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Department of Endocrinology and Metabolism, Kyung Hee University College of Medicine, Seoul, Korea
Copyright © 2020 Korean Endocrine Society
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
CONFLICTS OF INTEREST
No potential conflict of interest relevant to this article was reported.
Size | Function | Hormone | Pathology (WHO)a | Morphofunctional subclassificationa |
---|---|---|---|---|
Microadenoma Macroadenoma Giant adenoma |
Functioning Non-functioning |
Prolactin | Lactotroph adenoma (LA) |
Sparsely granulated LA Densely granulated LA Acidophilic stem cell adenoma |
Growth hormone | Somatotroph adenoma (SA) |
Densely granulated SA Sparsely granulated SA Mammosomatotroph adenoma Mixed somatotroph and lactotroph adenoma |
||
Adrenocorticotropic hormone | Corticotroph adenoma (CA) |
Sparsely granulated CA Densely granulated CA Acidophilic stem cell adenoma |
||
Thyroid-stimulating hormone | Thyrotroph adenoma | |||
Luteinizing hormone/follicular-stimulating hormone | Gonadotroph adenoma (GA) null cell adenoma | Sparsely granulated GA | ||
Plurihormonal | Plurihormonal adenoma |
Plurihormonal PIT1-positive adenoma Adenomas with unusual IHC combinations |
||
Double adenoma | Distinct adenomas |
WHO, World Health Organization; PIT1, pituitary-specific positive transcription factor 1; IHC, immunohistochemical.
a Adapted from Laws et al. [10], with permission from Springer Nature.