Fig. 1Papillary thyroid microcarcinoma (PTMC) patients were grouped by treatment type and matched by thyrotropin (TSH) levels for comparisons between groups. TT, total thyroidectomy; RAI, radioactive iodine remnant ablation.
Table 1Baseline Characteristics of Patients with Papillary Thyroid Microcarcinoma
Characteristic |
Total population |
Post-matchinga
|
TT only (n=107) |
TT-RAI (n=182) |
P value |
TT only (n=100) |
TT-RAI (n=100) |
P value |
Age, yr |
54.24±8.99 |
52.91±9.47 |
0.24 |
54.13±8.71 |
52.87±9.68 |
0.33 |
Female sex |
96 (90) |
150 (82) |
0.13 |
93 (93) |
83 (83) |
0.14 |
Marital status |
|
|
|
|
|
|
Married |
86 (80) |
164 (90) |
0.031 |
83 (83) |
90 (90) |
0.21 |
Education level |
|
|
|
|
|
|
College degree or higher |
40 (37) |
86 (47) |
0.13 |
39 (39) |
43 (43) |
0.67 |
Current employment status |
|
|
|
|
|
|
Employed |
46 (43) |
90 (49) |
0.34 |
42 (42) |
51 (51) |
0.26 |
Socioeconomic status |
|
|
0.11 |
|
|
0.07 |
Upper |
49 (46) |
64 (35) |
45 (45) |
31 (31) |
Middle |
40 (37) |
92 (50) |
39 (39) |
55 (55) |
Lower |
18 (17) |
27 (15) |
16 (16) |
14 (14) |
Serum TSH, mIU/Lb
|
0.35±4.85 |
0.16±4.39 |
<0.001 |
0.30±4.34 |
0.25±4.42 |
0.38 |
Table 2Pathologic Findings and Radioactive Iodine Dose of the Patients
Variable |
TT only (n=107) |
TT-RAI (n=182) |
TNM stage |
|
|
T1 |
107 (100) |
182 (100) |
Microscopic ETE |
2 (1.9) |
116 (63.4) |
N0 |
107 (100) |
76 (41.8) |
N1a |
- |
106 (58.2) |
M0 |
107 (100) |
182 (100) |
RAI preparation |
|
|
T4 withdrawal |
- |
142 (78.0) |
rhTSH |
- |
40 (22.0) |
RAI dose |
|
|
1.11 GBq (30 mCi) |
- |
72 (39.6) |
2.96 GBq (80 mCi) |
- |
110 (60.4) |
Table 3Quality of Life Parameters According to Treatment
Variable |
Total population |
Post-matchinga |
TT only (n = 107) |
TT-RAI (n = 182) |
P value |
TT only (n = 100) |
TT-RAI (n = 100) |
P value |
SF-12 v2 |
|
|
|
|
|
|
PCS |
50.44±6.50 |
50.16±6.81 |
0.72 |
50.83±6.45 |
49.40±6.97 |
0.13 |
Physical functioning |
49.19±8.72 |
49.50± 8.15 |
0.76 |
49.74±8.16 |
48.11±8.21 |
0.16 |
Role-physical |
46.94±7.54 |
47.12±8.06 |
0.86 |
47.05±7.55 |
46.46±7.86 |
0.59 |
Bodily pain |
52.25±6.98 |
51.78±8.23 |
0.62 |
52.32±6.66 |
51.33±8.04 |
0.34 |
General health |
49.96±6.33 |
48.82±7.30 |
0.18 |
49.96±6.19 |
48.05±7.29 |
<0.05 |
MCS |
48.14±9.24 |
48.13±8.96 |
0.99 |
47.83±9.24 |
47.50±8.34 |
0.78 |
Vitality |
49.71±10.92 |
49.55±10.20 |
0.90 |
49.56±11.04 |
48.97±9.93 |
0.69 |
Social functioning |
51.91±8.57 |
51.77±7.94 |
0.86 |
52.28±7.94 |
51.74±7.81 |
0.63 |
Role-emotional |
45.16±9.93 |
44.80±10.73 |
0.78 |
45.05±9.82 |
43.44±10.22 |
0.26 |
Mental health |
48.88±9.08 |
49.40±9.01 |
0.64 |
48.49±9.25 |
48.66±8.94 |
0.89 |
THYCA-QoL |
|
|
|
|
|
|
Neuromuscular |
48.21±15.40 |
49.73±16.08 |
0.43 |
48.08±14.60 |
50.83±15.51 |
0.20 |
Voice |
37.73±14.36 |
37.84±16.69 |
0.95 |
37.75±14.10 |
38.25±15.67 |
0.81 |
Concentration |
41.59±16.45 |
38.94±16.00 |
0.18 |
40.50±15.30 |
39.88±16.35 |
0.78 |
Sympathetic |
44.16±17.62 |
45.28±19.13 |
0.62 |
43.75±17.18 |
45.91±19.19 |
0.40 |
Throat/mouth |
38.40±10.60 |
39.84±13.84 |
0.32 |
38.42±10.65 |
40.25±12.37 |
0.26 |
Psychological |
44.04±13.61 |
44.54±14.47 |
0.77 |
43.94±12.79 |
45.69±13.75 |
0.35 |
Sensory |
48.13±19.10 |
49.18±18.33 |
0.65 |
47.88±18.97 |
50.00±18.63 |
0.43 |
Problems with scar |
38.55±21.52 |
35.85±19.20 |
0.27 |
38.25±20.86 |
36.25±19.26 |
0.48 |
Felt chilly |
34.58±15.22 |
38.60±19.05 |
0.05 |
33.50±13.40 |
38.75±19.59 |
<0.05 |
Tingling hands/feet |
48.83±17.97 |
50.41±20.60 |
0.51 |
48.25±17.86 |
51.00±20.08 |
0.31 |
Gained weight |
44.86±24.46 |
43.96±22.40 |
0.75 |
45.00±24.36 |
47.75±23.33 |
0.42 |
Headache |
40.65±17.69 |
42.58±19.49 |
0.40 |
40.50±17.69 |
42.50±18.97 |
0.44 |
Less interest in sex |
42.06±18.04 |
42.86±18.50 |
0.72 |
42.25±17.30 |
40.75±16.54 |
0.53 |
Fear of progression |
|
|
|
|
|
|
Affective reactions |
1.93±0.71 |
1.95±0.83 |
0.86 |
1.94±0.70 |
1.96±0.81 |
0.80 |
Partnership/family |
1.83±0.68 |
1.93±0.92 |
0.30 |
1.84±0.69 |
1.90±0.73 |
0.53 |
Work |
1.53±0.72 |
1.51±0.75 |
0.87 |
1.51±0.73 |
1.44±0.65 |
0.48 |
Loss of autonomy |
1.58±0.62 |
1.61±0.71 |
0.76 |
1.59±0.63 |
1.61±0.67 |
0.84 |
Coping with anxiety |
2.89±0.83 |
3.06±0.94 |
0.13 |
2.89±0.81 |
3.08±0.97 |
0.13 |