed Tomography-Based Body Composition after Adrenalectomy in Patients with Pheochromocytoma
Yousun Ko, Heeryoel Jeong, Seungwoo Khang, Jeongjin Lee, Kyung Won Kim, Beom-Jun Kim
Cancers.2022; 14(8): 1967. CrossRef
Evaluation and Management of Bone Health in Patients with Thyroid Diseases: a Position Statement from the Korean Thyroid Association
A Ram Hong, Hwa Young Ahn, Bu Kyung Kim, Seong Hee Ahn, So Young Park, Min-Hee Kim, Jeongmin Lee, Sun Wook Cho, Ho-Cheol Kang
International Journal of Thyroidology.2022; 15(1): 1. CrossRef
Pheochromocytoma with Retroperitoneal Metastasis: A Case Report
建新崔
Advances in Clinical Medicine.2021; 11(05): 2239. CrossRef

Clinical Study
Identification of Novel Genetic Variants Related to Trabecular Bone Score in Community-Dwelling Older Adults: Sung Hye Kong, Ji Won Yoon, Jung Hee Kim, JooYong Park, Jiyeob Choi, Ji Hyun Lee, A Ram Hong, Nam H. Cho, Chan Soo Shin; Endocrinol Metab. 2020;35(4):801-810. Published online November 24, 2020; DOI: https://doi.org/10.3803/EnM.2020.735

5,245 View
118 Download
1 Web of Science
1 Crossref

Abstract PDF Supplementary Material PubReader ePub

Background
As the genetic variants of trabecular bone microarchitecture are not well-understood, we performed a genome-wide association study to identify genetic determinants of bone microarchitecture analyzed by trabecular bone score (TBS).
Methods
TBS-associated genes were discovered in the Ansung cohort (discovery cohort), a community-based rural cohort in Korea, and then validated in the Gene-Environment Interaction and Phenotype (GENIE) cohort (validation cohort), consisting of subjects who underwent health check-up programs. In the discovery cohort, 2,451 participants were investigated for 1.42 million genotyped and imputed markers.
Results
In the validation cohort, identified as significant variants were evaluated in 2,733 participants. An intronic variant in iroquois homeobox 3 (IRX3), rs1815994, was significantly associated with TBS in men (P=3.74E-05 in the discovery cohort, P=0.027 in the validation cohort). Another intronic variant in mitogen-activated protein kinase kinase 5 (MAP2K5), rs11630730, was significantly associated with TBS in women (P=3.05E-09 in the discovery cohort, P=0.041 in the validation cohort). Men with the rs1815994 variant and women with the rs11630730 variant had lower TBS and lumbar spine bone mineral density. The detrimental effects of the rs1815994 variant in men and rs11630730 variant in women were also identified in association analysis (β=–0.0281, β=–0.0465, respectively).
Conclusion
In this study, the rs1815994 near IRX3 in men and rs11630730 near MAP2K5 in women were associated with deterioration of the bone microarchitecture. It is the first study to determine the association of genetic variants with TBS. Further studies are needed to confirm our findings and identify additional variants contributing to the trabecular bone microarchitecture.

Citations

Citations to this article as recorded by

Neural EGFL like 1 as a novel gene for Trabecular Bone Score in older adults: The Bushehr Elderly Health (BEH) program
Mohammad Bidkhori, Mahdi Akbarzadeh, Noushin Fahimfar, Mina Jahangiri, Sahar Seddiq, Bagher Larijani, Iraj Nabipour, Mahsa Mohammad Amoli, Nekoo Panahi, Abbas Dehghan, Kourosh Holakouie-Naieni, Afshin Ostovar, Dengshun Miao
PLOS ONE.2024; 19(9): e0309401. CrossRef

Clinical Study
Stimulated Salivary Cortisol as a Noninvasive Diagnostic Tool for Adrenal Insufficiency: Yoon Ji Kim, Jung Hee Kim, A Ram Hong, Kyeong Seon Park, Sang Wan Kim, Chan Soo Shin, Seong Yeon Kim; Endocrinol Metab. 2020;35(3):628-635. Published online September 22, 2020; DOI: https://doi.org/10.3803/EnM.2020.707

6,859 View
216 Download
14 Web of Science
15 Crossref

Abstract PDF PubReader ePub

Background
Salivary cortisol is routinely used as a diagnostic test for Cushing syndrome. The diagnostic use of salivary cortisol for adrenal insufficiency (AI), however, is less established. We aimed to investigate the utility of morning basal and adrenocorticotropic hormone-stimulated salivary cortisol in diagnosing AI in Korean adults.
Methods
We prospectively included 120 subjects (female, n=70) from Seoul National University Hospital. AI was defined as a stimulated serum cortisol level of <496.8 nmol/L during the short Synacthen test (SST). Serum and saliva samples were drawn between 8:00 AM and 10:00 AM. Salivary cortisol levels were measured using an enzyme immunoassay kit.
Results
Thirty-four patients were diagnosed with AI according to the SST results. Age, sex, body mass index, serum albumin levels, and serum creatinine levels did not significantly differ between the normal and AI groups. Basal and stimulated salivary cortisol levels were positively correlated with basal (r=0.538) and stimulated serum cortisol levels (r=0.750), respectively (all P<0.001). Receiver operating characteristic curve analysis yielded a cutoff level of morning basal salivary cortisol of 3.2 nmol/L (sensitivity, 84.9%; specificity, 73.5%; area under the curve [AUC]=0.822). The optimal cutoff value of stimulated salivary cortisol was 13.2 nmol/L (sensitivity, 90.7%; specificity, 94.1%; AUC=0.959). Subjects with a stimulated salivary cortisol level above 13.2 nmol/L but a stimulated serum cortisol level below 496.8 nmol/L (n=2) had lower serum albumin levels than those showing a concordant response.
Conclusion
The diagnostic performance of stimulated salivary cortisol measurements after the SST was comparable to serum cortisol measurements for diagnosing AI.

Citations

Citations to this article as recorded by

Extensive expertise in endocrinology: adrenal crisis in assisted reproduction and pregnancy
Ulla Feldt-Rasmussen
European Journal of Endocrinology.2024; 190(1): R10. CrossRef
Turning Antibodies into Ratiometric Bioluminescent Sensors for Competition-Based Homogeneous Immunoassays
Eva A. van Aalen, Joep J. J. Lurvink, Leandra Vermeulen, Benice van Gerven, Yan Ni, Remco Arts, Maarten Merkx
ACS Sensors.2024; 9(3): 1401. CrossRef
A Contemporary Approach to the Diagnosis and Management of Adrenal Insufficiency
Suranut Charoensri, Richard J. Auchus
Endocrinology and Metabolism.2024; 39(1): 73. CrossRef
Insuficiencia suprarrenal
A.E. Ortiz-Flores, M. Araujo-Castro, E. Pascual-Corrales, H.F. Escobar-Morreale
Medicine - Programa de Formación Médica Continuada Acreditado.2024; 14(13): 718. CrossRef
Utility of Salivary Cortisol and Cortisone in the Diagnostics of Adrenal Insufficiency
Kåre Kvam Hellan, Martin Lyngstad, Paal Methlie, Kristian Løvås, Eystein Sverre Husebye, Grethe Åstrøm Ueland
The Journal of Clinical Endocrinology & Metabolism.2024;[Epub] CrossRef
Post-Traumatic Hypopituitarism
Nissa Blocher
Current Physical Medicine and Rehabilitation Reports.2024;[Epub] CrossRef
Diagnostic strategies in adrenal insufficiency
Vasiliki Siampanopoulou, Elisavet Tasouli, Anna Angelousi
Current Opinion in Endocrinology, Diabetes & Obesity.2023; 30(3): 141. CrossRef
The association between neuropeptide oxytocin and neuropsychiatric disorders after orthopedic surgery stress in older patients
Wanru Dong, Zengbo Ding, Xiao Wu, Ran Wan, Ying Liu, Liubao Pei, Weili Zhu
BMC Geriatrics.2023;[Epub] CrossRef
The Reliability of Salivary Cortisol Compared to Serum Cortisol for Diagnosing Adrenal Insufficiency with the Gold Standard ACTH Stimulation Test in Children
Silvia Ciancia, Sjoerd A. A. van den Berg, Erica L. T. van den Akker
Children.2023; 10(9): 1569. CrossRef
РІВЕНЬ СТРЕСУ В ДІТЕЙ ШКІЛЬНОГО ВІКУ З COVID-19
Г. А. Павлишин, О. І. Панченко
Здобутки клінічної і експериментальної медицини.2023; (4): 119. CrossRef
Secondary adrenal suppression related to high doses of inhaled corticosteroids in patients with severe asthma
Mariana Lobato, João Gaspar-Marques, Pedro Carreiro-Martins, Paula Leiria-Pinto
Annals of Allergy, Asthma & Immunology.2022; 128(4): 464. CrossRef
Clinical and Technical Aspects in Free Cortisol Measurement
Man Ho Choi
Endocrinology and Metabolism.2022; 37(4): 599. CrossRef
Continuous biomarker monitoring with single molecule resolution by measuring free particle motion
Alissa D. Buskermolen, Yu-Ting Lin, Laura van Smeden, Rik B. van Haaften, Junhong Yan, Khulan Sergelen, Arthur M. de Jong, Menno W. J. Prins
Nature Communications.2022;[Epub] CrossRef
Reversible Immunosensor for the Continuous Monitoring of Cortisol in Blood Plasma Sampled with Microdialysis
Laura van Smeden, Annet Saris, Khulan Sergelen, Arthur M. de Jong, Junhong Yan, Menno W. J. Prins
ACS Sensors.2022; 7(10): 3041. CrossRef
Adrenal insufficiency in HIV/AIDS: a review
Simon Mifsud, Zachary Gauci, Mark Gruppetta, Charles Mallia Azzopardi, Stephen Fava
Expert Review of Endocrinology & Metabolism.2021; 16(6): 351. CrossRef

Clinical Study
Low Predictive Value of FRAX Adjusted by Trabecular Bone Score for Osteoporotic Fractures in Korean Women: A Community-Based Cohort Study: Hana Kim, Jung Hee Kim, Min Joo Kim, A Ram Hong, HyungJin Choi, EuJeong Ku, Ji Hyun Lee, Chan Soo Shin, Nam H. Cho; Endocrinol Metab. 2020;35(2):359-366. Published online June 24, 2020; DOI: https://doi.org/10.3803/EnM.2020.35.2.359

6,804 View
141 Download
11 Web of Science
12 Crossref

Abstract PDF PubReader ePub

Background
The value of the Fracture Risk Assessment Tool (FRAX) and the trabecular bone score (TBS) for assessing osteoporotic fracture risk has not been fully elucidated in Koreans. We conducted this study to clarify the predictive value of FRAX adjusted by TBS for osteoporotic fractures in Korean women.
Methods
After screening 7,192 eligible subjects from the Ansung cohort, 1,165 women aged 45 to 76 years with available bone mineral density (BMD) and TBS data were enrolled in this study. We assessed their clinical risk factors for osteoporotic fractures and evaluated the predictive value of FRAX with or without BMD and TBS.
Results
During the mean follow-up period of 7.5 years, 99 (8.5%) women suffered major osteoporotic fractures (MOFs) and 28 (2.4%) experienced hip fractures. FRAX without BMD, BMD-adjusted FRAX, and TBS-adjusted FRAX were significantly associated with the risk of MOFs (hazard ratio [HR] per percent increase, 1.08; 95% confidence interval [CI], 1.03 to 1.14; HR, 1.09; 95% CI, 1.03 to 1.15; and HR, 1.07; 95% CI, 1.02 to 1.13, respectively). However, BMD-adjusted FRAX and TBS-adjusted FRAX did not predict MOFs better than FRAX without BMD based on the Harrell’s C statistic. FRAX probabilities showed limited value for predicting hip fractures. The cut-off values of FRAX without BMD, FRAX with BMD, and FRAX with BMD adjusted by TBS for predicting MOFs were 7.2%, 5.0%, and 6.7%, respectively.
Conclusion
FRAX with BMD and TBS adjustment did not show better predictive value for osteoporotic fractures in this study than FRAX without adjustment. Moreover, the cut-off values of FRAX probabilities for treatment might be lower in Korean women than in other countries.

Citations

Citations to this article as recorded by

Update on the utility of trabecular bone score (TBS) in clinical practice for the management of osteoporosis: a systematic review by the Egyptian Academy of Bone and Muscle Health
Yasser El Miedany, Walaa Elwakil, Mohammed Hassan Abu-Zaid, Safaa Mahran
Egyptian Rheumatology and Rehabilitation.2024;[Epub] CrossRef
Enhancing Osteoporosis Management: A Thorough Examination of Surgical Techniques and Their Effects on Patient Outcomes
Mihnea Popa, Adrian Cursaru, Bogdan Cretu, Sergiu Iordache, Georgian L Iacobescu, Razvan Spiridonica, Bogdan Serban, Catalin Cirstoiu
Cureus.2024;[Epub] CrossRef
Imaging bone turnover assessment through volumetric density-adjusted standardized uptake value using quantitative bone SPECT/CT in osteoporosis
Dong Yun Lee, Jungsu S. Oh, Ji Wan Kim, Seung Hun Lee, Beom-Jun Kim, Jung-Min Koh, Jae Seung Kim, Jin-Sook Ryu
EJNMMI Research.2024;[Epub] CrossRef
Comparison of predictive value of FRAX, trabecular bone score, and bone mineral density for vertebral fractures in systemic sclerosis: A cross-sectional study
Kyung-Ann Lee, Hyun-Joo Kim, Hyun-Sook Kim
Medicine.2023; 102(2): e32580. CrossRef
Screening for the primary prevention of fragility fractures among adults aged 40 years and older in primary care: systematic reviews of the effects and acceptability of screening and treatment, and the accuracy of risk prediction tools
Michelle Gates, Jennifer Pillay, Megan Nuspl, Aireen Wingert, Ben Vandermeer, Lisa Hartling
Systematic Reviews.2023;[Epub] CrossRef
Chronic airway disease as a major risk factor for fractures in osteopenic women: Nationwide cohort study
Sung Hye Kong, Ae Jeong Jo, Chan Mi Park, Kyun Ik Park, Ji Eun Yun, Jung Hee Kim
Frontiers in Endocrinology.2023;[Epub] CrossRef
Update on the clinical use of trabecular bone score (TBS) in the management of osteoporosis: results of an expert group meeting organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Disease
Enisa Shevroja, Jean-Yves Reginster, Olivier Lamy, Nasser Al-Daghri, Manju Chandran, Anne-Laurence Demoux-Baiada, Lynn Kohlmeier, Marie-Paule Lecart, Daniel Messina, Bruno Muzzi Camargos, Juraj Payer, Sansin Tuzun, Nicola Veronese, Cyrus Cooper, Eugene V.
Osteoporosis International.2023; 34(9): 1501. CrossRef
Comparison of HU histogram analysis and BMD for proximal femoral fragility fracture assessment: a retrospective single-center case–control study
Sun-Young Park, Hong Il Ha, Injae Lee, Hyun Kyung Lim
European Radiology.2022; 32(3): 1448. CrossRef
Association of Trabecular Bone Score-Adjusted Fracture Risk Assessment Tool with Coronary Artery Calcification in Women
Tzyy-Ling Chuang, Yuh-Feng Wang, Malcolm Koo, Mei-Hua Chuang
Diagnostics.2022; 12(1): 178. CrossRef
Risk of osteoporotic fracture in women using the FRAX tool with and without bone mineral density score in patients followed at a tertiary outpatient clinic ‒ An observational study
Maria Helena Sampaio Favarato, Maria Flora de Almeida, Arnaldo Lichtenstein, Milton de Arruda Martins, Mario Ferreira Junior
Clinics.2022; 77: 100015. CrossRef
Comparison of Trabecular Bone Score–Adjusted Fracture Risk Assessment (TBS-FRAX) and FRAX Tools for Identification of High Fracture Risk among Taiwanese Adults Aged 50 to 90 Years with or without Prediabetes and Diabetes
Tzyy-Ling Chuang, Mei-Hua Chuang, Yuh-Feng Wang, Malcolm Koo
Medicina.2022; 58(12): 1766. CrossRef
Application of the Trabecular Bone Score in Clinical Practice
Sung Hye Kong, Namki Hong, Jin-Woo Kim, Deog Yoon Kim, Jung Hee Kim
Journal of Bone Metabolism.2021; 28(2): 101. CrossRef

Endocrine Research
Transformation of Mature Osteoblasts into Bone Lining Cells and RNA Sequencing-Based Transcriptome Profiling of Mouse Bone during Mechanical Unloading: A Ram Hong, Kwangsoo Kim, Ji Yeon Lee, Jae-Yeon Yang, Jung Hee Kim, Chan Soo Shin, Sang Wan Kim; Endocrinol Metab. 2020;35(2):456-469. Published online June 24, 2020; DOI: https://doi.org/10.3803/EnM.2020.35.2.456; Correction in: Endocrinol Metab 2021;36(6):1314

8,587 View
179 Download
11 Web of Science
12 Crossref

Abstract PDF Supplementary Material PubReader ePub

Background
We investigated RNA sequencing-based transcriptome profiling and the transformation of mature osteoblasts into bone lining cells (BLCs) through a lineage tracing study to better understand the effect of mechanical unloading on bone loss.
Methods
Dmp1-CreERt2(+):Rosa26R mice were injected with 1 mg of 4-hydroxy-tamoxifen three times a week starting at postnatal week 7, and subjected to a combination of botulinum toxin injection with left hindlimb tenotomy starting at postnatal week 8 to 10. The animals were euthanized at postnatal weeks 8, 9, 10, and 12. We quantified the number and thickness of X-gal(+) cells on the periosteum of the right and left femoral bones at each time point.
Results
Two weeks after unloading, a significant decrease in the number and a subtle change in the thickness of X-gal(+) cells were observed in the left hindlimbs compared with the right hindlimbs. At 4 weeks after unloading, the decrease in the thickness was accelerated in the left hindlimbs, although the number of labeled cells was comparable. RNA sequencing analysis showed downregulation of 315 genes in the left hindlimbs at 2 and 4 weeks after unloading. Of these, Xirp2, AMPD1, Mettl11b, NEXN, CYP2E1, Bche, Ppp1r3c, Tceal7, and Gadl1 were upregulated during osteoblastogenic/osteocytic and myogenic differentiation in vitro.
Conclusion
These findings demonstrate that mechanical unloading can accelerate the transformation of mature osteoblasts into BLCs in the early stages of bone loss in vivo. Furthermore, some of the genes involved in this process may have a pleiotropic effect on both bone and muscle.

Citations

Citations to this article as recorded by

Synthetic composites versus calcium phosphate cements in bone regeneration: A narrative review
Oana Dima, Andreea Cristiana Didilescu, Claudiu Constantin Manole, Cornelis Pameijer, Claudiu Călin
Annals of Anatomy - Anatomischer Anzeiger.2024; 255: 152273. CrossRef
Insights and implications of sexual dimorphism in osteoporosis
Yuan-Yuan Zhang, Na Xie, Xiao-Dong Sun, Edouard C. Nice, Yih-Cherng Liou, Canhua Huang, Huili Zhu, Zhisen Shen
Bone Research.2024;[Epub] CrossRef
Rationale of using magnetically sensitive biomaterials in bone tissue therapy: a review
Pavel A. Markov, Elena Y. Kostromina, Anatoliy D. Fesyun, Petr S. Eremin
Bulletin of Rehabilitation Medicine.2024; 23(3): 69. CrossRef
METTLing in Stem Cell and Cancer Biology
John G. Tooley, James P. Catlin, Christine E. Schaner Tooley
Stem Cell Reviews and Reports.2023; 19(1): 76. CrossRef
Three's a crowd – why did three N-terminal methyltransferases evolve for one job?
Meghan M. Conner, Christine E. Schaner Tooley
Journal of Cell Science.2023;[Epub] CrossRef
Unlocking the mysteries of alpha-N-terminal methylation and its diverse regulatory functions
Panyue Chen, Rong Huang, Tony R. Hazbun
Journal of Biological Chemistry.2023; 299(7): 104843. CrossRef
Examining Mechanisms for Voltage-Sensitive Calcium Channel-Mediated Secretion Events in Bone Cells
Perla C. Reyes Fernandez, Christian S. Wright, Mary C. Farach-Carson, William R. Thompson
Calcified Tissue International.2023; 113(1): 126. CrossRef
Reactivation of Bone Lining Cells are Attenuated Over Repeated Anti-sclerostin Antibody Administration
A Ram Hong, Jae-Yeon Yang, Ji Yeon Lee, Joonho Suh, Yun-Sil Lee, Jung-Eun Kim, Sang Wan Kim
Calcified Tissue International.2022; 111(5): 495. CrossRef
Purine metabolism in the development of osteoporosis
Keda Yang, Jie Li, Lin Tao
Biomedicine & Pharmacotherapy.2022; 155: 113784. CrossRef
Effects of Gabapentin and Pregabalin on Calcium Homeostasis: Implications for Physical Rehabilitation of Musculoskeletal Tissues
Perla C. Reyes Fernandez, Christian S. Wright, Stuart J. Warden, Julia Hum, Mary C. Farach-Carson, William R. Thompson
Current Osteoporosis Reports.2022; 20(6): 365. CrossRef
Calvaria Bone Transcriptome in Mouse Models of Osteogenesis Imperfecta
Pierre Moffatt, Iris Boraschi-Diaz, Juliana Marulanda, Ghalib Bardai, Frank Rauch
International Journal of Molecular Sciences.2021; 22(10): 5290. CrossRef
Age-related neurodegeneration and cognitive impairments of NRMT1 knockout mice are preceded by misregulation of RB and abnormal neural stem cell development
James P. Catlin, Leandro N. Marziali, Benjamin Rein, Zhen Yan, M. Laura Feltri, Christine E. Schaner Tooley
Cell Death & Disease.2021;[Epub] CrossRef

Bone Metabolism
Effects of Resistance Exercise on Bone Health: A Ram Hong, Sang Wan Kim; Endocrinol Metab. 2018;33(4):435-444. Published online November 30, 2018; DOI: https://doi.org/10.3803/EnM.2018.33.4.435

28,142 View
436 Download
119 Web of Science
124 Crossref

Abstract PDF PubReader ePub

The prevalence of chronic diseases including osteoporosis and sarcopenia increases as the population ages. Osteoporosis and sarcopenia are commonly associated with genetics, mechanical factors, and hormonal factors and primarily associated with aging. Many older populations, particularly those with frailty, are likely to have concurrent osteoporosis and sarcopenia, further increasing their risk of disease-related complications. Because bones and muscles are closely interconnected by anatomy, metabolic profile, and chemical components, a diagnosis should be considered for both sarcopenia and osteoporosis, which may be treated with optimal therapeutic interventions eliciting pleiotropic effects on both bones and muscles. Exercise training has been recommended as a promising therapeutic strategy to encounter the loss of bone and muscle mass due to osteosarcopenia. To stimulate the osteogenic effects for bone mass accretion, bone tissues must be exposed to mechanical load exceeding those experienced during daily living activities. Of the several exercise training programs, resistance exercise (RE) is known to be highly beneficial for the preservation of bone and muscle mass. This review summarizes the mechanisms of RE for the preservation of bone and muscle mass and supports the clinical evidences for the use of RE as a therapeutic option in osteosarcopenia.

Citations

Citations to this article as recorded by

Decoding osteoporosis: Understanding the disease, exploring current and new therapies and emerging targets
Dhruvee Patel, Bhagawati Saxena
Journal of Orthopaedic Reports.2025; 4(4): 100472. CrossRef
Effect of COVID‐19 pandemic on lifestyle and bone mineral density in young adults
Darina Falbová, Viktória Kovalčíková, Radoslav Beňuš, Simona Sulis, Lenka Vorobeľová
American Journal of Human Biology.2024;[Epub] CrossRef
Obesity, diabetes and risk of bone fragility: How BMAT behavior is affected by metabolic disturbances and its influence on bone health
Gregório Corrêa Guimarães, João Bosco Costa Coelho, João Gabriel Oliveira Silva, Ana Carolina Chalfun de Sant’Ana, Cássia Alves Carrilho de Sá, Júlia Marques Moreno, Lívia Marçal Reis, Camila Souza de Oliveira Guimarães
Osteoporosis International.2024; 35(4): 575. CrossRef
Bone mineral density after exercise training in patients with chronic kidney disease stages 3 to 5: a sub-study of RENEXC—a randomized controlled trial
Vaida Petrauskiene, Matthias Hellberg, Philippa Svensson, Yunan Zhou, Naomi Clyne
Clinical Kidney Journal.2024;[Epub] CrossRef
Atp6v1h Deficiency Blocks Bone Loss in Simulated Microgravity Mice through the Fos-Jun-Src-Integrin Pathway
Zanyan Zhao, Xiangpu Wang, Yu Ma, Xiaohong Duan
International Journal of Molecular Sciences.2024; 25(1): 637. CrossRef
Exercise and Musculoskeletal Health in Men With Low Bone Mineral Density: A Systematic Review
Katherine Hu, Maree Cassimatis, Christian Girgis
Archives of Rehabilitation Research and Clinical Translation.2024; 6(1): 100313. CrossRef
Influence of 8-weeks of supervised static stretching or resistance training of pectoral major muscles on maximal strength, muscle thickness and range of motion
Tim Wohlann, Konstantin Warneke, Vincent Kalder, David G. Behm, Tobias Schmidt, Stephan Schiemann
European Journal of Applied Physiology.2024; 124(6): 1885. CrossRef
High-Protein Diets during either Resistance or Concurrent Training Have No Detrimental Effect on Bone Parameters in Resistance-Trained Males
Reza Bagheri, Zohreh Karimi, Zeynabalsadat Mousavi, Mahdi Ziaee Bashirzad, Donny M. Camera, Ramin Sadeghi, Vahid Reza Dabbagh, Mehdi Kargarfard, Frederic Dutheil
Nutrients.2024; 16(2): 325. CrossRef
Cafeteria Diet Can Affect Bone Microarchitecture in Sedentary and Trained Male Rats
Marcio Koiti Saito, Beatriz Kawano de Oliveira, Ana Paula Macedo, Caio Sorrentino dos Santos, Ricardo Tadeu Lopes, Jéssica Suzuki Yamanaka, Antonio Carlos Shimano
Journal of Clinical Densitometry.2024; 27(2): 101467. CrossRef
The Relationship Among Probable SARCopenia, Osteoporosis and SuprasPinatus Tendon Tears in Postmenopausal Women: The SARCOSP Study
Murat Kara, Özgür Kara, Mahmut Esad Durmuş, Pelin Analay, Fatıma Edibe Şener, Beyza Nur Çıtır, Gizem Olgu Korkmaz, Zeliha Ünlü, Tülay Tiftik, Eda Gürçay, Cevriye Mülkoğlu, Berkay Yalçınkaya, Fatih Bağcıer, Mahmud Fazıl Aksakal, Kübra Erdoğan, Ahmet Sertçe
Calcified Tissue International.2024; 114(4): 340. CrossRef
Low Bone Mass in Ambulatory Spinal Muscular Atrophy: A Proactive Approach for an Often-Overlooked Impairment
Caitlin Trancho, Bailey Stickney, Stacy Kinirons, David Uher, Cara H. Kanner, Ashwini K. Rao, Michael P. McDermott, Carol Ewing Garber, Darryl C. De Vivo, Jacqueline Montes
Journal of Clinical Medicine.2024; 13(5): 1336. CrossRef
DXA-based appendicular composition measures in healthy aging Caucasian Greek women: a cross-sectional study
Stavroula J. Theodorou, Daphne J. Theodorou, Vassiliki Kigka, Ioannis Gkiatas, Andreas Fotopoulos
Rheumatology International.2024; 44(9): 1715. CrossRef
Predictors of Hand Grip Strength in Adults Without Sarcopenia: Data From the NHANES, 2013–2014
Mansour M Alotaibi
Current Developments in Nutrition.2024; 8(5): 102149. CrossRef
Why don't women engage in muscle strength exercise? An integrative review
A. M. Stimson, C. Anderson, A.‐M. Holt, A. J. Henderson
Health Promotion Journal of Australia.2024;[Epub] CrossRef
Plant-Based Diets versus the Mediterranean Dietary Pattern and Their Socio-Demographic Determinants in the Spanish Population: Influence on Health and Lifestyle Habits
Elena Sandri, Marco Sguanci, Eva Cantín Larumbe, Germán Cerdá Olmedo, Lisa Ursula Werner, Michela Piredda, Stefano Mancin
Nutrients.2024; 16(9): 1278. CrossRef
Exercise-Induced Alterations in Irisin and Osteocalcin Levels: A Comparative Analysis Across Different Training Modalities
P. Adilakshmi, V. Suganthi, K. Balu Mahendran, K. Satyanarayana Rao, B. Savithri
Cureus.2024;[Epub] CrossRef
A comprehensive review on glucocorticoids induced osteoporosis: A medication caused disease
Asim Rahman, Md Faheem Haider
Steroids.2024; 207: 109440. CrossRef
Unilateral avascular necrosis of the right hip in an HIV patient with tearing of the rectus femoris and adductor longus muscles
Syed Raza, Nazia Khan
BMJ Case Reports.2024; 17(5): e258709. CrossRef
Knowledge, attitude, and practice toward osteoporosis among patients with chronic kidney disease in Zhejiang
Pengjie Xu, Nadan Zhao, Jiangdong Wang
Medicine.2024; 103(20): e38153. CrossRef
The role of exercise in aromatase inhibitor‐induced arthralgia
Kerstin Yu, Pauline Portes, G. Stephen Morris, Laura Huang, Elizabeth R. Felix, Gary J. Farkas, Diana Molinares, Eduard Tiozzo
PM&R.2024;[Epub] CrossRef
Effectiveness of interventions to prevent or reverse pre-frailty and frailty in middle-aged community dwelling adults: A systematic review
Tom H. Brennan, Lucy K. Lewis, Susan J. Gordon, Ivanka Prichard
Preventive Medicine.2024; 185: 108008. CrossRef
What is the force required to treat trismus in patients undergoing oral cavity free flap reconstruction?
Emma Charters, Jamie Loy, Kai Cheng, Masako Dunn, Timothy Manzie, Boyang Wan, Vinay Tumuluri, Jonathan R. Clark
Head & Neck.2024;[Epub] CrossRef
Bone remodeling in survivors of pediatric hematopoietic stem cell transplantation: Impact of heavy resistance training
Lise Marie Krogh, Anne Nissen, Sarah Weischendorff, Bolette Hartmann, Jesper Løvind Andersen, Jens Juul Holst, Kaspar Sørensen, Martin Kaj Fridh, Abigail Louise Mackey, Klaus Müller
Pediatric Blood & Cancer.2024;[Epub] CrossRef
The Interplay of Nutrition, Exercise, and Dietary Intervention for Enhanced Performance of Athletes and General Well-Being of Non-Athletes: A Review
Oghenerume Lucky Emakpor, Great Iruoghene Edo, Emad Yousif, Princess Oghenekeno Samuel, Agatha Ngukuran Jikah, Khalid Zainulabdeen, Athraa Abdulameer Mohammed, Winifred Ndudi, Susan Chinedu Nwachukwu, Ufuoma Ugbune, Joy Johnson Agbo, Irene Ebosereme Ainya
OBM Integrative and Complementary Medicine.2024; 09(02): 1. CrossRef
Dietary content and combined training, but not daily physical activity, are associated with 6-month bone mineral changes in adolescents with obesity: A Secondary analysis of the PAC-MAnO trial
Antonio Videira-Silva, Inês Santos, Dalise Freaza, Mariana Gameiro, Luis B. Sardinha, Helena Fonseca
European Journal of Pediatrics.2024; 183(9): 3969. CrossRef
Prevalence and risk factors of osteopenia and osteoporosis among postmenopausal women: A cross‐sectional study from Jordan
Manar H. Abu Khurmah, Mohammad J. Alkhatatbeh, Osama Y. Alshogran, Hamza M. Alarda
Public Health Nursing.2024; 41(5): 996. CrossRef
Optimizing serum electrolyte levels in stroke patients: a multimodal approach with soymilk supplementation
Babak Esmealy, Leyla Esmealy, Leila Gholizadeh, Saeid Nikookheslat, Vahid Sari-Sarraf
Annals of Medicine & Surgery.2024; 86(9): 5230. CrossRef
An In Vitro Orbital Flow Model to Study Mechanical Loading Effects on Osteoblasts
Subburaman Mohan, Ritika Surisetty, Kesavan Chandrasekhar
Biology.2024; 13(9): 646. CrossRef
Dairy and Exercise for Bone Health: Evidence from Randomized Controlled Trials and Recommendations for Future Research
Nicholas Cheng, Andrea R. Josse
Current Osteoporosis Reports.2024;[Epub] CrossRef
Yaşlılarda Sarkopeni ve Toplumsal Katılım
Merve Arı, Gülfidan Başer, Nursen İlçin
Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi.2024;[Epub] CrossRef
From Cells to Environment: Exploring the Interplay between Factors Shaping Bone Health and Disease
Samradhi Singh, Devojit Kumar Sarma, Vinod Verma, Ravinder Nagpal, Manoj Kumar
Medicina.2023; 59(9): 1546. CrossRef
Effect of resistance exercise on bone health of old aged individuals: Review
A. Khanna
Science & Sports.2023; 38(4): 323. CrossRef
Relationship between physical exercise and COVID-19 (SARS-CoV-2): systematic review
Robson Chacon Castoldi, Juliana Cristina de Ângelo, Thiago Teixeira Pereira, Rodrigo Martins Dias, Fábio Juliano Negrão
Sport Sciences for Health.2023; 19(1): 55. CrossRef
Impact of Physical Rehabilitation on Bone Biomarkers in Non-Metastatic Breast Cancer Women: A Systematic Review and Meta-Analysis
Alessandro de Sire, Lorenzo Lippi, Nicola Marotta, Arianna Folli, Dario Calafiore, Stefano Moalli, Alessio Turco, Antonio Ammendolia, Nicola Fusco, Marco Invernizzi
International Journal of Molecular Sciences.2023; 24(2): 921. CrossRef
Does wing use and disuse cause behavioural and musculoskeletal changes in domestic fowl ( Gallus gallus domesticus )?
Renée C. Garant, Bret W. Tobalske, Neila Ben Sassi, Nienke van Staaveren, Dan Tulpan, Tina Widowski, Donald R. Powers, Alexandra Harlander-Matauschek
Royal Society Open Science.2023;[Epub] CrossRef
Increased fat mass negatively influences femoral neck bone mineral density in men but not women
Nipith Charoenngam, Caroline M. Apovian, Chatlert Pongchaiyakul
Frontiers in Endocrinology.2023;[Epub] CrossRef
Influence of Strength Training Variables on Neuromuscular and Morphological Adaptations in Prepubertal Children: A Systematic Review
Alberto Sánchez Pastor, Carlos García-Sánchez, Moisés Marquina Nieto, Alfonso de la Rubia
International Journal of Environmental Research and Public Health.2023; 20(6): 4833. CrossRef
The Role of Oxidative Stress in Multiple Exercise-Regulated Bone Homeostasis
Haoyang Gao, Yilong Zhao, Linlin Zhao, Zhikun Wang, Kai Yan, Bo Gao, Lingli Zhang
Aging and disease.2023; 14(5): 1555. CrossRef
Kadınlarda Fiziksel Aktivite ve Egzersizin Osteoporozu Önleme ve Tedavi Edici Rolü
Sümena HAREKET, İlknur NAZ GÜRŞAN
Cumhuriyet Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi.2023; 8(1): 73. CrossRef
Osteosarcopenia as a satellite of aging
B. I. Isaeva, K. M. Alieva-Kharkharova
Meditsinskiy sovet = Medical Council.2023; 17(9): 130. CrossRef
Examining Physical Wellness as the Fundamental Element for Achieving Holistic Well-Being in Older Persons: Review of Literature and Practical Application in Daily Life
Sheng-Te Hung, Yi-Chen Cheng, Chieh-Chen Wu, Chun-Hsien Su
Journal of Multidisciplinary Healthcare.2023; Volume 16: 1889. CrossRef
Effects of Exercise, Rehabilitation, and Nutritional Approaches on Body Composition and Bone Density in People with Multiple Sclerosis: A Systematic Review and Meta-Analysis
Natascia Rinaldo, Alba Pasini, Sofia Straudi, Giovanni Piva, Anna Crepaldi, Andrea Baroni, Lorenzo Caruso, Fabio Manfredini, Nicola Lamberti
Journal of Functional Morphology and Kinesiology.2023; 8(3): 132. CrossRef
Changes in Desk-Based Workers’ Sitting, Standing, and Stepping Time: Short- and Longer-Term Effects on Musculoskeletal Pain
FRANCIS Q. S. DZAKPASU, NEVILLE OWEN, ALISON CARVER, CHRISTIAN J. BRAKENRIDGE, ELIZABETH G. EAKIN, GENEVIEVE N. HEALY, ANTHONY D. LAMONTAGNE, MARJ MOODIE, PIETER COENEN, LEON STRAKER, DAVID W. DUNSTAN
Medicine & Science in Sports & Exercise.2023; 55(12): 2241. CrossRef
Shared decision making in sarcopenia treatment
Kang An, Zengxiang Wu, Yu Qiu, Mengjia Pan, Lin Zhang, Zhenmei An, Shuangqing Li
Frontiers in Public Health.2023;[Epub] CrossRef
Effects of combined traditional Chinese medicine therapy in patients of lower limbs injuries with osteoporosis: A retrospective paired cohort study
Yu-Hua Lu, Chi-Hsiang Chung, Chien-Jung Lin, Li-Jen Tsai, Kuang-Chung Shih, Chieh-Hua Lu, Wu-Chien Chien
Medicine.2023; 102(49): e36489. CrossRef
The theory of planned behavior and strength training in college-aged women
Diana Cuy Castellanos, Corinne M. Daprano, Clarissa Blevins, Anne Crecelius
Journal of American College Health.2022; 70(3): 837. CrossRef
The effect of exercise for improving bone health in cancer survivors — A systematic review and meta-analysis
Benjamin Singh, Kellie Toohey
Journal of Science and Medicine in Sport.2022; 25(1): 31. CrossRef
The role of estrogens in osteosarcopenia: from biology to potential dual therapeutic effects
A. Mandelli, E. Tacconi, I. Levinger, G. Duque, A. Hayes
Climacteric.2022; 25(1): 81. CrossRef
Changes in blood bone markers after the first and second bouts of whole‐body eccentric exercises
Tsang‐Hai Huang, Kazunori Nosaka, Trevor C. Chen
Scandinavian Journal of Medicine & Science in Sports.2022; 32(3): 521. CrossRef
Questions Individuals with Cardiac Conditions Engaging in Exercise often Ask Health Fitness Professionals: Research-Based Responses
Kirk D. Hendrickson, Cindy Haskin-Popp, Barry A. Franklin
ACSM'S Health & Fitness Journal.2022; 26(2): 29. CrossRef
Effects of Different Types of Exercise on Kidney Diseases
Hamid Arazi, Majid Mohabbat, Payam Saidie, Akram Falahati, Katsuhiko Suzuki
Sports.2022; 10(3): 42. CrossRef
Sport Activity Load and Skeletomuscular Robustness in Elite Youth Athletes
Irina Kalabiska, Annamaria Zsakai, Dorina Annar, Robert M. Malina, Tamas Szabo
International Journal of Environmental Research and Public Health.2022; 19(9): 5083. CrossRef
A pas de deux of osteoporosis and sarcopenia: osteosarcopenia
O. V. Yakushevskaya, S. V. Yureneva, V. I. Komedina
Meditsinskiy sovet = Medical Council.2022; (6): 116. CrossRef
The Effect of Endurance and Endurance-Strength Training on Bone Health and Body Composition in Centrally Obese Women—A Randomised Pilot Trial
Małgorzata Jamka, Sylwia E. Piotrowska-Brudnicka, Joanna Karolkiewicz, Damian Skrypnik, Paweł Bogdański, Judyta Cielecka-Piontek, Gulnara Sultanova, Jarosław Walkowiak, Edyta Mądry
Healthcare.2022; 10(5): 821. CrossRef
Kinematic and Kinetic Characteristics of Repetitive Countermovement Jumps with Accentuated Eccentric Loading
Micah Gross, Jan Seiler, Bastien Grédy, Fabian Lüthy
Sports.2022; 10(5): 74. CrossRef
Osteosarcopenia: A Narrative Review on Clinical Studies
Angela Polito, Lorenzo Barnaba, Donatella Ciarapica, Elena Azzini
International Journal of Molecular Sciences.2022; 23(10): 5591. CrossRef
Efficacy of Bracing on Thoracic Kyphotic Angle and Functionality in Women with Osteoporosis: A Systematic Review
Beatriz Sánchez-Pinto-Pinto, Carlos Romero-Morales, Daniel López-López, Carmen de-Labra, Guillermo García-Pérez-de-Sevilla
Medicina.2022; 58(6): 693. CrossRef
Are There Any Differences Between the Effect of Resistance and Aerobic Training on Spatial Learning and Memory in the Rat Model of AD?
Khadijeh Ebrahimi, Behrouz Baghaiee
Journal of Clinical Research in Paramedical Sciences.2022;[Epub] CrossRef
Effects of Whole-Body Vibration on Breast Cancer Bone Metastasis and Vascularization in Mice
Takeshi Matsumoto, Akihiro Mukohara
Calcified Tissue International.2022; 111(5): 535. CrossRef
Current Status of the Diagnosis and Management of Osteoporosis
Agustín Aibar-Almazán, Ana Voltes-Martínez, Yolanda Castellote-Caballero, Diego Fernando Afanador-Restrepo, María del Carmen Carcelén-Fraile, Elena López-Ruiz
International Journal of Molecular Sciences.2022; 23(16): 9465. CrossRef
Methodological Proposal for Strength and Power Training in Older Athletes: A Narrative Review
Emilio Jofré-Saldía, Álvaro Villalobos-Gorigoitía, Gemma Gea-García
Current Aging Science.2022; 15(2): 135. CrossRef
Robotic Walking to Mitigate Bone Mineral Density Decline and Adverse Body Composition in Individuals With Incomplete Spinal Cord Injury
Claire Shackleton, Robert Evans, Sacha West, Wayne Derman, Yumna Albertus
American Journal of Physical Medicine & Rehabilitation.2022; 101(10): 931. CrossRef
Exploration of Aging-Care Parameters to Predict Mortality of Patients Aged 80-Years and Above with Community-Acquired Pneumonia
Chunxin Lv, Wen Shi, Teng Pan, Houshen Li, Weixiong Peng, Jiayi Xu, Jinhai Deng
Clinical Interventions in Aging.2022; Volume 17: 1379. CrossRef
Pharmacological, Nutritional, and Rehabilitative Interventions to Improve the Complex Management of Osteoporosis in Patients with Chronic Obstructive Pulmonary Disease: A Narrative Review
Alessandro de Sire, Lorenzo Lippi, Vittorio Aprile, Dario Calafiore, Arianna Folli, Francesco D’Abrosca, Stefano Moalli, Marco Lucchi, Antonio Ammendolia, Marco Invernizzi
Journal of Personalized Medicine.2022; 12(10): 1626. CrossRef
Resistance circuit training combined with hypoxia stimulates bone system of older adults: A randomized trial
Alba Camacho-Cardenosa, Marta Camacho-Cardenosa, Ismael Martínez-Guardado, Alejo Leal, José María Villa Andrada, Rafael Timón
Experimental Gerontology.2022; 169: 111983. CrossRef
Effects of Strength Training on BDNF in Healthy Young Adults
Miroslaw Babiarz, Radoslaw Laskowski, Tomasz Grzywacz
International Journal of Environmental Research and Public Health.2022; 19(21): 13795. CrossRef
Celecoxib impairs primary human myoblast proliferation and differentiation independent of cyclooxygenase 2 inhibition
Ronald W. Matheny, Alexander L. Kolb, Alyssa V. Geddis, Brandon M. Roberts
Physiological Reports.2022;[Epub] CrossRef
The effects on type 2 diabetes mellitus mouse femoral bone achieved by anti-osteoporosis exercise interventions
Miao Zhang, Yuexuan Li, Lifei Liu, Mei Huang, Miao Wang, Jun Zou
Frontiers in Endocrinology.2022;[Epub] CrossRef
Physical Activity and Post-Transcriptional Regulation of Aging Decay: Modulation of Pathways in Postmenopausal Osteoporosis
Federica Vita, Sebastiano Gangemi, Giovanni Pioggia, Fabio Trimarchi, Debora Di Mauro
Medicina.2022; 58(6): 767. CrossRef
Sclerostin as a biomarker of physical exercise in osteoporosis: A narrative review
Anna Oniszczuk, Agnieszka Kaczmarek, Mateusz Kaczmarek, Maria Ciałowicz, Ersan Arslan, Ana Filipa Silva, Filipe Manuel Clemente, Eugenia Murawska-Ciałowicz
Frontiers in Endocrinology.2022;[Epub] CrossRef
Exercise and Bone Health in Cancer: Enemy or Ally?
Alice Avancini, Giulia Benato, Anita Borsati, Luca Oliviero, Lorenzo Belluomini, Marco Sposito, Daniela Tregnago, Ilaria Trestini, Jessica Insolda, Francesca Zacchi, Elena Fiorio, Federico Schena, Michele Milella, Sara Pilotto
Cancers.2022; 14(24): 6078. CrossRef
Composite Indices of Femoral Neck Strength in Middle-Aged Inactive Subjects Vs Former Football Players
Boutros Finianos, Gautier Zunquin, Rawad El Hage
Journal of Clinical Densitometry.2021; 24(2): 214. CrossRef
Relationship between bone strength index of the hemiparetic tibial diaphysis and muscle strength in people with chronic stroke: influence of muscle contraction type and speed
Z. Yang, T. Miller, M. Y. C. Pang
Osteoporosis International.2021; 32(5): 951. CrossRef
Effect of 12 months of creatine supplementation and whole-body resistance training on measures of bone, muscle and strength in older males
Darren G Candow, Philip D Chilibeck, Julianne Gordon, Emelie Vogt, Tim Landeryou, Mojtaba Kaviani, Lisa Paus-Jensen
Nutrition and Health.2021; 27(2): 151. CrossRef
Effects of 6-Month Multimodal Physical Exercise Program on Bone Mineral Density, Fall Risk, Balance, and Gait in Patients with Alzheimer’s Disease: A Controlled Clinical Trial
A. Silvia Puente-González, M. Carmen Sánchez-Sánchez, Eduardo J. Fernández-Rodríguez, J. Elicio Hernández-Xumet, Fausto J. Barbero-Iglesias, Roberto Méndez-Sánchez
Brain Sciences.2021; 11(1): 63. CrossRef
Resistance Training Modulates the Matrix Metalloproteinase-2 Activity in Different Trabecular Bones in Aged Rats
Ivo Vieira de Sousa Neto, João Luiz Quaglioti Durigan, Gonçalo Carreiro de Farias Junior, Fabio Henrique Bogni, Amanda Lima Ruivo, Juliana Oliveira de Araújo, Keico Okino Nonaka, Heloísa Selistre-de-Araújo, Rita de Cássia Marqueti
Clinical Interventions in Aging.2021; Volume 16: 71. CrossRef
Resistance Exercise in Prostate Cancer Patients: a Short Review
Andrej Zdravkovic, Timothy Hasenoehrl, Richard Crevenna
Current Physical Medicine and Rehabilitation Reports.2021; 9(1): 32. CrossRef
Sturz, Sarkopenie und Osteoporose
Marcus Köller
Journal für Mineralstoffwechsel & Muskuloskelettale Erkrankungen.2021; 28(1): 19. CrossRef
Effects of marathon race on selected myokines and sclerostin in middle-aged male amateur runners
Ewa Śliwicka, Tomasz Cisoń, Łucja Pilaczyńska-Szcześniak, Andrzej Ziemba, Anna Straburzyńska-Lupa
Scientific Reports.2021;[Epub] CrossRef
Lower extremity joint loading during Bounce rope skip in comparison to run and walk
Rajani Mullerpatan, Triveni Shetty, Yuvraj Singh, Bela Agarwal
Journal of Bodywork and Movement Therapies.2021; 26: 1. CrossRef
Powerlifting exercise performance and muscle mass indices and their relationship with bone mineral density
Daniel A. Hackett, Angelo Sabag
Sport Sciences for Health.2021; 17(3): 735. CrossRef
Physical Activity and Bone Health in Men: A Systematic Review and Meta-Analysis
Maureen C. Ashe, Isis Kelly dos Santos, Nicola Y. Edward, Laura A. Burnett, Rosanne Barnes, Lena Fleig, Joseph H. Puyat, Joanna E. M. Sale, Heather A. McKay, Lora M Giangregorio
Journal of Bone Metabolism.2021; 28(1): 27. CrossRef
Pathophysiology and treatment of osteoporosis: challenges for clinical practice in older people
J. Barnsley, G. Buckland, P. E. Chan, A. Ong, A. S. Ramos, M. Baxter, F. Laskou, E. M. Dennison, C. Cooper, Harnish P. Patel
Aging Clinical and Experimental Research.2021; 33(4): 759. CrossRef
Sarcopenia and Bone Mass Loss as Risks during Aging on Female Elderly with Light Activity
Yoni Astuti, Zulkhah Noor, Rahmah Rahmah
Open Access Macedonian Journal of Medical Sciences.2021; 9(T4): 168. CrossRef
Effect of intradialytic exercise on bone profile in hemodialysis patients
Howaida Abdelhameed Elshinnawy, Ahmed Mohamed Bakr Bakr Mohamed, Dina Abou Bakr Farrag, Moustafa Abd Elnassier AbdElgawad
Egyptian Rheumatology and Rehabilitation.2021;[Epub] CrossRef
Osteoporosis guidelines from a rehabilitation perspective: systematic analysis and quality appraisal using AGREE II
Giovanni IOLASCON, Alessandro de SIRE, Claudio CURCI, Marco PAOLETTA, Sara LIGUORI, Dario CALAFIORE, Francesca GIMIGLIANO, Antimo MORETTI
European Journal of Physical and Rehabilitation Medicine.2021;[Epub] CrossRef
A Case Study of an 87-Year-Old Male Bodybuilder with Complex Health Conditions
Daniel A. Hackett, Lachlan Mitchell, Guy C. Wilson, Trinidad Valenzuela, Matthew Hollings, Maria Fiatarone Singh
Medicina.2021; 57(7): 664. CrossRef
Frailty Pathogenesis, Assessment, and Management in Older Adults With COVID-19
Quan She, Bo Chen, Wen Liu, Min Li, Weihong Zhao, Jianqing Wu
Frontiers in Medicine.2021;[Epub] CrossRef
Optimization of transdisciplinary management of elderly with femur proximal extremity fracture: A patient-tailored plan from orthopaedics to rehabilitation
Alessandro de Sire, Marco Invernizzi, Alessio Baricich, Lorenzo Lippi, Antonio Ammendolia, Federico Alberto Grassi, Massimiliano Leigheb
World Journal of Orthopedics.2021; 12(7): 456. CrossRef
International Exercise Recommendations in Older Adults (ICFSR): Expert Consensus Guidelines
Mikel Izquierdo, R.A. Merchant, J.E. Morley, S.D. Anker, I. Aprahamian, H. Arai, M. Aubertin-Leheudre, R. Bernabei, E.L. Cadore, M. Cesari, L.-K. Chen, P. de Souto Barreto, G. Duque, L. Ferrucci, R.A. Fielding, A. García-Hermoso, L.M. Gutiérrez-Robledo, S
The Journal of nutrition, health and aging.2021; 25(7): 824. CrossRef
Intra-bone nuclear DNA variability and STR typing success in Second World War first ribs
Laura Božič, Tajda Benedik Bevc, Eva Podovšovnik, Tomaž Zupanc, Irena Zupanič Pajnič
International Journal of Legal Medicine.2021; 135(6): 2199. CrossRef
Can Resistance Exercise Be a Tool for Healthy Aging in Post-Menopausal Women with Type 1 Diabetes?
Zeinab Momeni, Jessica E. Logan, Ronald J. Sigal, Jane E. Yardley
International Journal of Environmental Research and Public Health.2021; 18(16): 8716. CrossRef
Role of the Myokine Irisin on Bone Homeostasis: Review of the Current Evidence
Amanda Kornel, Danja J. Den Hartogh, Panagiota Klentrou, Evangelia Tsiani
International Journal of Molecular Sciences.2021; 22(17): 9136. CrossRef
Prevalence and Correlates of Muscle-Strengthening Activity Participation in Croatia: A Cross-Sectional Study in a National Representative Sample of 4561 Adults
Hrvoje Radašević, Jelena Čvrljak, Željko Pedišić, Danijel Jurakić
International Journal of Environmental Research and Public Health.2021; 18(17): 8905. CrossRef
Intra-bone nuclear DNA variability and STR typing success in Second World War 12th thoracic vertebrae
Tajda Benedik Bevc, Laura Božič, Eva Podovšovnik, Tomaž Zupanc, Irena Zupanič Pajnič
Forensic Science International: Genetics.2021; 55: 102587. CrossRef
Vascular Ageing and Aerobic Exercise
Michaela Kozakova, Carlo Palombo
International Journal of Environmental Research and Public Health.2021; 18(20): 10666. CrossRef
Efficacy of Creatine Supplementation and Resistance Training on Area and Density of Bone and Muscle in Older Adults
DARREN G. CANDOW, PHILIP D. CHILIBECK, JULIANNE J. GORDON, SAIJA KONTULAINEN
Medicine & Science in Sports & Exercise.2021; 53(11): 2388. CrossRef
Perspectives of personalized approach to prevention and treatment of anticonvulsant-induced osteoporosis via action on vitamin D exchange and VDR expression
E. A. Dontseva, V. V. Trefilova, T. E. Popova, M. M. Petrova, M. Al-Zamil
Personalized Psychiatry and Neurology.2021; 1(2): 46. CrossRef
Bone health in adolescence
Maria R. AMBROSIO, Ludovica ALIBERTI, Irene GAGLIARDI, Paola FRANCESCHETTI, Maria C. ZATELLI
Minerva Obstetrics and Gynecology.2021;[Epub] CrossRef
To Evaluate the Awareness and Prevention of Osteoporosis in Patients Attending Orthopaedics Outdoor Clinics in a Tertiary Level Hospital
Annie Sandhu, Dharminder Singh, Akashdeep Singh, Kuldip Singh Sand
Trends in Medical Research.2021; 16(2): 73. CrossRef
Novel Insights into the Pathogenesis of Spinal Sarcopenia and Related Therapeutic Approaches: A Narrative Review
Yu-Kai Kuo, Yu-Ching Lin, Ching-Yu Lee, Chih-Yu Chen, Jowy Tani, Tsung-Jen Huang, Hsi Chang, Meng-Huang Wu
International Journal of Molecular Sciences.2020; 21(8): 3010. CrossRef
Multifactorial effects of hyperglycaemia, hyperinsulinemia and inflammation on bone remodelling in type 2 diabetes mellitus
V.A. Shahen, M. Gerbaix, S. Koeppenkastrop, S.F. Lim, K.E. McFarlane, Amanda N.L. Nguyen, X.Y. Peng, N.B. Weiss, T.C. Brennan-Speranza
Cytokine & Growth Factor Reviews.2020; 55: 109. CrossRef
Effect of pre-treatment of strength training and raloxifene in periestropause on bone healing
Melise Jacon Peres-Ueno, Fernanda Fernandes, Victor Gustavo Balera Brito, Ângela Cristina Nicola, Camila Tami Stringhetta-Garcia, Robson Chacon Castoldi, Amanda Pinatti Menezes, Paulo Cézar Ciarlini, Mário Jeferson Quirino Louzada, Sandra Helena Penha Oli
Bone.2020; 134: 115285. CrossRef
Physical rehabilitation of patients with osteoporosis
E.D. Yehudina, O.S. Kalashnikova
Voprosy kurortologii, fizioterapii i lechebnoi fizicheskoi kul'tury.2020; 97(2): 78. CrossRef
RANKL/RANK/OPG Pathway: A Mechanism Involved in Exercise-Induced Bone Remodeling
Mohammad Tobeiha, Mohammed H. Moghadasian, Negin Amin, Sadegh Jafarnejad
BioMed Research International.2020; 2020: 1. CrossRef
Effects of muscular strength training and growth hormone (GH) supplementation on femoral bone tissue: analysis by Raman spectroscopy, dual-energy X-ray absorptiometry, and mechanical resistance
Robson Chacon Castoldi, Guilherme Akio Tamura Ozaki, Thiago Alves Garcia, Ines Cristina Giometti, Tatiana Emy Koike, Regina Celi Trindade Camargo, João Domingos Augusto dos Santos Pereira, Carlos José Leopoldo Constantino, Mário Jefferson Quirino Louzada,
Lasers in Medical Science.2020; 35(2): 345. CrossRef
Approaches to the diagnosis and prevention of frailty
S. J. Woolford, O. Sohan, E. M. Dennison, C. Cooper, H. P. Patel
Aging Clinical and Experimental Research.2020; 32(9): 1629. CrossRef
The Impact of Exercise on Bone Health in Type 2 Diabetes Mellitus—a Systematic Review
R. Viggers, Z. Al-Mashhadi, R. Fuglsang-Nielsen, S. Gregersen, J. Starup-Linde
Current Osteoporosis Reports.2020; 18(4): 357. CrossRef
Transformation of Mature Osteoblasts into Bone Lining Cells and RNA Sequencing-Based Transcriptome Profiling of Mouse Bone during Mechanical Unloading
A Ram Hong, Kwangsoo Kim, Ji Yeon Lee, Jae-Yeon Yang, Jung Hee Kim, Chan Soo Shin, Sang Wan Kim
Endocrinology and Metabolism.2020; 35(2): 456. CrossRef
Physical Exercise Potentials Against Viral Diseases Like COVID-19 in the Elderly
Sandra Amatriain-Fernández, Thomas Gronwald, Eric Murillo-Rodríguez, Claudio Imperatori, Alexandre Francisco Solano, Alexandra Latini, Henning Budde
Frontiers in Medicine.2020;[Epub] CrossRef
Osteosarcopenia: beyond age-related muscle and bone loss
Gabriela Fagundes Belchior, Ben Kirk, Evela Aparecida Pereira da Silva, Gustavo Duque
European Geriatric Medicine.2020; 11(5): 715. CrossRef
Mediating role of physical fitness and fat mass on the associations between physical activity and bone health in youth
Duarte Henriques-Neto, João Pedro Magalhães, Pedro Júdice, Megan Hetherington-Rauth, Miguel Peralta, Adilson Marques, Luís B. Sardinha
Journal of Sports Sciences.2020; 38(24): 2811. CrossRef
Impact of physical activity and exercise on bone health in patients with chronic kidney disease: a systematic review of observational and experimental studies
Daniela F. Cardoso, Elisa A. Marques, Diogo V. Leal, Aníbal Ferreira, Luke A. Baker, Alice C. Smith, João L. Viana
BMC Nephrology.2020;[Epub] CrossRef
Short and medium-term effects of a multicomponent physical exercise program with a Mediterranean diet on bone mineral density, gait, balance, and fall risk for patients with Alzheimer disease
Ana Silvia Puente-González, Felipe Sánchez-González, Juan Elicio Hernández-Xumet, María Carmen Sánchez-Sánchez, Fausto José Barbero-Iglesias, Roberto Méndez-Sánchez
Medicine.2020; 99(38): e22385. CrossRef
Sarcopenia during COVID-19 lockdown restrictions: long-term health effects of short-term muscle loss
Richard Kirwan, Deaglan McCullough, Tom Butler, Fatima Perez de Heredia, Ian G. Davies, Claire Stewart
GeroScience.2020; 42(6): 1547. CrossRef
Acute Effects of Two Types of Dumbbell Exercise on Oxygenated Hemodynamic Concentration of Cerebral Activation in Healthy Young Male Adults: A Functional Near-Infrared Spectroscopy Study
Yana Wang, Jiaojiao Lü, Jifeng Rong, Linjie Song, Wei Wang, Yifan Jiang, Yu Liu, Lingyan Huang
Frontiers in Human Neuroscience.2020;[Epub] CrossRef
Muscle-Derived Lumican Stimulates Bone Formation via Integrin α2β1 and the Downstream ERK Signal
Jin Young Lee, So Jeong Park, Da Ae Kim, Seung Hun Lee, Jung-Min Koh, Beom-Jun Kim
Frontiers in Cell and Developmental Biology.2020;[Epub] CrossRef
Analysis of Age-Based Bone Mineral Density in the Korean Adult Population Using Dual-Energy X-ray Absorptiometry
Jung Chul Lee, Chong Hoon Lee, Dong Wha Chung, Hee Joo Lee, Jae Yong Park
Applied Sciences.2020; 10(23): 8469. CrossRef
Preventive Moderate Continuous Running-Exercise Conditioning Improves the Healing of Non-Critical Size Bone Defects in Male Wistar Rats: A Pilot Study Using µCT
Céline Bourzac, Morad Bensidhoum, Mathieu Manassero, Christine Chappard, Nicolas Michoux, Stéphane Pallu, Hugues Portier
Life.2020; 10(12): 308. CrossRef
BONE MINERAL DENSITY: AN ANALYSIS OF WEIGHT BEARING, RESISTANCE AND IMPACT PHYSICAL ACTIVITIES
Arvind Malik, Sonia Malik, Vishal Dahiya
PARIPEX INDIAN JOURNAL OF RESEARCH.2020; : 1. CrossRef
Effects of ursolic acid on muscle mass and bone microstructure in rats with casting-induced muscle atrophy
Yun Seok Kang, Eun Bi Noh, Sang Hyun Kim
Journal of Exercise Nutrition & Biochemistry.2019; 23(3): 45. CrossRef
Osteoporosis and Sarcopenia Increase Frailty Syndrome in the Elderly
Emanuela A. Greco, Peter Pietschmann, Silvia Migliaccio
Frontiers in Endocrinology.2019;[Epub] CrossRef
Associations of Health-Related Quality of Life, Fear of Falling and Objective Measures of Physical Function with Bone Health in Postmenopausal Women with Low Bone Mass
Anoohya Gandham, Lachlan B. McMillan, Carrie-Anne Ng, Ludovic Humbert, Maxine P. Bonham, Ayse Zengin, Peter R. Ebeling, David Scott
Journal of Clinical Medicine.2019; 8(9): 1370. CrossRef
Osteoblasts are “educated” by crosstalk with metastatic breast cancer cells in the bone tumor microenvironment
Alexus D. Kolb, Alison B. Shupp, Dimpi Mukhopadhyay, Frank C. Marini, Karen M. Bussard
Breast Cancer Research.2019;[Epub] CrossRef

Clinical Study
Characteristics of Korean Patients with Primary Adrenal Insufficiency: A Registry-Based Nationwide Survey in Korea: A Ram Hong, Ohk-Hyun Ryu, Seong Yeon Kim, Sang Wan Kim; Endocrinol Metab. 2017;32(4):466-474. Published online December 14, 2017; DOI: https://doi.org/10.3803/EnM.2017.32.4.466

6,516 View
65 Download
14 Web of Science
12 Crossref

Abstract PDF Supplementary Material PubReader

Background

Primary adrenal insufficiency (PAI) is a rare, potentially life-threatening condition. There are few Korean studies on PAI, and most have had small sample sizes. We aimed to examine the etiology, clinical characteristics, treatment, and mortality of PAI in Korean patients.

Methods

A nationwide, multicenter, registry-based survey was conducted to identify adults diagnosed with or treated for PAI at 30 secondary or tertiary care institutions in Korea between 2000 and 2014.

Results

A total of 269 patients with PAI were identified. The prevalence of PAI was 4.17 per million. The estimated incidence was 0.45 per million per year. The mean age at diagnosis was 49.0 years, and PAI was more prevalent in men. Adrenal tuberculosis was the most common cause of PAI in patients diagnosed before 2000; for those diagnosed thereafter, adrenal metastasis and tuberculosis were comparable leading causes. The etiology of PAI was not identified in 34.9% of cases. Of the patients receiving glucocorticoid replacement therapy, prednisolone was more frequently administered than hydrocortisone (69.4% vs. 26.5%, respectively), and only 27.1% of all patients received fludrocortisone. We observed an increased prevalence of metabolic disease and osteoporosis during the follow-up period (median, 60.2 months). The observed overall mortality and disease-specific mortality rates were 11.9% and 3.1%, respectively.

Conclusion

The prevalence of PAI is significantly lower in Koreans than in reports from Western countries. The high frequency undetermined etiology in patients with PAI suggests the need to reveal accurate etiology of PAI in Korea.

Citations

Citations to this article as recorded by

Genetic and phenotypic spectrum of non-21-hydroxylase-deficiency primary adrenal insufficiency in childhood: data from 111 Chinese patients
Ying Duan, Wanqi Zheng, Yu Xia, Huiwen Zhang, Lili Liang, Ruifang Wang, Yi Yang, Kaichuang Zhang, Deyun Lu, Yuning Sun, Lianshu Han, Yongguo Yu, Xuefan Gu, Yu Sun, Bing Xiao, Wenjuan Qiu
Journal of Medical Genetics.2024; 61(1): 27. CrossRef
Approach to the Patient: Diagnosis of Primary Adrenal Insufficiency in Adults
Marianne Øksnes, Eystein S Husebye
The Journal of Clinical Endocrinology & Metabolism.2023; 109(1): 269. CrossRef
Epidemiology and Causes of Primary Adrenal Insufficiency in Children: A Population-Based Study
Joonatan Borchers, Eero Pukkala, Outi Mäkitie, Saila Laakso
The Journal of Clinical Endocrinology & Metabolism.2023; 108(11): 2879. CrossRef
Primary Adrenal Insufficiency in Acute Progressive Systemic Inflammation Accompanied by Latent Tuberculosis: A Case Report
Kasumi Nishikawa, Mizuki Nitta, Shoma Tanaka, Chiaki Sano, Ryuichi Ohta
Cureus.2023;[Epub] CrossRef
What factors have impact on glucocorticoid replacement in adrenal insufficiency: a real-life study
S. Puglisi, A. Rossini, I. Tabaro, S. Cannavò, F. Ferrau’, M. Ragonese, G. Borretta, M. Pellegrino, F. Dughera, A. Parisi, A. Latina, A. Pia, M. Terzolo, G. Reimondo
Journal of Endocrinological Investigation.2021; 44(4): 865. CrossRef
Adrenal insufficiency
Eystein S Husebye, Simon H Pearce, Nils P Krone, Olle Kämpe
The Lancet.2021; 397(10274): 613. CrossRef
Towards the tailoring of glucocorticoid replacement in adrenal insufficiency: the Italian Society of Endocrinology Expert Opinion
A. M. Isidori, G. Arnaldi, M. Boscaro, A. Falorni, C. Giordano, R. Giordano, R. Pivonello, C. Pozza, E. Sbardella, C. Simeoli, C. Scaroni, A. Lenzi
Journal of Endocrinological Investigation.2020; 43(5): 683. CrossRef
Novel ABCD1 Gene Mutation in a Korean Patient with X-Linked Adrenoleukodystrophy Presenting with Addison's Disease
Yun Kyung Cho, Seo-Young Lee, Sang-Wook Kim
Endocrinology and Metabolism.2020; 35(1): 188. CrossRef
Encountering COVID-19 as Endocrinologists
Eun-Jung Rhee, Jung Hee Kim, Sun Joon Moon, Won-Young Lee
Endocrinology and Metabolism.2020; 35(2): 197. CrossRef
Prednisolone is associated with a worse bone mineral density in primary adrenal insufficiency
Kathrin R Frey, Tina Kienitz, Julia Schulz, Manfred Ventz, Kathrin Zopf, Marcus Quinkler
Endocrine Connections.2018; 7(6): 811. CrossRef
The potential role for infections in the pathogenesis of autoimmune Addison’s disease
A Hellesen, E Bratland
Clinical and Experimental Immunology.2018; 195(1): 52. CrossRef
Evaluation and Treatment of Adrenal Dysfunction in the Primary Care Environment
Shannon Cole
Nursing Clinics of North America.2018; 53(3): 385. CrossRef

Clinical Study
Diagnostic Role of Captopril Challenge Test in Korean Subjects with High Aldosterone-to-Renin Ratios: Jung Hee Kim, Kyeong Seon Park, A Ram Hong, Chan Soo Shin, Seong Yeon Kim, Sang Wan Kim; Endocrinol Metab. 2016;31(2):277-283. Published online May 13, 2016; DOI: https://doi.org/10.3803/EnM.2016.31.2.277

5,940 View
54 Download
16 Web of Science
15 Crossref

Abstract PDF PubReader

Background

Diagnosis of primary aldosteronism (PA) begins with aldosterone-to-renin ratio (ARR) measurement followed by confirmative tests. However, the ARR has high false positive rates which led to unnecessary confirmatory tests. Captopril challenge test (CCT) has been used as one of confirmatory tests, but the accuracy of it in the diagnosis of PA is still controversial. We aimed to examine the clinical efficacy of CCT as a post-screening test in PA.

Methods

In a prospective study, we enrolled subjects with suspected PA who had hypertension and ARR >20 (ng/dL)/(ng/mL/hr). Sixty-four patients who underwent both the saline infusion test and the CCT were included.

Results

The diagnostic performance of plasma aldosterone concentration (PAC) post-CCT was greater than that of ARR post-CCT and ARR pre-CCT in PA (area under the curve=0.956, 0.797, and 0.748, respectively; P=0.001). A cut-off value of 13 ng/dL showed the highest diagnostic odds ratio considering PAC post-CCT at 60 and 90 minutes. A PAC post-CCT of 19 ng/dL had a specificity of 100%, which can be used as a cut-off value for the confirmative test. Determining the diagnostic performance of PAC post-CCT at 90 minutes was sufficient for PA diagnosis. Subjects with PAC post-CCT at 90 minutes <13 ng/dL are less likely to have PA, and those with PAC post-CCT at 90 minutes ≥13 but <19 ng/dL should undergo secondary confirmatory tests.

Conclusion

The CCT test may be a reliable post-screening test to avoid the hospitalization in the setting of falsely elevated ARR screening tests.

Citations

Citations to this article as recorded by

Captopril's influence on Danio rerio embryonic development: Unveiling significant toxic outcomes at environmentally relevant concentrations
Fernando García-Valdespino, Gustavo Axel Elizalde-Velázquez, Selene Elizabeth Herrera-Vázquez, Leobardo Manuel Gómez-Oliván
Science of The Total Environment.2024; 933: 173179. CrossRef
Comparison of four confirmatory tests for the diagnosis of primary aldosteronism: Bayesian analysis in the absence of a gold standard
Hang Shen, Wenjin Luo, Jinbo Hu, Jun Yang, Ying Song, Xiangjun Chen, Yi Yang, Linqiang Ma, Qingfeng Cheng, Zhihong Wang, Qifu Li, Shumin Yang, Qifu Li, Ying Song, Shumin Yang, Wenwen He, Mei Mei, Jinbo Hu, Suxin Luo, Kangla Liao, Yao Zhang, Yunfeng He, Yi
Endocrine.2024; 85(3): 1417. CrossRef
Exclusion Tests in Unilateral Primary Aldosteronism (ExcluPA) Study
Rui Zhu, Tungalagtamir Shagjaa, Giacomo Rossitto, Brasilina Caroccia, Teresa Maria Seccia, Dario Gregori, Gian Paolo Rossi
The Journal of Clinical Endocrinology & Metabolism.2023; 108(2): 496. CrossRef
Captopril challenge test in the diagnosis of primary aldosteronism: consistency between 1- and 2- h sampling
Xinyu Liu, Chao Guo, Jin Bian, Sufang Hao, Ying Lou, Huimin Zhang, Xianliang Zhou, Jun Cai, Wenjun Ma
Frontiers in Endocrinology.2023;[Epub] CrossRef
Performance of Confirmatory Tests for Diagnosing Primary Aldosteronism: a Systematic Review and Meta-Analysis
Alexander A. Leung, Christopher J. Symonds, Gregory L. Hundemer, Paul E. Ronksley, Diane L. Lorenzetti, Janice L. Pasieka, Adrian Harvey, Gregory A. Kline
Hypertension.2022; 79(8): 1835. CrossRef
Baseline Plasma Aldosterone Level and Renin Activity Allowing Omission of Confirmatory Testing in Primary Aldosteronism
Junji Kawashima, Eiichi Araki, Mitsuhide Naruse, Isao Kurihara, Katsutoshi Takahashi, Kouichi Tamura, Hiroki Kobayashi, Shintaro Okamura, Shozo Miyauchi, Koichi Yamamoto, Shoichiro Izawa, Tomoko Suzuki, Akiyo Tanabe
The Journal of Clinical Endocrinology & Metabolism.2020; 105(5): e1990. CrossRef
The number of positive confirmatory tests is associated with the clinical presentation and incidence of cardiovascular and cerebrovascular events in primary aldosteronism
Aya Saiki, Daisuke Tamada, Reiko Hayashi, Kosuke Mukai, Tetsuhiro Kitamura, Mitsuyoshi Takahara, Michio Otsuki, Iichiro Shimomura
Hypertension Research.2019; 42(8): 1186. CrossRef
The characteristics of captopril challenge test–positive patients using various criteria
Satoshi Kidoguchi, Naoki Sugano, Naomi Hayashi-Ishikawa, Norihiko Morisawa, Goro Tokudome, Takashi Yokoo
Journal of the Renin-Angiotensin-Aldosterone System.2019; 20(3): 147032031987089. CrossRef
Confirmatory tests for the diagnosis of primary aldosteronism: A systematic review and meta‐analysis
Sicen Wu, Jun Yang, Jinbo Hu, Ying Song, Wenwen He, Shumin Yang, Rong Luo, Qifu Li
Clinical Endocrinology.2019; 90(5): 641. CrossRef
The captopril challenge test for diagnosing primary Aldosteronism in a Chinese population
Ke-ying Zhu, Yan Zhang, Wen-jing Zhang, Hong-yun Li, Wen-huan Feng, Da-long Zhu, Ping Li
BMC Endocrine Disorders.2019;[Epub] CrossRef
Confirmatory Tests for the Diagnosis of Primary Aldosteronism
Ying Song, Shumin Yang, Wenwen He, Jinbo Hu, Qingfeng Cheng, Yue Wang, Ting Luo, Linqiang Ma, Qianna Zhen, Suhua Zhang, Mei Mei, Zhihong Wang, Hua Qing, Dennis Bruemmer, Bin Peng, Qifu Li
Hypertension.2018; 71(1): 118. CrossRef
Evaluation of the Saline Infusion Test and the Captopril Challenge Test in Chinese Patients With Primary Aldosteronism
Xiao Meng, Yanyan Li, Xiaohao Wang, Jianwei Li, Yuping Liu, Yerong Yu
The Journal of Clinical Endocrinology & Metabolism.2018; 103(3): 853. CrossRef
Articles inEndocrinology and Metabolismin 2016
Won-Young Lee
Endocrinology and Metabolism.2017; 32(1): 62. CrossRef
Optimal follow-up strategies for adrenal incidentalomas: reappraisal of the 2016 ESE-ENSAT guidelines in real clinical practice
A Ram Hong, Jung Hee Kim, Kyeong Seon Park, Kyong Young Kim, Ji Hyun Lee, Sung Hye Kong, Seo Young Lee, Chan Soo Shin, Sang Wan Kim, Seong Yeon Kim
European Journal of Endocrinology.2017; 177(6): 475. CrossRef
Agkihpin, a novel SVTLE from Gloydius halys Pallas, promotes platelet aggregation in vitro and inhibits thrombus formation in vivo in murine models of thrombosis
Huiqiong Xie, Miao Huang, Qiping Hu, Kejian Sun, Huayu Wu, Wei Shu, Xiaolong Li, Ling Fang
Toxicon.2016; 122: 78. CrossRef

Clinical Study
Radiographic Characteristics of Adrenal Masses in Oncologic Patients: Ji Hyun Lee, Eun Ky Kim, A Ram Hong, Eun Roh, Jae Hyun Bae, Jung Hee Kim, Chan Soo Shin, Seong Yeon Kim, Sang Wan Kim; Endocrinol Metab. 2016;31(1):147-152. Published online March 16, 2016; DOI: https://doi.org/10.3803/EnM.2016.31.1.147

5,275 View
44 Download
9 Web of Science
8 Crossref

Abstract PDF PubReader

Background

We aimed to assess the usefulness of pre-contrast Hounsfield unit (HU) and mass size on computed tomography to differentiate adrenal mass found incidentally in oncologic patients.

Methods

From 2000 to 2012, 131 oncologic patients with adrenal incidentaloma were reviewed retrospectively. Receiver operating characteristic (ROC) curves were applied to determine the optimal cut-off value of the mean HU and size for detecting adrenal metastasis.

Results

The median age was 18 years, and 80 patients were male. The initial mass size was 18 mm, and 71 (54.2%) of these were on the left side. A bilateral adrenal mass was found in 11 patients (8.4%). Biochemically functional masses were observed in 9.2% of patients. Thirty-six out of 119 patients with nonfunctional masses underwent adrenalectomy, which revealed metastasis in 13. The primary cancers were lung cancer (n=4), renal cell carcinoma (n=2), lymphoma (n=2), hepatocellular carcinoma (n=2), breast cancer (n=1), and others (n=2). The area under the curve for the size and HU for clinically suspicious metastasis were 0.839 (95% confidence interval [CI], 0.761 to 0.900; P<0.001) and 0.959 (95% CI, 0.898 to 0.988; P<0.001), respectively. The cut-off value to distinguish between metastasis and benign masses were 22 mm for size and 20 for HU.

Conclusion

ROC curve results suggest that pre-contrast HU >20 can be used as a diagnostic reference to suggest metastasis in oncologic patients with adrenal masses.

Citations

Citations to this article as recorded by

Risk of malignancy in adrenal tumors in patients with a history of cancer
Radosław Samsel, Karolina Nowak, Lucyna Papierska, Edyta Karpeta, Katarzyna Roszkowska-Purska, Wacław Smiertka, Tomasz Ostrowski, Eryk Chrapowicki, Alan Grabowski, Dorota Leszczyńska, Andrzej Cichocki
Frontiers in Oncology.2023;[Epub] CrossRef
Adrenal Tumors Found During Staging and Surveillance for Colorectal Cancer: Benign Incidentalomas or Metastatic Disease?
Mio Yanagisawa, Dania G. Malik, Thomas W. Loehfelm, Ghaneh Fananapazir, Michael T. Corwin, Michael J. Campbell
World Journal of Surgery.2020; 44(7): 2282. CrossRef
Predictive factors for adrenal metastasis in extra‐adrenal malignancy patients with solitary adrenal mass
Kyeong‐Hyeon Byeon, Yun‐Sok Ha, Seock‐Hwan Choi, Bum Soo Kim, Hyun Tae Kim, Eun Sang Yoo, Tae Gyun Kwon, Jun Nyung Lee, Tae‐Hwan Kim
Journal of Surgical Oncology.2018; 118(8): 1271. CrossRef
Combining Washout and Noncontrast Data From Adrenal Protocol CT
Chaan S. Ng, Emre Altinmakas, Wei Wei, Payel Ghosh, Xiao Li, Elizabeth G. Grubbs, Nancy A. Perrier, Victor G. Prieto, Jeffrey E. Lee, Brian P. Hobbs
Academic Radiology.2018; 25(7): 861. CrossRef
Evaluation of quantitative parameters for distinguishing pheochromocytoma from other adrenal tumors
Youichi Ohno, Masakatsu Sone, Daisuke Taura, Toshinari Yamasaki, Katsutoshi Kojima, Kyoko Honda-Kohmo, Yorihide Fukuda, Koji Matsuo, Toshihito Fujii, Akihiro Yasoda, Osamu Ogawa, Nobuya Inagaki
Hypertension Research.2018; 41(3): 165. CrossRef
Articles inEndocrinology and Metabolismin 2016
Won-Young Lee
Endocrinology and Metabolism.2017; 32(1): 62. CrossRef
The Diverse Clinical Presentations of Adrenal Lymphoma
Awais Masood, Anna Tumyan, Daniel R. Nussenzveig, Dara N. Wakefield, Diana Barb, Hans K. Ghayee, Naim M. Maalouf
AACE Clinical Case Reports.2017; 3(4): 307. CrossRef
Optimal follow-up strategies for adrenal incidentalomas: reappraisal of the 2016 ESE-ENSAT guidelines in real clinical practice
A Ram Hong, Jung Hee Kim, Kyeong Seon Park, Kyong Young Kim, Ji Hyun Lee, Sung Hye Kong, Seo Young Lee, Chan Soo Shin, Sang Wan Kim, Seong Yeon Kim
European Journal of Endocrinology.2017; 177(6): 475. CrossRef

Adrenal gland
Limited Diagnostic Utility of Plasma Adrenocorticotropic Hormone for Differentiation between Adrenal Cushing Syndrome and Cushing Disease: A Ram Hong, Jung Hee Kim, Eun Shil Hong, I Kyeong Kim, Kyeong Seon Park, Chang Ho Ahn, Sang Wan Kim, Chan Soo Shin, Seong Yeon Kim; Endocrinol Metab. 2015;30(3):297-304. Published online August 4, 2015; DOI: https://doi.org/10.3803/EnM.2015.30.3.297

5,729 View
74 Download
10 Web of Science
10 Crossref

Abstract PDF PubReader

Background

Measurement of the plasma adrenocorticotropic hormone (ACTH) level has been recommended as the first diagnostic test for differentiating between ACTH-independent Cushing syndrome (CS) and ACTH-dependent CS. When plasma ACTH values are inconclusive, a differential diagnosis of CS can be made based upon measurement of the serum dehydroepiandrosterone sulfate (DHEA-S) level and results of the high-dose dexamethasone suppression test (HDST). The aim of this study was to assess the utility of plasma ACTH to differentiate adrenal CS from Cushing' disease (CD) and compare it with that of the HDST results and serum DHEA-S level.

Methods

We performed a retrospective, multicenter study from January 2000 to May 2012 involving 92 patients with endogenous CS. The levels of plasma ACTH, serum cortisol, 24-hour urine free cortisol (UFC) after the HDST, and serum DHEA-S were measured.

Results

Fifty-seven patients had adrenal CS and 35 patients had CD. The area under the curve of plasma ACTH, serum DHEA-S, percentage suppression of serum cortisol, and UFC after HDST were 0.954, 0.841, 0.950, and 0.997, respectively (all P<0.001). The cut-off values for plasma ACTH, percentage suppression of serum cortisol, and UFC after HDST were 5.3 pmol/L, 33.3%, and 61.6%, respectively. The sensitivity and specificity of plasma ACTH measurement were 84.2% and 94.3%, those of serum cortisol were 95.8% and 90.6%, and those of UFC after the HDST were 97.9% and 96.7%, respectively.

Conclusion

Significant overlap in plasma ACTH levels was seen between patients with adrenal CS and those with CD. The HDST may be useful in differentiating between these forms of the disease, especially when the plasma ACTH level alone is not conclusive.

Citations

Citations to this article as recorded by

Development of diagnostic algorithm for Cushing’s syndrome: a tertiary centre experience
A. Efthymiadis, H. Loo, B. Shine, T. James, B. Keevil, J. W. Tomlinson, A. Pal, R. Pofi
Journal of Endocrinological Investigation.2024;[Epub] CrossRef
Eurasian clinical guidelines for the diagnosis and treatment of secondary (symptomatic) forms of arterial hypertension (2022)
I. E. Chazova, N. M. Chikhladze, N. V. Blinova, Zh. E. Belaya, N. M. Danilov, E. M. Elfimova, A. Yu. Litvin, L. Ya. Rozhinskaya, N. Yu. Sviridenko, M. Yu. Shvetsov, V. A. Azizov, E. A. Grigorenko, N. P. Mit’kovskaja, I. I. Mustafaev, A. G. Polupanov, A. S
Eurasian heart journal.2023; (1): 6. CrossRef
Diagnosis and Management of Pituitary Adenomas
Nicholas A. Tritos, Karen K. Miller
JAMA.2023; 329(16): 1386. CrossRef
Distinct serum steroid profiles between adrenal Cushing syndrome and Cushing disease
Chang Gao, Li Ding, Xiaona Zhang, Menghua Yuan, Shaofang Tang, Wei Li, Yuanyuan Ye, Ming Liu, Qing He
Frontiers in Endocrinology.2023;[Epub] CrossRef
The Importance of DHEA-S Levels in Cushing’s Syndrome; Is There a Cut-off Value in the Differential Diagnosis?
Sema Ciftci, Ozlem Soyluk, Alev Selek, Selvinaz Erol, Zeliha Hekimsoy, Ayse Esen, Huseyin Dursun, Serdar Sahin, Gonca Oruk, Meral Mert, Huseyin Soylu, Banu Sarer Yurekli, Melek Eda Ertorer, Tulay Omma, Mehtap Evran, Mine Adas, Seher Tanrikulu, Kadriye Ayd
Hormone and Metabolic Research.2022; 54(04): 232. CrossRef
Epidemiology and Comorbidity of Adrenal Cushing Syndrome: A Nationwide Cohort Study
Chang Ho Ahn, Jung Hee Kim, Man Young Park, Sang Wan Kim
The Journal of Clinical Endocrinology & Metabolism.2021; 106(3): e1362. CrossRef
Metabolic changes in serum steroids for diagnosing and subtyping Cushing’s syndrome
Chang Ho Ahn, Chaelin Lee, Jaeyoon Shim, Sung Hye Kong, Su-jin Kim, Yong Hwy Kim, Kyu Eun Lee, Chan Soo Shin, Jung Hee Kim, Man Ho Choi
The Journal of Steroid Biochemistry and Molecular Biology.2021; 210: 105856. CrossRef
Clinical and Molecular Characteristics of PRKACA L206R Mutant Cortisol-Producing Adenomas in Korean Patients
Insoon Jang, Su-jin Kim, Ra-Young Song, Kwangsoo Kim, Seongmin Choi, Jang-Seok Lee, Min-Kyeong Gwon, Moon Woo Seong, Kyu Eun Lee, Jung Hee Kim
Endocrinology and Metabolism.2021; 36(6): 1287. CrossRef
Clinical Parameters to Distinguish Silent Corticotroph Adenomas from Other Nonfunctioning Pituitary Adenomas
Daham Kim, Cheol Ryong Ku, Se Hee Park, Ju Hyung Moon, Eui Hyun Kim, Sun Ho Kim, Eun Jig Lee
World Neurosurgery.2018; 115: e464. CrossRef
Cushing's syndrome: a practical approach to diagnosis and differential diagnoses
Joseph M Pappachan, Christian Hariman, Mahamood Edavalath, Julian Waldron, Fahmy W Hanna
Journal of Clinical Pathology.2017; 70(4): 350. CrossRef

Thyroid
The Frequency and Clinical Implications of the BRAF^V600E Mutation in Papillary Thyroid Cancer Patients in Korea Over the Past Two Decades: A Ram Hong, Jung Ah Lim, Tae Hyuk Kim, Hoon Sung Choi, Won Sang Yoo, Hye Sook Min, Jae Kyung Won, Kyu Eun Lee, Kyeong Cheon Jung, Do Joon Park, Young Joo Park; Endocrinol Metab. 2014;29(4):505-513. Published online December 29, 2014; DOI: https://doi.org/10.3803/EnM.2014.29.4.505

4,492 View
46 Download
49 Web of Science
41 Crossref

Abstract PDF PubReader

Background

Over the past several decades, there has been a rapid worldwide increase in the prevalence of papillary thyroid cancer (PTC) as well as a number of changes in the clinicopathological characteristics of this disease. BRAF^V600E, which is a mutation of the proto-oncogene BRAF, has become the most frequent genetic mutation associated with PTC, particularly in Korea. Thus, the present study investigated whether the prevalence of the BRAF^V600E mutation has increased over the past two decades in the Korean population and whether various PTC-related clinicopathological characteristics have changed.

Methods

The present study included 2,624 patients who underwent a thyroidectomy for PTC during two preselected periods; 1995 to 2003 and 2009 to 2012. The BRAF^V600E mutation status of each patient was confirmed using the polymerase chain reaction-restriction fragment length polymorphism method or by the direct sequencing of DNA.

Results

The prevalence of the BRAF^V600E mutation in Korean PTC patients increased from 62.2% to 73.7% (P=0.001) over the last two decades. Additionally, there was a greater degree of extrathyroidal extension (ETE) and lymph node metastasis in 2009 to 2012 patients with the BRAF^V600E mutation and a higher frequency of thyroiditis and follicular variant-PTC in 2009 to 2012 patients with wild-type BRAF. However, only the frequency of ETE was significantly higher in 1995 to 2003 patients with the BRAF^V600E mutation (P=0.047). Long-term recurrence rates during a 10-year median follow-up did not differ based on BRAF^V600E mutation status.

Conclusion

The BRAF^V600E mutation rate in Korean PTC patients has been persistently high (approximately 70%) over the past two decades and continues to increase. The present findings demonstrate that BRAF^V600E-positive PTC was associated with more aggressive clinicopathological features, especially in patients who were recently diagnosed, suggesting that BRAF^V600E mutation status may be a useful prognostic factor for PTC in patients recently diagnosed with this disease.

Citations

Citations to this article as recorded by

Genetic alterations and allele frequency of BRAF V600E and TERT mutation in papillary thyroid carcinoma with intermediate-to-high recurrence risk: a retrospective study
Jiayu Huang, Jiazhi Wang, Jingchao Xv, Jingran Wang, Guangzhi Wang, Yongfu Zhao
Clinical and Experimental Medicine.2024;[Epub] CrossRef
The Association between Lymphocytic Thyroiditis and Papillary Thyroid Cancer Harboring Mutant BRAF: A Systematic Review and Meta-Analysis
Sumathy Perampalam, Katherine Wu, Matti Gild, Lyndal Tacon, Martyn Bullock, Roderick Clifton-Bligh
Thyroid®.2024; 34(9): 1082. CrossRef
Association between Thyroid Profile Levels and Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Retrospective Study
Yu-Shan Hsieh, Ting-Teng Yang, Chung-Huei Hsu, Yan-Yu Lin
Reports.2024; 7(3): 78. CrossRef
Genetic and Clinicopathologic Characteristics of Papillary Thyroid Carcinoma in the Chinese Population: High BRAF Mutation Allele Frequency, Multiple Driver Gene Mutations, and RET Fusion May Indicate More Advanced TN Stage
Zhihong Wang, Peng Tang, Surong Hua, Junyi Gao, Bin Zhang, Hua Wan, Qixi Wu, Jiaxin Zhang, Ge Chen
OncoTargets and Therapy.2022; Volume 15: 147. CrossRef
Clinical significance of multi-genic assay in identifying aggressive papillary thyroid carcinoma
Lingfeng Tang, Xiujie Shu, Daixing Hu, Chang Deng, Haoyu Ren, Xinliang Su
American Journal of Otolaryngology.2022; 43(5): 103563. CrossRef
TERT Promoter and BRAF V600E Mutations in Papillary Thyroid Cancer: A Single-Institution Experience in Korea
Min Jhi Kim, Jin Kyong Kim, Gi Jeong Kim, Sang-Wook Kang, Jandee Lee, Jong Ju Jeong, Woong Youn Chung, Daham Kim, Kee-Hyun Nam
Cancers.2022; 14(19): 4928. CrossRef
Diagnostic and prognostic value of a 7-panel mutation testing in thyroid nodules with indeterminate cytology: the SWEETMAC study
Stéphane Bardet, Nicolas Goardon, Justine Lequesne, Dominique Vaur, Renaud Ciappuccini, Alexandra Leconte, Hervé Monpeyssen, Virginie Saguet-Rysanek, Bénédicte Clarisse, Audrey Lasne-Cardon, Fabrice Ménégaux, Laurence Leenhardt, Camille Buffet
Endocrine.2021; 71(2): 407. CrossRef
VE1 immunohistochemistry is an adjunct tool for detection of BRAFV600E mutation: Validation in thyroid cancer patients
Faiza A. Rashid, Sobia Tabassum, Mosin S. Khan, Hifzur R. Ansari, Muhammad Asif, Ahmareen K. Sheikh, Syed Sameer Aga
Journal of Clinical Laboratory Analysis.2021;[Epub] CrossRef
Gene Mutation Analysis in Papillary Thyroid Carcinoma Using a Multi-Gene Panel in China
Qiang Wang, Ning Zhao, Jun Zhang
International Journal of General Medicine.2021; Volume 14: 5139. CrossRef
Null Association between BRAF V600E Mutation and Tumor Recurrence in Patients with Papillary Thyroid Microcarcinoma in South Korea
Ji Yoon Kim, Kyoung Jin Kim, Jae Hyun Bae, Joo Hyung Kim, Nam Hoon Kim, Hee Young Kim, Hoon Yub Kim, Seung-Kuk Baek, Sin Gon Kim, Kwang Yoon Jung, Kyeong Jin Kim
International Journal of Thyroidology.2021; 14(2): 135. CrossRef
Do BRAFV600E mutation and sodium-iodide symporter expression affect the response to radioactive iodine therapy in patients with papillary thyroid carcinoma?
Rania Makboul, Nadia M. Mostafa, Heba E.M. El-Deek, Noha A. Aboulhagag, Mahmoud R. Shehata, Yasser G. Abdelhafez
Nuclear Medicine Communications.2020; 41(5): 416. CrossRef
Genomic and Transcriptomic Characteristics According to Size of Papillary Thyroid Microcarcinoma
Young Shin Song, Byung-Hee Kang, Seungbok Lee, Seong-Keun Yoo, Young Sik Choi, Jungsun Park, Dong Yoon Park, Kyu Eun Lee, Jeong-Sun Seo, Young Joo Park
Cancers.2020; 12(5): 1345. CrossRef
The clinical usefulness of chemokine C-X-C Motif Ligand 12 as a diagnostic marker for Papillary Thyroid Carcinoma
SangAh Lee, JaeHyuck Choi, SukJu Cho, JeeWon Chang, YoungHee Maeng
Indian Journal of Pathology and Microbiology.2020; 63(4): 544. CrossRef
Association between BRAFV600E Mutations and Clinicopathological Features of Papillary Thyroid Microcarcinoma (PTMC)
Sung Min Lee, Cho Rok Lee, Sang-Wook Kang, Jandee Lee, Jong Ju Jeong, Kee-Hyun Nam, Woong Youn Chung, Cheong Soo Park
Journal of Endocrine Surgery.2019; 19(3): 76. CrossRef
The role of Slit2 as a tumor suppressor in thyroid cancer
Min Ji Jeon, Seonhee Lim, Mi-hyeon You, Yangsoon Park, Dong Eun Song, Soyoung Sim, Tae Yong Kim, Young Kee Shong, Won Bae Kim, Won Gu Kim
Molecular and Cellular Endocrinology.2019; 483: 87. CrossRef
BRAF mutation in papillary thyroid cancer—Prevalence and clinical correlation in a South‐East Asian cohort
Xueying Goh, Jeffery Lum, Samantha Peiling Yang, Siok Bee Chionh, Evelyn Koay, Lily Chiu, Rajeev Parameswaran, Kee Yuan Ngiam, Thomas Kwok Seng Loh, Min En Nga, Chwee Ming Lim
Clinical Otolaryngology.2019; 44(2): 114. CrossRef
Clinical Characteristics of Subtypes of Follicular Variant Papillary Thyroid Carcinoma
Min Joo Kim, Jae-Kyung Won, Kyeong Cheon Jung, Ji-hoon Kim, Sun Wook Cho, Do Joon Park, Young Joo Park
Thyroid.2018; 28(3): 311. CrossRef
Prevalence ofBRAFV600EMutation in Follicular Variant of Papillary Thyroid Carcinoma and Non-Invasive Follicular Tumor with Papillary-Like Nuclear Features (NIFTP) in aBRAFV600EPrevalent Area
Hyereen Kim, Bo Hyun Kim, Young Keum Kim, Jeong Mi Kim, Seo Young Oh, Eun Heui Kim, Min Jin Lee, Jong Ho Kim, Yun Kyung Jeon, Sang Soo Kim, Byung Joo Lee, Yong Ki Kim, In Joo Kim
Journal of Korean Medical Science.2018;[Epub] CrossRef
Case–Control Study of Papillary Thyroid Carcinoma on Urinary and Dietary Iodine Status in South Korea
Joon‐Hyop Lee, Ra‐Yeong Song, Jin Wook Yi, Hyeong Won Yu, Hyungju Kwon, Su‐jin Kim, Young Jun Chai, June Young Choi, Jae Hoon Moon, Kyu Eun Lee, Young Joo Park, Sue K. Park
World Journal of Surgery.2018; 42(5): 1424. CrossRef
Thyroid nodules with discordant results of ultrasonographic and fine-needle aspiration findings
Min Joo Kim, Ka Hee Yi
Journal of the Korean Medical Association.2018; 61(4): 225. CrossRef
Genetic landscape of papillary thyroid carcinoma in the Chinese population
Jialong Liang, Wanshi Cai, Dongdong Feng, Huajing Teng, Fengbiao Mao, Yi Jiang, Shanshan Hu, Xianfeng Li, Yujie Zhang, Baoguo Liu, Zhong Sheng Sun
The Journal of Pathology.2018; 244(2): 215. CrossRef
Changes in the clinicopathological characteristics and genetic alterations of follicular thyroid cancer
Young Shin Song, Jung Ah Lim, Hye Sook Min, Min Joo Kim, Hoon Sung Choi, Sun Wook Cho, Jae Hoon Moon, Ka Hee Yi, Do Joon Park, Bo Youn Cho, Young Joo Park
European Journal of Endocrinology.2017; 177(6): 465. CrossRef
Genetic Alterations and Their Clinical Implications in High-Recurrence Risk Papillary Thyroid Cancer
Min-Young Lee, Bo Mi Ku, Hae Su Kim, Ji Yun Lee, Sung Hee Lim, Jong-Mu Sun, Se-Hoon Lee, Keunchil Park, Young Lyun Oh, Mineui Hong, Han-Sin Jeong, Young-Ik Son, Chung-Hwan Baek, Myung-Ju Ahn
Cancer Research and Treatment.2017; 49(4): 906. CrossRef
Role and relevance of BRAF mutations in risk stratifying patients of papillary thyroid cancers along with a review of literature
A Krishnamurthy, V Ramshankar, K Murherkar, S Vidyarani, GC Raghunandhan, A Das, PB Desai, K Albert
Indian Journal of Cancer.2017; 54(1): 372. CrossRef
The changing characteristics and molecular profiles of papillary thyroid carcinoma over time: a systematic review
Huy Gia Vuong, Ahmed M.A. Altibi, Amr Hesham Abdelhamid, Phuong Uyen Duong Ngoc, Vo Duy Quan, Mohamed Yousef Tantawi, Mohamed Elfil, Tran Le Huy Vu, Ahmed Elgebaly, Naoki Oishi, Tadao Nakazawa, Kenji Hirayama, Ryohei Katoh, Nguyen Tien Huy, Tetsuo Kondo
Oncotarget.2017; 8(6): 10637. CrossRef
Current trends of practical issues concerning micropapillary thyroid carcinoma
Yoon Se Lee, Byung-Joo Lee, Hyun Joon Hong, Kang-Dae Lee
Medicine.2017; 96(45): e8596. CrossRef
Dynamic Risk Stratification for Predicting Recurrence in Patients with Differentiated Thyroid Cancer Treated Without Radioactive Iodine Remnant Ablation Therapy
Suyeon Park, Won Gu Kim, Eyun Song, Hye-Seon Oh, Mijin Kim, Hyemi Kwon, Min Ji Jeon, Tae Yong Kim, Young Kee Shong, Won Bae Kim
Thyroid.2017; 27(4): 524. CrossRef
Associations between BRAFV600E and prognostic factors and poor outcomes in papillary thyroid carcinoma: a meta-analysis
Chunping Liu, Tianwen Chen, Zeming Liu
World Journal of Surgical Oncology.2016;[Epub] CrossRef
Clinical utility of TERT promoter mutations and ALK rearrangement in thyroid cancer patients with a high prevalence of the BRAF V600E mutation
Ja Seong Bae, Yourha Kim, Sora Jeon, Se Hee Kim, Tae Jung Kim, Sohee Lee, Min-Hee Kim, Dong Jun Lim, Youn Soo Lee, Chan Kwon Jung
Diagnostic Pathology.2016;[Epub] CrossRef
Genomic Alterations of Anaplastic Thyroid Carcinoma Detected by Targeted Massive Parallel Sequencing in a BRAFV600E Mutation-Prevalent Area
Min Ji Jeon, Sung-Min Chun, Deokhoon Kim, Hyemi Kwon, Eun Kyung Jang, Tae Yong Kim, Won Bae Kim, Young Kee Shong, Se Jin Jang, Dong Eun Song, Won Gu Kim
Thyroid.2016; 26(5): 683. CrossRef
BRAF and Epithelial-Mesenchymal Transition: Lessons From Papillary Thyroid Carcinoma and Primary Cutaneous Melanoma
Brendon Mitchell, Jagdish K. Dhingra, Meera Mahalingam
Advances in Anatomic Pathology.2016; 23(4): 244. CrossRef
Molecular Diagnosis Using Residual Liquid-Based Cytology Materials for Patients with Nondiagnostic or Indeterminate Thyroid Nodules
Hyemi Kwon, Won Gu Kim, Markus Eszlinger, Ralf Paschke, Dong Eun Song, Mijin Kim, Suyeon Park, Min Ji Jeon, Tae Yong Kim, Young Kee Shong, Won Bae Kim
Endocrinology and Metabolism.2016; 31(4): 586. CrossRef
Effect of Hashimoto thyroiditis on low‐dose radioactive‐iodine remnant ablation
Hyungju Kwon, June Young Choi, Jae Hoon Moon, Hyo Jin Park, Won Woo Lee, Kyu Eun Lee
Head & Neck.2016;[Epub] CrossRef
Low Prevalence of Somatic TERT Promoter Mutations in Classic Papillary Thyroid Carcinoma
Min Ji Jeon, Won Gu Kim, Soyoung Sim, Seonhee Lim, Hyemi Kwon, Tae Yong Kim, Young Kee Shong, Won Bae Kim
Endocrinology and Metabolism.2016; 31(1): 100. CrossRef
Genetic alterations of differentiated thyroid carcinoma in iodine‐rich and iodine‐deficient countries
Huy Gia Vuong, Tetsuo Kondo, Naoki Oishi, Tadao Nakazawa, Kunio Mochizuki, Tomohiro Inoue, Ippei Tahara, Kazunari Kasai, Mitsuyoshi Hirokawa, Thong Minh Tran, Ryohei Katoh
Cancer Medicine.2016; 5(8): 1883. CrossRef
Prognostic effects of TERT promoter mutations are enhanced by coexistence with BRAF or RAS mutations and strengthen the risk prediction by the ATA or TNM staging system in differentiated thyroid cancer patients
Young Shin Song, Jung Ah Lim, Hoonsung Choi, Jae‐Kyung Won, Jae Hoon Moon, Sun Wook Cho, Kyu Eun Lee, Young Joo Park, Ka Hee Yi, Do Joon Park, Jeong‐Sun Seo
Cancer.2016; 122(9): 1370. CrossRef
Prognostic Significance of TERT Promoter Mutations in Papillary Thyroid Carcinomas in a BRAFV600E Mutation–Prevalent Population
Seung Eun Lee, Tae Sook Hwang, Yoon-La Choi, Hye Seung Han, Wan Seop Kim, Min Hye Jang, Suk Kyeong Kim, Jung Hyun Yang
Thyroid.2016; 26(7): 901. CrossRef
Mutation Profile of Well-Differentiated Thyroid Cancer in Asians
Young Shin Song, Jung Ah Lim, Young Joo Park
Endocrinology and Metabolism.2015; 30(3): 252. CrossRef
Articles in 'Endocrinology and Metabolism' in 2014
Won-Young Lee
Endocrinology and Metabolism.2015; 30(1): 47. CrossRef
Molecular Diagnosis for Cytologically Indeterminate Thyroid Nodules
Tae Sook Hwang
International Journal of Thyroidology.2015; 8(2): 153. CrossRef
Negative Expression of CPSF2 Predicts a Poorer Clinical Outcome in Patients with Papillary Thyroid Carcinoma
Tae Yon Sung, Mijin Kim, Tae Yong Kim, Won Gu Kim, Yangsoon Park, Dong Eun Song, Su-Yeon Park, Hyemi Kwon, Yun Mi Choi, Eun Kyung Jang, Min Ji Jeon, Young Kee Shong, Suck Joon Hong, Won Bae Kim
Thyroid.2015; 25(9): 1020. CrossRef

Adrenal gland
Adrenocorticotropic Hormone-Independent Cushing Syndrome with Bilateral Cortisol-Secreting Adenomas: Eu Jeong Ku, A Ram Hong, Ye An Kim, Jae Hyun Bae, Mee Soo Chang, Sang Wan Kim; Endocrinol Metab. 2013;28(2):133-137. Published online June 18, 2013; DOI: https://doi.org/10.3803/EnM.2013.28.2.133

4,558 View
45 Download
9 Web of Science
10 Crossref

Abstract PDF PubReader

A 48-year-old woman was incidentally found to have bilateral adrenal masses, 2.8 cm in diameter on the right, and 2.3 cm and 1.7 cm in diameter on the left, by abdominal computed tomography. The patient had a medical history of hypertension, which was not being controlled by carvedilol, at a dose of 25 mg daily. She presented with signs and symptoms that suggested Cushing Syndrome. We diagnosed adrenocorticotropic hormone (ACTH)-independent Cushing Syndrome based on the results of basal and dynamic hormone tests. Adrenal vein sampling (AVS) was performed to localize a functioning adrenal cortical mass. AVS results were consistent with hypersecretion of cortisol from both adrenal glands, with a cortisol lateralization ratio of 1.1. Upon bilateral laparoscopic adrenalectomy, bilateral ACTH-independent adrenal adenomas were found. The patient's signs and symptoms of Cushing Syndrome improved after surgery just as the blood pressure was normalized. After surgery, the patient was started on glucocorticoid and mineralocorticoid replacement therapy.

Citations

Citations to this article as recorded by

Recent Advances in the Clinical Application of Adrenal Vein Sampling
Shan Zhong, Tianyue Zhang, Minzhi He, Hanxiao Yu, Zhenjie Liu, Zhongyi Li, Xiaoxiao Song, Xiaohong Xu
Frontiers in Endocrinology.2022;[Epub] CrossRef
The role of adrenal venous sampling (AVS) in primary bilateral macronodular adrenocortical hyperplasia (PBMAH): a study of 16 patients
German Rubinstein, Andrea Osswald, Leah Theresa Braun, Frederick Vogel, Matthias Kroiss, Stefan Pilz, Sinan Deniz, Laura Aigner, Thomas Knösel, Jérôme Bertherat, Lucas Bouys, Roland Ladurner, Anna Riester, Martin Bidlingmaier, Felix Beuschlein, Martin Rei
Endocrine.2022; 76(2): 434. CrossRef
Concomitant coexistence of ACTH‐dependent and independent Cushing syndrome
Ach Taieb, Saad Ghada, Gorchène Asma, Ben Abdelkrim Asma, Kacem Maha, Ach Koussay
Clinical Case Reports.2022;[Epub] CrossRef
The Value of Adrenal Androgens for Correcting Cortisol Lateralization in Adrenal Venous Sampling in Patients with Normal Cortisol Secretion
Wenjing Zhang, Keying Zhu, Hongyun Li, Yan Zhang, Dalong Zhu, Xuebin Zhang, Ping Li
International Journal of Endocrinology.2019; 2019: 1. CrossRef
Adrenal venous sampling in patients with ACTH-independent hypercortisolism
Eleni Papakokkinou, Hugo Jakobsson, Augustinas Sakinis, Andreas Muth, Bo Wängberg, Olof Ehn, Gudmundur Johannsson, Oskar Ragnarsson
Endocrine.2019; 66(2): 338. CrossRef
ACTH-independent Cushing’s syndrome with bilateral cortisol-secreting adrenal adenomas: a case report and review of literatures
Jia Wei, Sheyu Li, Qilin Liu, Yuchun Zhu, Nianwei Wu, Ying Tang, Qianrui Li, Kaiyun Ren, Qianying Zhang, Yerong Yu, Zhenmei An, Jing Chen, Jianwei Li
BMC Endocrine Disorders.2018;[Epub] CrossRef
A case of adrenal Cushing’s syndrome with bilateral adrenal masses
Ya-Wun Guo, Chii-Min Hwu, Justin Ging-Shing Won, Chia-Huei Chu, Liang-Yu Lin
Endocrinology, Diabetes & Metabolism Case Reports.2016;[Epub] CrossRef
Bilateral Adrenocortical Masses Producing Aldosterone and Cortisol Independently
Seung-Eun Lee, Jae Hyeon Kim, You-Bin Lee, Hyeri Seok, In Seub Shin, Yeong Hee Eun, Jung-Han Kim, Young Lyun Oh
Endocrinology and Metabolism.2015; 30(4): 607. CrossRef
Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
Won-Young Lee
Endocrinology and Metabolism.2014; 29(3): 251. CrossRef
A Case of Bilateral ACTH-independent Adrenal Adenomas with Cushing's Syndrome Treated by Ipsilateral Total and Contralateral Partial Laparoscopic Adrenalectomy
Seung Ah Park, Dong min Jung, Soon young Kim, Nan Young Choi, Tae-jun Kim, Yong kyun Kim, Seong kyun Na, Chul Sik Kim, Seong Jin Lee, Sung-Hee Ihm, Jun Goo Kang
The Korean Journal of Obesity.2013; 22(4): 254. CrossRef

Author index